Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal batteries.This study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer interactions.Unlike other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal batteries.The introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based ligands.This is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)kinetics.Consequently,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

Peripheral carbazole units-decorated MR emitter containing B−N covalent bond for highly efficient green OLEDs with low roll-off

Boron−nitrogen doped multiple resonance(BN-MR)emitters,characterized by B−N covalent bonds,offer distinctive advantages as pivotal building blocks for facile access to novel MR emitters featuring narrowband spectra and high efficiency.However,there remains a scarcity of exploration concerning synthetic methods and structural derivations to expand the library of novel BN-MR emitters.Herein,we present the synthesis of a BN-MR emitter,tCz[B−N]N,through a one-pot borylation reaction directed by the amine group,achieving an impressive yield of 94%.The emitter is decorated by incorporating two 3,6-di-tbutylcarbazole(tCz)units into a B−N covalent bond doped BN-MR parent molecule via para-C−π−D and para-N−π−D conjugations.This peripheral decoration strategy enhances the reverse intersystem crossing process and shifts the emission band towards the pure green region,peaking at 526 nm with a narrowband full-width at half maximum(FWHM)of 41 nm.Consequently,organic light emitting diodes(OLEDs)employing this emitter achieved a maximum external quantum efficiency(EQEmax)value of 27.7%,with minimal efficiency roll-off.Even at a practical luminance of 1000 cd·m^(−2),the device maintains a high EQE value of 24.6%.

Decreasing productivity of pine forests on the southern edge of the Mongolian Plateau as indicated by tree rings

Vegetation productivity on the southern edge of the Inner Mongolian Plateau,which plays a vital role in the ecological environment and in the arable and pasto-ral production in this region,can be characterized by the NDVI(normalized difference vegetation index).However,the observed NDVI data span only the last~40 years.The growth of Pinus tabulaeformis Carr.is strongly correlated with the NDVI,making it a valuable proxy for extend-ing the length of observed NDVI datasets.In this study,we reconstructed an NDVI series for 1776–2021 for the Daqing Mountains,based on a tree-ring width chronology.The reconstructed data accounted for 55%of the variance in the observed data,and its statistical characteristics and validation indicate that the reconstruction is dependable.Spatial correlation analysis demonstrated the consistency of climate signals in central Inner Mongolia in both the arable and pastoral zones.The results of superposed epoch analysis revealed a good temporal consistency between drought and flood events and the reconstructed NDVI sequence in this region.

Dimethyl acridine-based self-assembled monolayer as a hole transport layer for highly efficient inverted perovskite solar cells

Self-assembled monolayers(SAMs)have recently emerged as excellent hole transport materials in inverted perovskite solar cells(PSCs)owing to their ability to minimize parasitic absorption,regulate energy level alignment,and passivate perovskite defects.Herein,we design and synthesize a novel dimethyl acridinebased SAM,[2-(9,10-dihydro-9,9-dimethylacridine-10-yl)ethyl]phosphonic acid(2PADmA),and employ it as a hole-transporting layer in inverted PSCs.Experimental results show that the 2PADmA SAM can modulate perovskite crystallization,facilitate carrier transport,passivate perovskite defects,and reduce nonradiative recombination.Consequently,the 2PADmA-based device achieves an enhanced power conversion efficiency(PCE)of 24.01%and an improved fill factor(FF)of 83.92%compared to the commonly reported[2-(9H-carbazol-9-yl)ethyl]phosphonic acid(2PACz)-based control device with a PCE of 22.32%and FF of 78.42%,while both devices exhibit comparable open-circuit voltage and short-circuit current density.In addition,2PADmA-based devices exhibit outstanding dark storage and thermal stabilities,retaining approximately~98%and 87%of their initial PCEs after 1080 h of dark storage and 400 h of heating at 85°C,respectively,both considerably superior to the control device.

