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Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast 被引量:2
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作者 XIAOTi-Qiao ZHANGGui-Lin +3 位作者 XUHong-Jie TIANYu-Lian HUANGWan-Xia ZHUPei-Ping 《Nuclear Science and Techniques》 SCIE CAS CSCD 2003年第4期217-221,共5页
An experimental study on nondestructive X-ray imaging of inner structure of soft tissues in phase con-trast has been conducted with Beijing Synchrotron Radiation Facility (BSRF). Modification to the beamline setupwas ... An experimental study on nondestructive X-ray imaging of inner structure of soft tissues in phase con-trast has been conducted with Beijing Synchrotron Radiation Facility (BSRF). Modification to the beamline setupwas made to enlarge the X-ray beam section and consequently larger samples could be imaged. In-line setup was em-ployed for experiments. Results on a series of samples were given and soft-tissue details of less than 50 μm inside afresh goldfish were obtained. Diagnosis of tumor in its early stage was also investigated taking SD rats as the model.Tumor at the size of ~ 100μm was observed. Potential of this technique in clinic diagnosis was discussed. 展开更多
关键词 X射线成像 北京 同步加速器辐射装置 BSRF 肿瘤诊断
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Recent progress of nuclear liquid gas phase transition 被引量:1
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作者 MAYu-Gang SHENWen-Qing 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第1期4-29,共26页
Recent progress on nuclear liquid gas phase transition (LGPT) has been reviewed, especially for the signals of LGPT in heavy ion collisions. These signals include the power-law charge distribution, cluster emission ra... Recent progress on nuclear liquid gas phase transition (LGPT) has been reviewed, especially for the signals of LGPT in heavy ion collisions. These signals include the power-law charge distribution, cluster emission rate, nuclear Zipf law, bimodality, the largest fluctuation of the fragments, Δ-scaling, caloric curve, phase coexis- tence diagram, critical temperature, critical exponent analysis, negative specific heat capacity and spinodal instability etc. The systematic works of the authors on experimental and theoretical LGPT are also introduced. 展开更多
关键词 核液化气相变 LGPT 重离子碰撞 临界温度 热量曲线
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Radiolabeling of N-Succinimidyl-3-[(125)~I]iodobenzoate intermediate 被引量:1
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作者 WANGLi-Hua WANGYong-Xian YINDuan-Zhi LIJun-Ling 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第1期43-45,共3页
Organostannanes were important precursors which was easy to radioiodinate. N-Succinimidyl-3- (tri-n-butylstannyl) benzoate (STB) was radiolabeled using Iodogen to get radioactive N-Succinimidyl-3-iodobenzo- ate (S125I... Organostannanes were important precursors which was easy to radioiodinate. N-Succinimidyl-3- (tri-n-butylstannyl) benzoate (STB) was radiolabeled using Iodogen to get radioactive N-Succinimidyl-3-iodobenzo- ate (S125IB) with 96% of high radiochemical yield. The optimization of labeling condition was explored in this study. S125IB was stable at room temperature in dark. Cold SIB was prepared as a standard and IR and NMR results were given in this article. 展开更多
关键词 放射性同位素示踪 STB 稳定性 放射化学
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Avidin chase reduces side effects of radioimmunotherapy in nude mice bearing human colon carcinoma 被引量:1
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作者 Gui-PingLi Yong-XianWang +2 位作者 KaiHuang HuiZhang Chun-FuZhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第13期1917-1921,共5页
AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)wa... AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)was biotinylated with NHS-biotin, and then radiolabeled with 188Re by the direct method. 188Re-labeledbiotinylated anti-CEA McAb (188Re-CEA McAb-Bt) was intravenously injected followed by intravenous injection of avidin after 24 h. SPECT imaging and biodistribution study were performed at 28-48 h after the injection of 188Re-CEA McAb-Bt. Three groups of nude mice subcutaneously grafted with human colon carcinoma were treated 7 d after the graft. Mice in the avidin chase group received intravenous injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg) followed by intravenous injection of cold avidin (80 μg) after 24 h. Mice in the control group (treated group without avidin chase) only received the injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg), another control group (non-treated group) only received 0.1 mL normal saline solution. Toxicity was evaluated on the basis of change of body weight and peripheral WBC counts, and therapy effects were determined by variation in tumor volume. Histological analysis of tumors was also performed.RESULTS: Avidin chase markedly accelerated the clearance of 188Re-CEA McAb-Bt from the blood and normal tissues. The tumor uptakes of 188Re-CEA Mc Ab-Bt at 28 h were 5.90 and 6.42% ID/g, respectively, in chase group and in non-chase group, while the tumor-to-background (T/NT) ratios were 3.19 and 0.56, respectively. The tumor uptake was slightly decreased by avidin chase, but the T/NT ratios were increased. In treated groups the growth rate of body weight and the number of WBC decreased after injection of 188Re-CEA McAb-Bt, and the WBC counts recovered earlier in the group with avidin chase than in the group without avidin chase. Compared to the nontreated group, treated groups with and without avidin chase showed significant anti-tumor effects.CONCLUSION: Avidin chase can effectively reduce the side effects of RIT, and improve therapeutic efficacy. 展开更多
