<p align="justify"> <span style="font-family:Verdana;">Satellite imagery is used for many activities in different areas of the planet, including searching for alternative and sustainabl...<p align="justify"> <span style="font-family:Verdana;">Satellite imagery is used for many activities in different areas of the planet, including searching for alternative and sustainable sources to meet growing energy demand to reduce greenhouse gas (GHG) emissions. One way to minimize these effects and expand energy parks is to encourage local generation through the use of renewable sources, such as solar energy, which is free and affordable in many regions of the planet, but that in Brazil is not yet a reality. In order to make an assertive decision when installing a solar power system, one needs to use tools that involve remote sensing and geographic information systems (GIS), and compile information and variables that are relevant to the subject of solar power generation and take into account the inherent geographic space. In this context, the main objective of this work is to develop a GIS model to identify areas with solar potential on a regional scale using active remote sensor images and previously available solar models. To validate the model, this study used an area on the island part of the city of Florianópolis in Santa Catarina State</span></span></span></a><span><span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;">—</span><span style="font-family:Verdana;">Brazil, which suffers from repeated climatic events which cause long power cuts, as its distribution occurs by air all over the island. Through the “solar analist” function of ArcGIS and the matrix bases derived from the Digital Model of the Space Shuttle Topography Mission (SRTM) with 30 m of spatial resolution and the supervised classification of panthromatic and multispectral images fused from LandSat 8 satellite, were generates indicative maps of the areas with solar potential. The results pointed to a high solar potential in the all year and that could be better explored by public managers and also by individual consumers.</span></span></span></span> </p>展开更多
The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex orientations.The vibration caused by the high-frequency units during regular operation is ...The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex orientations.The vibration caused by the high-frequency units during regular operation is supported by the foundation of the units,and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts,leading to variations in the dynamic response of the foundation.The high-frequency units yield significantly diverse outcomes under different startup conditions and times,resulting in failure to meet operational requirements,influencing the normal function of the tunnel,and causing harm to the foundation structure,personnel,and property in severe cases.This article formulates a finite element numerical computation model for solid elements using three-dimensional elastic body theory and integrates field measurements to substantiate and ascertain the crucial parameter configurations of the finite element model.By proposing a comprehensive startup timing function for high-frequency dynamic machines under different startup conditions,simulating the frequency andmagnitude variations during the startup process,and suggesting functions for changes in frequency and magnitude,a simulated startup schedule function for high-frequency machines is created through coupling.Taking into account the selection of the transient dynamic analysis step length,the dynamic response results for the lower dynamic foundation during its fundamental frequency crossing process are obtained.The validation checks if the structural magnitude surpasses the safety threshold during the critical phase of unit startup traversing the structural resonance region.The design recommendations for high-frequency units’dynamic foundations are provided,taking into account the startup process of the machine and ensuring the safe operation of the tunnel.展开更多
Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens...Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC<sup>®</sup> Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC<sup>®</sup>). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.展开更多
In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is somethi...In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is something to be invented,from the hole of the Real,the Unconscious truth,and the subjective experience.The relationships between playing,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowledge of oneself,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the analytical act,and transversalize psychoanalysis.In the practice,we listen to and witness processes of analysis that awaken an invention/reinvention of oneself,in the process of remembering,repeating,and elaborating,but also in what the transference relationship summons.Knowledge of oneself,does not guarantee a life without mishaps,sadness,and illusions,but allows the invention and recognition of knowledge and a style.The concept of Sinthome(2007),coined by Jacques Lacan,comes in the wake of the processes of self-invention and is a knowing-doing with the symptom,with the paradoxes of joyful suffering,producing,as a result,an art of saying.Therefore,in this communication,I will articulate elements of theory,practice,and psychoanalytic experience that allow us to expand knowledge of the themes of invention and imagination articulated with the concept of sinthome,their relationships with subjectivity,and the direction of psychoanalytic treatment.展开更多