Environmental arsenic(As)and its potential relationship with endemic disease in southwestern China

Many cases of an unknown disease exhibiting the clinical features of limb gangrene,blisters,ulceration,and exfoliation have been reported in Daping village(DV)in southwestern China.However,the pathogenesis is unknown and has puzzled doctors for many years.A preliminary study on heavy metals and symptoms indicated that arsenic might pose the greatest threat to the health of local residents.Here,to explore the sources of and factors influencing arsenic enrichment in DV,whose residents exhibit signs of arsenic poisoning,the As contents in soil,water,and plants were systematically measured.The results indicated high As contents in plant and soil samples obtained from the area,and the source of As may be linked to the weathering of black shale rock.Ingestion of soil and consumption of plants were the two main As exposure pathways among children and adults,respectively,and children exhibited a higher health risk than adults.We presume and emphasize that when extreme drought events occur,humans might face unusual risks resulting from exposure to toxic elements and the direct consumption of highly polluted water.Our study provides a new perspective and sheds light on the environmental geochemistry and health links of this disease.

Recent selection and introgression facilitated high-altitude adaptation in cattle

During the past 3000 years,cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia,ultraviolet(UV)radiation,and extreme cold.The genetic mechanism underlying this rapid adaptation is not yet well understood.Here,we present whole-genome resequencing data for 258 cattle from 32 cattle breeds/populations,including 89 Tibetan cattle representing eight populations distributed at altitudes ranging from 3400 m to 4300 m.Our genomic analysis revealed that Tibetan cattle exhibited a continuous phylogeographic cline from the East Asian taurine to the South Asian indicine ancestries.We found that recently selected genes in Tibetan cattle were related to body size(HMGA2 and NCAPG)and energy expenditure(DUOXA2).We identified signals of sympatric introgression from yak into Tibetan cattle at different altitudes,covering 0.64%–3.26%of their genomes,which included introgressed genes responsible for hypoxia response(EGLN1),cold adaptation(LRP11),DNA damage repair(LATS1),and UV radiation resistance(GNPAT).We observed that introgressed yak alleles were associated with noncoding variants,including those in present EGLN1.In Tibetan cattle,three yak introgressed SNPs in the EGLN1 promoter region reduced the expression of EGLN1,suggesting that these genomic variants enhance hypoxia tolerance.Taken together,our results indicated complex adaptation processes in Tibetan cattle,where recently selected genes and introgressed yak alleles jointly facilitated rapid adaptation to high-altitude environments.

Multiple Interaction Forces Construct Two-Dimensional Self-assembly Kagome Lattices on Au(111)

Comprehensive Summary Kagome lattices have garnered significant attention due to their promising applications in catalysis,electronics,and magnetics.Although many efforts have been paid to the design and synthesis of Kagome lattices,there is a limited focus on constructing this lattice by multiple interaction forces.In this work,we employ 2,7-dibromo-carbazole as precursors to successfully fabricate the two-dimensional self-assembly Kagome lattices stabled by multiple interaction forces on Au(111)substrate.Using low-temperature scanning tunneling microscopy,non-contact atomic force microscopy and density functional theory calculation,we visualize and identify the four interaction forces within Kagome lattices:Au—N coordination bonds,Au—H hydrogen bonds,Br—Br halogen bonds,and Br—H hydrogen bonds,respectively.This study provides a basic understanding for designing and constructing more complex Kagome lattices.

Coupled Pacific Rim megadroughts contributed to the fall of the MingDynasty’s capital in 1644 CE

Historical documents provide evidence for regional droughts preceding the political turmoil and fall of Beijing in 1644 CE,when more than 20 million people died in northern China during the late Ming famine period.However,the role climate and environmental changes may have played in this pivotal event in Chinese history remains unclear.Here,we provide tree-ring evidence of persistent megadroughts from1576 to 1593 CE and from 1628 to 1644 CE in northern China,which coincided with exceptionally cold summers just before the fall of Beijing.Our analysis reveals that these regional hydroclimatic extremes are part of a series of megadroughts along the Pacific Rim,which not only impacted the ecology and society of monsoonal northern China,but likely also exacerbated external geopolitical and economic pressures.This finding is corroborated by last millennium reanalysis data and numerical climate model simulations revealing internally driven Pacific sea surface temperature variations and the predominance of decadal scale La Ni?a-like conditions to be responsible for precipitation decreases over northern China,as well as extensive monsoon regions in the Americas.These teleconnection patterns provide a mechanistic explanation for reoccurring drought spells during the late Ming Dynasty and the environmental framework fostering the fall of Beijing in 1644 CE,and the subsequent demise of the Ming Dynasty.