关键词 Avidin chase RADIOIMMUNOTHERAPY Side effects Colon cancer Nude mice
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Drop Size Dependence of the Contact Angle of Nanodroplets 被引量:2
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作者 郭宏凯 方海平 《Chinese Physics Letters》 SCIE CAS CSCD 2005年第4期787-790,共4页
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Induced ion-channel instability
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作者 DAIZhi-Min 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第2期65-69,共5页
In this paper, a new mechanism of electromagnetic instability, the induced ion-channel instability, is stud- ied. It is based on the transverse driven betatron oscillation of relativistic electron beam induced by an a... In this paper, a new mechanism of electromagnetic instability, the induced ion-channel instability, is stud- ied. It is based on the transverse driven betatron oscillation of relativistic electron beam induced by an additional magnetic undulator with a period close to the betatron wavelength in an ion channel. As its amplitude is sensitive to the electron beam energy, the driven betatron oscillation may determine electron beam grouping in the ponderomotive potential by selecting the undulator strength and period, and it provides a new mechanism of electron bunching, re- sulting in electromagnetic instability. Under proper condition, a new free-electron laser based on this mechanism may be realized. 展开更多
关键词 自由电子激光器 离子轨道 不稳定性 从动共振 电子感应加速器
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Digital RF phase detector for Linac in FEL accelerator
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作者 YULu-Yang YINChong-Xian LIUDe-Kang 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第2期76-81,共6页
The digital RF (Radio Frequency) phase detector based on commercial PXI (PCI eXtensions for Instru- mentation) modules for the Linac is fully described in the paper. The DBM (Double Balance Mixer) is used as the phase... The digital RF (Radio Frequency) phase detector based on commercial PXI (PCI eXtensions for Instru- mentation) modules for the Linac is fully described in the paper. The DBM (Double Balance Mixer) is used as the phase detector and its control and data acquisition system is based on the PXI bus. The software adopts a curve fitting algorithm. The prototype has been tested in the laboratory and the good resolution, accuracy, reproducibility and re- liability are expected. The system does not present the problems of analog solution. 展开更多
关键词 数字射频相位探测器 双重平衡混合器 模拟解 FEL 加速器
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Phase servo tuner control system of SSRF 500MHz cavity
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作者 WANGFang. WANGGuang-Wei LUJian-Fa 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第1期1-3,共3页
Eight 500 MHz cavities are applied in the storage ring of the Shanghai Synchrotron Radiation Factility (SSRF). In order to tune the cavities for different changing parameters and operation modes, the control system is... Eight 500 MHz cavities are applied in the storage ring of the Shanghai Synchrotron Radiation Factility (SSRF). In order to tune the cavities for different changing parameters and operation modes, the control system is es- sential for operations. The tuning is achieved by synchronizing the drive signal and the cavity probe signal. The error signal defined as their subtraction is amplified and used to drive a stepping motor, which in turn moves a metallic plunger in or out of the cavity by programmable logic controller (PLC). The tune speed is set to be 1kHz/s. 展开更多
关键词 相位伺服调谐器 控制系统 SSRF 空腔谐振器 上海 同步加速器辐射装置 可编程序逻辑控制器
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Terahertz propagation in metal templates
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作者 HANJia-Guang ZHANGWei ZHUZhi-Yuan WANGZhen-Xia YULi-Ping SUNLi-Tao WANGTing-Tai 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第2期86-88,共3页
Terahertz (THz) propagation in a metal template has been theoretically demonstrated. The possible propagating frequencies and power transmittance have been calculated. The power transmittance curves are displayed with... Terahertz (THz) propagation in a metal template has been theoretically demonstrated. The possible propagating frequencies and power transmittance have been calculated. The power transmittance curves are displayed with different incident frequency and different geometric parameters. The oscillations of transmittance dependent on length of the template and the theoretical propagating bandwidth have been found. 展开更多
