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Influence of Tanshinone lla on heat shock protein 70,Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury 被引量:9
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作者 Li Zhang Weidong Gan Guoyao An 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第36期2882-2888,共7页
Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue isch... Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone Ila can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone lla, 0.5 hour prior to model establishment. Results showed that Tanshinone Ila promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone Ila, compared with positive control Danshen injection. 展开更多
关键词 Tanshinone Ila DANSHEN spinal ischemia/reperfusion injury heat shock protein 70 BCL-2 BAX cellapoptosis Chinese medicine neural regeneration
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Tanshinone IIa antagonizes spinal ischemia/reperfusion injury by interfering with upstream glutamic acid factors 被引量:2
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作者 Li Zhang Xiang Lin +1 位作者 Weinan Liu Jianhua Lin 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第20期1573-1577,共5页
Based on the hypothesis that upstream factor inhibition results in better treatment effects than downstream factor inhibition,the present study interfered with glutamic acid(Glu)-released upstream factors,such as Gl... Based on the hypothesis that upstream factor inhibition results in better treatment effects than downstream factor inhibition,the present study interfered with glutamic acid(Glu)-released upstream factors,such as Glu transporter function and Na+-K+-adenosine triphosphatases(ATPase)activity relativly.Rats with spinal cord ischemia/reperfusion injury received intraperitoneal injections of tanshinone Ila and Glu uptake and Na+-K+-ATPase activity were increased.Results showed that tanshinone Ila influenced Glu-released upstream factors following spinal ischemia/reperfusion injury and protected against spinal ischemia/reperfusion injury. 展开更多
关键词 spinal cord ischemia/reperfusion injury TANSHINONE glutamic acid transporter Na+-K+-ATPase neural regeneration
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