Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

Dietary parboiled rice(PR)has a low risk of disease,but little is known about the contribution of PR to the prevention of hyperlipidemia.The potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this study.Male C57BL/6J mice were fed with a normal diet,high-fat diet(HFD)containing refined rice(HFDRR)or PR(HFDPR).It was found that PR intervention improved lipid accumulation in mice.Transcriptomic data analysis revealed that 27 genes were up-regulated(mostly involved in lipid breakdown)and 86 genes were down-regulated(mostly involved in inflammatory responses)in the HFDPR group compared to the HFDRR group.And 15 differentially expressed genes(DEGs)were validated by quantitative real-time PCR(RT-qPCR),while protein interaction network showed that protein tyrosine phosphatase receptor type C(PTPRC)has a central role.The gut microbiota of mice was also altered after different dietary treatments,with higher ratio of Firmicutes and Bacteroidetes,increased abundances of Ruminococcaceae,Lachnospiraceae,Christensenellaceae,Porphyromonadaceae,Rikenellaceae and Prevotellaceae,and decreased abundances of Lactobacillaceae,Peptostreptococcaceae,Erysipelotrichaceae and Actinobacteria in the HFDRR group.In addition,it was observed that PPAR signaling pathway may act as a bridge between DEGs and differential gut microbiota.These results suggested that PR can prevent hyperlipidemia by modulating liver genes and gut microbiota.

Data-Driven Ai-and Bi-Soliton of the Cylindrical Korteweg-de Vries Equation via Prior-Information Physics-Informed Neural Networks

By the modifying loss function MSE and training area of physics-informed neural networks(PINNs),we propose a neural networks model,namely prior-information PINNs(PIPINNs).We demonstrate the advantages of PIPINNs by simulating Ai-and Bi-soliton solutions of the cylindrical Korteweg-de Vries(cKdV)equation.

Multiple paradoxical embolisms caused by central venous catheter thrombus passing through a patent foramen ovale: A case report

BACKGROUND To date,this is the first case of a paradoxical embolism(PDE)that concurrently manifested in the coronary and lower limb arteries and was secondary to a central venous catheter(CVC)thrombus via a patent foramen ovale(PFO).CASE SUMMARY Here,we report a case of simultaneous coronary and lower limb artery embolism in a PFO patient carrier of a CVC.The patient presented to the hospital with acute chest pain and lower limb fatigue.Doppler ultrasound showed a large thrombus in the right internal jugular vein,precisely at the tip of the CVC.Transthoracic and transesophageal echocardiography confirmed the existence of a PFO,with inducible right-to-left shunting by the Valsalva maneuver.The patient was administered an extended course of anticoagulation therapy,and then the CVC was successfully removed.Percutaneous PFO closure was not undertaken.There was no recurrence during follow-up.CONCLUSION Thus,CVC-associated thrombosis is a potential source for multiple PDE in PFO patients.

A thermodynamic-based model for modeling thermo-elastoplastic behaviors of saturated clayey soils considering bound water dehydration

The non-isothermal deformation of soft mudrocks or clay soils is one of the most critical issues in energy and environmental related geotechnics.Clay-related geomaterials hold complex microstructure and mineral composition,which brings difficulty in investigating their thermo-mechanical behaviors.Previous studies pay little attention to the difference between a thermal plastic strain and the strain from clay dehydration.In this study,a new constitutive model is proposed for describing the thermoelastoplastic behaviors of clayey soils under water-saturated condition.The effect of temperature variation and mechanical loading on elastoplastic strains and dehydration are investigated.The thermodynamics laws and the unconventional plasticity are applied to quantify the thermo-mechanical behavior.The irreversible strain is captured by using Cam-Clay plasticity and subloading yield surface concept.The dehydration strain is described by utilizing a novel method based on generalized thermodynamics approach and Helmholtz free energy function.The internal variables,and the first and second laws of thermodynamics are applied in the model.The hardening rule is established by implementing the laws of physical conservation,energy dissipation,and plastic flow.The proposed model is validated using specially designed thermal consolidation tests on laboratory prepared heavily consolidated clayey soils and some published data of clayey soils with different geological origins.