The origin of elementary particle mass is considered as a function of n-valued graviton quanta. To develop this concept we begin in a cold region of “empty space” comprised of only microscopic gravitons oscillating ...The origin of elementary particle mass is considered as a function of n-valued graviton quanta. To develop this concept we begin in a cold region of “empty space” comprised of only microscopic gravitons oscillating at angular frequency ω. From opposite directions enters a pair of stray protons. Upon colliding, heat and energy are released. Customarily, this phase and what follows afterward would be described by Quantum Chromodynamics (QCD). Instead, we argue for an intermediary step. One in which neighboring gravitons absorb discrete amounts of plane-wave energy. Captured by the graviton, the planewave becomes a standing wave, whereupon its electromagnetic energy densities are converted into gravitational quanta. Immediately thereafter an elementary particle is formed and emitted, having both mass and spin. From absorption to conversion to emission occurs in less than 3.7 × 10−16 s. During this basic unit of hybrid time, general relativity and quantum physics unite into a common set of physical laws. As additional stray protons collide the process continues. Over eons, vast regions of spacetime become populated with low-mass particles. These we recognize to be dark matter by its effects on large scale structures in the universe. Its counterpart, dark energy, arises when the conversion of gravitational quanta to particle emission is interrupted. This causes the gravitational quanta to be ejected. It is recognized by its large scale effects on the universe.展开更多
Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of years.Cupping therapy is reported to be a relatively safe practice e...Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of years.Cupping therapy is reported to be a relatively safe practice especially if performed by qualified therapists.Subconjunctival hemorrhage(SCH)is a common cause of eye redness and can be classified into traumatic and spontaneous.Case presentation:This case report discussed an adverse event related to wet cupping therapy.The patient developed SCH one day after performing cupping therapy.He was completely recovered after 2 weeks.This case report should increase the knowledge of cupping therapists regarding increasing safety of patient when performing wet cupping therapy on specific body parts especially,head,neck and cervical areas.Furthermore,it highlighted the importance of conducting research regarding the mechanical and physiological effects of cupping therapy.Conclusion:Adverse events related to cupping therapy should be reported with every patient.Cupping therapists should be aware of this possible mild adverse event.To the best of our knowledge,this is the first published adult case of SCH related to wet cupping therapy session.More studies are critically needed for evaluation of cupping therapy effects and adverse events especially when performed on head and neck.展开更多
With economic progress and the continuous advancement of science and technology,the issue of employees substituting punch cards has gradually become a significant challenge in enterprise management.The purpose of this...With economic progress and the continuous advancement of science and technology,the issue of employees substituting punch cards has gradually become a significant challenge in enterprise management.The purpose of this paper is to discuss the causes,effects,and countermeasures of the employee punch card phenomenon,with the aim of providing effective management recommendations for Chinese enterprises.In practice,enterprises should flexibly apply the countermeasures proposed in this paper according to their specific circumstances to prevent substitute punch card incidents and improve overall management efficiency.展开更多
A case of Qinghuayuan tunnel excavation below the existing Beijing Subway Line 10 is presented.The new Qinghuayuan tunnel,part of the Beijing-Zhangjiakou High-speed Railway,was excavated by a shield machine with an ou...A case of Qinghuayuan tunnel excavation below the existing Beijing Subway Line 10 is presented.The new Qinghuayuan tunnel,part of the Beijing-Zhangjiakou High-speed Railway,was excavated by a shield machine with an outer diameter of 12.2 m.The existing subway was excavated by shallow tunnelling method.The project layout,geological conditions,reinforcement measures,operational parameters of shield machine and monitoring results of the project are introduced.During the Qinghuayuan tunnel excavation below the existing subway,total thrust,shield driving speed,cutterhead rotation speed and torque were manually controlled below the average values obtained from the previous monitoring of this project,which could effectively reduce the disturbance of the surrounding soil induced by shield excavation.The Gaussian fitting function can appropriately fit both the ground and the existing subway settlements.The trough width is influenced not only by the excavation overburden depth,but also by the forepoling reinforcement and tail void grouting measures.展开更多
Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision making.Although liver biopsy has been considered the gold standard for staging...Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision making.Although liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability.Over the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable performance.Besides the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy.In addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk.However,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions.These methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve accuracy.In this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice.展开更多
Rice bran is a solid residue from rice polishing that is used in animal nutrition and rice oil production. Cultivation conditions with agro-toxics, lipids instability, and tendency for mycotoxin contamination restrict...Rice bran is a solid residue from rice polishing that is used in animal nutrition and rice oil production. Cultivation conditions with agro-toxics, lipids instability, and tendency for mycotoxin contamination restrict its application in human nutrition. Therefore, organic agriculture is an alternative to use the properties of rice bran. Rice bran beverage is a new cereal product from organic rice. This work presents the preliminary results of the chemical and rheological studies of a bath pasteurized rice bran beverage. Compared with integral defatted milk, soy extracts, and brown rice low-fat milk, the rice bran beverage studied in this work presents itself as an important source of minerals and unsaturated lipids. All essential amino acids were found in this product. Glutamic and aspartic acids were predominant. Bath pasteurization at boiling water temperature for 15 and 30 min was adequate for microbiological safety. Refrigeration storage for 20 days, evaluated by pH and acidity variations, was ideal for assessment of the beverage conservation time. The beverage viscosity was of the Newtonian standard behavior, and its viscosity during storage was not a good parameter to evaluate shelf life. Sensory preference tests showed positive perspectives for this new beverage.展开更多
The relationship between environmental quality and economic growth has been a hot topic for decades.After years of rapid industrialization and urbanization,China’s environmental challenges are approaching a turning p...The relationship between environmental quality and economic growth has been a hot topic for decades.After years of rapid industrialization and urbanization,China’s environmental challenges are approaching a turning point.Following the principles of ecological civilization construction,China is on its way to maintaining high-quality and green economic development.On 10 June 2020,the Chinese Government reported the key findings of the Second National General Survey of Pollution Sources(fiscal year 2017),which provides strong quantitative evidence of progress toward ecological civilization.In terms of our comparison between the two National General Surveys in 2007 and 2017,it was found that environmental pollution,measured in terms of many wastewater and air emission pollutant discharges,is decreasing despite the steady growth in economic activities—and at a noticeably fast pace.Other national and local governments can adopt some of China’s ecological civilization practices,within their own individual contexts.展开更多
This paper aimed to evaluate the effects of different concentrations of cadmium on growth rates, photosynthetic pigments, photosynthetic performance, biochemical parameters and structure of chloroplasts in G. domingen...This paper aimed to evaluate the effects of different concentrations of cadmium on growth rates, photosynthetic pigments, photosynthetic performance, biochemical parameters and structure of chloroplasts in G. domingensis. To accomplish this, apical segments of G. domingensis were cultivated with different concentrations of cadmium, ranging from 100 to 300 μM, over a period of 16 days, and were processed for transmission electron microscopy analysis. The plants exposed to cadmium showed chloroplast alteration, especially degeneration of thylakoids and a decrease in the concentration of photosynthetic pigments, such as chlorophyll a and phycobiliproteins. However, the volume of plastoglobuli increased. As a defense mechanism, the plants treated with cadmium showed an increase in glutathione reductase activity. These results agree with the decreased photosynthetic performance and relative electron transport rate observed after exposure of algae to cadmium. Taken together, these findings strongly indicate that cadmium negatively affects the ultrastructure and metabolism of the agarophyte G. domingensis, thus posing a threat to the economic vitality of this red macroalga.展开更多
AIM;TO report present state of iatrogenic drug-induced esophageal injury(DIEI)induced by medications in a private clinic. METHODS:Iatrogenic drug-induced esophageal injury (DIEI)induced by medications has been more fr...AIM;TO report present state of iatrogenic drug-induced esophageal injury(DIEI)induced by medications in a private clinic. METHODS:Iatrogenic drug-induced esophageal injury (DIEI)induced by medications has been more frequently reported.In a private clinic we encountered 36 cases of esophageal ulcerations complicating doxycycline therapy in a mainly younger Saudi population(median age 29 years). RESULTS:The most frequent presenting symptoms were odynophagia,retrosternal burning pain and dysphagia(94 %, 75 % and 56 %,respectively).The diagnosis was according to medical history and confirmed by endoscopy in all patients. Beside withdrawal of doxycycline,when feasible,all patients were treated with a proton-pump inhibitor(PPI)and a prokinetic.Thirty patients who reported to the clinic after treatment were improved within 1-7(median 1.7)days. CONCLUSION:Esophageal ulceration has to be suspected in younger patients with odynophagia,retrosternal burning pain and/or dysphagia during the treatment with doxycycline.展开更多