On-surface Synthesis of Multiple Non-benzenoid Carbohelicenes Fused with Fluorene Unit(s)

Comprehensive Summary Carbohelicenes have garnered considerable attention for their inherent chirality and structural flexibility.Increasing multi-helicity and incorporating non-six-membered rings to substitute benzenoid rings within helicenes are effective strategies for introducing unique photoelectric properties.Despite the disclosure of numerous helicenes,the inaccessible precursors and the lack of synthetic routes pose a challenge in achieving desired helicene structures fused with non-benzenoid rings.Herein,we report the synthesis of multiple non-benzenoid carbohelicenes fused with fluorene unit(s)through intramolecular cyclodehydrogenation of 9,10-di(naphthalen-1-yl)anthracene on Au(111)surface.Two potential cyclodehydrogenation manners between naphthyl and anthracene lead to the formation of fluorene-fused[5]helicene and[4]helicene moiety.Consequently,a total of four stable products were observed.The atomic topographies of products are characterized by bond-resolving scanning tunneling microscopy.The chiral helicity of targeted products can be switched by tip manipulation.Density-functional-theory calculations unveils the reaction pathway of four products.The comparative analysis of their respective energy barriers exhibits a correlation with the experimentally determined yields.Furthermore,we synthesize the polymer chains incorporating non-benzenoid carbohelicenes via the Ullmann reaction of 2,6-dibromo-9,10-di(1-naphthyl)anthracene precursors.Our work proposes a synthetic methodology for several novel helicene-like structures fused with fluorene units and the polymer bearing helicene subunits,thus highlighting the immense potential of these compounds in the application fields of luminescent electronic devices.

Enhanced thermal constant B of diamond films for ultrahigh sensitivity negative temperature coefficient thermistors

Negative temperature coefficient(NTC)thermistor plays a crucial role in science research and engineering applications for precise temperature monitoring.Although great progress has been achieved in NTC materials,enhancing sensitivity and maintaining this high sensitivity along with linearity across extensive temperature ranges remain a significant challenge.In this study,we introduce a diamondbased thermistor(DT)characterized by its outstanding sensitivity,swift response time,and broad temperature monitoring capabilities.The temperature constant B for this DT,measured from 30 to 300°C(B30/300),achieves an exceptional value of 8012 K,which notably exceeds the temperature sensing capabilities of previously reported NTC thermistors within this extensive range.Moreover,diamond’s unique thermal conductivity and stability significantly boost the response speed and durability of the DT,offering substantial advantages over traditional ceramic thermistors.The enhanced temperature-sensitive properties of the DT are attributed to the presence of impurity elements in polycrystalline diamond.Impedance analysis indicates a hopping conduction mechanism,likely involving C-H or C-N dipoles at the diamond grain boundaries.This study marks a significant leap forward in diamond thermistor technology and sheds light on the mechanisms of thermal active conduction in diamond materials.

Manipulation of Na_(3)V_(2)(PO_(4))_(2)F_(3) via aluminum doping to alter local electron states toward an advanced cathode for sodiumion batteries

With its unique 3D skeleton structure and exceptional cyclic stability,the Na^(+)superionic conducto(NASICON)-type Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)has been con sidered as a competitive cathode material for advanced Na ion batteries.However,the release of fluorine during th heat treatment leads to the formation of an additional phas Na_(3)V_(2)(PO_(4))_(3)(NVP),which results in a low-voltage plateau and compromises the energy density.Herein,we modulat the local electronic states of the V site by aluminum sub stitution to strengthen the stability of F.The results confirm that the aluminum introduction not only changes the loca electron states of V sites,significantly reducing the for mation of NVP by-product from 6.71 wt%to 1.01 wt%but also effectively reduces the band gap,improving th electronic conductivity of NVPF.The optimized Na_(3)V_(1.9)Al_(0.1)(PO_(4))_(2)F_(3)exhibits higher energy density of 340 Wh·kg^(-1)and excellent rate performance of 106.7 mAh·g^(-1)at 10C compared with the pristine cathode.