Visualization and early warning analysis of damage degree of surrounding rock mass in underground powerhouse

Based on the underground powerhouse of Shuangjiangkou hydropower station,Octree theory is adopted to define the indices of the microseismic(MS)spatial aggregation degree and the deviation values of MS count and energy.The relationship between the MS multiple parameters and surrounding rock mass instability is established from three aspects:time,space,and strength.Supplemented by the center frequency of the signal evolution characteristics,A fuzzy comprehensive evaluation model and the evolution trend of the MS event center frequency are constructed to quantitatively describe the early warning state of the surrounding rock mass instability.The results show that the multilevel tree structure and voxels generated based on the Octree theory fit relatively well with the set of MS points in threedimensional space.The fuzzy comprehensive evaluation model based on MS spatial aggregation and MS count and energy deviation values enables three-dimensional visualization of the potential damage area and damage extent of the surrounding rock mass.The warning time and potential damage zone quantified are highly consistent with the characteristics of MS precursors,with wide recognition and field investigation results,which fully validate the rationality and applicability of the proposed method.These findings can provide references for the early warning of surrounding rock mass instability in similar underground engineering.

Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene

AIM: To study the inhibitory effect of baculovirus- mediated normal epithelial cell specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo. METHODS: We first constructed recombinant baculovirus vectors and then transfected them into gastric cancer cells (SGC-7901). Efficiency of the baculovirus for gene transfer into SGC-7901 cells and cell growth curves were detected by fluorescence microscopy, Western blot and 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro, respectively. The therapeutic effect of this gene therapy on GC was confirmed in xenografted nude mice. Tumor growth was determined by tumor volume, and expression of NES1 in tumor was analyzed by immunohistochemistry. RESULTS: Baculovirus vectors were successfully transfected into SGC-7901 cells. SGC-7901 cells transfected with the NES1 gene inhibited cell growth. In the Bac-NES1 treated group, tumor growth was significantly reduced with a high level of NES1 expression CONCLUSION: Baculovirus-mediated NES1 gene can be used in gene therapy for GC.

Risk factors for intraocular metastasis of primary liver cancer in diabetic patients:Alpha-fetoprotein and cancer antigen 125

BACKGROUND In rare instances,primary liver cancer can be associated with intraocular metastasis(IOM).AIM To investigate the correlation between a diverse range of clinical characteristics and IOM in diabetic patients with primary liver cancer,and to determine potential risk factors in predicting IOM.METHODS We recruited a total of 722 diabetic patients with primary liver cancer.The differences between the IOM and non-intraocular metastasis(NIOM)groups in these patients were assessed using the chi-squared test and Student’s t-test.Binary logistic regression analysis was subsequently used to determine risk factors.Finally,the diagnostic value of IOM in this cohort with primary liver cancer was analyzed by receiver operating characteristic(ROC)curve analysis.RESULTS In all,13 patients had IOM.There were no remarkable intergroup differences with respect to age,sex,histopathological sub-types,or blood biochemical parameters.However,the IOM group had significantly higher alpha-fetoprotein(AFP)and cancer antigen 125(CA125)values than the NIOM group.Binary logistic regression identified AFP and CA125 to be significant risk factors for IOM in diabetic patients with primary liver cancer.ROC curve analysis showed that the area under the curve values for AFP and CA125 were 0.727 and 0.796,with the cut-off values of 994.20 ng/mL and 120.23 U/mL,respectively.The sensitivity and speci
city for AFP were 92.3%and 59.9%,while those for CA125 were 84.6%and 70.1%,respectively.CONCLUSION Elevated AFP and CA125 represent significant risk factors for IOM in diabetic patients with primary liver cancer.

