Influence of Phosphorus Content and Magnetic Annealing on Soft Magnetic Properties of Electrodeposited Amorphous FeMnP Alloy Films

In this work, we investigated the influence of phosphorus and magnetic anneal on the soft magnetic properties of electrodeposited FeMnP alloy films prepared by changing sodium hypophosphite concentrations. X-ray diffraction radiation patterns showed an amorphous structure of electrodeposited alloy films. The saturation magnetization and coercivity value decreased from 586 emu/cc to 346 emu/cc, and 52 Oe to 18 Oe, with the P content increased, respectively. The absorption resonance peak became broad as the P content increased, and the natural resonance frequency decreased from 1.8 GHz to 0.6 GHz, with the P content increasing. Magnetic annealing of samples reduced the magnetic damping, and natural resonance frequency increased by about 1.8 GHz and 3.5 GHz for the sample with lower and higher P content. The film structure with lower P content changed at 300˚C, while the structure remains unchanged for the films with higher P content. Thus, the crystallization temperature could depend on the P content in the film. FeMnP alloy films could be used in high-frequency devices.

Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis

BACKGROUND Alterations in plasma and intestinal metabolites contribute to the pathogenesis and progression of alcohol-related liver cirrhosis(ALC).AIM To explore the common and different metabolites in the plasma and feces of patients with ALC and evaluate their clinical implications.METHODS According to the inclusion and exclusion criteria,27 patients with ALC and 24 healthy controls(HCs)were selected,and plasma and feces samples were collected.Liver function,blood routine,and other indicators were detected with automatic biochemical and blood routine analyzers.Liquid chromatography-mass spectrometry was used to detect the plasma and feces metabolites of the two groups and the metabolomics of plasma and feces.Also,the correlation between metabolites and clinical features was analyzed.RESULTS More than 300 common metabolites were identified in the plasma and feces of patients with ALC.Pathway analysis showed that these metabolites are enriched in bile acid and amino acid metabolic pathways.Compared to HCs,patients with ALC had a higher level of glycocholic acid(GCA)and taurocholic acid(TCA)in plasma and a lower level of deoxycholic acid(DCA)in the feces,while L-threonine,L-phenylalanine,and L-tyrosine increased simultaneously in plasma and feces.GCA,TCA,L-methionine,L-phenylalanine,and L-tyrosine in plasma were positively correlated with total bilirubin(TBil),prothrombin time(PT),and maddrey discriminant function score(MDF)and negatively correlated with cholinesterase(CHE)and albumin(ALB).The DCA in feces was negatively correlated with TBil,MDF,and PT and positively correlated with CHE and ALB.Moreover,we established a P/S BA ratio of plasma primary bile acid(GCA and TCA)to fecal secondary bile acid(DCA),which was relevant to TBil,PT,and MDF score.CONCLUSION The enrichment of GCA,TCA,L-phenylalanine,L-tyrosine,and L-methionine in the plasma of patients with ALC and the reduction of DCA in feces were related to the severity of ALC.These metabolites may be used as indicators to evaluate the progression of alcohol-related liver cirrhosis.

Asymmetric magnetoimpedance effect and dipolar interactions of FINEMET/SiO_(2)/FePd composite ribbons

The dipolar interactions are investigated through the asymmetric magneto-impedance in FINEMET/SiO_(2)/FePd composite ribbons.The interface between the hard(FePd layer)phase and soft(FINEMET ribbon)phase is coherent by SiO_(2)layer in FINEMET/SiO_(2)/FePd composite ribbons,which effectively induces dipolar interactions.The contribution of dipolar interaction to the bias field(Hb)by asymmetrical giant magneto-impedance and magnetic properties is analyzed.The results show that Hb response decreases with the increase of the SiO_(2)layer thickness,indicating that the linear region near-zero field can be tuned by the thickness of SiO_(2)layer.These results allow the GMI ratio(58%)and characteristic frequency(500 kHz)to be optimized.The transverse and longitudinal magnetic domain structures of FINEMET ribbon and FePd film are confirmed,respectively.The composite ribbons with high GMI ratio and low frequency can be applied to linear magnetic sensors.

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully understood.Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic spines.However,the function of CNKSR2 in the cytoplasm remains to be elucidated.In this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2.Through a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome.We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290.Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2.When we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal genes.This manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and motility.Furthermore,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder.Our findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

Argatroban is a synthetic thrombin inhibitor approved by U.S.Food and Drug Administration for the treatment of thrombosis.However,whether it plays a role in the repair of spinal cord injury is unknown.In this study,we established a rat model of T10 moderate spinal cord injury using an NYU Impactor ModerⅢand performed intraperitoneal injection of argatroban for 3 consecutive days.Our results showed that argatroban effectively promoted neurological function recovery after spinal cord injury and decreased thrombin expression and activity in the local injured spinal cord.RNA sequencing transcriptomic analysis revealed that the differentially expressed genes in the argatroban-treated group were enriched in the JAK2/STAT3 pathway,which is involved in astrogliosis and glial scar formation.Western blotting and immunofluorescence results showed that argatroban downregulated the expression of the thrombin receptor PAR1 in the injured spinal cord and the JAK2/STAT3 signal pathway.Argatroban also inhibited the activation and proliferation of astrocytes and reduced glial scar formation in the spinal cord.Taken together,these findings suggest that argatroban may inhibit astrogliosis by inhibiting the thrombin-mediated PAR1/JAK2/STAT3 signal pathway,thereby promoting the recovery of neurological function after spinal cord injury.