关键词 金属样板 传播频率 功率透射率 兆兆赫技术 波导管
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Characteristics of coherent diffraction terahertz radiation at SDUV-FEL
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作者 LIUAi-Qin LIUGui-Min DAIZhi-Min 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第2期70-75,共6页
Coherent diffraction radiation (CDR), generated by relativistic femtosecond electron bunches passing through an aperture in a metallic foil, is becoming widely used as a high brightness, coherent, polarized, and broad... Coherent diffraction radiation (CDR), generated by relativistic femtosecond electron bunches passing through an aperture in a metallic foil, is becoming widely used as a high brightness, coherent, polarized, and broad- band terahertz radiation source. It is one of the most promising technique for non-destructive beam diagnostics in ac- celerators. In this paper, how to produce CDR is studied by utilizing femtosecond electron bunches at wavelengths equal to or longer than the bunch length with the aperture size at the condition of a≤γλ/(2π), which is provided by Shanghai Deep Ultraviolet-Free Electron Laser (SDUV-FEL) facility. General characteristics of CDR at SDUV-FEL are analyzed and numerically calculated. The results show that the radiance of this radiation within the frequency range from 0.2 up to 5 terahertz greatly exceeds that available from conventional black body radiation or synchrotron radiation. 展开更多
关键词 一致衍射辐射 太赫辐射源 SDUV-FEL 金属薄片 同步加速器
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Studies on aggregation-propensities and secondary structural transformations of proteins
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作者 JlLi-Na GAOYong-Guang +3 位作者 ZHANGFeng LIHong-Tao HUHong-Yu HUJun 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第1期6-11,共6页
The insoluble and fibrillar aggregates of some proteins are thought to be the pathological cause of neu- rodegenerative diseases. The aggregation-propensities of different types of proteins were investigated by Thiofl... The insoluble and fibrillar aggregates of some proteins are thought to be the pathological cause of neu- rodegenerative diseases. The aggregation-propensities of different types of proteins were investigated by Thioflavine T fluorescence assay and atomic force microscopy imaging. Then, the structural transformations of the proteins from aqueous state to solid state were studied by circular dichroism spectroscopy. The results indicate that proteins of dif- ferent secondary structure show variations in their aggregation-propensities, together with their various structural transformations from aqueous state to solid state. Our studies imply that the structural transformation of proteins from solution to solid state is closely associated with their aggregation-propensities, which will provide insight into the molecular mechanism of protein aggregation in neurodegenerative diseases. 展开更多
关键词 聚集性质 次要结构变换 原子力学显微镜成像法 周期分色光谱 蛋白质 ThT荧光
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The property of Si/SiGe/Si heterostructure during thermal budget characterized by HRXRD
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作者 CHENChang-Chun LIUZhi-Hong +4 位作者 HUANGWen-Tao DOUWei-Zhi ZHANGWei TSIENPei-Hsin ZHUDe-Zhang 《Nuclear Science and Techniques》 SCIE CAS CSCD 2003年第4期238-241,共4页
Si/SiGe/Si heterostructures grown by ultra-high-vacuum chemical vapor deposition (UHVCVD) werecharacterized by Rutherford backscattering/Channeling (RBS/C) together with high resolution X ray diffraction(HRXRD). High ... Si/SiGe/Si heterostructures grown by ultra-high-vacuum chemical vapor deposition (UHVCVD) werecharacterized by Rutherford backscattering/Channeling (RBS/C) together with high resolution X ray diffraction(HRXRD). High quality SiGe base layer was obtained. The Si/SiGe/Si heterostructures were subject to conventionalfurnace annealing and rapid thermal annealing with temperature between 750 ℃ and 910 ℃. Both strain and its re-laxation degree in SiGe layer are calculated by HRXRD combined with elastic theory, which are never reported inother literatures. The rapid thermal annealing at elevated temperature between 880 ℃ and 910 ℃ for very short timehad almost no influence on the strain in Si0.84Ge0. 16 epilayer. However, high temperature (900℃) furnace annealingfor 1h prompted the strain in Si0.84Ge0.16 layer to relax. 展开更多
关键词 Si/SiGe/Si异质结构 热平衡 HRXRD 超高真空化学气相沉积 UHVCVD X射线衍射
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Theoretical calculation and experimental studies of rare tricyclic nucleoside derivative
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作者 ZHAOHongwei DOUDaying WANGWenfeng WUGuozhong YAOSide 《辐射研究与辐射工艺学报》 CAS CSCD 北大核心 2005年第2期76-76,共1页
关键词 三环核苷衍生物 激光光解 脉冲辐射分解 电离势能 辐射化学
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Study of radiation-induced grafting of acrylic acid-sodium styrene sulfonate onto poly (tetrafluoroethylene-co-hexafluoropropylene) film