神经退行性疾病研究及治疗新方向:核糖体相关蛋白质量控制

Ribosome-associated protein quality control (RQC) is a surveillance system that detects translation stalling events and degrades incomplete or defective polypeptides. This process maintains protein homeostasis and protects cells from proteotoxic stress. Evidence of compromised RQC functionality has been observed in the aging process and in several age-related neurodegenerative afflictions, including amyotrophic lateral sclerosis, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD)。

Transcription factor OsWRKY11 induces rice heading at low concentrations but inhibits rice heading at high concentrations

The heading date of rice is a crucial agronomic characteristic that influences its adaptability to different regions and its productivity potential.Despite the involvement of WRKY transcription factors in various biological processes related to development,the precise mechanisms through which these transcription factors regulate the heading date in rice have not been well elucidated.The present study identified OsWRKY11 as a WRKY transcription factor which exhibits a pivotal function in the regulation of the heading date in rice through a comprehensive screening of a clustered regularly interspaced palindromic repeats(CRISPR)-CRISPR-associated nuclease 9 mutant library that specifically targets the WRKY genes in rice.The heading date of oswrky11 mutant plants and OsWRKY11-overexpressing plants was delayed compared with that of the wild-type plants under short-day and long-day conditions.Mechanistic investigation revealed that OsWRKY11 exerts dual effects on transcriptional promotion and suppression through direct and indirect DNA binding,respectively.Under normal conditions,OsWRKY11 facilitates flowering by directly inducing the expression of OsMADS14 and OsMADS15.The presence of elevated levels of OsWRKY11 protein promote formation of a ternary protein complex involving OsWRKY11,Heading date 1(Hd1),and Days to heading date 8(DTH8),and this complex then suppresses the expression of Ehd1,which leads to a delay in the heading date.Subsequent investigation revealed that a mild drought condition resulted in a modest increase in OsWRKY11 expression,promoting heading.Conversely,under severe drought conditions,a significant upregulation of OsWRKY11 led to the suppression of Ehd1 expression,ultimately causing a delay in heading date.Our findings uncover a previously unacknowledged mechanism through which the transcription factor OsWRKY11 exerts a dual impact on the heading date by directly and indirectly binding to the promoters of target genes.

Indacenodithiophene-based single-component ambipolar polymer for high-performance vertical organic electrochemical transistors and inverters

Single-component ambipolar polymers are highly desirable for organic electrochem-ical transistors(OECTs)and integration into complementary logic circuits with reduced process complexity.However,they often suffer from imbalanced p-type and n-type characteristics and/or stability issues.Herein,a novel single-component ambipolar polymer,namely,gIDT–BBT is reported based on indacenodithiophene(IDT)as the electron donor,benzobisthiadiazole(BBT)as the electron acceptor and oligo ethylene glycol(OEG)as the side chain.Benefitting from the extended backbone planarity and rigidity of IDT,pronounced electron-withdrawing capabil-ity of BBT,favored ionic transport from OEG together with vertical OECT device structure,a nearly balanced ambipolar OECT performance is achieved for gIDT–BBT,revealing a high transconductance of 155.05±1.58/27.28±0.92 mS,a high current on/off ratio>10^(6) and an excellent operational stability under both p-type and n-type operation conditions.With gIDT–BBT in hand,furthermore,vertically stacked complementary inverters are successfully fabricated to show a maximum voltage gain of 28 V V^(-1)(V_(IN)=0.9 V)and stable operation over 1000 switching cycles,and then used for efficient electrooculogram recording.This work provides a new approach for the development of ambipolar single-component organic mixed ionic–electronic conductors and establishes a foundation for the manufacture of high-performance ambipolar OECTs and associated complementary circuits.

The haplotype-resolved T2T genome assembly of the wild potato species Solanum commersonii provides molecular insights into its freezing tolerance

Dear Editor,The potato is the most important tuber crop,playing an important role in ensuring world food security.The genome of the cultivated species(DM,a doubled monoploid type)was first released in 2011 and has been continually updated as the most popular reference(Yang et al.,2023).Recently,a high-quality assembly of tetraploid C88 was released(Bao et al.,2022).

New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity

Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-membered ring system,while compounds 3-5 are characterized by progressively truncated carbon skeletons,containing 18,17,and 16 carbons,respectively.In addition,four known compounds 6-9 were also identified.Their structures were elucidated using advanced spectroscopic tech-niques,including nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),ultra-violet(UV),infrared radiation(IR),optical rotatory dispersion(ORD),DP4+analysis and electronic circular dichroism(ECD),sup-ported by quantum chemical calculations.Compounds 1-9 were evaluated for their anti-MRSA activity.Among them,compound 6 demonstrated significant anti-MRSA activity,with a minimum inhibitory concentration(MIC)of 16 μg·mL^(-1).

