Objective:Glioblastomas are highly vascularized malignant tumors.We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed glioblastoma.Methods:This multicente...Objective:Glioblastomas are highly vascularized malignant tumors.We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed glioblastoma.Methods:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November 2020.Patients underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/d.The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned treatment.The median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant therapy.Five patients discontinued treatment due to AEs.HEG1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter PFS.Conclusions:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable toxicity.HEG1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.展开更多
The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage applications.Here,cooperative ...The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage applications.Here,cooperative Pb-C composites consisting of single atom Pb and carbon-encapsulated PbO nanoparticles were prepared by freeze-drying technique and pyrolytic reduction to address above obstacles.The innovative use of Pb^(2+)to cross-link sodium alginate enabled a uniform distribution of Pb in the composites,generating Pb-C-PbO three-phase heterostructure.Experimental analysis and theoretical calculations revealed the synergistic interactions between single-atom Pb and PbO nanoparticles in suppressing parasitic hydrogen evolution and promoting the adsorption of Pb atoms.The presence of monatomic Pb and PbO enhanced the affinity of the composites for the negative active materials and facilitated the transformation of the active materials from bulk into spherical shapes to enhance the specific surface area,thereby counteracting sulphation.Through the coordinated integration of various functionalities offered by Pb@C-x,the cycle life of the battery at HRPSoC reaches 7025 cycles,which is two times for LCB with pure carbon materials.Additionally,the discharge capacity increased from 3.52 to 3.79 Ah.This study provides substantial insights into the construction of Pb-C composites for LCBs to inhibit negative sulphation and hydrogen evolution.展开更多
Objective:Little progress has been made in recent years using first-line chemotherapy,including gemcitabine combined with nab-paclitaxel,FOLFIRINOX,and NALIRIFOX,for advanced pancreatic adenocarcinoma(APC).In addition...Objective:Little progress has been made in recent years using first-line chemotherapy,including gemcitabine combined with nab-paclitaxel,FOLFIRINOX,and NALIRIFOX,for advanced pancreatic adenocarcinoma(APC).In addition,the optimal second-line chemotherapy regimen has not been determined.This study aimed to compare the effectiveness of different types of second-line chemotherapy for APC.Methods:Patients with APC who received first-line treatment from January 2008 to January 2021 were considered eligible for this retrospective analysis.The primary and secondary endpoints were overall survival(OS)and progression-free survival(PFS),respectively.Results:Four hundred and thirty-seven and 617 patients were treated with 5-fluorouracil-and gemcitabine-based chemotherapy as first-line treatment,respectively.Demographic and clinical features,except age and liver metastasis,were comparable between the two groups(P<0.05).The median OS was 8.8 and 7.8 months in patients who received a 5-fluorouracil-and gemcitabine-based combined regimen for first-line therapy,respectively(HR=1.244,95%CI=1.090–1.419;P<0.001).The median OS was 5.6 and 1.9 months in patients who received second-line chemotherapy and supportive care,respectively(HR=0.766,95%CI=0.677–0.867;P<0.001).The median PFS was not significantly differently between gemcitabine or 5-fluorouracil monotherapy and combination therapy.Conclusions:A 5-fluorouracil-or gemcitabine-based combined regimen was shown to be as effective as a single 5-fluorouracil or gemcitabine regimen as second-line therapy for patients with APC.展开更多
The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit sate...The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit satellites.Fengyun-3E(FY-3E)was launched successfully on 5 July 2021 in China.As an early-morning-orbit satellite,FY-3E can help form a complete three-orbit observation system together with the mid-morning and afternoon satellites in the current mainstream operational system.In this study,we investigate the added benefit of FY-3E microwave sounding observations to the midmorning-orbit Meteorological Operational satellite-B(Met Op-B)and afternoon-orbit Fengyun-3D(FY-3D)microwave observations in the Chinese Meteorological Administration global forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the global coverage of microwave temperature and humidity sounding data by 14.8% and 10.6%,respectively.It enables the CMA-GFS to achieve nearly 100% global coverage of microwave-sounding observations at each analysis time.Furthermore,after effective quality control and bias correction,the global biases and standard deviations of the differences between observations and model simulations are also reduced.Based on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onboard Met Op-B,and the MWTS-2 and MWHS-2 onboard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the global prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.展开更多
