As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety...As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety,it is necessary to carry out research on the dynamic modeling of the cracked blade and breathing crack-induced vibration mechanisms.This paper summarizes the current research status on the dynamics of cracked blade,and the related topics mainly include four aspects:crack propagation path,mechanical model of open and breathing cracks,dynamic modeling methods of cracked blades such as lumped mass model,semi-analytical model and finite element model,and dynamic characteristics of cracked blades.The review will provide valuable references for future studies on dynamics and fault diagnosis of cracked blade in aeroengine.展开更多
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been ex...Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy.展开更多
A high-performance single-pole single-throw(SPST) RF switch for mobile phone RF front-end modules(FEMs) was designed and characterized in a 0.13 μm partially depleted silicon-on-insulator(PD SOI) process. In this pap...A high-performance single-pole single-throw(SPST) RF switch for mobile phone RF front-end modules(FEMs) was designed and characterized in a 0.13 μm partially depleted silicon-on-insulator(PD SOI) process. In this paper, the traditional seriesshunt configuration design was improved by introducing a suitably large DC bias resistor and leakage-preventing PMOS, together with the floating body technique. The performance of the RF switch is greatly improved. Furthermore, a new Ron × Coff testing method is also proposed. The size of this SPST RF switch is 0.2 mm2. This switch can be widely used for present 4 G and forthcoming 5 G mobile phone FEMs.展开更多
The abutment connection with the crown is fundamental to the structural stability of the implant system and to the prevention of mechanical exertion that can compromise the success of the implant treatment. The aim of...The abutment connection with the crown is fundamental to the structural stability of the implant system and to the prevention of mechanical exertion that can compromise the success of the implant treatment. The aim of this study is to clarify the difference in the stress distribution patterns between implants with internal and external-hex connections with the crown using the Finite Element Method (FEM). Material and Methods: The internal and external-hex connections of the Neoss and 3i implant systems respectively, are considered. The geometrical properties of the implant systems are modeled using three-dimensional (3D) brick elements. Loading conditions include a masticatory force of 200, 500 and 1000N applied to the occlusal surface of the crown along with an abutment screw torque of 110, 320 and 550Nmm. The von Mises stress distributions in the crown are examined for all loading conditions. Assumptions made in the modeling include: 1. half of the implant system is modeled and symmetrical boundary conditions applied;2. temperature sensitive elements are used to replicate the torque within the abutment screw. Results: The connection type strongly influences the resulting stress characteristics within the crown. The magnitude of stress produced by the internal-hex implant system is generally lower than that of the external-hex system. The internal-hex system held an advantage by including the use of an abutment between the abutment screw and the crown. Conclusions: The geometrical design of the external-hex system tends to induce stress concentrations in the crown at a distance of 2.89mm from the apex. At this location the torque applied to the abutment screw also affects the stresses, so that the compressive stresses on the right hand side of the crown are increased. The internal-hex system has reduced stress concentrations in the crown. However, because the torque is transferred through the abutment screw to the abutment contact, changing the torque has greater effect on this hex system than the masticatory force. Overall the masticatory force is more influential on the stress within the crown for the external-hex system and the torque is more influential on the internal-hex system.展开更多
Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte ...Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated.展开更多
为解决传统遥感干旱指数侧重于对单一响应因子的监测,缺乏对干旱综合评估的问题,本文结合气象观测资料和多源遥感数据,择优选择TVDI、RVI、PDI和GVMI日产品数据作为自变量,与卫星过境相邻时刻气象观测资料计算的MCI指数为因变量,采用随...为解决传统遥感干旱指数侧重于对单一响应因子的监测,缺乏对干旱综合评估的问题,本文结合气象观测资料和多源遥感数据,择优选择TVDI、RVI、PDI和GVMI日产品数据作为自变量,与卫星过境相邻时刻气象观测资料计算的MCI指数为因变量,采用随机森林回归算法(Random Forest Regression,RFR)构建综合遥感干旱监测模型。结果表明:与传统最小二乘法模型(Ordinary Least Squares,OLS)相比,RFR模型训练集和测试集精度均优于OLS模型。RFR训练集R值为0.97,RMSE为0.33,测试集R值为0.90,RMSE为0.53;OLS模型训练集R值为0.78,RMSE值为0.73,测试R值为0.76,RMSE值为0.79,表明RFR模型在表征区域旱情时比OLS模型更加优秀。在2022年西南地区旱情监测评估中,RFR遥感干旱监测结果与MCI指数时空分布较为一致,能较好地表征区域旱情的时空动态变化特征,体现了RFR模型在实际干旱监测过程中的实用性。但RFR干旱监测精度与区域站点个数和站点空间分布有关,在站点个数较多,站点分布均匀的区域,RFR干旱监测模型精度较高。展开更多
On June 24,2021,a 40-year-old reinforced concrete flat plate structure building in Miami suffered a sudden partial collapse.This study analyzed the overall performance and key components of the collapsed building base...On June 24,2021,a 40-year-old reinforced concrete flat plate structure building in Miami suffered a sudden partial collapse.This study analyzed the overall performance and key components of the collapsed building based on the building design codes(ACI-318 and GB 50010).Punching shear and post-punching performances of typical slabcolumn joints are also studied through the refined finite element analysis.The collapse process was simulated and visualized using a physics engine.By way of these analyses,weak design points of the collapsed building are highlighted.The differences between the reinforcement detailing of the collapsed building and the requirements of the current Chinese code are discussed,together with a comparison of the punching shear and post-punching performances.The simulated collapse procedure and debris distribution are compared with the actual collapse scenes.展开更多