Directional solidification casting technology of heavy-duty gas turbine blade with liquid metal cooling(LMC) process

In this work, some important factors such as ceramic shell strength, heat preservation temperature, standing time and withdrawal rate, which influence the formability of directionally solidified large-size blades of heavy-duty gas turbine with the liquid metal cooling(LMC) process, were studied through the method of microstructure analysis combining. The results show that the ceramic shell with medium strength(the high temperature flexural strength is 8 MPa, the flexural strength after thermal shock resistance is 12 MPa and the residual flexural strength is 20 MPa) can prevent the rupture and runout of the blade. The appropriate temperature(1,520 ℃ for upper region and 1,500 ℃ for lower region) of the heating furnace can eliminate the wide-angle grain boundary, the deviation of grain and the run-out caused by the shell crack. The holding time after pouring(3-5 min) can promote the growth of competitive grains and avoid a great deviation of columnar grains along the crystal orientation <001>, resulting in a straight and uniform grain structure. In addition, to avoid the formation of wrinkles and to ensure a smooth blade surface, the withdrawal rate should be no greater than the growth rate of grain. It is also found that the dendritic space of the blade decreases with the rise of solidification rate, and increases with the enlarging distance between the solidification position and the chill plate.

Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation

BACKGROUND Diabetes mellitus is a metabolic disorder characterized by prolonged elevation of blood glucose due to various causes.Currently,the relationship between diabetic retinopathy(DR)and altered connectivity of brain function is unclear.AIM To investigate the relationship between this brain activity and clinical manifestations and behaviors of DR patients by using the amplitude of low-frequency fluctuation(ALFF)technique.METHODS Twenty-four DR patients and 24 healthy controls(HCs)matched for age and gender were enrolled.We measured and recorded average ALFF values of DR patients and HCs and then classified them using receiver operating characteristic(ROC)curves.RESULTS ALFF values of both left and right posterior cerebellar lobe and right anterior cingulate gyrus were remarkably higher in the DR patients than in the HCs;however,DR patients had lower values in the bilateral calcarine area.ROC curve analysis of different brain regions demonstrated high accuracy in the area under the curve analysis.There was no significant relationship between mean ALFF values for different regions and clinical presentations in DR patients.Neuronal synchronization abnormalities in some brain regions of DR patients were associated with cognitive and visual disorders.CONCLUSION Abnormal spontaneous brain activity was observed in many areas of DR patients’brains,which may suggest a possible link between clinical manifestations and behaviors in DR patients.

All boron-based 2D material as anode material in Li-ion batteries

To design the high-energy-density Li-ion batteries, the anode materials with high specific capacity haveattracted much attention. In this work, we adopt the first principles calculations to investigate the pos-sibility of a new two dimensional boron material, named Be, as anode material for Li-ion batteries. Thecalculated results show that the maximum theoretical specific capacity of Bc is 1653mAh g-1 （LiBl.s）.Additionally, the energy barriers of Li ion and Li vacancy diffusion are 330 meV and 110 meV, respec-tively, which imply fast charge and discharge ability for B6 as an anode material. The theoretical findingsreported in this work suggest that BG is a potential candidate as anode material of high-energy-density Li-ion batteries.

Stability analysis of surrounding rock mass in underground powerhouse considering damage effect of microfractures

A high-precision microseismic(MS)monitoring system was built to monitor surrounding rock microfractures in the underground powerhouse on the left bank of Shuangjiangkou Hydropower Station.The surrounding rock damage area with spatiotemporal clustering of MS activities was studied for qualitative analysis of the damage mechanism of surrounding rock microfractures,based on the source parameters of MS events.The surrounding rock microfracture scale characterized by the source radius of MS events was considered to establish the constitutive relation.MS information was imported into the model for numerical analysis using fast Lagrangian analysis of continuain 3 dimensions(FLAC^(3D)).The results indicated that the numerical simulation results considering MS damage can better reflect the actual situation of the field.The surrounding rock microfractures mainly showed mixed failure characteristics.Shear failures appeared in localized areas while the fracture scale of sections from K0e33 m to K0e15 m on the vault was large.The deformation increment caused by microfracture damage in the shallow surrounding rock of the top arch accounted for 10%e13%,and the stress decrement in the surrounding rock caused by microfracture damage accounted for about 10%.

