期刊文献+
共找到2,886篇文章
< 1 2 145 >
每页显示 20 50 100
Reflections on Designing the Curriculum for the Undergraduate English Majors--A Case Study of Shenzhen University
1
作者 Yi Liu 《Sino-US English Teaching》 2005年第2期59-61,共3页
When college students choose foreign languages as their majors, what are they supposed to learn? The traditional approach is to make a systematic study of the literatures of the target language, which used to be the ... When college students choose foreign languages as their majors, what are they supposed to learn? The traditional approach is to make a systematic study of the literatures of the target language, which used to be the practice of Chinese universities before 1949. Taiwan-based universities still carry that line of practice. After the People's Republic of China was founded, Chinese universities adopted the Soviet model, and Russian was taught across board in the foreign language departments of Chinese universities. As students had no foundation in Russian, the curriculum had to include a big proportion of language training, thus cutting down on the load of literary components. Other foreign language majors soon followed suit. Ever since China opened its doors to the outside and carried out economic reforms in 1979, linguistic courses have been introduced into the curriculum, such as general linguistics, lexicology and rhetoric. In the time of market economy, literature was considered irrelevant to the market economy, and the curriculum for language learning tended to be more practical, skill-based and business oriented. The top-down sanction of this popular value worked to turn situations from bad to worse: the National Syllabus for Juniors and Seniors Majoring in English (1990) excluded English Literature, American Literature and Linguistics from the list of required courses while making Reading and Writing compulsory. Correspondingly, language skill courses have become dominant in the curriculum and foreign language departments in China risk degenerating into language training schools. 展开更多
关键词 深圳大学 英语教学 课堂内容 交流方式 学习环境
下载PDF
Delayed Employment Among College Students in Guangdong-Taking Shenzhen University as an Example
2
作者 Jialiang Yang Feng Ding +1 位作者 Jing Sun Yujie Deng 《Journal of Contemporary Educational Research》 2022年第1期29-33,共5页
Changes in social structure and macro-environment have gradually made“delayed employment”a key area of social concern.This paper assumes the college students from Shenzhen University as research subjects,conducts a ... Changes in social structure and macro-environment have gradually made“delayed employment”a key area of social concern.This paper assumes the college students from Shenzhen University as research subjects,conducts a special research on delayed employment,explores the employment needs and status quo of college students,analyzes the causes and results of this phenomenon,as well as provides students with a more comprehensive and accurate understanding of employment.This paper also aims to increase the employment rate of graduates,enable reasonable allocation and management of human resources,as well as improve the quality of employment in the society. 展开更多
关键词 Delayed employment GRADUATES Employment policy
下载PDF
Effects of Seasonal and Temperature Variations on the Association between Nitrogen Dioxide Exposure and First-Aid Incidence for Neurological Diseases in Shenzhen,China
3
作者 Tongyu Yang Qingqing Wang +8 位作者 Yuchen Tian Siyi Chen Yilei Ma Peng Wang Suli Huang Ji Peng Jinquan Cheng Jing Hu Ping Yin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第10期1213-1220,共8页
Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditi... Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditions.In 2016,these disorders affected 276 million people worldwide and were the second leading cause of death that year[1].This highlights the urgent need for effective prevention,treatment,and support strategies.The etiology of neurological disorders is multifaceted and involves genetic,environmental,physiological,and social factors[2]. 展开更多
关键词 prevention ALZHEIMER DEATH
下载PDF
Epidemiological and Subtype Characterization of Influenza Viruses Infection in Children in Shenzhen, China during Three Consecutive Seasons (January 2016-December 2018)
4
作者 Yaxian Kuang Ruihong Ma +3 位作者 Lei Jia Qiang Yao Chenhui Zhang Xiaoying Fu 《Open Journal of Pediatrics》 2024年第5期851-864,共14页