Cultivated rice(Oryza sativa L.),one of the most widely grown and important crops worldwide,is believed to have been domesticated from the ancestral wild rice(Oryza rufipogon Griff.)thousands of years ago(Cheng et al....Cultivated rice(Oryza sativa L.),one of the most widely grown and important crops worldwide,is believed to have been domesticated from the ancestral wild rice(Oryza rufipogon Griff.)thousands of years ago(Cheng et al.2003;Khush 1997;Fuller et al.2010).展开更多
Lignin-derived porous carbons have emerged as promising electrode materials for supercapacitors.However,the challenge remains in designing and controlling their structure to achieve ideal electrochemical performance d...Lignin-derived porous carbons have emerged as promising electrode materials for supercapacitors.However,the challenge remains in designing and controlling their structure to achieve ideal electrochemical performance due to the complex molecular structure of lignin and its intricate chemical reactions during the activation process.In this study,three porous carbons were synthesized from lignin by spray drying and chemical activation with vary-ing KOH ratios.The specific surface area and structural order of the prepared porous carbon continued to increase with the increase of the KOH ratio.Thermogravimetric-mass spectrometry(TG-MS)was employed to track the molecular fragments generated during the pyrolysis of KOH-activated lignin,and the mechanism of the thermochemical conversion was investigated.During the thermochemical conversion of lignin,KOH facili-tated the removal of H2 and CO,leading to the formation of not only more micropores and mesopores,but also more ordered carbon structures.The pore structure exhibited a greater impact than the carbon structure on the electrochemical performance of porous carbon.The optimized porous carbon exhibited a capacitance of 256 F g-1 at a current density of 0.2 A g-1,making it an ideal electrode material for high-performance supercapacitors.展开更多
In animals,heat stress(HS)disrupts spermatogenesis,reducing sperm quality and,in severe cases,potentially inducing the loss of male reproductive function.Melatonin confers significant resistance to oxidative stress an...In animals,heat stress(HS)disrupts spermatogenesis,reducing sperm quality and,in severe cases,potentially inducing the loss of male reproductive function.Melatonin confers significant resistance to oxidative stress and apoptosis;however,its specific effects on rat spermatocytes and the mechanism underlying its anti-HS effects remain inadequately explored.Therefore,this study aimed to analyze the effects of melatonin at different concentrations on sperm cell activity in heat-stressed rats.Modeling heat stress injury,sperm viability and density assay,sperm plasma membrane integrity analysis,and oxidative stress assay of testicular tissue were conducted.The results revealed that HS caused sperm cell injury.However,the intraperitoneal injection of melatonin effectively improved spermatozoa quality,and a dose of 1 mM significantly alleviated the HS-induced damage.Moreover,HS increased the levels of oxidative and endoplasmic reticulum(ES)stress in rat testicular tissues,inducing germ cell apoptosis and pathological changes.Similarly,melatonin treatment improved sperm cell viability and density,inhibited germ cell apoptosis,and reduced oxidative and ES stress levels.Overall,melatonin effectively reduced the adverse effects of HS on rat sperm cells,and an intraperitoneal injection of 1 mM(0.6966 mg)melatonin facilitated the normal production of spermatozoa.Notably,its mechanism may involve reduced ES and oxidative stress levels in testicular tissues,increased expression of the anti-apoptotic protein Bcl-2,and inhibition of germ cell apoptosis.展开更多
Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted ...Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted from January 2020 to December 2022 were divided into the reference group and the experimental group by random numerical table. On the basis of symptomatic treatment, the control group was combined with conventional nursing measures and breathing exercises, while the experimental group was treated with psychological nursing on the basis of the control group, and the pulmonary function indexes and adverse mood of the two groups before and after nursing were compared. Results: There was no difference in SAS score, SDS score and pulmonary function indexes between the two groups before intervention (P > 0.05), and the SAS score in the experimental group was the SDS score was lower than that of the control group, and FEV1, FEV1% and FEV1/FVC were higher than those of the control group, and the P < 0.05 was lower.展开更多
Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients...Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.展开更多
