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Research center of biomanufacturing in Xi'an Jiaotong University 被引量:1
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作者 Ling Wang Dichen Li +1 位作者 Jiankang He Bingheng Lu 《Bio-Design and Manufacturing》 SCIE 2018年第4期280-288,共9页
Xi'an Jiaotong University (XJTU)has carded out the research of additive manufacturing (AM)since 1993,who is one of the earliest institutes majoring in AM.After 20years of effort,XJTU has made great progress on the... Xi'an Jiaotong University (XJTU)has carded out the research of additive manufacturing (AM)since 1993,who is one of the earliest institutes majoring in AM.After 20years of effort,XJTU has made great progress on the additive manufacturing of polymer,metals,ceramics,composite materials and intelligent materials.XJTU has established a research team that features the engineering application of rapid manufacturing system. 展开更多
关键词 Xi'an Jiaotong UNIVERSITY
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Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures
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作者 Bo Wang Da Shi +1 位作者 Yin-Di Sun Bo Dong 《World Journal of Psychiatry》 SCIE 2025年第1期83-92,共10页
BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar fractures.This kind of fracture is easily comb... BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar fractures.This kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation treatment.Young patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative emotions.AIM To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation outcomes.METHODS This study retrospectively analyzed 100 patients admitted to the orthopedic department of Honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June 2023.The general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social support.The Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on rehabilitation.RESULTS According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)groups.Statistically significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety groups.Both depression(r=0.207,P=0.038)and anxiety scores(r=0.473,P<0.001)were significantly and positively correlated with negative life events.The difference in negative life event scores as well as SSRS total and item scores was statist-ically significant between patients in the non-depression and depression groups(P<0.05).The difference between the non-anxiety and anxiety groups was statistically significant(P<0.05)in the negative life event scores as well as the total SSRS scores.Additionally,JOA scores were significantly lower in both anxious and depressed patients.CONCLUSION Young patients with thoracolumbar fractures are prone to anxiety and depression.Patients’anxiety and depression are closely associated with social pressure,which reduces the life pressure of young patients with thoracolumbar fractures,enhances social support,and improves the psychology of anxiety and depression.,which affects patients’recovery. 展开更多
关键词 Patients with thoracolumbar fractures ANXIETY DEPRESSION Social pressure Social support
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Influencing factors analysis of spontaneous knee joint osteoarthritis among middle aged and old aged pople in Xi'an 被引量:4
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作者 王伟 王坤正 +4 位作者 党晓谦 柏传毅 王春生 时志斌 马树强 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第3期179-184,共6页
Objective:To explore the prevalence rate of knee joint osteoarthritis and its pathogenetic fea- tures among the middle-aged and old aged people in the urban and rural area of Xi'an.Methods:From May to October 2005... Objective:To explore the prevalence rate of knee joint osteoarthritis and its pathogenetic fea- tures among the middle-aged and old aged people in the urban and rural area of Xi'an.Methods:From May to October 2005,1538 Han nationality above 40 years in Xi'an were investigated according to strati- fied and cluster random sampling.The same questionnaire was delivered to subjects who had been given normotopia and lateral position radiographic examination in both knees.Excluded from etiological arthri- tis,some subjects with clinical symptoms and a radiographic grade (beyond Kellgren & Lawrence gradeⅡ) were finally diagnosed as spontaneous knee joint osteoarthritis.All analyses were performed with SPSS 13.0 and t test,U test.Single factor analysis and multiple logistic regression analysis were used to analyze dates.Results:The total prevalence of spontaneous knee joint osteoarthritis was 12.1% with 2.5% and 2.1% for right and left knees,respectively.The prevalence of knee joint osteoarthritis in wom- en was 2.5 times of that in men (17.2% vs 6.8%,P=0.000).the osteophyte prevalence in women was 2.3 times of that in men (26.5% vs 11.4%,P=0.000).The prevalence of knee joint osteoarthritis and osteophyte increased with the growth of age.So did the symptomatic knee,except for the age group of 56- 60 years and 66-70 years.The prevalence of symptomatic knee joint for urban area was significantly higher than that for rural area (56.3% vs 45.3%,P=0.003).In women,the prevalence of knee joint os- teoarthritis increased significantly with the increasing of body mass index,which had not been observed in men.Female and obesity are the risk factors for osteoarthritis,but bean and its products and meat could prevent the osteoarthritis.Conclusion:Old age,female and obesity serve as risk factors for knee joint os- teoarthritis. 展开更多