Plan asymmetric buildings are very susceptible to earthquake induced damage due to lateral torsional coupling, and the corners of these systems suffer heavy damage during earthquakes. Therefore, it is important to inv...Plan asymmetric buildings are very susceptible to earthquake induced damage due to lateral torsional coupling, and the corners of these systems suffer heavy damage during earthquakes. Therefore, it is important to investigate the seismic behavior of an asymmetric plan building with MR dampers. In this study, the effectiveness of MR damper-based control systems has been investigated for seismic hazard mitigation of a plan asymmetric building. Furthermore, the infl uence of the building parameters and damper command voltage on the control performance is examined through parametric study. The building parameters chosen are eccentricity ratio and frequency ratio. The results show that the MR damper-based control systems are effective for plan asymmetric systems.展开更多
Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in bio...Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.展开更多
Despite the current interest in the potential medical use of Cannabis, it is worth remembering that cannabis is not a new drug, with both a nonmedical and medical history supporting its effectiveness.This history adva...Despite the current interest in the potential medical use of Cannabis, it is worth remembering that cannabis is not a new drug, with both a nonmedical and medical history supporting its effectiveness.This history advanced in scientific strength and importance worldwide when Professor Raphael Mechoulam and colleagues initiated their pioneering discoveries in 1971.At first, Mechoulam et al.(1972) achieved the complete synthesis of the pure compounds from hashish(including △1-tetrahydrocannabinol and other neutral cannabinoids such as cannabigerol, cannabichromene, and cannabicyclol), and established their molecular structures.展开更多
In this article,we derive the Lp-boundedness of the variation operators associated with the heat semigroup which is generated by the high order Schrodinger type operator(—Δ)^2+V%2 in R%n(n≥5)with V being a nonnegat...In this article,we derive the Lp-boundedness of the variation operators associated with the heat semigroup which is generated by the high order Schrodinger type operator(—Δ)^2+V%2 in R%n(n≥5)with V being a nonnegative potential satisfying the reverse Holder inequality.Furt her more,we prove the boundedness of the variation operators on associated Morrey spaces.In the proof of the main results,we always make use of the variation inequalities associated with the hea t semigroup genera ted by the biharmonic operator(-Δ)2.展开更多
Esterification is an important process in the food industry and can be carried out via homogeneous or heterogeneous catalysis.The homogeneous catalyst,despite providing high conversion,can cause corrosion in reactors,...Esterification is an important process in the food industry and can be carried out via homogeneous or heterogeneous catalysis.The homogeneous catalyst,despite providing high conversion,can cause corrosion in reactors,which is not observed with the use of heterogeneous catalysts.However,some of these catalysts require a high process temperature and may lose their catalytic activity with reuse.Thus,catalytic membranes have been proposed as a promising alternative.The combination of catalysis and separation in a single module provides greater conversion,reduction of excess reagents,compact industrial plant,making the process more efficient.Within this context,this work aims to present a literature review on the catalytic membrane for the synthesis of esters,improving the understanding of the production and development.This review examines the materials,catalysts used,and synthetic pathways.A comparison between the methods,as well as limitations and gaps in the literature,are highlighted.展开更多
Nine 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives were synthesized through the reaction between 2-hydroxy-1,4-naphthalen-1,4-dione and different aromatic alde-hydes in water applying ultrasonic...Nine 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives were synthesized through the reaction between 2-hydroxy-1,4-naphthalen-1,4-dione and different aromatic alde-hydes in water applying ultrasonic irradiation for 5 min at room temperature and microwave irradiation for 15 min at 70°;C. Two of the nine derivatives, compounds 3-e and 3-i, obtained from 3-bromo-hydroxybenzaldehyde and 5-methylfuran-2-carbaldehyde, respectively, are previously unpublished. The structures of all compounds were established on the basis of their spectral data and mass analysis. The attractive features of this synthesis protocol include mild conditions, high atom-economy and excellent yields with the elimination of water as the only by-product.展开更多