<strong>Background:</strong> Cisplatin, a chemotherapeutic agent, is widely used in the treatment of malignant tumors. Nephrotoxicity, especially acute kidney injury (AKI), is the most common and severe ad...<strong>Background:</strong> Cisplatin, a chemotherapeutic agent, is widely used in the treatment of malignant tumors. Nephrotoxicity, especially acute kidney injury (AKI), is the most common and severe adverse reaction of cisplatin. Resveratrol and ginsenoside Rg1, two natural products, have been found to have renal protective effects. However, the effects and the mechanisms in cisplatin-induced AKI need further investigation. <strong>Methods:</strong> The mouse models of cisplatin-induced AKI and several treatment groups were established. Male C57BL/6 mice were divided into five groups: saline control group, cisplatin injury group, resveratrol treatment group, Rg1 treatment group, resveratrol and Rg1 combined treatment group. Serological analysis of serum urea nitrogen was aimed to reflect the function of kidney, and histological analysis of renal tissue sections was aimed to assess the damage of proximal convoluted tubules. The expression levels of autophagy-related proteins Beclin 1 and LC3 were detected by western blotting and qRT-PCR respectively. <strong>Results:</strong> The renal function was improved and renal damage was alleviated in Rg1 and resveratrol alone or combined treatment groups compared with the cisplatin injury group. For the mechanism, treatment with Rg1 and resveratrol alone or in combination decreased the expressions of Beclin 1 both at protein and mRNA levels, decreased LC3II/I protein levels, indicating that autophagy was inhibited by treatment with Rg1 and resveratrol alone or in combination. <strong>Conclusion:</strong> Resveratrol and Rg1 alleviated the kidney damage caused by cisplatin, and reduced autophagy was involved in the renoprotective effects of resveratrol and Rg1 against cisplatin-induced AKI. This study may provide new evidence to alleviate cisplatin-induced AKI.展开更多
While the signal field + ASE noise pass through a span of transmission fiber, a dispersion compensation grating and a fiber amplifier(with the generation of ASE noise), the nonlinear Fokker-Plank equations, describing...While the signal field + ASE noise pass through a span of transmission fiber, a dispersion compensation grating and a fiber amplifier(with the generation of ASE noise), the nonlinear Fokker-Plank equations, describing the probability transforms of the field, are established and solved. Based on these statistical theories, the probability distributions of the signal + ASE noise field through 50km NZDSF, a dispersion compensation grating and a fiber amplifier link, are obtained. The dispersion and nonlinear effects in transmission fiber induce frequency offsets in the probability distribution of field and they cannot be dissipated by dispersion compensation. The generation of ASE noise in the amplifier will accelerate this frequency offset.展开更多
基金primarily financially supported by the National Natural Science Foundation of China(No.51871245)the National Key R&D Program of China(No.2017YFE0301505)State Key Laboratory for Powder Metallurgy as well as State Key Laboratory of Light Weight and High Strength Structural Materials,Central South University,China。
基金supported by the National Natural Science Foundation of China(Grant No.82272744)Natural Science Foundation of Guangdong Province(Grant No.2022A1515010814)Sun Yat-sen University Clinical Research 5010 Program(Grant No.2022008).
文摘Objective:Glioblastomas are highly vascularized malignant tumors.We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed glioblastoma.Methods:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November 2020.Patients underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/d.The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned treatment.The median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant therapy.Five patients discontinued treatment due to AEs.HEG1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter PFS.Conclusions:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable toxicity.HEG1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.
基金supported by the National Natural Science Foundation of China (52064028,22002054)Yunnan Fundamental Research Projects (202401AT070334,202101AS070013)Yunnan Provincial Major Science and Technology Special Plan Projects (202202AF080002)。
文摘The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage applications.Here,cooperative Pb-C composites consisting of single atom Pb and carbon-encapsulated PbO nanoparticles were prepared by freeze-drying technique and pyrolytic reduction to address above obstacles.The innovative use of Pb^(2+)to cross-link sodium alginate enabled a uniform distribution of Pb in the composites,generating Pb-C-PbO three-phase heterostructure.Experimental analysis and theoretical calculations revealed the synergistic interactions between single-atom Pb and PbO nanoparticles in suppressing parasitic hydrogen evolution and promoting the adsorption of Pb atoms.The presence of monatomic Pb and PbO enhanced the affinity of the composites for the negative active materials and facilitated the transformation of the active materials from bulk into spherical shapes to enhance the specific surface area,thereby counteracting sulphation.Through the coordinated integration of various functionalities offered by Pb@C-x,the cycle life of the battery at HRPSoC reaches 7025 cycles,which is two times for LCB with pure carbon materials.Additionally,the discharge capacity increased from 3.52 to 3.79 Ah.This study provides substantial insights into the construction of Pb-C composites for LCBs to inhibit negative sulphation and hydrogen evolution.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2021YFA1201100)the National Natural Science Foundation of China(Grant No.82072657).