关键词 OSTEOARTHRITIS KNEE SPONTANEOUS EPIDEMIOLOGY middle and old aged
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Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model 被引量:3
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作者 Yi-Chao Chai Guo-Xin Dang +6 位作者 Hai-Qi He Jian-Hua Shi Hong-Ke Zhang Rui-Tao Zhang Bo Wang Liang-Shuo Hu Yi Lv 《World Journal of Gastroenterology》 SCIE CAS 2017年第40期7221-7231,共11页
AIM To compare the effect of University of Wisconsin(UW) solution with or without metformin, an AMP-activated protein kinase(AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex... AIM To compare the effect of University of Wisconsin(UW) solution with or without metformin, an AMP-activated protein kinase(AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion(HMP).METHODS Eighteen young(4 mo old) and 18 aged(17 mo old)healthy male SD rats were selected and randomly divided into three groups: control group, UW solution perfusion group(UWP), and UW solution with metformin perfusion group(MUWP). Aspartate aminotransferase(AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH), interleukin-18(IL-18), and tumor necrosis factor-alpha(TNF-α) in the perfused liquid were tested. The expression levels of AMPK and endothelial nitric oxide synthase(e NOS) in liver sinusoidal endothelial cells were also examined.Additionally, microscopic evaluation of the harvested perfused liver tissue samples was done. RESULTS AST, ALT, LDH, IL-18 and TNF-α levels in the young and aged liver-perfused liquid were, respectively,significantly lower in the MUWP group than in the UWP group(P < 0.05), but no significant differences were found between the young and aged MUWP groups.Metformin increased the expression of AMPK and e NOS protein levels, and promoted the extracellular release of nitric oxide through activation of the AMPK-e NOS mediated pathway. Histological examination revealed that in the MUWP group, the extent of liver cells and tissue damage was significantly reduced compared with the UWP group.CONCLUSION The addition of metformin to the UW preservative solution for ex vivo HMP can reduce rat liver injury during cold ischemia, with significant protective effects on livers, especially of aged rats. 展开更多
关键词 METFORMIN AMP-activated protein kinase Cold ischemia injury Hypothermic machine perfusion Liver Grafts
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Comprehensive Analysis of 9-year Running Data of A^2/O-MBR in Xi an Siyuan University 被引量:8
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作者 Xuemei ZHANG Jingyuan HAO +3 位作者 Qinghua MA Dong LI Bo FU Baolan QIN 《Meteorological and Environmental Research》 CAS 2020年第5期139-143,共5页
Since September 2011,A 2/O-MBR wastewater treatment plant in Xi'an Siyuan University has been successfully running without replacing any of membrane modules.A total of 6.661 million m^3 of campus wastewater has be... Since September 2011,A 2/O-MBR wastewater treatment plant in Xi'an Siyuan University has been successfully running without replacing any of membrane modules.A total of 6.661 million m^3 of campus wastewater has been treated,and 4.405 million m^3 of water reaching the national urban miscellaneous water standard has been reclaimed and reused.A total of 25 km pipeline,5 pits,scenery fountains,lakes,and 12 pump stations have been constructed for flushing toilets,irrigating green grass lawn and afforest,and cleaning hardened pavement.The design and construction of 5 pits,scenery fountains,and lakes are important to meet the national urban miscellaneous water standard under occasional phosphorus and/or nitrogen exceed concentration.The unit water cost is 4.19 yuan/m^3,including membrane modules depreciation and amortization.After the A 2/O-MBR system passes the membrane modules depreciation and amortization period,the unit water cost is 2.82 yuan/m^3.The water productivity of the membrane stack rises first at the beginning of operation,reaches the maximum value,and then decreases.The average annual transmembrane pressure difference increases by 1.12 kPa.The average VMD of industrial permeability decreases annually by 0.45 m^3. 展开更多
关键词 Wastewater treatment and reuse system A 2/O-MBR system Economic feasibility Industrial permeability Membrane fouling
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Chemical Characteristics of Carbonaceous Aerosols During Dust Storms over Xi'an in China 被引量:2
