This study used an anodic etching(AE)method to construct a hierarchical rough surface on the surface of the Cu-bearing antibacterial titanium alloy,Ti-xCu(x=3,5,7 wt%),a three-dimensional structure with nested micro-/...This study used an anodic etching(AE)method to construct a hierarchical rough surface on the surface of the Cu-bearing antibacterial titanium alloy,Ti-xCu(x=3,5,7 wt%),a three-dimensional structure with nested micro-/submicro-pores and internal cavities,which is conducive to the adhesion and growth of bone cells.After AE treatment,with increase of the Cu content in the alloy,the surface of Ti-Cu alloy became sharper,with more fine micropores and internal cavities,thus increasing the surface area.The results indicated that the AE/Ti-Cu alloy exhibited good antibacterial properties and had the effect of inhibiting bacterial biofilm formation.AE treatment could increase the Cu ions release of Ti-Cu alloy in saline,and the higher the Cu content in the alloy,the more Cu ions release,resulting in stronger antibacterial performance of the alloy.AE/Ti-Cu alloy showed excellent biocompatibility,similar to the pure Ti.Therefore,anodic etching is a safe and effective surface treatment method for Ti-Cu alloy,with good clinical application prospects.展开更多
Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzy...Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.展开更多
基金financially supported by the Natural Science Foundation of Liaoning Province(No.2022-MS-079).
文摘This study used an anodic etching(AE)method to construct a hierarchical rough surface on the surface of the Cu-bearing antibacterial titanium alloy,Ti-xCu(x=3,5,7 wt%),a three-dimensional structure with nested micro-/submicro-pores and internal cavities,which is conducive to the adhesion and growth of bone cells.After AE treatment,with increase of the Cu content in the alloy,the surface of Ti-Cu alloy became sharper,with more fine micropores and internal cavities,thus increasing the surface area.The results indicated that the AE/Ti-Cu alloy exhibited good antibacterial properties and had the effect of inhibiting bacterial biofilm formation.AE treatment could increase the Cu ions release of Ti-Cu alloy in saline,and the higher the Cu content in the alloy,the more Cu ions release,resulting in stronger antibacterial performance of the alloy.AE/Ti-Cu alloy showed excellent biocompatibility,similar to the pure Ti.Therefore,anodic etching is a safe and effective surface treatment method for Ti-Cu alloy,with good clinical application prospects.
基金The authors acknowledge financial support from National Natural Science Foundation of China(Nos.81873918,51631009)Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center(Grant No.18-006-9-01)Key Research and Serving Local Area Projects of the Educational Department of Liaoning Province,China(Grant No.ZF2019005).
文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.