文摘Objective:Little progress has been made in recent years using first-line chemotherapy,including gemcitabine combined with nab-paclitaxel,FOLFIRINOX,and NALIRIFOX,for advanced pancreatic adenocarcinoma(APC).In addition,the optimal second-line chemotherapy regimen has not been determined.This study aimed to compare the effectiveness of different types of second-line chemotherapy for APC.Methods:Patients with APC who received first-line treatment from January 2008 to January 2021 were considered eligible for this retrospective analysis.The primary and secondary endpoints were overall survival(OS)and progression-free survival(PFS),respectively.Results:Four hundred and thirty-seven and 617 patients were treated with 5-fluorouracil-and gemcitabine-based chemotherapy as first-line treatment,respectively.Demographic and clinical features,except age and liver metastasis,were comparable between the two groups(P<0.05).The median OS was 8.8 and 7.8 months in patients who received a 5-fluorouracil-and gemcitabine-based combined regimen for first-line therapy,respectively(HR=1.244,95%CI=1.090–1.419;P<0.001).The median OS was 5.6 and 1.9 months in patients who received second-line chemotherapy and supportive care,respectively(HR=0.766,95%CI=0.677–0.867;P<0.001).The median PFS was not significantly differently between gemcitabine or 5-fluorouracil monotherapy and combination therapy.Conclusions:A 5-fluorouracil-or gemcitabine-based combined regimen was shown to be as effective as a single 5-fluorouracil or gemcitabine regimen as second-line therapy for patients with APC.
基金jointly supported by the National Key Research and Development Program of China(Grant No.2022YFC3004002)the Fengyun Application Pioneering Project(FY-APP-2021.0201)FY-3 Meteorological Satellite Ground Application System Project[FY-3(03)-AS-11.08]。
文摘The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit satellites.Fengyun-3E(FY-3E)was launched successfully on 5 July 2021 in China.As an early-morning-orbit satellite,FY-3E can help form a complete three-orbit observation system together with the mid-morning and afternoon satellites in the current mainstream operational system.In this study,we investigate the added benefit of FY-3E microwave sounding observations to the midmorning-orbit Meteorological Operational satellite-B(Met Op-B)and afternoon-orbit Fengyun-3D(FY-3D)microwave observations in the Chinese Meteorological Administration global forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the global coverage of microwave temperature and humidity sounding data by 14.8% and 10.6%,respectively.It enables the CMA-GFS to achieve nearly 100% global coverage of microwave-sounding observations at each analysis time.Furthermore,after effective quality control and bias correction,the global biases and standard deviations of the differences between observations and model simulations are also reduced.Based on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onboard Met Op-B,and the MWTS-2 and MWHS-2 onboard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the global prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.
基金financed by the National Natural Science Foundation of China(32060174,32360085 and 32160079)the Natural Science Foundation of Guangxi Province,China(2020GXNSFAA297236 and 2020GXNSFAA297211)+2 种基金the Fellowship of China Postdoctoral Science Foundation,China(2021M693175)the State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources,China(SKLCUSA-a202007)the Innovation Project of Guangxi Graduate Education,China(YCBZ2023037).
文摘Cultivated rice(Oryza sativa L.),one of the most widely grown and important crops worldwide,is believed to have been domesticated from the ancestral wild rice(Oryza rufipogon Griff.)thousands of years ago(Cheng et al.2003;Khush 1997;Fuller et al.2010).
基金funding from the Key Research and Development Projects of Zhejiang Province(2022C01236)and the Ningbo Top Talent Project.
文摘Lignin-derived porous carbons have emerged as promising electrode materials for supercapacitors.However,the challenge remains in designing and controlling their structure to achieve ideal electrochemical performance due to the complex molecular structure of lignin and its intricate chemical reactions during the activation process.In this study,three porous carbons were synthesized from lignin by spray drying and chemical activation with vary-ing KOH ratios.The specific surface area and structural order of the prepared porous carbon continued to increase with the increase of the KOH ratio.Thermogravimetric-mass spectrometry(TG-MS)was employed to track the molecular fragments generated during the pyrolysis of KOH-activated lignin,and the mechanism of the thermochemical conversion was investigated.During the thermochemical conversion of lignin,KOH facili-tated the removal of H2 and CO,leading to the formation of not only more micropores and mesopores,but also more ordered carbon structures.The pore structure exhibited a greater impact than the carbon structure on the electrochemical performance of porous carbon.The optimized porous carbon exhibited a capacitance of 256 F g-1 at a current density of 0.2 A g-1,making it an ideal electrode material for high-performance supercapacitors.
基金the National Key Research and Development Program of China(No.2020YFC1909700)the National Natural Science Foundation of China(Nos.51974207,51774215).