Background: Children with seasonal influenza infection cause a significant burden of disease each year in the pediatric clinic. Influenza A and B viruses are the major types responsible for illness. A better understan... Background: Children with seasonal influenza infection cause a significant burden of disease each year in the pediatric clinic. Influenza A and B viruses are the major types responsible for illness. A better understanding of the periodicity facilitates the prevention and control of influenza in children. Objective: This study aims to analyze the epidemiological patterns and subtype characterization of influenza viruses among children in Shenzhen, China. Methods: Influenza samples were collected by nasopharyngeal swabs from influenza like illness patients in Shenzhen Children’s Hospital from January 2016 to December 2018. The positive cases and influenza subtypes were determined by gold labeled antigen detection and reverse transcriptase polymerase chain reaction. The influenza periodicity and age, subtype distribution as well as the association between climate parameters and different influenza subtypes were analyzed by SPSS 22.0. Results: The influenza positive rate during 2016-2018 was 21.0%, with a highest positive rate in the year 2018. The positive rate varied by month, season, and year describing a sequence of peaks presenting primarily in all year including spring, summer and winter. The characteristics of influenza peak were different in each year, with a spring peak in 2016 and a summer plus a winter-spring peaks in 2017 and 2018. In addition, influenza B exhibited a winter-spring seasonal pattern while influenza A displayed a more variable seasonality, highlighting influenza B rather than influenza A which had a negative association with climate parameters. Influenza-positive cases were older than influenza-negative cases (P P Conclusion: Influenza activity in children from Shenzhen typically displays both winter-spring and summer peaks. Influenza A epidemic occurred separately or co-circulated with influenza B, with a winter-spring pattern for influenza B and a much more variable seasonality for influenza A. Influenza B had a negative association with climate parameters. In addition, hospitalization with influenza often occurs in younger individuals infected with influenza A. 展开更多
关键词 INFLUENZA Influenza Like Illness Gold Labeled Antigen Detection Reverse Transcriptase Polymerase Chain Reaction Influenza A Influenza B
下载PDF
Exploration of the Current Situation and Mechanism Innovation of University Education Management under the New Situation
5
作者 Yuanfei Xue Minna Sun 《Journal of Contemporary Educational Research》 2024年第10期220-226,共7页
In the new era,university education management should be oriented toward the cultivation of innovative talents and the construction of a comprehensive education system.It should develop capable and qualified higher-le... In the new era,university education management should be oriented toward the cultivation of innovative talents and the construction of a comprehensive education system.It should develop capable and qualified higher-level talents in response to the social demand for talent application,thereby enhancing the overall educational competitiveness of universities and driving deep reforms in educational activities.However,in current educational practice,efficient educational management often focuses on curriculum development and cultural education,with insufficient attention paid to the development of students’comprehensive literacy.The talent cultivation and education programs are not yet perfect.This article explores the current situation of university education management activities under the new situation and considers practical methods for innovating university education management mechanisms. 展开更多
关键词 University education management New situation Talent cultivation
下载PDF
College of Physics and Energy, Shenzhen University
6
作者 Location 《Frontiers of physics》 SCIE CSCD 2017年第4期F0003-F0003,共1页
Established in 1985 and composed of five teaching units and ten research institutes. Five teaching units include Department of Physics, Department of Applied Physics, Department of Nuclear Science and Technology, Cent... Established in 1985 and composed of five teaching units and ten research institutes. Five teaching units include Department of Physics, Department of Applied Physics, Department of Nuclear Science and Technology, Center of University Physics Teaching and Center of Experimental Physics Teaching. Ten research institutes include Institute of Nuclear Technology Application, Institute of Thin Film Physics, Institute of Condensed Matter Physics, Institute of Breath Test Technology, the Joint Laboratory of Plasma Physics, the Joint Laboratory of Sensor Technology, the Joint Laboratory of High-purity germanium, Institute of National Energy Nuclear Power Operation and Life Management Technology R&=D Center and the Center of Safety Technology of Nuclear Power Operation, Institute of Nuclear Safety Technology, the Engineering Laboratory of Optical Fiber Sensor Technology. There are 91 faculty members including one academician of Chinese Academy of Sciences, four experts of National "100-Elite Program", 15 professors and 29 associate professors. 展开更多
关键词 Mrs. Yeping Zhang College of Physics and Energy Shenzhen University
原文传递
Research on Innovation of Fair Competition Review System in Shenzhen
7
作者 WANG Yu LI Changsheng 《Management Studies》 2023年第4期202-214,共13页