Relationship between Waist Circumference, Waist-Height Ratio, Body Fat Percentage, Visceral Fat and Bone Mineral Density in Middle-Aged and Elderly Zhuang of China

Objective: To understand the correlation between different degrees of obesity and bone mineral density (BMD). Methods: 772 cases (300 men and 472 females) of Zhuang over 40 years old were randomly selected. The BMD and T score were calculated by measuring the right heel bone using a quantitative-ultrasound densitometer. Body composition index of body weight, waist circumference (WC), waist height ratio (WtHR), body fat percentage (BFP) and visceral fat (VF) were measured using a bioelectrical impedance method. Results: The BMI, WC, and WtHR of the male osteoporosis group were lower than those of the normal bone mass (NBM) group (P Conclusion: BMI is positively correlated with BMD in Zhuang. BFP has a greater correlation with female BMD, and a small reduction in BFP can result in a significant decrease in BMD. BMD of male was positively correlated with abdominal obesity indicators (WC, WtHR, VF). However, abdominal obesity has no obvious effect on the promotion of BMD in women, and increased WtHR can lead to a decrease in BMD. Zhuang can appropriately increase the amount of fat within the normal weight range. At the same time, reasonable exercise and balanced nutrition to avoid excessive obesity or low body weight can reduce the incidence of osteoporosis and osteoporosis fractures.

High-performance self-organized Si nanocomposite anode for lithium-ion batteries

Silicon is being investigated extensively as an anodic material for next-generation lithium ion batteries for portable energy storage and electric vehicles.However,the large changes in volume during cycling lead to the breakdown of the conductive network in Si anodes and the formation of an unstable solid-electrolyte interface,resulting in capacity fading.Here,we demonstrate nanoparticles with a Si@Mn22.6Si5.4C4@C double-shell structure and the formation of self-organized Si-Mn-C nanocomposite anodes during the lithiation/delithiation process.The anode consists of amorphous Si particles less than 10 nm in diameter and separated by an interconnected conductive/buffer network,which exhibits excellent charge transfer kinetics and charge/discharge performances.A stable specific capacity of 1100 mAh·g-1 at 100 mA·g-1 and a coulombic efficiency of 99.2%after 30 cycles are achieved.Additionally,a rate capacity of 343 mAh·g-1 and a coulombic efficiency of 99.4%at 12000 mA·g-1 are also attainable.Owing to its simplicity and applicability,this strategy for improving electrode performance paves a way for the development of high-performance Si-based anodic materials for lithium ion batteries.

Field Test Summary of Two Kinds of Electronic Detonator for Seismic Exploration

Electronic detonators are widely used because of their advantages in real-time supervision of the whole life cycle (Zang, 2022). Due to the high requirements of the time difference synchronization between the electronic initiation system and the seismic wave recording system, the Electronic detonator has not been widely used for Seismic exploration (Yang, 2020). This paper expounds the systematic and scientific test method from the aspects of the comprehensive performance of electronic detonators for exploration, the compatibility between the electronic detonator initiation system and the geophysical blasting machine system, the constraints of the geophysical explosion-related collaborative Danling managment cloud platform, and the quality of data collected by electronic detonator blasting in wells., and based on the analysis of the test results, the problems that need to be improved in the application of electronic detonators and detonation systems in the large-scale production of geophysical prospecting industry are put forward. .

