AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP ...AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain.展开更多
Attachment theory suggests that anxious attachment is associated with hypervigilance to threatening social stimuli, and avoidant attachment with avoidance or suppression of processing such stimuli. Twenty-five student...Attachment theory suggests that anxious attachment is associated with hypervigilance to threatening social stimuli, and avoidant attachment with avoidance or suppression of processing such stimuli. Twenty-five students viewed angry, fearful and neutral female faces in four visual oddball tasks, and completed the Attachment Style Questionnaire, the Autonomy-Connectedness Scale, and Anxiety and Depression subscales of the Symptom Checklist-90. When the oddballs were angry faces in a background of neutral frequents, we found higher levels of autonomy and secure attachment to be related to larger N100 and smaller P300 amplitudes;higher levels of anxious attachment were, on the contrary, associated with smaller N100 and larger P300 amplitudes. Variation in attachment is related to approaching, or withdrawing from threatening stimuli, and ERP-techniques add to our understanding of how the attachment system actually works.展开更多
Background: Depression is common in cardiac patients and has been associated with adverse clinical outcome. However, little is known about predictors of the onset of depressive symptoms. We examined predictors of the ...Background: Depression is common in cardiac patients and has been associated with adverse clinical outcome. However, little is known about predictors of the onset of depressive symptoms. We examined predictors of the onset of depressive symptoms at 12 months post- percutaneous coronary intervention(PCI) in patients treated in the drug- eluting stent era. Methods: Unselected patients, free from depressive symptoms at 6 months with a depression score at 12 months treated with PCI with either drug- eluting or bare stent implantation as part of the RESEARCH registry qualified for inclusion in the current study. Patients completed the Hospital Anxiety and Depression Scale at 6 and 12 months and the Type D Personality Scale(DS14) at 6 months post- PCI. Six months was used as the baseline assessment. Results: Of 542 patients, 41(8% ) had developed significant depressive symptoms at 12 months. The occurrence of a new cardiac event between 6 and 12 months post- index event did not influence the incidence of depressive symptoms at 12 months. Depressive patients were more likely to have a type D personality(34% vs 16% , P=.003) and diabetes(24% vs 11% , P=.01) than nondepressive patients. Type D personality(odds ratio 3.04, 95% CI 1.50- 6.16) and diabetes(odds ratio 2.75, 95% CI 1.25- 6.05) were independent predictors of the onset of depressive symptoms 12 months post- PCI in adjusted analyses. In patients with neither risk factors(type D or diabetes), the incidence of depression was 5.1% with the incidence more than doubling to 13.2% and 30% for each additional risk factor. Conclusions: Type D personality and diabetes comprise risk factors for the onset of depressive symptoms post- PCI. In clinical practice, patients with these risk factors should be identified and considered for psychosocial intervention targeting depression to enhance secondary prevention.展开更多
Individuals often get lost behind the diagnosis of Alzheimer’s disease (AD) while widespread differences between these patients are morecommon than similarities. Socioemotional Selectivity Theory (SST) suggests that ...Individuals often get lost behind the diagnosis of Alzheimer’s disease (AD) while widespread differences between these patients are morecommon than similarities. Socioemotional Selectivity Theory (SST) suggests that as we age our goals change from future-oriented (acquiringnew information) to present-oriented (enhancing the emotional, especially positive, meaning of encounters). The goal of the current article is to examine whether the principles of SST might also apply for people with AD. Some aspects of SST are found especially in the early stages of AD when awareness is often intact and cognitive impairment is relatively limited. This review has clinical significance for the treatment of AD because it focuses on what is important to the individual rather than treating patients as a homogenous group. It also highlights the importance of social networks and emphasizes the role of the proxy in AD care. Lastly, it suggests that if those with AD (like the healthy elderly) have a positivity bias then positive emotional stimuli/wording/instructions could usefully be employed in their daily treatment. I suggest that SST may be a useful starting point when attempting to address what matters to individuals with AD and conclude by providing a few suggestions for future studies.展开更多
To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed thi...To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed this paper by Shah et al,and found that promising as it is,this study has some methodological shortcomings,such as:cross-sectional nature of the study,lack of initial evaluations of quality of life and regular follow-ups to determine the dynamics and real directions of changes in quality of life.We therefore concluded that the results of the study by Shah et al are biased and,although very promising,should not be considered as scientifically relevant.展开更多