The Shenzhen Fair Competition Review System has experienced internal review and cross-examination since its inception.However,it is still dominated by the self-review of policy-making organs,with a lack of effective c... The Shenzhen Fair Competition Review System has experienced internal review and cross-examination since its inception.However,it is still dominated by the self-review of policy-making organs,with a lack of effective control and restraint mechanisms.In addition,insufficient compensatory effect of the external review has led to weak effectiveness of social supervision.Shenzhen is currently the pilot of an independent fair competition review system.The Fair Competition Commission can be set up as an independent review body.Then,the operational mechanism should be improved and the constraints and incentives should be set up scientifically.Last but not the least,by strengthening the social supervision network for fair competition review,the legality and rationality of a wide range of local regulations,rules,and normative documents will be reviewed,thereby regulating the behavior of policy-making organs. 展开更多
关键词 independent review review agency restraint mechanisms
下载PDF
Metal-organic framework-based single-atom electro-/ photocatalysts: Synthesis, energy applications, and opportunities 被引量:2
8
作者 Munir Ahmad Jiahui Chen +10 位作者 Jianwen Liu Yan Zhang Zhongxin Song Shahzad Afzal Waseem Raza Liaqat Zeb Andleeb Mehmood Arshad Hussain Jiujun Zhang Xian-Zhu Fu Jing-Li Luo 《Carbon Energy》 SCIE EI CAS CSCD 2024年第1期1-43,共43页
Single-atom catalysts(SACs)have gained substantial attention because of their exceptional catalytic properties.However,the high surface energy limits their synthesis,thus creating significant challenges for further de... Single-atom catalysts(SACs)have gained substantial attention because of their exceptional catalytic properties.However,the high surface energy limits their synthesis,thus creating significant challenges for further development.In the last few years,metal–organic frameworks(MOFs)have received significant consideration as ideal candidates for synthesizing SACs due to their tailorable chemistry,tunable morphologies,high porosity,and chemical/thermal stability.From this perspective,this review thoroughly summarizes the previously reported methods and possible future approaches for constructing MOF-based(MOF-derived-supported and MOF-supported)SACs.Then,MOF-based SAC's identification techniques are briefly assessed to understand their coordination environments,local electronic structures,spatial distributions,and catalytic/electrochemical reaction mechanisms.This review systematically highlights several photocatalytic and electrocatalytic applications of MOF-based SACs for energy conversion and storage,including hydrogen evolution reactions,oxygen evolution reactions,O_(2)/CO_(2)/N_(2) reduction reactions,fuel cells,and rechargeable batteries.Some light is also shed on the future development of this highly exciting field by highlighting the advantages and limitations of MOF-based SACs. 展开更多
关键词 carbon energy generation MOF-derived-supported MOF-supported single atoms
下载PDF
A mixed-coordination electron trapping-enabled high-precision touch-sensitive screen for wearable devices 被引量:1
9
作者 Xi Zhang Junchi Ma +5 位作者 Hualin Deng Jinming Zhong Kaichen Xu Qiang Wu Bo Wen Dongfeng Diao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第4期413-427,共15页
Touch-sensitive screens are crucial components of wearable devices.Materials such as reduced graphene oxide(rGO),carbon nanotubes(CNTs),and graphene offer promising solutions for flexible touch-sensitive screens.Howev... Touch-sensitive screens are crucial components of wearable devices.Materials such as reduced graphene oxide(rGO),carbon nanotubes(CNTs),and graphene offer promising solutions for flexible touch-sensitive screens.However,when stacked with flexible substrates to form multilayered capacitive touching sensors,these materials often suffer from substrate delamination in response to deformation;this is due to the materials having different Young’s modulus values.Delamination results in failure to offer accurate touch screen recognition.In this work,we demonstrate an induced charge-based mutual capacitive touching sensor capable of high-precision touch sensing.This is enabled by electron trapping and polarization effects related to mixed-coordinated bonding between copper nanoparticles and vertically grown graphene nanosheets.Here,we used an electron cyclotron resonance system to directly fabricate graphene-metal nanofilms(GMNFs)using carbon and copper,which are firmly adhered to flexible substrates.After being subjected to 3000 bending actions,we observed almost no change in touch sensitivity.The screen interaction system,which has a signal-to-noise ratio of 41.16 dB and resolution of 650 dpi,was tested using a handwritten Chinese character recognition trial and achieved an accuracy of 94.82%.Taken together,these results show the promise of touch-sensitive screens that use directly fabricated GMNFs for wearable devices. 展开更多
关键词 Flexible touch-sensitive screen Graphene-metal nanofilms Mixed coordination Wearable device
下载PDF
Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models 被引量:2
10
作者 Yachen Xie Michael Z.Hou +1 位作者 Hejuan Liu Cunbao Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1262-1279,共18页