Technoeconomically competitive four-terminal perovskite/graphenesilicon tandem solar cells with over 20% efficiency

Perovskite/Silicon(PS) tandem solar cells have attracted much interest over recent years. However, the most popular crystalline silicon solar cells utilized in tandems require complicated fabrication processes mainly including texturization, diffusion, passivation and metallization, which takes up much cost in photovoltaic market. Here, we report a facile graphene/silicon(Gr/Si) solar cell featuring of lowtemperature( 200 °C) processing and an efficiency of 13.56%. For reducing the heat dissipation loss of high energy photon, the perovskite solar cell(PSC) with a wide band gap of 1.76 e V was adopted as the top cell for the tandem. To reduce the loss of parasitic absorption in hole transport layers(HTLs),thickness of Spiro-OMe TAD is re-optimized by compromising the efficiency and the optical transmittance of the devices. As a result, the semitransparent top perovskite solar cell yields a highest efficiency of13.35%. Furthermore, we firstly achieved a low-temperature-processed four-terminal(4-T) perovskite/graphene-silicon(PGS) heterojunction tandem solar cell with the efficiency of 20.37%. The levelized cost of electricity(LCOE) of PGS 4-T modules were estimated to a competitive price, exhibiting much greater potential for practical application compared to that of PS 4-T modules.

Analysis of rockburst mechanism and warning based on microseismic moment tensors and dynamic Bayesian networks

One of the major factors inhibiting the construction of deep underground projects is the risk posed by rockbursts.A study was conducted on the access tunnel of the Shuangjiangkou hydropower station to determine the evolutionary mechanism of microfractures within the surrounding rock mass during rockburst development and develop a rockburst warning model.The study area was chosen through the combination of field studies with an analysis of the spatial and temporal distribution of microseismic(MS)events.The moment tensor inversion method was adopted to study rockburst mechanism,and a dynamic Bayesian network(DBN)was applied to investigating the sensitivity of MS source parameters for rockburst warnings.A MS multivariable rockburst warning model was proposed and validated using two case studies.The results indicate that fractures in the surrounding rock mass during the development of strain-structure rockbursts initially show shear failure and are then followed by tensile failure.The effectiveness of the DBN-based rockburst warning model was demonstrated using self-validation and K-fold cross-validation.Moment magnitude and source radius are the most sensitive factors based on an investigation of the influence on the parent and child nodes in the model,which can serve as important standards for rockburst warnings.The proposed rockburst warning model was found to be effective when applied to two actual projects.

Microseismic monitoring and forecasting of dynamic disasters in underground hydropower projects in southwest China:A review

The underground hydropower projects in Southwest China is characterized by large excavation sizes,high geostresses,complicated geological conditions and multiple construction processes.Various disasters such as collapses,large deformations,rockbursts are frequently encountered,resulting in serious casualties and huge economic losses.This review mainly presents some representative results on microseismic(MS)monitoring and forecasting for disasters in hydropower underground engineering.First,a set of new denoising,spectral analysis,and location methods were developed for better identification and location of MS signals.Then,the tempo-spatial characteristics of MS events were analyzed to understand the relationship between field construction and damages of surrounding rocks.Combined with field construction,geological data,numerical simulation and parametric analysis of MS sources,the focal mechanism of MS events was revealed.A damage constitutive model considering MS fracturing size was put forward and feedback analysis considering the MS damage of underground surrounding rocks was conducted.Next,an MS multi-parameter based risk assessment and early warning method for dynamic disasters were proposed.The technology for control of the damage and deformation of underground surrounding rocks was proposed for underground caverns.Finally,two typical underground powerhouses were selected as case studies.These achievements can provide significant references for prevention and control of dynamic disasters for underground engineering with similar complicated geological conditions.