An adequate approach to reducing school absenteeism should focus on medical absenteeism as this is the most prevalent form of school absenteeism. The objective of this study is to explore the health condition of pre-v...An adequate approach to reducing school absenteeism should focus on medical absenteeism as this is the most prevalent form of school absenteeism. The objective of this study is to explore the health condition of pre-vocational secondary students with extensive medical absenteeism from a biopsychosocial perspective. Data were obtained from medical assessments and Strengths and Difficulties Questionnaires (SDQs) of students with medical absence above threshold criteria (i.e. reported sick four times in 12 school weeks or more than six consecutive school days) who were referred to a youth health care physician. The results showed that the students had a mean absence rate of 14% in 12 school weeks. Of all students, 43.5% had a diagnosed disease and 81.5% had problems such as physical complaints not yet diagnosed, psychosocial problems, lifestyle problems and sleeping difficulties. Four groups could be distinguished: 13.4% with a diagnosed disease and no problem, 30.1% with a diagnosed disease and a problem, 51.5% with a problem and no diagnosed disease and 5.1% without a diagnosed disease or problem. Significantly higher scores of the Total difficulties-scale on the SDQ were found (mean 10.5;SD 5.8) in the study group, compared to a reference group (mean 9.1;SD 4.9). In conclusion, this study shows that when using the aforementioned criteria for extensive medical absenteeism to intervene with the absence, students with a mean absence rate of 14% in 12 school weeks are identified. If there was a diagnosed disease, it was accompanied by problems about twice as often. More than half of the students’ absence was caused by problems rather than a disease. The great diversity of these problems calls for a personalized approach. A broad perspective, including medical expertise, is needed to distinguish between emerging mental and physical diseases, psychosocial and lifestyle problems.展开更多
The lack of an account of rationality in The Structure of Scientific Revolutions was a lacuna which Thomas Kuhn acutely felt. In this paper, I argue that Herbert Simon's notion of "satisficing" provides a formally ...The lack of an account of rationality in The Structure of Scientific Revolutions was a lacuna which Thomas Kuhn acutely felt. In this paper, I argue that Herbert Simon's notion of "satisficing" provides a formally well-developed and empirically well-established theory of rationality that fits well with Kuhn's general characterization of science. I start by considering two rival interpretations of the problem of Kuhnian rationality and introduce Simon's notion of satisficing. In Section 3, I show how satisficing can be used to interpret paradigm, change, rational theory-choice, relativism, and progress. On this account, Kuhnian scientists are not irrational. Rather they employ the same computational mechanism which allows humans to play chess.展开更多
Two studies examined the question of whether photograph taking of an event influences the positivity of the evaluations of the event at a later point in time.Memories of photographed events yielded higher positivity r...Two studies examined the question of whether photograph taking of an event influences the positivity of the evaluations of the event at a later point in time.Memories of photographed events yielded higher positivity ratings than memories that were not photographed.Although we expected fading of positivity ratings to occur more slowly over a period of two months for memories of photographed events,we found faster affect fading for those memories in Study 2 instead.The findings of the two studies support the idea that taking photographs of events sustains the affective reconstruction of autobiographical memories,regardless of whether these events are special,such as vacation memories,or more mundane,such as memories of the past weekend.展开更多
The slippery slope framework(SSF)of tax compliance postulates that taxpayers’compliance behaviour depends on the two dimensions:trust in authorities and power of authorities.In an attempt to overcome common-method bi...The slippery slope framework(SSF)of tax compliance postulates that taxpayers’compliance behaviour depends on the two dimensions:trust in authorities and power of authorities.In an attempt to overcome common-method biases,the present study tests the main assumptions of the SSF with a sample of 44 countries/regions.Country/region-level trust and power indices are calculated based on experimental data involving 14,509 participants and related to shadow economy estimates and–as an alternative indicator of non-compliance–corruption indices.The results indicate that both trust and power are negatively related to the size of the shadow economy and the extent of corruption.These results emphasise the importance of both SSF dimensions in combating tax evasion and counterproductive behaviour within a society in general.展开更多
The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment.As the lesion itself,as ...The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment.As the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to assess.The number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after treatment.In this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types.Based on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.展开更多