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作者 李旭祥 曹军骥 +3 位作者 Judith CHOW 韩永明 李顺诚 John WATSON 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2008年第5期847-855,共9页
Characterization of carbonaceous aerosols including CC (carbonate carbon), OC (organic carbon), and EC (elemental carbon) were investigated at Xi'an, China, near Asian dust source regions in spring 2002. OC var... Characterization of carbonaceous aerosols including CC (carbonate carbon), OC (organic carbon), and EC (elemental carbon) were investigated at Xi'an, China, near Asian dust source regions in spring 2002. OC varied between 8.2 and 63.7μgm^- 3, while EC ranged between 2.4 and 17.2 μ m^-3 during the observation period. OC variations followed a similar pattern to EC and the correlation coefficient between OC and EC is 0.89 (n=31). The average percentage of total carbon (TC, sum of CC, OC, and EC) in PM2.5 during dust storm (DS) events was 13.6%, which is lower than that during non-dust storm (NDS) periods (22.7%). CC, OC, and EC accounted for 12.9%, 70.7%, and 16.4% of TC during DS events, respectively. The average ratio of OC/EC was 5.0 in DS events and 3.3 in NDS periods. The OC-EC correlation (R^2=0.76, n=6) was good in DS events, while it was stronger (R^2=0.90, n=25) in NDS periods. The percentage of watersoluble OC (WSOC) in TC accounted for 15.7%, and varied between 13.3% and 22.3% during DS events. The distribution of eight carbon fractions indicated that local emissions such as motor vehicle exhaust were the dominant contributors to carbonaceous particles. During DS events, soil dust dominated the chemical composition, contributing 69% to the PM2.5 mass, followed by organic matter (12.8%), sulfate (4%), EC (2.2%), and chloride (1.6%). Consequently, CC was mainly entrained by Asian dust. However, even in the atmosphere near Asian dust source regions, OC and EC in atmospheric dust were controlled by local emission rather titan the transport of Asian dust. 展开更多
关键词 carbonate carbon organic carbon elemental carbon dust storm
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Urban Design Based on Protection of Historic Space of Cultural Heritage:A Case Study of Urban Design of Dongguan District in Xi'an
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作者 TIAN Wen XU Jian XU Bo 《Journal of Landscape Research》 2017年第2期113-116,共4页
Located in the east of Xi'an, Dongguan District is the area to the east of the Ming City wall.There is a great deal of precious architectural heritages in the area, including shrines such as the Wangji Temple, the... Located in the east of Xi'an, Dongguan District is the area to the east of the Ming City wall.There is a great deal of precious architectural heritages in the area, including shrines such as the Wangji Temple, the Baxian Temple, the Catholic Church and the Laomu Temple, as well as protected dwellings such as the Xingqing Palace, the royal palace of the flouring period of the Tang Dynasty, and the Courtyard of Family Xi, etc.. Currently, securing Dongguan District protection and development has confronted with severe challenges. Based on the in-depth investigation of the status quo and objective analysis of pros and cons, this paper gives a clear definition for Dongguan District protection and development, and profoundly analyses courtyards, streets, landscape environment and human environment of the Dongguan District, so as to formulate protective methods as well as measures and explore development approaches. 展开更多
关键词 Cultural heritage Historic street Urban public space
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Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis 被引量:2
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作者 Xue Bai Rongzhan Fu +5 位作者 Yannan Liu Jianjun Deng Qiang Fei Zhiguang Duan Chenhui Zhu Daidi Fan 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第2期259-275,共17页
The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains unclear.Therefo... The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains unclear.Therefore,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune regulation.Our results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic Desulfovibrio.Subsequent metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune response.Furthermore,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling pathway.These results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon tumors.More importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut microbiota.In summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC. 展开更多
关键词 Colorectal cancer GINSENOSIDE Immune cells Gut microbiota
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Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma 被引量:1