Wind and Snow Impacts on Urban Space Planning:A Multiphase Numerical Simulation

The wind and snow environment outside the planned space plays a key role in the comfort and safety of the human habitat in severe cold regions. Traditional studies of the external environment of human settlements, however, frequently overlook the combined impacts of wind and snow environments. Furthermore, in urban meteorological studies, it is impossible to accurately assess the wind and snow environment in specific areas or locations. In this study, a refined Computational Fluid Dynamics(CFD) multiphase flow numerical method was used to simulate a planning space's wind and snow environment. The study classified the Snowstorm Weather Grade(SWG) by incorporating the Snowstorm Weather Index(SWI) to generate calculation results of the wind environment and snow environment. In particular, 150 measurement points in the planning space were chosen for analysis and evaluation of their wind and snow environments. The results demonstrated that the SWI index can effectively correlate to the wind and snow environment calculation results. In addition, the graph of SWI showed that 55% of the measurement points had a moderate wind and snow grade SWI, which exceeds the average grade for the entire region. The practical application shows that the wind and snow environment assessment indexes and technical methods developed in this paper can be successfully applied to wind and snow environment studies in other cold cities.

“多元化二段式”教学模式在眼科学专业硕士研究生培养中的实践应用

目的:探讨“多元化二段式”教学模式在眼科学专业硕士研究生培养中的应用效果。方法:选取32名2017届、2018届和2019届的眼科学专业硕士研究生,将每届研究生都随机均分为研究组和对照组(各16人)。研究组采用“多元化二段式”教学模式进行教学;对照组采用传统教学模式进行教学。同组不同届研究生的教学内容相同,教学老师相同,教学时间为33mo的临床实践期,研究时间为2014~2019年,通过对研究组和对照组的眼科学专业硕士研究生的临床实践进行对比,从临床专业考核、科研能力考核、综合考核成绩、学生满意度及梦焦虑自评分数来分析“多元化二段式”教学模式与传统教学模式的不同。考试内容相同,评分标准统一。结果:研究组满意度评分为101.38±6.29分,综合成绩84.22±4.58分,梦焦虑评分17.31±5.20分;对照组满意度评分为59.13±9.61分,综合成绩75.72±5.14分,梦焦虑评分25.75±3.32分。研究组临床技能、科研创新、综合成绩的评分均高于对照组,而梦焦虑评分低于对照组(均P<0.05)。梦焦虑评分与教学模式满意度评分、学生满意度评分呈负相关(r=-0.746、-0.618,均P<0.05)。结论:“多元化二段式”教学模式相较于传统教学模式提高了眼科学专业硕士研究生理论知识、科研创新、身心健康等的综合素质,是目前眼科学专业硕士研究生教学的最佳模式。

前交叉韧带前内入路解剖单束重建与过顶位单束重建的疗效比较

目的比较解剖位单束(ASB)重建与过顶位单束(OSB)重建前交叉韧带(ACL)的临床疗效。方法回顾性分析2015年3月-2017年9月该院收治的44例ACL断裂的单膝ACL损伤患者的临床资料。采用ASB重建手术22例(ASB组),采用OSB重建手术22例(OSB组)。两组患者性别、年龄、病程、国际膝关节文献委员会(IKDC)评分和Lysholm评分等一般资料比较,差异均无统计学意义(P>0.05),具有可比性。结果两组患者均获得随访,时间为6~12个月,平均8.6个月,术后6个月随访时,在膝关节活动度方面,ASB组无屈曲、伸直受限;OSB组1例伸直受限5°,无屈曲受限;在Lachman试验方面,ASB组均为阴性,OSB组术后Ⅰ度3例,但止点硬。两组Lachman试验阴性率比较,差异无统计学意义(P>0.05);两组轴移试验阴性率比较,差异有统计学意义(P<0.05)。两组IKDC评分、Lysholm评分术前术后比较,差异均有统计学意义(P<0.05);两组术后6个月IKDC评分、Lysholm评分比较,差异均无统计学意义(P>0.05)。结论关节镜下采用ASB重建ACL,在控制膝关节旋转稳定性方面优于传统OSB重建。