This study explores the possibility of opening a policy window for the adoption of the FAIR Guidelines—that data be Findable, Accessible, Interoperable, and Reusable(FAIR)—in Uganda’s e Health sector. Although the ...This study explores the possibility of opening a policy window for the adoption of the FAIR Guidelines—that data be Findable, Accessible, Interoperable, and Reusable(FAIR)—in Uganda’s e Health sector. Although the FAIR Guidelines were not mentioned in any of the policy documents relevant to Uganda’s e Health sector, the study found that 83% of the documents mentioned FAIR Equivalent efforts, such as the adoption of the National Identification Number(NIN) as a unique identifier in Uganda’s national Electronic Health Management Information System(e HMIS)(findability), the planned/ongoing integration of various information systems(interoperability), and the alignment of various projects with international best practices/standards(reusability). A FAIR Equivalency Score(FE-Score), devised in this study as an aggregate score of the mention of the equivalent of FAIR facets in the policy documents, showed that the documents at the core of Uganda’s digital health/e Health policy have the highest score of all the documents analysed, indicating that there is a degree of alignment between Uganda’s National e Health Vision and the FAIR Guidelines. Therefore, it can be concluded that favourable conditions exist for the adoption and implementation of the FAIR Guidelines in Uganda’s e Health sector. Hence, it is recommended that the FAIR community adopt a capacity building strategy through organisations with a worldwide mandate, such as the World Health Organization, to promote the adoption of the FAIR Guidelines as part of international best practices.展开更多
This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and reusable.The implem...This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and reusable.The implementation of these principles is designed to lead to the stewardship of data as FAIR digital objects and the establishment of the Internet of FAIR Data and Services(IFDS).If implementation reaches a tipping point,IFDS has the potential to revolutionize how data is managed by making machine and human readable data discoverable for reuse.Accordingly,this article examines the expansion of the implementation of FAIR Guiding Principles,especially how and in which geographies(locations)and areas(topic domains)implementation is taking place.A literature review of academic articles published between 2016 and 2019 on the use of FAIR Guiding Principles is presented.The investigation also includes an analysis of the domains in the IFDS Implementation Networks(INs).Its uptake has been mainly in the Western hemisphere.The investigation found that implementation of FAIR Guiding Principles has taken firm hold in the domain of bio and natural sciences.To achieve a tipping point for FAIR implementation,it is now time to ensure the inclusion of non-European ascendants and of other scientific domains.Apart from equal opportunity and genuine global partnership issues,a permanent European bias poses challenges with regard to the representativeness and validity of data and could limit the potential of IFDS to reach across continental boundaries.The article concludes that,despite efforts to be inclusive,acceptance of the FAIR Guiding Principles and IFDS in different scientific communities is limited and there is a need to act now to prevent dampening of the momentum in the development and implementation of the IFDS.It is further concluded that policy entrepreneurs and the GO FAIR INs may contribute to making the FAIR Guiding Principles more flexible in including different research epistemologies,especially through its GO CHANGE pillar.展开更多
The FAIR Guidelines were conceptualised and coined as guidelines for Findable, Accessible, Interoperable and Reusable(FAIR) data at a conference held at the Lorentz Centre in Leiden in 2014. A relatively short period ...The FAIR Guidelines were conceptualised and coined as guidelines for Findable, Accessible, Interoperable and Reusable(FAIR) data at a conference held at the Lorentz Centre in Leiden in 2014. A relatively short period of time after this conference, the FAIR Guidelines made it onto the public policy agenda of the European Union. Following the concept of Kingdon, policy entrepreneurs played a critical role in creating a policy window for this idea to reach the agenda by linking it to the policy of establishing a European Open Science Cloud(EOSC). Tracing the development from idea to policy, this study highlights the critical role that expert committees play in the European Union. The permeability of the complex governance structure is increased by these committees, which allow experts to link up with the institutions and use the committees to launch new ideas. The High Level Expert Groups on the EOSC provided the platform from which the FAIR Guidelines were launched, and this culminated in the adoption of the FAIR Guidelines as a requirement for all European-funded science. As a result, the FAIR Guidelines have become an obligatory part of data management in European-funded research in 2020 and are now followed by other funders worldwide.展开更多
文摘AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain.