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作者 Jingjing Wang Qi Su +9 位作者 Kun Chen Qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu Cheng Cheng Kaihui Tu Huaizhen He Yanmin Zhang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第2期211-224,共14页
Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. Ho... Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC. 展开更多
关键词 PYRIMETHAMINE BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib
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Exploring impedance spectrum for lithium-ion batteries diagnosis and prognosis:A comprehensive review 被引量:2
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作者 Xinghao Du Jinhao Meng +2 位作者 Yassine Amirat Fei Gao Mohamed Benbouzid 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第8期464-483,I0010,共21页
Lithium-ion batteries have extensive usage in various energy storage needs,owing to their notable benefits of high energy density and long lifespan.The monitoring of battery states and failure identification are indis... Lithium-ion batteries have extensive usage in various energy storage needs,owing to their notable benefits of high energy density and long lifespan.The monitoring of battery states and failure identification are indispensable for guaranteeing the secure and optimal functionality of the batteries.The impedance spectrum has garnered growing interest due to its ability to provide a valuable understanding of material characteristics and electrochemical processes.To inspire further progress in the investigation and application of the battery impedance spectrum,this paper provides a comprehensive review of the determination and utilization of the impedance spectrum.The sources of impedance inaccuracies are systematically analyzed in terms of frequency response characteristics.The applicability of utilizing diverse impedance features for the diagnosis and prognosis of batteries is further elaborated.Finally,challenges and prospects for future research are discussed. 展开更多
关键词 Lithium-ion battery Impedance spectrum Temperature monitoring Failure diagnosis Health prognosis
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Management of non-alcoholic fatty liver disease:Lifestyle changes 被引量:1
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作者 Hao Lv Yang Liu 《World Journal of Gastroenterology》 SCIE CAS 2024年第22期2829-2833,共5页
In this editorial,we commented on a recently released manuscript by Zeng et al in the World Journal of Gastroenterology.We focused specifically on lifestyle changes in patients with non-alcoholic fatty liver disease(N... In this editorial,we commented on a recently released manuscript by Zeng et al in the World Journal of Gastroenterology.We focused specifically on lifestyle changes in patients with non-alcoholic fatty liver disease(NAFLD).NAFLD is a hepatic manifestation of the metabolic syndrome,which ultimately leads to advanced hepatic fibrosis,cirrhosis,and hepatocellular carcinoma and affects more than 25%of the population globally.Existing therapeutic strategies against NAFLD such as pharmacologic therapies focus on liver protection,anti-inflammation,and regulating disease-related metabolic disorder symptoms.Although several drugs are in late-stage development,potent drugs against the diseases are lacking.Additionally,existing surgical approaches such as bariatric surgery are not routinely used to treat NAFLD.Intervening in patients’unhealthy lifestyles,such as weight loss through dietary changes and exercises to ameliorate patientassociated metabolic disorders and metabolic syndrome,is the first-line treatment for patients with NAFLD.With sufficient intrinsic motivation and adherence,the management of unhealthy lifestyles can reduce the severity of the disease,improve the quality of life,and increase the survival expectancy of patients with NAFLD. 展开更多
关键词 Non-alcoholic fatty liver disease LIFESTYLE physical activity Physical exercise Low-calorie diet Mediterranean diet
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A 16-bit 18-MSPS flash-assisted SAR ADC with hybrid synchronous and asynchronous control logic 被引量:1
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作者 Junyao Ji Xinao Ji +5 位作者 Ziyu Zhou Zhichao Dai Xuhui Chen Jie Zhang Zheng Jiang Hong Zhang 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期3-12,共10页
This paper presents a 16-bit,18-MSPS(million samples per second)flash-assisted successive-approximation-register(SAR)analog-to-digital converter(ADC)utilizing hybrid synchronous and asynchronous(HYSAS)timing control l... This paper presents a 16-bit,18-MSPS(million samples per second)flash-assisted successive-approximation-register(SAR)analog-to-digital converter(ADC)utilizing hybrid synchronous and asynchronous(HYSAS)timing control logic based on an on-chip delay-locked loop(DLL).The HYSAS scheme can provide a longer settling time for the capacitive digital-to-analog converter(CDAC)than the synchronous and asynchronous SAR ADC.Therefore,the issue of incomplete settling or ringing in the DAC voltage for cases of either on-chip or off-chip reference voltage can be solved to a large extent.In addition,the fore-ground calibration of the CDAC’s mismatch is performed with a finite-impulse-response bandpass filter(FIR-BPF)based least-mean-square(LMS)algorithm in an off-chip FPGA(field programmable gate array).Fabricated in 40-nm CMOS process,the proto-type ADC achieves 94.02-dB spurious-free dynamic range(SFDR),and 75.98-dB signal-to-noise-and-distortion ratio(SNDR)for a 2.88-MHz input under 18-MSPS sampling rate. 展开更多