This paper proposes a method for multi-model ensemble forecasting based on Bayesian model averaging (BMA), aiming to improve the accuracy of tropical cyclone (TC) intensity forecasts, especially forecasts of minim...This paper proposes a method for multi-model ensemble forecasting based on Bayesian model averaging (BMA), aiming to improve the accuracy of tropical cyclone (TC) intensity forecasts, especially forecasts of minimum surface pressure at the cyclone center (Pmin)' The multi-model ensemble comprises three operational forecast models: the Global Forecast System (GFS) of NCEP, the Hurricane Weather Research and Forecasting (HWRF) models of NCEP, and the Integrated Forecasting System (IFS) of ECMWF. The mean of a predictive distribution is taken as the BMA forecast. In this investigation, bias correction of the minimum surface pressure was applied at each forecast lead time, and the distribution (or probability density function, PDF) of emin was used and transformed. Based on summer season forecasts for three years, we found that the intensity errors in TC forecast from the three models var-ied significantly. The HWRF had a much smaller intensity error for short lead-time forecasts. To demonstrate the proposed methodology, cross validation was implemented to ensure more efficient use of the sample data and more reliable testing. Comparative analysis shows that BMA for this three-model ensemble, after bias correction and distri-bution transformation, provided more accurate forecasts than did the best of the ensemble members (HWRF), with a 5%-7% decrease in root-mean-square error on average. BMA also outperformed the multi-model ensemble, and it produced "predictive variance" that represented the forecast uncertainty of the member models. In a word, the BMA method used in the multi-model ensemble forecasting was successful in TC intensity forecasts, and it has the poten-tial to be applied to routine operational forecasting.展开更多
基金supported by the National Natural Science Foundation of China (Grant no.11972112,12032015,12121002 and 12202368)the Natural Science Foundation of Sichuan Province (Grant Nos.2022NSFSC1997).
文摘As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety,it is necessary to carry out research on the dynamic modeling of the cracked blade and breathing crack-induced vibration mechanisms.This paper summarizes the current research status on the dynamics of cracked blade,and the related topics mainly include four aspects:crack propagation path,mechanical model of open and breathing cracks,dynamic modeling methods of cracked blades such as lumped mass model,semi-analytical model and finite element model,and dynamic characteristics of cracked blades.The review will provide valuable references for future studies on dynamics and fault diagnosis of cracked blade in aeroengine.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.81772406,81974341,81991511,81625015,and 81902268)the Natural Science Foundation of Guangdong Province(2020A1515010207 and 2022A1515010431)the China Postdoctoral Science Foundation(2019M663264 and 2019TQ0385).
文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy.
文摘A high-performance single-pole single-throw(SPST) RF switch for mobile phone RF front-end modules(FEMs) was designed and characterized in a 0.13 μm partially depleted silicon-on-insulator(PD SOI) process. In this paper, the traditional seriesshunt configuration design was improved by introducing a suitably large DC bias resistor and leakage-preventing PMOS, together with the floating body technique. The performance of the RF switch is greatly improved. Furthermore, a new Ron × Coff testing method is also proposed. The size of this SPST RF switch is 0.2 mm2. This switch can be widely used for present 4 G and forthcoming 5 G mobile phone FEMs.
文摘The abutment connection with the crown is fundamental to the structural stability of the implant system and to the prevention of mechanical exertion that can compromise the success of the implant treatment. The aim of this study is to clarify the difference in the stress distribution patterns between implants with internal and external-hex connections with the crown using the Finite Element Method (FEM). Material and Methods: The internal and external-hex connections of the Neoss and 3i implant systems respectively, are considered. The geometrical properties of the implant systems are modeled using three-dimensional (3D) brick elements. Loading conditions include a masticatory force of 200, 500 and 1000N applied to the occlusal surface of the crown along with an abutment screw torque of 110, 320 and 550Nmm. The von Mises stress distributions in the crown are examined for all loading conditions. Assumptions made in the modeling include: 1. half of the implant system is modeled and symmetrical boundary conditions applied;2. temperature sensitive elements are used to replicate the torque within the abutment screw. Results: The connection type strongly influences the resulting stress characteristics within the crown. The magnitude of stress produced by the internal-hex implant system is generally lower than that of the external-hex system. The internal-hex system held an advantage by including the use of an abutment between the abutment screw and the crown. Conclusions: The geometrical design of the external-hex system tends to induce stress concentrations in the crown at a distance of 2.89mm from the apex. At this location the torque applied to the abutment screw also affects the stresses, so that the compressive stresses on the right hand side of the crown are increased. The internal-hex system has reduced stress concentrations in the crown. However, because the torque is transferred through the abutment screw to the abutment contact, changing the torque has greater effect on this hex system than the masticatory force. Overall the masticatory force is more influential on the stress within the crown for the external-hex system and the torque is more influential on the internal-hex system.