文摘Attachment theory suggests that anxious attachment is associated with hypervigilance to threatening social stimuli, and avoidant attachment with avoidance or suppression of processing such stimuli. Twenty-five students viewed angry, fearful and neutral female faces in four visual oddball tasks, and completed the Attachment Style Questionnaire, the Autonomy-Connectedness Scale, and Anxiety and Depression subscales of the Symptom Checklist-90. When the oddballs were angry faces in a background of neutral frequents, we found higher levels of autonomy and secure attachment to be related to larger N100 and smaller P300 amplitudes;higher levels of anxious attachment were, on the contrary, associated with smaller N100 and larger P300 amplitudes. Variation in attachment is related to approaching, or withdrawing from threatening stimuli, and ERP-techniques add to our understanding of how the attachment system actually works.
文摘Background: Depression is common in cardiac patients and has been associated with adverse clinical outcome. However, little is known about predictors of the onset of depressive symptoms. We examined predictors of the onset of depressive symptoms at 12 months post- percutaneous coronary intervention(PCI) in patients treated in the drug- eluting stent era. Methods: Unselected patients, free from depressive symptoms at 6 months with a depression score at 12 months treated with PCI with either drug- eluting or bare stent implantation as part of the RESEARCH registry qualified for inclusion in the current study. Patients completed the Hospital Anxiety and Depression Scale at 6 and 12 months and the Type D Personality Scale(DS14) at 6 months post- PCI. Six months was used as the baseline assessment. Results: Of 542 patients, 41(8% ) had developed significant depressive symptoms at 12 months. The occurrence of a new cardiac event between 6 and 12 months post- index event did not influence the incidence of depressive symptoms at 12 months. Depressive patients were more likely to have a type D personality(34% vs 16% , P=.003) and diabetes(24% vs 11% , P=.01) than nondepressive patients. Type D personality(odds ratio 3.04, 95% CI 1.50- 6.16) and diabetes(odds ratio 2.75, 95% CI 1.25- 6.05) were independent predictors of the onset of depressive symptoms 12 months post- PCI in adjusted analyses. In patients with neither risk factors(type D or diabetes), the incidence of depression was 5.1% with the incidence more than doubling to 13.2% and 30% for each additional risk factor. Conclusions: Type D personality and diabetes comprise risk factors for the onset of depressive symptoms post- PCI. In clinical practice, patients with these risk factors should be identified and considered for psychosocial intervention targeting depression to enhance secondary prevention.
文摘Individuals often get lost behind the diagnosis of Alzheimer’s disease (AD) while widespread differences between these patients are morecommon than similarities. Socioemotional Selectivity Theory (SST) suggests that as we age our goals change from future-oriented (acquiringnew information) to present-oriented (enhancing the emotional, especially positive, meaning of encounters). The goal of the current article is to examine whether the principles of SST might also apply for people with AD. Some aspects of SST are found especially in the early stages of AD when awareness is often intact and cognitive impairment is relatively limited. This review has clinical significance for the treatment of AD because it focuses on what is important to the individual rather than treating patients as a homogenous group. It also highlights the importance of social networks and emphasizes the role of the proxy in AD care. Lastly, it suggests that if those with AD (like the healthy elderly) have a positivity bias then positive emotional stimuli/wording/instructions could usefully be employed in their daily treatment. I suggest that SST may be a useful starting point when attempting to address what matters to individuals with AD and conclude by providing a few suggestions for future studies.