关键词 SAR ADC control logic reference ringing DAC incomplete settling
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From concept to commercialization:A review of tubular solid oxide fuel cell technology 被引量:1
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作者 Ruyan Chen Yuan Gao +4 位作者 Jiutao Gao Huiyu Zhang Martin Motola Muhammad Bilal Hanif Cheng-Xin Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第10期79-109,I0003,共32页
The reduced sealing difficulty of tubular solid oxide fuel cells(SOFCs)makes the stacking of tubular cell groups relatively easy,and the thermal stress constraints during stack operation are smaller,which helps the st... The reduced sealing difficulty of tubular solid oxide fuel cells(SOFCs)makes the stacking of tubular cell groups relatively easy,and the thermal stress constraints during stack operation are smaller,which helps the stack to operate stably for a long time.The special design of tubular SOFC structures can completely solve the problem of high-temperature sealing,especially in the design of multiple single-cell series integrated into one tube,where each cell tube is equivalent to a small electric stack,with unique characteristics of high voltage and low current output,which can significantly reduce the ohmic polarization loss of tubular cells.This paper provides an overview of typical tubular SOFC structural designs both domestically and internationally.Based on the geometric structure of tubular SOFCs,they can be divided into bamboo tubes,bamboo flat tubes,single-section tubes,and single-section flat tube structures.Meanwhile,this article provides an overview of commonly used materials and preparation methods for tubular SOFCs,including commonly used materials and preparation methods for support and functional layers,as well as a comparison of commonly used preparation methods for microtubule SOFCs,It introduced the three most important parts of building a fuel cell stack:manifold,current collector,and ceramic adhesive,and also provided a detailed introduction to the power generation systems of different tubular SOFCs,Finally,the development prospects of tubular SOFCs were discussed. 展开更多
关键词 Tubular solid oxide fuel cell Support material Geometric structure Preparation methods STACK
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Precision targeting in hepatocellular carcinoma:Exploring ligandreceptor mediated nanotherapy 被引量:1
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作者 Xia-Qing Zhou Ya-Ping Li Shuang-Suo Dang 《World Journal of Hepatology》 2024年第2期164-176,共13页
Hepatocellular carcinoma(HCC)is the most common primary liver cancer and poses a major challenge to global health due to its high morbidity and mortality.Conventional chemotherapy is usually targeted to patients with ... Hepatocellular carcinoma(HCC)is the most common primary liver cancer and poses a major challenge to global health due to its high morbidity and mortality.Conventional chemotherapy is usually targeted to patients with intermediate to advanced stages,but it is often ineffective and suffers from problems such as multidrug resistance,rapid drug clearance,nonspecific targeting,high side effects,and low drug accumulation in tumor cells.In response to these limitations,recent advances in nanoparticle-mediated targeted drug delivery technologies have emerged as breakthrough approaches for the treatment of HCC.This review focuses on recent advances in nanoparticle-based targeted drug delivery systems,with special attention to various receptors overexpressed on HCC cells.These receptors are key to enhancing the specificity and efficacy of nanoparticle delivery and represent a new paradigm for actively targeting and combating HCC.We comprehensively summarize the current understanding of these receptors,their role in nanoparticle targeting,and the impact of such targeted therapies on HCC.By gaining a deeper understanding of the receptor-mediated mechanisms of these innovative therapies,more effective and precise treatment of HCC can be achieved. 展开更多
关键词 TARGETING Hepatocellular carcinoma RECEPTOR NANOMEDICINE CHEMOTHERAPY
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Relationship between Kawasaki disease and abdominal pain 被引量:1
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作者 Yan Pan Fu-Yong Jiao 《World Journal of Clinical Cases》 SCIE 2024年第17期2932-2934,共3页
