Narrative nursing for negative emotions in patients with acute pancreatitis:Based on model construction and application

BACKGROUND Acute pancreatitis(AP),as a common acute abdomen disease,has a high incidence rate worldwide and is often accompanied by severe complications.Negative emotions lead to increased secretion of stress hormones,elevated blood sugar levels,and enhanced insulin resistance,which in turn increases the risk of AP and significantly affects the patient's quality of life.Therefore,exploring the intervention effects of narrative nursing programs on the negative emotions of patients with AP is not only helpful in alleviating psychological stress and improving quality of life but also has significant implications for improving disease outcomes and prognosis.AIM To construct a narrative nursing model for negative emotions in patients with AP and verify its efficacy in application.METHODS Through Delphi expert consultation,a narrative nursing model for negative emotions in patients with AP was constructed.A non-randomized quasi-experimental study design was used in this study.A total of 92 patients with AP with negative emotions admitted to a tertiary hospital in Nantong City of Jiangsu Province,China from September 2022 to August 2023 were recruited by convenience sampling,among whom 46 patients admitted from September 2022 to February 2023 were included in the observation group,and 46 patients from March to August 2023 were selected as control group.The observation group received narrative nursing plan,while the control group was given with routine nursing.Self-rating anxiety scale(SAS),self-rating depression scale(SDS),positive and negative affect scale(PANAS),caring behavior scale,patient satisfaction scale and 36-item short form health survey questionnaire(SF-36)were used to evaluate their emotions,satisfaction and caring behaviors in the two groups on the day of discharge,1-and 3-month following discharge.RESULTS According to the inclusion and exclusion criteria,a total of 45 cases in the intervention group and 44 cases in the control group eventually recruited and completed in the study.On the day of discharge,the intervention group showed significantly lower scores of SAS,SDS and negative emotion(28.57±4.52 vs 17.4±4.44,P<0.001),whereas evidently higher outcomes in the positive emotion score,Caring behavior scale score and satisfaction score compared to the control group(P<0.05).Repeated measurement analysis of variance showed that significant between-group differences were found in time effect,inter-group effect and interaction effect of SAS and PANAS scores as well as in time effect and inter-group effect of SF-36 scores(P<0.05);the SF-36 scores of two groups at 3 months after discharge were higher than those at 1 month after discharge(P<0.05).CONCLUSION The application of narrative nursing protocols has demonstrated significant effectiveness in alleviating anxiety,ameliorating negative emotions,and enhancing satisfaction among patients with AP.

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

A case of chemical eye injuries and aspiration pneumonia caused by occupational acute chemical poisoning

Dear editor,According to the China’s National Standard Diagnostic Criteria of Occupational Diseases,occupational acute chemical poisoning refers to the short-term exposure of workers to several chemicals during production,resulting in corresponding organ damage.Herein,we report a case of chemical eye injuries and aspiration pneumonia caused by acute chemical poisoning in the chemical industry.

Bibliometrics and visual analysis for clinical research on intervention of traditional Chinese medicine nursing technology on rheumatoid arthritis

Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.

Beware of the serious harm of veterinary drug poisoning:a case report

Veterinary drugs are substances(including pharmaceutical feed additives)used to prevent,treat,and diagnose diseases or regulate the physiological functions of animals.Veterinary drug poisoning in humans is relatively rare both in China and the rest of the world.Here,we report a case of death from veterinary drug poisoning from avermectin-closantel.Avermectin-closantel is a broad-spectrum antiparasitic drug,which has high efficacy against a variety of trematodes and nematodes.

