Objective To explore whether the changes on lipids profile induced by oral contraceptives could be reduced through alternatively administering two oral contraceptives of different formulations (either predominant in p...Objective To explore whether the changes on lipids profile induced by oral contraceptives could be reduced through alternatively administering two oral contraceptives of different formulations (either predominant in progestogen or estrogen) Materials &. Methods A total of 59 women aged 25- 45 were divided into two treatment groups.The subjects in Group A received oral contraceptive A (Oc A: NET 0. 600 mg + EE 0. 035 mg) and B (OcB: LNG 0. 15mg + EEO. 03 mg) alternatively during 12 treatment cycles. Each contraceptive was administrated for three cycles consecutively with starting from OcA. The subjects in the B group received OcB only during 12 treatment cycles. Fasting blood were drawn before treatment, at the end of each trimester treatment and at the end of one cycle after stopping treatment respectively. The concentrations of lipids and apolipoproteins were measured.Results OcA increased the levels of triglyceride(TG) , total cholesterol (TC), high density lipoprotein-cholesterol(HDL-c) , and apolipoprotein AI (apo AI) with statistical significance, whereas OcB significantly decreased all parameters above. As compared with the control group, the overall mean of variation in the study group was much less than that of the control group.Conclusion It indicates that the impacts of oral contraceptives on lipids profile could be moderated by means of alternatively administering Ocs of two different formulations , with estrogen-dominant or progestogen-dominant.展开更多
The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volu...The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.展开更多
基金This study was supported by the State Family Planning Committee
文摘Objective To explore whether the changes on lipids profile induced by oral contraceptives could be reduced through alternatively administering two oral contraceptives of different formulations (either predominant in progestogen or estrogen) Materials &. Methods A total of 59 women aged 25- 45 were divided into two treatment groups.The subjects in Group A received oral contraceptive A (Oc A: NET 0. 600 mg + EE 0. 035 mg) and B (OcB: LNG 0. 15mg + EEO. 03 mg) alternatively during 12 treatment cycles. Each contraceptive was administrated for three cycles consecutively with starting from OcA. The subjects in the B group received OcB only during 12 treatment cycles. Fasting blood were drawn before treatment, at the end of each trimester treatment and at the end of one cycle after stopping treatment respectively. The concentrations of lipids and apolipoproteins were measured.Results OcA increased the levels of triglyceride(TG) , total cholesterol (TC), high density lipoprotein-cholesterol(HDL-c) , and apolipoprotein AI (apo AI) with statistical significance, whereas OcB significantly decreased all parameters above. As compared with the control group, the overall mean of variation in the study group was much less than that of the control group.Conclusion It indicates that the impacts of oral contraceptives on lipids profile could be moderated by means of alternatively administering Ocs of two different formulations , with estrogen-dominant or progestogen-dominant.
文摘The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.