文摘<p align="justify"> <span style="font-family:Verdana;">Satellite imagery is used for many activities in different areas of the planet, including searching for alternative and sustainable sources to meet growing energy demand to reduce greenhouse gas (GHG) emissions. One way to minimize these effects and expand energy parks is to encourage local generation through the use of renewable sources, such as solar energy, which is free and affordable in many regions of the planet, but that in Brazil is not yet a reality. In order to make an assertive decision when installing a solar power system, one needs to use tools that involve remote sensing and geographic information systems (GIS), and compile information and variables that are relevant to the subject of solar power generation and take into account the inherent geographic space. In this context, the main objective of this work is to develop a GIS model to identify areas with solar potential on a regional scale using active remote sensor images and previously available solar models. To validate the model, this study used an area on the island part of the city of Florianópolis in Santa Catarina State</span></span></span></a><span><span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;">—</span><span style="font-family:Verdana;">Brazil, which suffers from repeated climatic events which cause long power cuts, as its distribution occurs by air all over the island. Through the “solar analist” function of ArcGIS and the matrix bases derived from the Digital Model of the Space Shuttle Topography Mission (SRTM) with 30 m of spatial resolution and the supervised classification of panthromatic and multispectral images fused from LandSat 8 satellite, were generates indicative maps of the areas with solar potential. The results pointed to a high solar potential in the all year and that could be better explored by public managers and also by individual consumers.</span></span></span></span> </p>
基金Smart Integration Key Technologies and Application Demonstrations of Large Scale Underground Space Disaster Prevention and Reduction in Guangzhou International Financial City([2021]–KJ058).
文摘The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex orientations.The vibration caused by the high-frequency units during regular operation is supported by the foundation of the units,and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts,leading to variations in the dynamic response of the foundation.The high-frequency units yield significantly diverse outcomes under different startup conditions and times,resulting in failure to meet operational requirements,influencing the normal function of the tunnel,and causing harm to the foundation structure,personnel,and property in severe cases.This article formulates a finite element numerical computation model for solid elements using three-dimensional elastic body theory and integrates field measurements to substantiate and ascertain the crucial parameter configurations of the finite element model.By proposing a comprehensive startup timing function for high-frequency dynamic machines under different startup conditions,simulating the frequency andmagnitude variations during the startup process,and suggesting functions for changes in frequency and magnitude,a simulated startup schedule function for high-frequency machines is created through coupling.Taking into account the selection of the transient dynamic analysis step length,the dynamic response results for the lower dynamic foundation during its fundamental frequency crossing process are obtained.The validation checks if the structural magnitude surpasses the safety threshold during the critical phase of unit startup traversing the structural resonance region.The design recommendations for high-frequency units’dynamic foundations are provided,taking into account the startup process of the machine and ensuring the safe operation of the tunnel.
文摘Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC<sup>®</sup> Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC<sup>®</sup>). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.
文摘In the Freudian-Lacanian field,there is an important distinction between knowledge and truth.The truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes us.Knowledge,in turn,is something to be invented,from the hole of the Real,the Unconscious truth,and the subjective experience.The relationships between playing,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowledge of oneself,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the analytical act,and transversalize psychoanalysis.In the practice,we listen to and witness processes of analysis that awaken an invention/reinvention of oneself,in the process of remembering,repeating,and elaborating,but also in what the transference relationship summons.Knowledge of oneself,does not guarantee a life without mishaps,sadness,and illusions,but allows the invention and recognition of knowledge and a style.The concept of Sinthome(2007),coined by Jacques Lacan,comes in the wake of the processes of self-invention and is a knowing-doing with the symptom,with the paradoxes of joyful suffering,producing,as a result,an art of saying.Therefore,in this communication,I will articulate elements of theory,practice,and psychoanalytic experience that allow us to expand knowledge of the themes of invention and imagination articulated with the concept of sinthome,their relationships with subjectivity,and the direction of psychoanalytic treatment.