Changes in Health Consciousness of Nursing Students in Japan after Acquiring Medical Care Knowledge from a Nursing School

Background: Health consciousness in daily life is very important because lifestyle habits, such as dietary and exercise habits, sleep, and smoking, are involved in the development and progression of lifestyle-related diseases, such as cancer, heart diseases, stroke, liver diseases, kidney diseases, and diabetes. Purpose: In this study, we surveyed to see if the health consciousness increased and what behaviors in daily life changed in students of a nursing school (Seiwa Nursing College, Tokyo, Japan) after they learned medical care knowledge required to become a nurse. Results: After learning medical care knowledge for 3 years, the students were found to have a higher level of health consciousness in the third year than they did in the first year. They applied the medical care knowledge they learned in daily life. All data were collected in 2019. Conclusions: The medical care knowledge learned in a nursing school was demonstrated to serve as information to increase the health consciousness.

Repeated measurements of depression and outcomes in patients receiving hemodialysis

Objective:Depression appears to be common among the patients with end-stage renal disease(ESRD).Therefore,how to comprehensively analyze the changes in depression and its impact on patient outcomes is an impor tant research direction.The objectives of this study were to assess changes in depression and whether depression can be used to predict outcomes in patients receiving hemodialysis.Methods:In a longitudinal study,317 patients receiving hemodialysis from two hospitals were investigated.Depression was assessed using the Hamilton Depression Scale(HAMDS)at baseline.Outcomes data(survival and mor tality)were collected from baseline to the end of follow-up 2 years later.Mor tality was assessed using Cox propor tional hazards analysis.Results:The HAMDS score and percentage of high scores increased at three time points.Moreover,the changes were statistically significant.Surviving patients had significantly lower HAMDS scores.Through multivariate Cox regression analysis,age and depression can be used to predict mor tality(P<0.05),and the relative risks(RRs)were 1.032 and 1.069,respectively.Conclusions:Depression in patients receiving hemodialysis is worse.Moreover,baseline depression is an independent predictor of outcomes.Patients receiving hemodialysis should be focused on improving their psychological complications.A systematic and individual psychological health promotion plan must also be incorporated into the health education plan for patients receiving hemodialysis.

Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR

Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.

Comparative Analysis of Steel Plates and PLA Used for Joint Repair in Humans and Canines

The exploration of fracture internal fixation materials has been one of the research hotspots in the field of biomedical materials.The traditional internal fixation material for fracture is metal fixation.Although its mechanical strength is very large,it can not be degraded and absorbed in human body after implantation of human body or canine joint,which requires a secondary operation to remove,which not only brings pain to patients,but also causes economic pay.[1]Therefore,the development of a biodegradable fracture internal fixation material has become the goal of many researchers.Polylactic acid(PLA)is nontoxic and harmless,has good biocompatibility and strong mechanical properties.It can be degraded in vivo after implantation.The degradation products are CO2 and H2O.[2]For the study of the feasibility of polylactic acid as a substitute for common fracture fixation materials,18 northern Chinese pastoral dogs were randomly divided into blank group,PLA group and plate group.The data were recorded according to the Wakitani score from the first week to the fifteenth week after operation.First,all the indexes were divided into two categories by principal component analysis[3],then the blank group,steel plate group and PLA group were fitted and compared.Finally,it is concluded that PLA is more beneficial to joint repair than steel plate.

Association between hip abductor function,rear-foot dynamic alignment,and dynamic knee valgus during single-leg squats and drop landings