基金supported by grants from Natural Science Foundation of China grant No 82172491 (CN)National Natural Science Funds for Excellent Young Scholar No 82322044 (CN)+2 种基金National Key Research and Development Program of China (2022YFC3601902)Youth Talent Support Programme of Guangdong Provincial Association for Science and Technology (SKXRC202308)State-funded postdoctoral researcher program No GZC20231062 (CN)。
文摘Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated.
文摘为解决传统遥感干旱指数侧重于对单一响应因子的监测,缺乏对干旱综合评估的问题,本文结合气象观测资料和多源遥感数据,择优选择TVDI、RVI、PDI和GVMI日产品数据作为自变量,与卫星过境相邻时刻气象观测资料计算的MCI指数为因变量,采用随机森林回归算法(Random Forest Regression,RFR)构建综合遥感干旱监测模型。结果表明:与传统最小二乘法模型(Ordinary Least Squares,OLS)相比,RFR模型训练集和测试集精度均优于OLS模型。RFR训练集R值为0.97,RMSE为0.33,测试集R值为0.90,RMSE为0.53;OLS模型训练集R值为0.78,RMSE值为0.73,测试R值为0.76,RMSE值为0.79,表明RFR模型在表征区域旱情时比OLS模型更加优秀。在2022年西南地区旱情监测评估中,RFR遥感干旱监测结果与MCI指数时空分布较为一致,能较好地表征区域旱情的时空动态变化特征,体现了RFR模型在实际干旱监测过程中的实用性。但RFR干旱监测精度与区域站点个数和站点空间分布有关,在站点个数较多,站点分布均匀的区域,RFR干旱监测模型精度较高。
基金the financial support received from The National Key R&D Program(No.2019YFE0112800)the National Natural Science Foundation of China(Grant No.51778341)the Australian Research Council through an ARC Discovery Project(No.DP150100606).
文摘On June 24,2021,a 40-year-old reinforced concrete flat plate structure building in Miami suffered a sudden partial collapse.This study analyzed the overall performance and key components of the collapsed building based on the building design codes(ACI-318 and GB 50010).Punching shear and post-punching performances of typical slabcolumn joints are also studied through the refined finite element analysis.The collapse process was simulated and visualized using a physics engine.By way of these analyses,weak design points of the collapsed building are highlighted.The differences between the reinforcement detailing of the collapsed building and the requirements of the current Chinese code are discussed,together with a comparison of the punching shear and post-punching performances.The simulated collapse procedure and debris distribution are compared with the actual collapse scenes.
基金Supported by the National Natural Science Foundation of China(40830957)China Meteorological Administration Special Public Welfare Research Fund(GYHY201106018)+2 种基金National Basic Research and Development(973)Program of China(2011CB421504)National Science and Technology Support Program of China(2010BAC51B05)Knowledge Innovation Project of the Chinese Academy of Sciences(KZCX2-YW-Q1-02)
文摘This paper proposes a method for multi-model ensemble forecasting based on Bayesian model averaging (BMA), aiming to improve the accuracy of tropical cyclone (TC) intensity forecasts, especially forecasts of minimum surface pressure at the cyclone center (Pmin)' The multi-model ensemble comprises three operational forecast models: the Global Forecast System (GFS) of NCEP, the Hurricane Weather Research and Forecasting (HWRF) models of NCEP, and the Integrated Forecasting System (IFS) of ECMWF. The mean of a predictive distribution is taken as the BMA forecast. In this investigation, bias correction of the minimum surface pressure was applied at each forecast lead time, and the distribution (or probability density function, PDF) of emin was used and transformed. Based on summer season forecasts for three years, we found that the intensity errors in TC forecast from the three models var-ied significantly. The HWRF had a much smaller intensity error for short lead-time forecasts. To demonstrate the proposed methodology, cross validation was implemented to ensure more efficient use of the sample data and more reliable testing. Comparative analysis shows that BMA for this three-model ensemble, after bias correction and distri-bution transformation, provided more accurate forecasts than did the best of the ensemble members (HWRF), with a 5%-7% decrease in root-mean-square error on average. BMA also outperformed the multi-model ensemble, and it produced "predictive variance" that represented the forecast uncertainty of the member models. In a word, the BMA method used in the multi-model ensemble forecasting was successful in TC intensity forecasts, and it has the poten-tial to be applied to routine operational forecasting.