NIR regeneration and visible luminescence modification in photochromic glass:A novel encryption and 3D optical storage medium

Photochromic glass shows great promise for 3D optical information encryption and storage applications.The formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochromic glass research.However,extending this approach to other metal nanoclusters remains a challenge.In this study,we present a pioneering method for crafting photochromic glass with reliably adjustable dual-mode luminescence in both the NIR and visible spectra.This was achieved by leveraging bimetallic clusters of bismuth,resulting in a distinct and novel photochromic glass.When rare-earth-doped,bismuth-based glass is irradiated with a 473 nm laser,and it undergoes a color transformation from yellow to red,accompanied by visible and broad NIR luminescence.This phenomenon is attributed to the formation of laserinduced(Bi^(+),Bi^(0))nanoclusters.We achieved reversible manipulation of the NIR luminescence of these nanoclusters and visible rare-earth luminescence by alternating exposure to a 473 nm laser and thermal stimulation.Information patterns can be inscribed and erased on a glass surface or in 3D space,and the readout is enabled by modulating visible and NIR luminescence.This study introduces a pioneering strategy for designing photochromic glasses with extensive NIR luminescence and significant potential for applications in highcapacity information encryption,optical data storage,optical communication,and NIR imaging.The exploration of bimetallic cluster formation in Bi represents a vital contribution to the advancement of multifunctional glass systems with augmented optical functionalities and versatile applications.

Safety,immunogenicity,and preliminary efficacy of a randomized clinical trial ofomicron XBB.1.5-containing bivalent mRNA vaccine

Periodically updating coronavirus disease 19(COVID-19)vaccines that offer broad-spectrum protection is needed giventhe strong immune evasion by the circulating omicron sublineages.The effectiveness of prototype and BA.4/5-containing bivalent mRNA vaccines is reduced when XBB subvariants predominate.We initiated an observer-blinded,threearms study in 376 patients in Chinese individuals aged from 18 to 55 years old who had previously received three dosesCOVID-19 vaccine.Immunogenicity in terms of neutralizing antibodies elicited by a 30-mg dose of XBB.1.5-containingbivalent vaccine(RQ3027),a 30-mg dose of BA.2/BA.5-Alpha/Beta bivalent vaccine(RQ3025)and their precedent 30-mg Alpha/Beta(combined mutations)monovalent mRNA vaccine(RQ3013)and safety are primary and secondary endpoints,respectively.We recorded prescribed COVID-19 cases to explore the preliminary efficacy of three vaccines.RQ3027 and RQ3025 boosters elicited superior neutralizing antibodies(NAbs)against XBB.1.5,XBB.1.16,XBB.1.9.1,and JN.1 compared to RQ3013 at day 14 in participants without SARS-CoV-2 infection.All study vaccines were welltolerated without serious adverse reactions identified.The incidence rates per 1000 person-years of COVID-19 casesduring the 2nd-19th week after randomization were lowest in RQ3027.Overall,our data show that XBB.1.5-containingbivalent booster generated superior immunogenicity and better protection against newer severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants compared to BA.2/BA.5-containing bivalent and Alpha/Beta monovalentwith no new safety concerns.

Evolution and legacy of East Asian aurochs

Aurochs(Bos primigenius),once widely distributed in Afro-Eurasia,became extinct in the early 1600 s.However,their phylogeography and relative contributions to domestic cattle remain unknown.In this study,we analyzed 16 genomes of ancient aurochs and three mitogenomes of ancient bison(Bison priscus)excavated in East Asia,dating from 43,000 to 3,590 years ago.These newly generated data with previously published genomic information on aurochs as well as ancient/extant domestic cattle worldwide through genome analysis.Ourfindings revealed significant genetic divergence between East Asian aurochs and their European,Near Eastern,and African counterparts on the basis of both mitochondrial and nuclear genomic data.Furthermore,we identified evidence of geneflow from East Asian aurochs into ancient and present-day taurine cattle,suggesting their potential role in facilitating the environmental adaptation of domestic cattle.

Harnessing the power of mosquito gut microbiome in disease control

Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is un-derscored by some staggering statistics:over 3.9 billion people in more than 120 countries confront the imminent threat of some of the most epidemiologically significant mosquito-borne viruses;in 2021 alone,malaria accounted for 247 million cases,resulting in an estimated 619,000 deaths globally.