Background： Preventing anterior cruciate ligament（ACL） injuries is very important for athletes, and dynamic knee valgus is considered a risk factor for non-contact ACL injury. However, little is known about whether the functions of the hip abductor and rear-foot increase dynamic knee valgus. A two-dimensional（2D） video-based screening test focused on hip abductor and rear-foot functions among factors involved in dynamic knee valgus. The present study determined associations between hip and rear-foot dynamic alignment and dynamic knee valgus.Methods： This cross-sectional study recruited 130 female basketball players（258 legs） from nine high-school teams. The players performed single-leg squats and single-leg drop landings to provide knee-in（KID） and hip-out（HOD） distances on 2D video images. Hip and rear-foot dynamic alignment was evaluated using a dynamic Trendelenburg test（DTT） and a dynamic heel-floor test（HFT）.Results： The Chi-square test revealed no significant difference in the prevalence of DTT-positivity between single-leg squats（28.7%） and singleleg drop landings（23.3%）. The prevalence of HFT-positivity was significantly greater during landings（51.4%） than during single-leg squats（31.0%, p 〈 0.01）. The KID values for both single-leg squats and single-leg drop landings were greater in the DTT-positive than in the DTTnegative group（15.1 5.4 cm and 20.2 7.5 cm, p 〈 0.001）. The HOD values were similarly greater in the DTT-positive group（15.2 1.9 cm and 17.6 2.8 cm, p 〈 0.001）. The KID values for both single-leg squats and single-leg drop landings were greater in the HFT-positive than in the HFT-negative group（12.2 5.1 cm, p 〈 0.01; 14.7 7.2 cm, p 〈 0.001）, whereas HOD values for these tasks did not significantly differ between the two groups.Conclusion： Dynamic hip mal-alignment might be associated with both greater KID and HOD, whereas rear-foot eversion is associated only with greater KID. Hip abductor and rear-foot dysfunction are important factors for dynamic knee valgus and thus evaluating DTT and HFT will help to prevent dynamic knee valgus.

Factors influencing the optimal selection of central venous access devices:A qualitative study of health care team members’perspectives

Objective:This study aimed to explore health care team members’understanding of the factors influencing the optimal selection of central venous access devices(CVADs).Methods:The data of the study was collected using semi-structured interviews.Twenty-six hospital medical staff(four hospital manager,15 head nurses,7 nurse)with experience in peripheral or central catheterization from four regions(Northern China,Southern China,Northwest China,and Qinghai-Tibet China)in China were interviewed between June and October 2021.Content analysis was used to analyze the data.Results:The results revealed five themes and 14 sub-themes.Patients:concerns,resources,requirements,and evaluation(security concerns,support resources,life requirements,evaluation among patients);nurses:awareness,knowledge,and popularizing methods(awareness of intravenous therapy,understanding of professional knowledge,forms of popularizing methods);doctors:support and involvement(support for decision-making,involvement in intravenous work);hospital managers:authority,quality control and continuing education(management of catheterization authority,quality control of intravenous infusion,investment in continuing education)and environment:differences and commonalities(differences in social support,and current commonalities).Conclusion:Nurses and other healthcare team members’understanding,selection,use,and recommendation of CVADs have an indirect effect on patients’decision-making.Therefore,hospital managers and government departments can indirectly strengthen medical team cooperation and improve learning education in order to improve the safety of patients receiving intravenous infusions.

Clinical analysis of pipeline dredging agent poisoning:A case report

BACKGROUND Pipeline dredging agents are new household deep cleaning products used to dredge blockages in kitchen and bathroom pipeline caused by grease,hair,vegetable residue,paper cotton fibre,and other organic substances.Pipeline dredging agents are corrosive chemicals that can cause poisoning through corrosive damage to the digestive tract;however,this has not been reported clinically.Therefore,this report emphasises that oral pipeline dredging agent poisoning can cause corrosive damage to the digestive tract and may have serious health consequences.CASE SUMMARY A 68-year-old man consumed liquor(200 m L) at approximately 13:00 on April 22,2021.At approximately 16:00,his family found him unresponsive with blackened lips,blood spots in the corners of the mouth,and blood stains on the ground,as well as an empty bottle of a pipeline dredging agent.One hour later,he was admitted to the emergency department of a local hospital.Considering the empty bottle,he was suspected to have sustained severe corrosive damage to the digestive tract and was transferred to our department at 23:15 on April 22,2021.He developed dysphagia and intermittent fever and experienced difficulty in opening his mouth throughout his hospital stay.The patient’s condition gradually stabilised.However,he suddenly developed respiratory failure on day 12,and endotracheal intubation and ventilator-assisted ventilation were performed.However,the patient died after 1.5 h despite emergency rescue efforts.CONCLUSION Pipeline dredging agents are highly corrosive and may cause corrosive damage to the digestive tract and asphyxia upon consumption.