基金Public Welfare Project of Zhejiang Province(Grant no.LGN22C170010 and LGD22C170001)。
文摘In animals,heat stress(HS)disrupts spermatogenesis,reducing sperm quality and,in severe cases,potentially inducing the loss of male reproductive function.Melatonin confers significant resistance to oxidative stress and apoptosis;however,its specific effects on rat spermatocytes and the mechanism underlying its anti-HS effects remain inadequately explored.Therefore,this study aimed to analyze the effects of melatonin at different concentrations on sperm cell activity in heat-stressed rats.Modeling heat stress injury,sperm viability and density assay,sperm plasma membrane integrity analysis,and oxidative stress assay of testicular tissue were conducted.The results revealed that HS caused sperm cell injury.However,the intraperitoneal injection of melatonin effectively improved spermatozoa quality,and a dose of 1 mM significantly alleviated the HS-induced damage.Moreover,HS increased the levels of oxidative and endoplasmic reticulum(ES)stress in rat testicular tissues,inducing germ cell apoptosis and pathological changes.Similarly,melatonin treatment improved sperm cell viability and density,inhibited germ cell apoptosis,and reduced oxidative and ES stress levels.Overall,melatonin effectively reduced the adverse effects of HS on rat sperm cells,and an intraperitoneal injection of 1 mM(0.6966 mg)melatonin facilitated the normal production of spermatozoa.Notably,its mechanism may involve reduced ES and oxidative stress levels in testicular tissues,increased expression of the anti-apoptotic protein Bcl-2,and inhibition of germ cell apoptosis.
文摘Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted from January 2020 to December 2022 were divided into the reference group and the experimental group by random numerical table. On the basis of symptomatic treatment, the control group was combined with conventional nursing measures and breathing exercises, while the experimental group was treated with psychological nursing on the basis of the control group, and the pulmonary function indexes and adverse mood of the two groups before and after nursing were compared. Results: There was no difference in SAS score, SDS score and pulmonary function indexes between the two groups before intervention (P > 0.05), and the SAS score in the experimental group was the SDS score was lower than that of the control group, and FEV1, FEV1% and FEV1/FVC were higher than those of the control group, and the P < 0.05 was lower.
文摘Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.
文摘<strong>Background:</strong> Cisplatin, a chemotherapeutic agent, is widely used in the treatment of malignant tumors. Nephrotoxicity, especially acute kidney injury (AKI), is the most common and severe adverse reaction of cisplatin. Resveratrol and ginsenoside Rg1, two natural products, have been found to have renal protective effects. However, the effects and the mechanisms in cisplatin-induced AKI need further investigation. <strong>Methods:</strong> The mouse models of cisplatin-induced AKI and several treatment groups were established. Male C57BL/6 mice were divided into five groups: saline control group, cisplatin injury group, resveratrol treatment group, Rg1 treatment group, resveratrol and Rg1 combined treatment group. Serological analysis of serum urea nitrogen was aimed to reflect the function of kidney, and histological analysis of renal tissue sections was aimed to assess the damage of proximal convoluted tubules. The expression levels of autophagy-related proteins Beclin 1 and LC3 were detected by western blotting and qRT-PCR respectively. <strong>Results:</strong> The renal function was improved and renal damage was alleviated in Rg1 and resveratrol alone or combined treatment groups compared with the cisplatin injury group. For the mechanism, treatment with Rg1 and resveratrol alone or in combination decreased the expressions of Beclin 1 both at protein and mRNA levels, decreased LC3II/I protein levels, indicating that autophagy was inhibited by treatment with Rg1 and resveratrol alone or in combination. <strong>Conclusion:</strong> Resveratrol and Rg1 alleviated the kidney damage caused by cisplatin, and reduced autophagy was involved in the renoprotective effects of resveratrol and Rg1 against cisplatin-induced AKI. This study may provide new evidence to alleviate cisplatin-induced AKI.
文摘While the signal field + ASE noise pass through a span of transmission fiber, a dispersion compensation grating and a fiber amplifier(with the generation of ASE noise), the nonlinear Fokker-Plank equations, describing the probability transforms of the field, are established and solved. Based on these statistical theories, the probability distributions of the signal + ASE noise field through 50km NZDSF, a dispersion compensation grating and a fiber amplifier link, are obtained. The dispersion and nonlinear effects in transmission fiber induce frequency offsets in the probability distribution of field and they cannot be dissipated by dispersion compensation. The generation of ASE noise in the amplifier will accelerate this frequency offset.