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,... Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first time.The results show that the anisotropic creep of shale exhibits a significant stress-dependent behavior.Under a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep time.Under high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is proposed.The model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep rate.The applicability of the five classical empirical creep models is quantitatively evaluated.It shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep deformation.Based on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are discussed.With abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation. 展开更多
关键词 Rock anisotropy Direct shear creep Creep compliance Steady-creep rate Empirical model Creep constitutive model
下载PDF
Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy 被引量:6
11
作者 Jinwang Ye Huali Wan +1 位作者 Sihua Chen Gong-Ping Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1489-1498,共10页
Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults.Primary features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neur... Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults.Primary features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neurofibrillary tangles,fo rmed by tau protein,in the cells.While there are amyloid-β-ta rgeting therapies for the treatment of Alzheimer’s disease,these therapies are costly and exhibit potential negative side effects.Mounting evidence suggests significant involvement of tau protein in Alzheimer’s disease-related neurodegeneration.As an important microtubule-associated protein,tau plays an important role in maintaining the stability of neuronal microtubules and promoting axonal growth.In fact,clinical studies have shown that abnormal phosphorylation of tau protein occurs before accumulation of amyloid-βin the brain.Various therapeutic strategies targeting tau protein have begun to emerge,and are considered possible methods to prevent and treat Alzheimer’s disease.Specifically,abnormalities in post-translational modifications of the tau protein,including aberrant phosphorylation,ubiquitination,small ubiquitin-like modifier(SUMO)ylation,acetylation,and truncation,contribute to its microtubule dissociation,misfolding,and subcellular missorting.This causes mitochondrial damage,synaptic impairments,gliosis,and neuroinflammation,eventually leading to neurodegeneration and cognitive deficits.This review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer’s disease and discusses tau-targeted treatment of Alzheimer’s disease. 展开更多
关键词 ACETYLATION Alzheimer’s disease cognitive deficits GLIOSIS mitochondria damage NEUROINFLAMMATION phosphorylation synaptic impairments TAU tau immunotherapy
下载PDF
Harness High-Temperature Thermal Energy via Elastic Thermoelectric Aerogels 被引量:1
12
作者 Hongxiong Li Zhaofu Ding +5 位作者 Quan Zhou Jun Chen Zhuoxin Liu Chunyu Du Lirong Liang Guangming Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第8期196-210,共15页
Despite notable progress in thermoelectric(TE)materials and devices,developing TE aerogels with high-temperature resistance,superior TE performance and excellent elasticity to enable self-powered high-temperature moni... Despite notable progress in thermoelectric(TE)materials and devices,developing TE aerogels with high-temperature resistance,superior TE performance and excellent elasticity to enable self-powered high-temperature monitoring/warning in industrial and wearable applications remains a great challenge.Herein,a highly elastic,flame-retardant and high-temperature-resistant TE aerogel,made of poly(3,4-ethylene dioxythiophene):poly(styrenesulfonate)/single-walled carbon nanotube(PEDOT:PSS/SWCNT)composites,has been fabricated,displaying attractive compression-induced power factor enhancement.The as-fabricated sensors with the aerogel can achieve accurately pressure stimuli detection and wide temperature range monitoring.Subsequently,a flexible TE generator is assembled,consisting of 25 aerogels connected in series,capable of delivering a maximum output power of 400μW when subjected to a temperature difference of 300 K.This demonstrates its outstanding high-temperature heat harvesting capability and promising application prospects for real-time temperature monitoring on industrial high-temperature pipelines.Moreover,the designed self-powered wearable sensing glove can realize precise wide-range temperature detection,high-temperature warning and accurate recognition of human hand gestures.The aerogel-based intelligent wearable sensing system developed for firefighters demonstrates the desired self-powered and highly sensitive high-temperature fire warning capability.Benefitting from these desirable properties,the elastic and high-temperature-resistant aerogels present various promising applications including self-powered high-temperature monitoring,industrial overheat warning,waste heat energy recycling and even wearable healthcare. 展开更多
关键词 THERMOELECTRICS AEROGEL SELF-POWERED High-temperature monitoring High-temperature warning
下载PDF
In vivo label-free measurement of blood flow velocity symmetry based on dual line scanning third-harmonic generation microscopy excited at the 1700 nm window 被引量:1
13