The correlation between socioeconomic status and health self-management in the elderly

Purpose:To determine the correlation between socioeconomic status and health selfmanagement in the elderly and to provide a scientific basis for the promotion of healthy ageing.Methods:We recruited 6173 people aged
60 years from three regions in Hebei Province using the multi-stage stratified cluster sampling method.The participants were surveyed using questionnaires.Results:The health self-management behaviours of elderly people differed with the area of residence,education level,and personal monthly income.An ordered probit model showed that behaviours were better in elderly people who lived in urban areas,who were educated to college level or higher,and with higher monthly incomes(p<0.05).Conclusion:Socioeconomic status plays a decisive role in health self-management in the elderly.We suggest appropriate measures for promoting health self-management among the elderly.

Effect of Silica Nanoparticles on Cultured Central Nervous System Cells

Nanotechnology is developing rapidly and the production of novel man-made nanoparticles is increasing. However, the effects of these particles on human health are unevaluated. Depending on particle size and the surface properties, nanoparticles may have the potential to affect human health. In recent studies, several silica nanoparticles (<100 nm) were shown to be penetrating into the brain. Thus, it is important to understand the influence of these nanoparticles on the central nervous system. In this study, we investigated the toxicological influence of nanoparticles on cortical cultured neurons isolated from embryonic day 18 Wister rats. Cortical cultured neurons at 21 days in vitro (DIV) were treated with 30 nm silica nanoparticles for 1 hr. Many neurons were damaged immediately more than at 0.01 mg/ml concentration of silica. Cell damage was also assessed using the lactate dehydrogenase (LDH) assay and the reactive oxygen species (ROS) assay. We revealed that the Neuro-toxicological mechanisms were due to membrane permeability. It was suggested that cell membrane permeability was enhanced because of ROS generation. Given these results, it will be important to determine the effect of nano-silica particles in vivo and identify the extent of neuronal damage.

TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial

Background:Hypoxia is a significant risk factor of hypertension.However,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy individuals.Oxygen saturation(SpO_(2))is often used for traditional monitoring of vital signs.This study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in altitude.The trial was registered at ClinicalTrials.gov(registration no.NCT06076057).Methods:Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 min.The Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement site.The Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 m.Results:Altogether,49 healthy volunteers were recruited between March 2023 and August 2023.With increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(P<0.01).During the ascent from 0 m,TcPO_(2)began to change statistically at 500 m(P<0.05),whereas SpO_(2)began to change statistically at 1000 m(P<0.05).At the same altitude,the difference in TcPO_(2)was greater than the difference in SpO_(2).At 1000 m,there were statistically significant changes in TcPO_(2)and SpO_(2)(P<0.001).At altitudes>500 m,statistical significance was identified between TcPO_(2)in both sexes(P<0.05).Statistical significance in TcPCO_(2)and heart rate was observed at the different elevations(P<0.05).Conclusion:In acutely changing low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).

Successful or pathological cognitive aging?Converging into a“frontal preservation,temporal impairment(FPTI)”hypothesis

Most elderly individuals experience cognitive decline with increasing age[1],some even suffer from pathological cognitive aging,such as dementia;however,there are exceptional elderly individuals who maintain superior cognitive performance,and they are referred to as those who have experienced successful cognitive aging(SCA)[2].The majority of research has been on pathological cognitive aging and its neural mechanisms,and much less is known about SCA[3].How is SCA characterized neuroanatomically?Specifically,whether SCA individuals’better cognitive maintenance is related to lessening pathological damage to the brain or to the higher preservation of specific brain characteristics that are not related to pathology?The neural mechanisms causing this wide array of individual cognitive differences in aging are largely unknown.