文摘The origin of elementary particle mass is considered as a function of n-valued graviton quanta. To develop this concept we begin in a cold region of “empty space” comprised of only microscopic gravitons oscillating at angular frequency ω. From opposite directions enters a pair of stray protons. Upon colliding, heat and energy are released. Customarily, this phase and what follows afterward would be described by Quantum Chromodynamics (QCD). Instead, we argue for an intermediary step. One in which neighboring gravitons absorb discrete amounts of plane-wave energy. Captured by the graviton, the planewave becomes a standing wave, whereupon its electromagnetic energy densities are converted into gravitational quanta. Immediately thereafter an elementary particle is formed and emitted, having both mass and spin. From absorption to conversion to emission occurs in less than 3.7 × 10−16 s. During this basic unit of hybrid time, general relativity and quantum physics unite into a common set of physical laws. As additional stray protons collide the process continues. Over eons, vast regions of spacetime become populated with low-mass particles. These we recognize to be dark matter by its effects on large scale structures in the universe. Its counterpart, dark energy, arises when the conversion of gravitational quanta to particle emission is interrupted. This causes the gravitational quanta to be ejected. It is recognized by its large scale effects on the universe.
文摘Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of years.Cupping therapy is reported to be a relatively safe practice especially if performed by qualified therapists.Subconjunctival hemorrhage(SCH)is a common cause of eye redness and can be classified into traumatic and spontaneous.Case presentation:This case report discussed an adverse event related to wet cupping therapy.The patient developed SCH one day after performing cupping therapy.He was completely recovered after 2 weeks.This case report should increase the knowledge of cupping therapists regarding increasing safety of patient when performing wet cupping therapy on specific body parts especially,head,neck and cervical areas.Furthermore,it highlighted the importance of conducting research regarding the mechanical and physiological effects of cupping therapy.Conclusion:Adverse events related to cupping therapy should be reported with every patient.Cupping therapists should be aware of this possible mild adverse event.To the best of our knowledge,this is the first published adult case of SCH related to wet cupping therapy session.More studies are critically needed for evaluation of cupping therapy effects and adverse events especially when performed on head and neck.
文摘With economic progress and the continuous advancement of science and technology,the issue of employees substituting punch cards has gradually become a significant challenge in enterprise management.The purpose of this paper is to discuss the causes,effects,and countermeasures of the employee punch card phenomenon,with the aim of providing effective management recommendations for Chinese enterprises.In practice,enterprises should flexibly apply the countermeasures proposed in this paper according to their specific circumstances to prevent substitute punch card incidents and improve overall management efficiency.
基金Project(U1934210)supported by the Key Project of High-speed Rail Joint Fund of National Natural Science Foundation of ChinaProject(8202037)supported by the Natural Science Foundation of Beijing,China。
文摘A case of Qinghuayuan tunnel excavation below the existing Beijing Subway Line 10 is presented.The new Qinghuayuan tunnel,part of the Beijing-Zhangjiakou High-speed Railway,was excavated by a shield machine with an outer diameter of 12.2 m.The existing subway was excavated by shallow tunnelling method.The project layout,geological conditions,reinforcement measures,operational parameters of shield machine and monitoring results of the project are introduced.During the Qinghuayuan tunnel excavation below the existing subway,total thrust,shield driving speed,cutterhead rotation speed and torque were manually controlled below the average values obtained from the previous monitoring of this project,which could effectively reduce the disturbance of the surrounding soil induced by shield excavation.The Gaussian fitting function can appropriately fit both the ground and the existing subway settlements.The trough width is influenced not only by the excavation overburden depth,but also by the forepoling reinforcement and tail void grouting measures.
文摘Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision making.Although liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability.Over the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable performance.Besides the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy.In addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk.However,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions.These methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve accuracy.In this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice.