Atmospheric nitrogen deposition affects forest plant and soil system carbon:nitrogen:phosphorus stoichiometric flexibility:A meta-analysis

Background:Nitrogen(N)deposition affects forest stoichiometric flexibility through changing soil nutrient availability to influence plant uptake.However,the effect of N deposition on the flexibility of carbon(C),N,and phosphorus(P)in forest plant-soil-microbe systems remains unclear.Methods:We conducted a meta-analysis based on 751 pairs of observations to evaluate the responses of plant,soil and microbial biomass C,N and P nutrients and stoichiometry to N addition in different N intensity(050,50–100,>100 kg·ha^(-1)·year^(-1)of N),duration(0–5,>5 year),method(understory,canopy),and matter(ammonium N,nitrate N,organic N,mixed N).Results:N addition significantly increased plant N:P(leaf:14.98%,root:13.29%),plant C:P(leaf:6.8%,root:25.44%),soil N:P(13.94%),soil C:P(10.86%),microbial biomass N:P(23.58%),microbial biomass C:P(12.62%),but reduced plant C:N(leaf:6.49%,root:9.02%).Furthermore,plant C:N:P stoichiometry changed significantly under short-term N inputs,while soil and microorganisms changed drastically under high N addition.Canopy N addition primarily affected plant C:N:P stoichiometry through altering plant N content,while understory N inputs altered more by influencing soil C and P content.Organic N significantly influenced plant and soil C:N and C:P,while ammonia N changed plant N:P.Plant C:P and soil C:N were strongly correlated with mean annual precipitation(MAT),and the C:N:P stoichiometric flexibility in soil and plant under N addition connected with soil depth.Besides,N addition decoupled the correlations between soil microorganisms and the plant.Conclusions:N addition significantly increased the C:P and N:P in soil,plant,and microbial biomass,reducing plant C:N,and aggravated forest P limitations.Significantly,these impacts were contingent on climate types,soil layers,and N input forms.The findings enhance our comprehension of the plant-soil system nutrient cycling mechanisms in forest ecosystems and plant strategy responses to N deposition.

Elimination of hepatitis B as a public health threat:Addressing the challenge and taking action

Despite the significant efforts made in recent years,the latest data from the World Health Organization indicates that there are substantial challenges in achieving the elimination of hepatitis B virus(HBV)infection by 2030.The article in the World Journal of Hepatology by Ismael et al highlighted the limited accessibility to screening and antiviral treatment for HBV infection in eastern Ethiopia.Therefore,the editorial comments on this article will focus on the current challenges and recent efforts in the prevention and treatment of chronic hepatitis B,particularly emphasizing the expansion of screening and antiviral therapy,as well as feasible strategies to improve accessibility for HBV testing,antiviral therapy,and adherence enhancement.

Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis

Intervertebral disc （IVD） degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal （NC） cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta （TGFβ）, decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease （DDD）. Knockout of TGFβ type II receptor （TβRII） or integrin αv in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading. Administration of RGD peptide, TGFβ, and αvβ6-neutralizing antibodies attenuated IVD degeneration. Thus, integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.

In-depth investigation on the factors affecting the performance of high oil-absorption resin by response surface method

A series of high oil-absorption resins with low cross-linking degree were synthesized by suspension polymerization using stearyl methacrylate(SMA),2-Ethylhexyl methacrylate(EHMA),and styrene(St)as monomers.Response surface methodology(RSM)with central composite design(CCD)was also applied to determine the optimal parameters that are mainly known to affect their synthesis.Thus,the effects of the monomer mass ratio(EHMA:SMA),the rigid monomer(St)dosage,the porous agent(acetone)dosage,and their pairwise interaction on the resin's oil-absorption capacity were analyzed,highlighting PSES-R_(2) as the resin with the optimum performance.The pure oil-absorption rates of PSES-R_(2) for gasoline,diesel,and kerosene were 11.19 g·g^(-1),16.25 g·g^(-1),and 14.84 g·g^(-1),respectively,while the oil removal rates from oily wastewater were 98.82%,65.11%,and 99.63%,respectively.