文摘To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed this paper by Shah et al,and found that promising as it is,this study has some methodological shortcomings,such as:cross-sectional nature of the study,lack of initial evaluations of quality of life and regular follow-ups to determine the dynamics and real directions of changes in quality of life.We therefore concluded that the results of the study by Shah et al are biased and,although very promising,should not be considered as scientifically relevant.
文摘An adequate approach to reducing school absenteeism should focus on medical absenteeism as this is the most prevalent form of school absenteeism. The objective of this study is to explore the health condition of pre-vocational secondary students with extensive medical absenteeism from a biopsychosocial perspective. Data were obtained from medical assessments and Strengths and Difficulties Questionnaires (SDQs) of students with medical absence above threshold criteria (i.e. reported sick four times in 12 school weeks or more than six consecutive school days) who were referred to a youth health care physician. The results showed that the students had a mean absence rate of 14% in 12 school weeks. Of all students, 43.5% had a diagnosed disease and 81.5% had problems such as physical complaints not yet diagnosed, psychosocial problems, lifestyle problems and sleeping difficulties. Four groups could be distinguished: 13.4% with a diagnosed disease and no problem, 30.1% with a diagnosed disease and a problem, 51.5% with a problem and no diagnosed disease and 5.1% without a diagnosed disease or problem. Significantly higher scores of the Total difficulties-scale on the SDQ were found (mean 10.5;SD 5.8) in the study group, compared to a reference group (mean 9.1;SD 4.9). In conclusion, this study shows that when using the aforementioned criteria for extensive medical absenteeism to intervene with the absence, students with a mean absence rate of 14% in 12 school weeks are identified. If there was a diagnosed disease, it was accompanied by problems about twice as often. More than half of the students’ absence was caused by problems rather than a disease. The great diversity of these problems calls for a personalized approach. A broad perspective, including medical expertise, is needed to distinguish between emerging mental and physical diseases, psychosocial and lifestyle problems.
文摘The lack of an account of rationality in The Structure of Scientific Revolutions was a lacuna which Thomas Kuhn acutely felt. In this paper, I argue that Herbert Simon's notion of "satisficing" provides a formally well-developed and empirically well-established theory of rationality that fits well with Kuhn's general characterization of science. I start by considering two rival interpretations of the problem of Kuhnian rationality and introduce Simon's notion of satisficing. In Section 3, I show how satisficing can be used to interpret paradigm, change, rational theory-choice, relativism, and progress. On this account, Kuhnian scientists are not irrational. Rather they employ the same computational mechanism which allows humans to play chess.
文摘Two studies examined the question of whether photograph taking of an event influences the positivity of the evaluations of the event at a later point in time.Memories of photographed events yielded higher positivity ratings than memories that were not photographed.Although we expected fading of positivity ratings to occur more slowly over a period of two months for memories of photographed events,we found faster affect fading for those memories in Study 2 instead.The findings of the two studies support the idea that taking photographs of events sustains the affective reconstruction of autobiographical memories,regardless of whether these events are special,such as vacation memories,or more mundane,such as memories of the past weekend.
基金the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme[Grant No.798824]for the drafting of this paper.This work was supported by the European Commission.
文摘The slippery slope framework(SSF)of tax compliance postulates that taxpayers’compliance behaviour depends on the two dimensions:trust in authorities and power of authorities.In an attempt to overcome common-method biases,the present study tests the main assumptions of the SSF with a sample of 44 countries/regions.Country/region-level trust and power indices are calculated based on experimental data involving 14,509 participants and related to shadow economy estimates and–as an alternative indicator of non-compliance–corruption indices.The results indicate that both trust and power are negatively related to the size of the shadow economy and the extent of corruption.These results emphasise the importance of both SSF dimensions in combating tax evasion and counterproductive behaviour within a society in general.
基金funded by the Fonds voor Wetenschappelijk Onderzoek for a senior post-doctoral fellowship.PCF is supported by funding from the Bernard Wolfe Health Neuroscience Fund(206368/Z/17/Z)His research is also supported by the NIHR Cambridge Biomedical Research Centre(BRC-1215-20014).
文摘The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment.As the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to assess.The number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after treatment.In this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types.Based on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.