作者 Hui Cheng Jincheng Zhong +1 位作者 Ping Qiu Ke Wang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第1期61-68,共8页
Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the in... Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions. 展开更多
关键词 1700 nm-Window third-harmonic generation imaging blood flow velocity
下载PDF
Room Temperature Synthesis of Vertically Aligned Amorphous Ultrathin NiCo-LDH Nanosheets Bifunctional Flexible Supercapacitor Electrodes 被引量:1
14
作者 Kwadwo Asare Owusu Zhaoyang Wang +7 位作者 Ali Saad Felix Ofori Boakye Muhammad Asim Mushtaq Muhammad Tahir Ghulam Yasin Dongqing Liu Zhengchun Peng Xingke Cai 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期277-286,共10页
Developing a simple scalable method to fabricate electrodes with high capacity and wide voltage range is desired for the real use of electrochemical supercapacitors.Herein,we synthesized amorphous NiCo-LDH nanosheets ... Developing a simple scalable method to fabricate electrodes with high capacity and wide voltage range is desired for the real use of electrochemical supercapacitors.Herein,we synthesized amorphous NiCo-LDH nanosheets vertically aligned on activated carbon cloth substrate,which was in situ transformed from Co-metal-organic framework materials nano-columns by a simple ion exchange process at room temperature.Due to the amorphous and vertically aligned ultrathin structure of NiCo-LDH,the NiCo-LDH/activated carbon cloth composites present high areal capacities of 3770 and 1480 mF cm^(-2)as cathode and anode at 2 mA cm^(-2),and 79.5%and 80%capacity have been preserved at 50 mA cm^(-2).In the meantime,they all showed excellent cycling performance with negligible change after>10000 cycles.By fabricating them into an asymmetric supercapacitor,the device achieves high energy densities(5.61 mWh cm^(-2)and 0.352 mW cm^(-3)).This work provides an innovative strategy for simplifying the design of supercapacitors as well as providing a new understanding of improving the rate capabilities/cycling stability of NiCo-LDH materials. 展开更多
关键词 amorphous nanosheets aqueous supercapacitor high volumetric/areal energy density NiCo-LDH room temperature synthesis
下载PDF
Understandings of Urban Sustainability in China:a Bibliometric Analysis Using Chinese Literatures 被引量:1
15
作者 WU Shuang YUE Yang LI Xuesong 《Journal of Geodesy and Geoinformation Science》 CSCD 2024年第1期105-122,共18页
Cities hold a critical responsibility for achieving the Sustainable Development Goals(SDGs)due to their high population density,extensive resource consumption,and significant economic contributions.To examine the pres... Cities hold a critical responsibility for achieving the Sustainable Development Goals(SDGs)due to their high population density,extensive resource consumption,and significant economic contributions.To examine the present state of understandings regarding urban sustainability(SDG 11:Sustainable Cities and Communities)within Chinese research communities,this study collected 15950 papers from 1994 to 2022 on the 12 indicators of SDG 11,from the China National Knowledge Infrastructure(CNKI),a hub of Chinese academic papers,that directly relate to policymaking.Significant research topics on SDG 11 were identified for each indicator using bibliometrics analysis approaches.The high-frequency keywords and clusters of keywords over the last three decades reveal that existing studies primarily concentrated on the physical aspects,such as transportation and environment,while there is a lack of consideration of societal aspects.This indicates a limited and biased understanding of the urban sustainability within the Chinese academic community.Hence,it is crucial to prioritize the societal aspects in order to develop a research agenda that further advances urban sustainability. 展开更多
关键词 urban sustainability SDG 11 BIBLIOMETRIC Chinese research communities
下载PDF
Functional dissection of parabrachial substrates in processing nociceptive information 被引量:1
16
作者 Jin Ke Wei-Cheng Lu +11 位作者 Hai-Yang Jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang 《Zoological Research》 SCIE CSCD 2024年第3期633-647,共15页
Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of sufferin... Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions. 展开更多
关键词 Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction SOMATOSENSORY
下载PDF
In vivo 3-photon fluorescence microscopy of white matter in mouse brain excited at the 1700 nm window 被引量:1
17
作者 Jie Huang Jincheng Zhong +3 位作者 Shen Tong Yingxian Zhang Ping Qiu Ke Wang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第5期81-87,共7页
White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imagi... White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models in vivo.The third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high scattering.Here,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the former.Our results indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo. 展开更多
关键词 Three-photon microscopy white matter MYELIN MitoTracker Red
下载PDF
Association between Meeting 24-Hour Movement Guidelines and Psychological Features of Chinese Emerging Adults 被引量:1
18
