Meta-Analysis of Bushen Huoxue Method in the Treatment of Recurrent Spontaneous Abortion Due to Prethrombotic State

Objective:To evaluate the effectiveness and safety of Bushen Huoxue prescription in the treatment of recurrent spontaneous abortion(RSA)due to prethrombotic state(PTS).Methods:Databases such as CNKI,WanFang,VIP,CBM,PubMed,Embase,and Cochrane Library were searched for randomized controlled trials on Bushen Huoxue prescription in treating RSA due to PTS from inception to March 2021;meta-analysis was performed by RevMan Version 5.3.0 following quality evaluation.Results:Seven trials were included,with 496 patients;the meta-analysis indicated that Bushen Huoxue prescription has advantages on the improvement of total clinical effective rate[RR=1.22,95%CI(1.10,1.35),Z=3.80(P=0.0001)],embryo survival rate at pregnancy of 12 weeks[RR=1.25,95%CI(1.10,1.41),Z=3.53(P=0.0004)],D-dimer levels[SMD=-1.59,95%CI(-2.20,-0.97),Z=5.07(P<0.00001)],and fibrinogen levels[MD=-1.00,95%CI(-1.29,-0.70),Z=6.61(P<0.00001)],but the statistical heterogeneity was significant;in terms of incidence of adverse reactions,there was no statistical difference between Bushen Huoxue prescription and western medicine.Conclusion:Compared with western medicine alone,Bushen Huoxue prescription alone or in combination with western medicine showed significant advantages in improving the overall clinical efficiency,embryonic survival rate at 12 weeks of pregnancy,and reducing D-dimer values as well as fibrinogen levels,without any significant difference in the incidence of adverse effects;however,the number of included studies is small and there are drawbacks,such as small sample size and low quality;therefore,high-quality clinical studies with large sample size and rigorous trial designs are needed in the future to provide a reliable basis for the effectiveness and safety of TCM in reducing the incidence of RSA due to prethrombotic state.

A clinical study on the treatment of obese polycystic ovary syndrome by electroacupuncture combined with moving cupping

Objective:Effect analysis of electroacupuncture combined with recircupping in treatment of obese polycystic ovary syndrome.Methods: From October 2016 to September 2018, 68 obese PCOS patients were diagnosed and treated in the department of gynaecology, affiliated hospital of shaanxi university of traditional Chinese medicine.Treatment group given cupping and tired walking tank with metformin therapy, the control group only oral metformin treatment, after continuous treatment of three menstrual cycles, observation comprehensive curative effect of two groups before and after treatment, TCM syndrome score, body weight, body mass index (BMI), waist hip ratio (WHR), sex hormone [luteinizing hormone (LH), testosterone (T)], blood sugar [fasting plasma glucose (FPG), fasting insulin (FINS), insulin resistance index (HOMA IR)] and blood lipid [triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC)] metabolic index, on two groups of curative effect are compared and discussed. Results:The total effective rate (83.33%) of the treatment group was higher than that of the control group (66.67%)(P<0.05).After treatment, TCM syndrome score of the two groups decreased significantly(P<0.01).The treatment group was significantly improved compared with the control group (P<0.01).Body weight, BMI, WHR of the two groups decreased significantly after treatment (P<0.01).The treatment group was better than the control group (P<0.05).After treatment, the LH and T values of the two groups decreased significantly (P<0.01).There was no significant difference in T value between the two groups (P>0.05), but the efficacy of LH in the treatment group was better than that in the control group (P<0.01).The levels of FINS, HOMA-IR and FPG in the two groups were significantly decreased after treatment (P<0.01).There was no significant difference in FPG between the two groups (P > 0.05), but the improvement of FINS and HOMA-IR in the treatment group was better than that in the control group (P< 0.01).After treatment, TG, LDL-C and TC levels in the two groups decreased (P< 0.01), while HDL-C levels in the treatment group increased (P< 0.01).There was no significant difference in HDL-C, LDL-C and TC between the two groups (P>0.05), but the efficacy of TG in the treatment group was better than that in the control group (P< 0.01).Conclusion: The curative effect of electroacupuncture and moving cupping combined with metformin is better than that of metformin alone, should be widely used.

Long-term safety and efficacy of CART-20 cells in patients with refractory or relapsed B-cell non-Hodgkin lymphoma:5-years follow-up results of the phase I and IIa trials

For refractory or relapsed(r/r)B-cell non-Hodgkin lymphoma(NHL),the response rates to conventional salvage chemotherapy are 27–44%.1 Chimeric antigen receptors(CARs)efficiently redirect T-cell specificity and cytotoxicity to cells expressing the targeted Ag in an HLA-independent manner.2 The early phase clinical trials of CART cells for(r/r)B-cell NHL have demonstrated promising results..