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作者 WANGHeng-Dong YEYin ZHANGXue-Bing QIUShi-Long 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第1期25-30,共6页
Poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) films were immersed in aqueous solution of acrylic acid (AA) and sodium styrene sulfonate (SSS), then irradiated by Co γ-rays at 25℃. The effects of reaction 60... Poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) films were immersed in aqueous solution of acrylic acid (AA) and sodium styrene sulfonate (SSS), then irradiated by Co γ-rays at 25℃. The effects of reaction 60 time,absorbed dose, dose-rate, inhibitor and monomer concentration on the grafting yield were studied. Grafting yields of both AA and SSS onto FEP, respectively, increase with irradiation dose, but some saturation will appear at high dose and monomer concentration. The grafting yield increases with reaction time and then levels off. The graft- ing of SSS onto FEP is more difficult than the grafting of AA. The analysis of grafted membranes using DSC and FT-IR have been done. 展开更多
关键词 人工放射嫁接法 苯乙烯磺酸钠 四氟乙烯-六氟丙烷 高聚物
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Use of sampling based correction for non-radioactivity X-ray energy calibration
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作者 CHENGCheng WEIYong-Bo JIANGDa-Zhen 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第3期167-170,共4页
As the requirement of non-radioactivity measurement has increased in recent years,various energy cali- bration methods applied in portable X-ray fluorescence (XRF) spectrometers have been developed. In this paper,a sa... As the requirement of non-radioactivity measurement has increased in recent years,various energy cali- bration methods applied in portable X-ray fluorescence (XRF) spectrometers have been developed. In this paper,a sampling based correction energy calibration has been discussed. In this method both history information and current state of the instrument are considered and relative high precision and reliability can be obtained. 展开更多
关键词 X-射线荧光谱仪 能量刻度 修正指数 辐射探测器
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Pulse radiolysis study on aqueous solution of nicotine
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作者 WANGShi-Long MEIWang +2 位作者 NIYa-Ming YAOSi-De, WANGWen-Feng 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第1期35-38,共4页
Nicotine has been studied for the first time by pulse radiolysis techniques. It has been found that hy- drated electrons, hydrogen radicals and hydroxyl radicals can react with nicotine to produce anion radicals and n... Nicotine has been studied for the first time by pulse radiolysis techniques. It has been found that hy- drated electrons, hydrogen radicals and hydroxyl radicals can react with nicotine to produce anion radicals and neu- tral radicals, respectively, and the related rate constants have been determined. 展开更多
关键词 脉冲射解 烟碱 直线加速器 N-甲-2-5-吡咯烷酮
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Isoscaling Behaviour in the Isospin-Dependent Quantum Molecular Dynamics Model 被引量:1
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作者 田文栋 马余刚 +12 位作者 蔡翔舟 陈金根 陈金辉 方德清 郭威 马春旺 马国亮 沈文庆 王鲲 魏义彬 颜廷志 钟晨 左嘉旭 《Chinese Physics Letters》 SCIE CAS CSCD 2005年第2期306-309,共4页
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Nano-manipulation of single DNA molecules
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作者 HUJun LUJun-Hong, +6 位作者 LIHai-Kuo ANHong-Jie WANGGuo-Hua WANGYing LIMin-Qian ZHANGYi LIBin 《Nuclear Science and Techniques》 SCIE CAS CSCD 2004年第3期140-143,共4页
Nano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotech- nology. This review paper will focus on the recent development of the manipulation of single DNA molecules based on ... Nano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotech- nology. This review paper will focus on the recent development of the manipulation of single DNA molecules based on atomic force microscopy (AFM). Precise manipulation has been realized including varied manipulating modes such as “cutting”, “pushing”, “folding”, “kneading”, “picking up”, “dipping”, etc. The cutting accuracy is dominated by the size of the AFM tip, which is usually 10nm or less. Single DNA fragments can be cut and picked up and then amplified by single molecule PCR. Thus positioning isolation and sequencing can be performed. 展开更多
关键词 单DNA分子 纳米操纵 原子力显微镜 分子梳 分子切割
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Photochemical synthesis and characterization of novel narrow size distribution core-shell magnetic nanogels
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作者 SUNHanwen YUJiahui +4 位作者 GONGPeijun XUDongmei HONGJun ZHANGChunfu YAOSide 《辐射研究与辐射工艺学报》 CAS CSCD 北大核心 2005年第2期73-73,共1页
关键词 磁性纳米凝胶体 光化学法 核-壳结构 颗粒分布
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Parallel Momentum Distribution of ^28Si Fragments from ^29P 被引量:1
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作者 魏义彬 马余刚 +22 位作者 蔡翔舟 钟晨 陈金根 张虎勇 方德清 王鲲 马国亮 郭威 田文栋 沈文庆 詹文龙 肖国青 徐瑚珊 孙志宇 李加兴 郭忠言 王猛 陈志强 胡正国 陈立新 李琛 毛瑞士 白洁 《Chinese Physics Letters》 SCIE CAS CSCD 2005年第1期61-64,共4页
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