作者 Yanjie Zhang Jin Kuang +2 位作者 Xun Luo Mengxian Zhao Xiaolei Liu 《International Journal of Mental Health Promotion》 2024年第5期399-406,共8页
Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated ... Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health problems.Previous studies have associated these changes with an unhealthy lifestyle.The 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual wellness.However,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be explored.This cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging adults.Methods:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this study.Each participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging adulthood.Multivariable logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four characteristics.Results:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)guidelines.Further,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.01),only sleep(β=0.61,95%CI:[0.01,1.21],p=0.04),physical activity+sedentary behavior(β=0.56,95%CI:[0.04,1.07),p=0.01),and physical activity+sleep(β=0.76,95%CI:[0.23,1.27],p=0.01).Conclusions:These findings suggest that adherence to the 24-h movement guidelines was associated with instability in Chinese emerging adults.Future studies are warranted to verify our findings to highlight the importance of maintaining a heath lifestyle to promote health in emerging adulthood. 展开更多
关键词 24-h movement behavior physical activity sedentary behavior SLEEP psychological health emerging adults
下载PDF
In-situ interfacial passivation and self-adaptability synergistically stabilizing all-solid-state lithium metal batteries 被引量:1
19
作者 Huanhui Chen Xing Cao +6 位作者 Moujie Huang Xiangzhong Ren Yubin Zhao Liang Yu Ya Liu Liubiao Zhong Yejun Qiu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第1期282-292,I0007,共12页
The function of solid electrolytes and the composition of solid electrolyte interphase(SEI)are highly significant for inhibiting the growth of Li dendrites.Herein,we report an in-situ interfacial passivation combined ... The function of solid electrolytes and the composition of solid electrolyte interphase(SEI)are highly significant for inhibiting the growth of Li dendrites.Herein,we report an in-situ interfacial passivation combined with self-adaptability strategy to reinforce Li_(0.33)La_(0.557)TiO_(3)(LLTO)-based solid-state batteries.Specifically,a functional SEI enriched with LiF/Li_(3)PO_(4) is formed by in-situ electrochemical conversion,which is greatly beneficial to improving interface compatibility and enhancing ion transport.While the polarized dielectric BaTiO_(3)-polyamic acid(BTO-PAA,BP)film greatly improves the Li-ion transport kinetics and homogenizes the Li deposition.As expected,the resulting electrolyte offers considerable ionic conductivity at room temperature(4.3 x 10~(-4)S cm^(-1))and appreciable electrochemical decomposition voltage(5.23 V)after electrochemical passivation.For Li-LiFePO_(4) batteries,it shows a high specific capacity of 153 mA h g^(-1)at 0.2C after 100 cycles and a long-term durability of 115 mA h g^(-1)at 1.0 C after 800 cycles.Additionally,a stable Li plating/stripping can be achieved for more than 900 h at 0.5 mA cm^(-2).The stabilization mechanisms are elucidated by ex-situ XRD,ex-situ XPS,and ex-situ FTIR techniques,and the corresponding results reveal that the interfacial passivation combined with polarization effect is an effective strategy for improving the electrochemical performance.The present study provides a deeper insight into the dynamic adjustment of electrode-electrolyte interfacial for solid-state lithium batteries. 展开更多
关键词 Solid-state lithium batteries Composite solid electrolyte In-situ polymerization Interfacial passivation layer Self-adaptability
下载PDF
Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke: an over 10-year intensive care survey 被引量:2
20
作者 Li Zhong Feifei Shuai +3 位作者 Conglin Wang Lipeng Han Zhifeng Liu Ming Wu 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第1期23-27,共5页
BACKGROUND:Heatstroke has become a common emergency event in hospitals.Procalcitonin(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heats... BACKGROUND:Heatstroke has become a common emergency event in hospitals.Procalcitonin(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains unclear.METHODS:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,inflammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day mortality.Correlation analysis,linear regression and curve fi tting were used to identify the relationship between PCT and RM.RESULTS:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)groups.PCT was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation II(APACHE II)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P<0.05).Interestingly,the results of curve fi tting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of<4.6 ng/mL.Survival analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill patients.Elevated PCT concentrations should be interpreted cautiously in patients with EHS in the ED. 展开更多
关键词 PROCALCITONIN MYOGLOBIN RHABDOMYOLYSIS Exertional heatstroke
下载PDF
上一页 1 2 145 下一页 到第
使用帮助 返回顶部