基金VODAN-Africathe Philips Foundation+2 种基金the Dutch Development Bank FMOCORDAIDthe GO FAIR Foundation for supporting this research
文摘This study explores the possibility of opening a policy window for the adoption of the FAIR Guidelines—that data be Findable, Accessible, Interoperable, and Reusable(FAIR)—in Uganda’s e Health sector. Although the FAIR Guidelines were not mentioned in any of the policy documents relevant to Uganda’s e Health sector, the study found that 83% of the documents mentioned FAIR Equivalent efforts, such as the adoption of the National Identification Number(NIN) as a unique identifier in Uganda’s national Electronic Health Management Information System(e HMIS)(findability), the planned/ongoing integration of various information systems(interoperability), and the alignment of various projects with international best practices/standards(reusability). A FAIR Equivalency Score(FE-Score), devised in this study as an aggregate score of the mention of the equivalent of FAIR facets in the policy documents, showed that the documents at the core of Uganda’s digital health/e Health policy have the highest score of all the documents analysed, indicating that there is a degree of alignment between Uganda’s National e Health Vision and the FAIR Guidelines. Therefore, it can be concluded that favourable conditions exist for the adoption and implementation of the FAIR Guidelines in Uganda’s e Health sector. Hence, it is recommended that the FAIR community adopt a capacity building strategy through organisations with a worldwide mandate, such as the World Health Organization, to promote the adoption of the FAIR Guidelines as part of international best practices.
文摘This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and reusable.The implementation of these principles is designed to lead to the stewardship of data as FAIR digital objects and the establishment of the Internet of FAIR Data and Services(IFDS).If implementation reaches a tipping point,IFDS has the potential to revolutionize how data is managed by making machine and human readable data discoverable for reuse.Accordingly,this article examines the expansion of the implementation of FAIR Guiding Principles,especially how and in which geographies(locations)and areas(topic domains)implementation is taking place.A literature review of academic articles published between 2016 and 2019 on the use of FAIR Guiding Principles is presented.The investigation also includes an analysis of the domains in the IFDS Implementation Networks(INs).Its uptake has been mainly in the Western hemisphere.The investigation found that implementation of FAIR Guiding Principles has taken firm hold in the domain of bio and natural sciences.To achieve a tipping point for FAIR implementation,it is now time to ensure the inclusion of non-European ascendants and of other scientific domains.Apart from equal opportunity and genuine global partnership issues,a permanent European bias poses challenges with regard to the representativeness and validity of data and could limit the potential of IFDS to reach across continental boundaries.The article concludes that,despite efforts to be inclusive,acceptance of the FAIR Guiding Principles and IFDS in different scientific communities is limited and there is a need to act now to prevent dampening of the momentum in the development and implementation of the IFDS.It is further concluded that policy entrepreneurs and the GO FAIR INs may contribute to making the FAIR Guiding Principles more flexible in including different research epistemologies,especially through its GO CHANGE pillar.
基金VODAN-Africathe Philips Foundation+2 种基金the Dutch Development Bank FMOCORDAIDthe GO FAIR Foundation for supporting this research
文摘The FAIR Guidelines were conceptualised and coined as guidelines for Findable, Accessible, Interoperable and Reusable(FAIR) data at a conference held at the Lorentz Centre in Leiden in 2014. A relatively short period of time after this conference, the FAIR Guidelines made it onto the public policy agenda of the European Union. Following the concept of Kingdon, policy entrepreneurs played a critical role in creating a policy window for this idea to reach the agenda by linking it to the policy of establishing a European Open Science Cloud(EOSC). Tracing the development from idea to policy, this study highlights the critical role that expert committees play in the European Union. The permeability of the complex governance structure is increased by these committees, which allow experts to link up with the institutions and use the committees to launch new ideas. The High Level Expert Groups on the EOSC provided the platform from which the FAIR Guidelines were launched, and this culminated in the adoption of the FAIR Guidelines as a requirement for all European-funded science. As a result, the FAIR Guidelines have become an obligatory part of data management in European-funded research in 2020 and are now followed by other funders worldwide.