文摘Rice bran is a solid residue from rice polishing that is used in animal nutrition and rice oil production. Cultivation conditions with agro-toxics, lipids instability, and tendency for mycotoxin contamination restrict its application in human nutrition. Therefore, organic agriculture is an alternative to use the properties of rice bran. Rice bran beverage is a new cereal product from organic rice. This work presents the preliminary results of the chemical and rheological studies of a bath pasteurized rice bran beverage. Compared with integral defatted milk, soy extracts, and brown rice low-fat milk, the rice bran beverage studied in this work presents itself as an important source of minerals and unsaturated lipids. All essential amino acids were found in this product. Glutamic and aspartic acids were predominant. Bath pasteurization at boiling water temperature for 15 and 30 min was adequate for microbiological safety. Refrigeration storage for 20 days, evaluated by pH and acidity variations, was ideal for assessment of the beverage conservation time. The beverage viscosity was of the Newtonian standard behavior, and its viscosity during storage was not a good parameter to evaluate shelf life. Sensory preference tests showed positive perspectives for this new beverage.
基金Huabo Duan acknowledges financial support from the China National Key Research and Development(R&D)Plan(2018YFB1502804)the Scientific Research Fund of Introduced High Talent of Shenzhen University(827-000044),China.
文摘The relationship between environmental quality and economic growth has been a hot topic for decades.After years of rapid industrialization and urbanization,China’s environmental challenges are approaching a turning point.Following the principles of ecological civilization construction,China is on its way to maintaining high-quality and green economic development.On 10 June 2020,the Chinese Government reported the key findings of the Second National General Survey of Pollution Sources(fiscal year 2017),which provides strong quantitative evidence of progress toward ecological civilization.In terms of our comparison between the two National General Surveys in 2007 and 2017,it was found that environmental pollution,measured in terms of many wastewater and air emission pollutant discharges,is decreasing despite the steady growth in economic activities—and at a noticeably fast pace.Other national and local governments can adopt some of China’s ecological civilization practices,within their own individual contexts.
文摘This paper aimed to evaluate the effects of different concentrations of cadmium on growth rates, photosynthetic pigments, photosynthetic performance, biochemical parameters and structure of chloroplasts in G. domingensis. To accomplish this, apical segments of G. domingensis were cultivated with different concentrations of cadmium, ranging from 100 to 300 μM, over a period of 16 days, and were processed for transmission electron microscopy analysis. The plants exposed to cadmium showed chloroplast alteration, especially degeneration of thylakoids and a decrease in the concentration of photosynthetic pigments, such as chlorophyll a and phycobiliproteins. However, the volume of plastoglobuli increased. As a defense mechanism, the plants treated with cadmium showed an increase in glutathione reductase activity. These results agree with the decreased photosynthetic performance and relative electron transport rate observed after exposure of algae to cadmium. Taken together, these findings strongly indicate that cadmium negatively affects the ultrastructure and metabolism of the agarophyte G. domingensis, thus posing a threat to the economic vitality of this red macroalga.
文摘AIM;TO report present state of iatrogenic drug-induced esophageal injury(DIEI)induced by medications in a private clinic. METHODS:Iatrogenic drug-induced esophageal injury (DIEI)induced by medications has been more frequently reported.In a private clinic we encountered 36 cases of esophageal ulcerations complicating doxycycline therapy in a mainly younger Saudi population(median age 29 years). RESULTS:The most frequent presenting symptoms were odynophagia,retrosternal burning pain and dysphagia(94 %, 75 % and 56 %,respectively).The diagnosis was according to medical history and confirmed by endoscopy in all patients. Beside withdrawal of doxycycline,when feasible,all patients were treated with a proton-pump inhibitor(PPI)and a prokinetic.Thirty patients who reported to the clinic after treatment were improved within 1-7(median 1.7)days. CONCLUSION:Esophageal ulceration has to be suspected in younger patients with odynophagia,retrosternal burning pain and/or dysphagia during the treatment with doxycycline.