This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases.Kawasaki disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral muco... This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases.Kawasaki disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral mucosal changes,and swelling of the extremities.This editorial aims to delve into the intricate relationship between KD and abdominal pain,drawing insights from recent research findings to provide a comprehensive understanding and potential avenues for future investigation. 展开更多
关键词 Kawasaki disease Abdominal pain RELATIONSHIP RESEARCH INVESTIGATION
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Current and further trajectories in designing functional materials for solid oxide electrochemical cells:A review of other reviews 被引量:2
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作者 Stanislav Baratov Elena Filonova +6 位作者 Anastasiya Ivanova Muhammad Bilal Hanif Muneeb Irshad Muhammad Zubair Khan Martin Motola Sajid Rauf Dmitry Medvedev 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第7期302-331,共30页
Complex oxides are an important class of materials with enormous potential for electrochemical appli-cations.Depending on their composition and structure,such complex oxides can exhibit either a single conductivity(ox... Complex oxides are an important class of materials with enormous potential for electrochemical appli-cations.Depending on their composition and structure,such complex oxides can exhibit either a single conductivity(oxygen-ionic or protonic,or n-type,or p-type electronic)or a combination thereof gener-ating distinct dual-conducting or even triple-conducting materials.These properties enable their use as diverse functional materials for solid oxide fuel cells,solid oxide electrolysis cells,permeable membranes,and gas sensors.The literature review shows that the field of solid oxide materials and related electro-chemical cells has a significant level of research engagement,with over 8,000 publications published since 2020.The manual analysis of such a large volume of material is challenging.However,by examining the review articles,it is possible to identify key patterns,recent achievements,prospects,and remaining obstacles.To perform such an analysis,the present article provides,for the first time,a comprehensive summary of previous review publications that have been published since 2020,with a special focus on solid oxide materials and electrochemical systems.Thus,this study provides an important reference for researchers specializing in the fields of solid state ionics,high-temperature electrochemistry,and energyconversiontechnologies. 展开更多
关键词 SOFCS SOECs PCFCS ELECTROCHEMISTRY Energy conversion Hydrogen energy Carbon neutrality
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Excess Activity Tuned by Distorted Tetrahedron in CoMoO_(4) for Oxygen Evolution 被引量:1
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作者 Hengbo Xiao Kai Chi +10 位作者 Hongxia Yin Xiangji Zhou Pengxiang Lei Peizhi Liu Jiakun Fang Xiuhong Li Songliu Yuan Zhen Zhang Yaqiong Su Junjie Guo Lihua Qian 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第1期247-252,共6页
Oxygen vacancies enable modulating surface reconstruction of transition metal oxides containing metal-oxygen polyhedrons into metallic oxyhydroxide for oxygen evolution reaction(OER),while revealing reconstructing mec... Oxygen vacancies enable modulating surface reconstruction of transition metal oxides containing metal-oxygen polyhedrons into metallic oxyhydroxide for oxygen evolution reaction(OER),while revealing reconstructing mechanism is stuck by the requirement to precisely control exact sites of these vacancies.Herein,oxygen vacancies are localized only within MoO_(4)tetrahedrons rather than CoO_(6)octahedrons in CoMoO_(4)catalyst,guaranteeing coherent reconstruction of CoO_(6)octahedrons into pure CoOOH with tunable activities for OER.Meanwhile,distorted tetrahedron accelerates the dissolution of Mo atoms into alkaline electrolyte,triggering spontaneous transition of partial CoMoO_(4)into Co(OH)_(2).CoO_(6)octahedrons in both CoMoO_(4)and Co(OH)_(2)can transform pure CoOOH completely at lower potential,resulting in excess intrinsic activity whose summit is identified by overpotential at 10 mA cm^(-2)with 22.9%reduction and Tafel slope with 65.3%reduction.Well-defined manipulation over the distorted polyhedrons offers one versatile knob to precisely modulate electronic structure of oxide catalysts with outstanding OER performance. 展开更多
关键词 metal-oxygen polyhedron oxygen evolution reaction oxygen vacancy Raman spectroscopy
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Recent progress in ternary mixed matrix membranes for CO_(2) separation 被引量:1
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作者 Zikang Qin Yulei Ma +13 位作者 Jing Wei Hongfang Guo Bangda Wang Jing Deng Chunhai Yi Nanwen Li Shouliang Yi Yi Deng Wentao Du Jian Shen Wenju Jiang Lu Yao Lin Yang Zhongde Dai 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第5期831-858,共28页
Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,s... Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsfillers and the polymer matrix,currently limit the gas sep-aration performance of MMMs.Ternary phase MMMs(consisting of afiller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation performance.This review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanofillers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy polymers.Based on this separation data,the challenges of ternary MMMs are also discussed.Finally,future directions for ternary MMMs are proposed. 展开更多
关键词 CO_(2) separation Mixed matrix membranes Ternary phase
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MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer
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作者 Haowei Zhang Qixin Li +9 位作者 Xiaolong Guo Hong Wu Chenhao Hu Gaixia Liu Tianyu Yu Xiake Hu Quanpeng Qiu Gang Guo Junjun She Yinnan Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第6期863-877,共15页
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeu... Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle programs and DNA repair.Among the elements that lead to DDP resistance,O^(6)-methylguanine(O^(6)-MG)-DNA-methyltransferase(MGMT),a DNA-repair enzyme,performs a quintessential role.In this study,we clarify the significant involvement of MGMT in conferring DDP resistance in CRC,elucidating the underlying mechanism of the regulatory actions of MGMT.A notable upregulation of MGMT in DDP-resistant cancer cells was found in our study,and MGMT repression amplifies the sensitivity of these cells to DDP treatment in vitro and in vivo.Conversely,in cancer cells,MGMT overexpression abolishes their sensitivity to DDP treatment.Mechanistically,the interaction between MGMT and cyclin dependent kinase 1(CDK1)inducing slow-cycling cells is attainted via the promotion of ubiquitination degradation of CDK1.Meanwhile,to achieve nonhomologous end joining,MGMT interacts with XRCC6 to resist chemotherapy drugs.Our transcriptome data from samples of 88 patients with CRC suggest that MGMT expression is co-related with the Wnt signaling pathway activation,and several Wnt inhibitors can repress drug-resistant cells.In summary,our results point out that MGMT is a potential therapeutic target and predictive marker of chemoresistance in CRC. 展开更多
关键词 Colorectal cancer MGMT Chemotherapy resistance Slow-cycling cells Nonhomologous end joining Wnt pathway
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Femtosecond laser fabrication of 3D vertically aligned micro-pore network on thick-film Li_(4)Ti_(5)O_(12)electrode for high-performance lithium storage
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作者 Quansheng Li Xiaofei Sun +4 位作者 Xuesong Mei Lingzhi Wang Minxing Yang Jianlei Cui Wenjun Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第8期250-262,I0006,共14页
The development of energy storage devices with high energy density relies heavily on thick film electrodes,but it is challenging due to the limited ion transport kinetics inherent in thick electrodes.Here,we report on... The development of energy storage devices with high energy density relies heavily on thick film electrodes,but it is challenging due to the limited ion transport kinetics inherent in thick electrodes.Here,we report on the preparation of a directional vertical array of micro-porous transport networks on LTO electrodes using a femtosecond laser processing strategy,enabling directional ion rapid transport and achieving good electrochemical performance in thick film electrodes.Various three-dimensional(3D)vertically aligned micro-pore networks are innovatively designed,and the structure,kinetics characteristics,and electrochemical performance of the prepared ion transport channels are analyzed and discussed by multiple characterization and testing methods.Furthermore,the rational mechanisms of electrode performance improvement are studied experimentally and simulated from two aspects of structural mechanics and transmission kinetics.The ion diffusion coefficient,rate performance at 60 C,and electrode interface area of the laser-optimized 60-15%micro-porous transport network electrodes increase by 25.2 times,2.2 times,and 2.15 times,respectively than those of untreated electrodes.Therefore,the preparation of 3D micro-porous transport networks by femtosecond laser on ultra-thick electrodes is a feasible way to develop high-energy batteries.In addition,the unique micro-porous transport network structure can be widely extended to design and explore other high-performance energy materials. 展开更多
关键词 Femtosecond laser Micro-porous transport networks Laser processing Thick film electrodes Ion transport kinetics
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