文摘Plan asymmetric buildings are very susceptible to earthquake induced damage due to lateral torsional coupling, and the corners of these systems suffer heavy damage during earthquakes. Therefore, it is important to investigate the seismic behavior of an asymmetric plan building with MR dampers. In this study, the effectiveness of MR damper-based control systems has been investigated for seismic hazard mitigation of a plan asymmetric building. Furthermore, the infl uence of the building parameters and damper command voltage on the control performance is examined through parametric study. The building parameters chosen are eccentricity ratio and frequency ratio. The results show that the MR damper-based control systems are effective for plan asymmetric systems.
基金supported by grants from Programa de Pos-graduacao em Neurociencias(PGN),Programa INCT-INOVAMED(grant No.465430/2014-7)Fundacao de Apoio à Pesquisa e Inovacao do Estado de Santa Catarina(FAPESC)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)。
文摘Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.
基金supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES)+3 种基金Fundacao de Apoio a Pesquisa do Estado de Santa Catarina(FAPESC)Programa INCT-INOVAMED(Grant465430/2014-7)Programa de PósGraduacao em Neurociências(PGN)a research productivity fellowship from the CNPq。
文摘Despite the current interest in the potential medical use of Cannabis, it is worth remembering that cannabis is not a new drug, with both a nonmedical and medical history supporting its effectiveness.This history advanced in scientific strength and importance worldwide when Professor Raphael Mechoulam and colleagues initiated their pioneering discoveries in 1971.At first, Mechoulam et al.(1972) achieved the complete synthesis of the pure compounds from hashish(including △1-tetrahydrocannabinol and other neutral cannabinoids such as cannabigerol, cannabichromene, and cannabicyclol), and established their molecular structures.
基金supported by the National Natural Science Foundation of China(11701453)Fundamental Research Funds for the Central Universities(31020180QD05)+2 种基金The second author was supported by the National Natural Science Foundation of China(11971431,11401525)the Natural Science Foundation of Zhejiang Province(LY18A010006)and the first Class Discipline of Zhejiang-A(Zhejiang Gongshang University-Statistics).
文摘In this article,we derive the Lp-boundedness of the variation operators associated with the heat semigroup which is generated by the high order Schrodinger type operator(—Δ)^2+V%2 in R%n(n≥5)with V being a nonnegative potential satisfying the reverse Holder inequality.Furt her more,we prove the boundedness of the variation operators on associated Morrey spaces.In the proof of the main results,we always make use of the variation inequalities associated with the hea t semigroup genera ted by the biharmonic operator(-Δ)2.
基金support from CAPES-Coorde nação de Aperfeiçoamento de Pessoal de Nível Superior(PROEX and PrInt Programs)CNPq-Conselho Nacional de Desenvolvimento Científico e Tecnológico(307576/2018-3 and 420275/2018-5)and FAPESC-Fundação de AmparoàPesquisa do Estado de Santa Catarina.
文摘Esterification is an important process in the food industry and can be carried out via homogeneous or heterogeneous catalysis.The homogeneous catalyst,despite providing high conversion,can cause corrosion in reactors,which is not observed with the use of heterogeneous catalysts.However,some of these catalysts require a high process temperature and may lose their catalytic activity with reuse.Thus,catalytic membranes have been proposed as a promising alternative.The combination of catalysis and separation in a single module provides greater conversion,reduction of excess reagents,compact industrial plant,making the process more efficient.Within this context,this work aims to present a literature review on the catalytic membrane for the synthesis of esters,improving the understanding of the production and development.This review examines the materials,catalysts used,and synthetic pathways.A comparison between the methods,as well as limitations and gaps in the literature,are highlighted.
文摘Nine 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives were synthesized through the reaction between 2-hydroxy-1,4-naphthalen-1,4-dione and different aromatic alde-hydes in water applying ultrasonic irradiation for 5 min at room temperature and microwave irradiation for 15 min at 70°;C. Two of the nine derivatives, compounds 3-e and 3-i, obtained from 3-bromo-hydroxybenzaldehyde and 5-methylfuran-2-carbaldehyde, respectively, are previously unpublished. The structures of all compounds were established on the basis of their spectral data and mass analysis. The attractive features of this synthesis protocol include mild conditions, high atom-economy and excellent yields with the elimination of water as the only by-product.