Amelanotic Malignant Melanoma Mimicking Hemangioma of the Hand: One Case Report and Literature Review

Introduction Malignant melanoma （MM） is one of the most deadly cancerst. Although the disease accounts for only about 4% of skin cancer related cases, it is responsible for about 79% of skin cancer deaths. Early diagnosis of MM is, therefore, essential for appropriate treatment decision and, in turn, may give patients the best chance for prolonged survival. About 6% to 8% of malignant melanomas lack typical pigmentation and tend to be managed as benign lesions, making accurate early diagnosis difficultt61. Though subungual MM is rare,

基于普通器件实现快1000倍的相机与机器视觉

在数码相机中,我们发现了一个重大缺陷,即从胶片相机继承的图像和视频模型阻碍了相机捕捉快速变化的光子世界。我们提出了一种新的视觉形式,称为视象(vform),这是一个比特序列阵列,其中每个比特表示光子的累积是否达到了一个阈值,从而可以记录和重建任何时刻场景的光强。仅使用消费级CMOS传感器和集成电路,开发了一种比传统相机快1000倍的脉冲相机。将视象看作生物视觉中的脉冲序列,进一步开发了基于脉冲神经网络的机器视觉系统,它可以将机器的速度和生物视觉的机理结合起来,从而实现了比人类视觉快1000倍的高速目标检测和跟踪,并通过辅助裁判和目标瞄准系统证明了脉冲相机和超级视觉系统的效用。视象模型和芯片有望从根本上改变图像和视频的概念以及摄影、电影和视觉媒体等相关行业,并开启一个全新的基于脉冲神经网络的速度自由的机器视觉时代。

Life cycle assessment of high concentration organic wastewater treatment by catalytic wet air oxidation

There have been many studies on life cycle assessment in sewage treatment,but there are scarce few studies on the treatment of industrial wastewater in combination with advanced oxidation technology,especially in catalytic wet air oxidation(CWAO).There are no cases of using actual industrialized data onto life cycle assessment.This paper uses Simapro 9.0 software to establish a life cycle assessment model for the treatment of high-concentration organic wastewater by CWAO,and comprehensively explains the impact on the environment from three aspects:the construction phase,the operation phase and the demolition phase.In addition,sensitivity analysis and uncertainty analysis were performed.The results showed that the key factors affecting the environment were marine ecotoxicity,mineral resource consumption and global warming,the operation stage had the greatest impact on the environment,which was related to high power consumption during operation and emissions from the treatment process.Sensitivity analysis showed that electricity consumption has the greatest impact on abiotic depletion and freshwater aquatic ecotoxicity,and it also proved that global warming is mainly caused by pollutant emissions during operation phase.Monte Carlo simulations found slightly higher uncertainty for abiotic depletion and toxicity-related impact categories.

具有同分异构体的磺化聚酰亚胺质子交换膜对全钒液流电池性能影响

由于具有同分异构结构的聚合物在性能方面具有明显的差异,文中以1,4,5,8-萘四甲酸酐(NTDA)为二酐单体,3,3’-二氨基二苯砜和4,4’-二氨基二苯砜提供同分异构结构单元,4,4'-二氨基-2,2'-二磺酸基-联苯水合物(BDSA)为磺化二胺单体,制备了2种具有不同空间构型的磺化聚酰亚胺(SPI),并将其作为质子交换膜(PEM)使用在全钒液流电池(VRFB)中。3,3’-二氨基二苯砜的螺旋结构可有效增强3-SPI化学结构的柔性,有助于分子链的缠结,使其具有优异的力学性能、尺寸稳定性和阻钒能力(8.08×10^(-8)cm^(2)/min)。4-SPI构型的离子电导率(47.21 mS/cm)与Nafion 212膜(49.37 mS/cm)相似,但离子选择性(4.25×10^(5)S·min/cm^(3))约是Nafion 212(1.08×10^(5)S·min/cm^(3))的4倍。在单电池测试中,4-SPI仍表现出良好的综合性能,在160 mA/cm^(2)电流密度下,能量效率(EE)达到77%。同时,4-SPI也表现出良好的稳定性,其EE在30次循环之后仍保持在84%以上。

右美托咪定滴鼻联合舒芬太尼在儿童肿瘤放射治疗中的应用研究

目的:比较右美托咪定滴鼻联合舒芬太尼和单独使用水合氯醛在儿童肿瘤放射治疗过程中的疗效。方法:选取2018年11月至2019年9月深圳市人民医院行肿瘤放疗的48例患儿作为研究对象,随机分组为接受右美托咪定滴鼻联合舒芬太尼组(DS组)和口服水合氯醛组(C组)。观察比较两组镇静起效时间、苏醒时间和放射治疗时间,以及镇静前后平均动脉血压(MAP)、心率(HR)和血氧饱和度(SpO2)的变化情况,并统计两组不良反应发生情况。结果:研究纳入48例患儿,其中DS组24例和C组23例纳入最终分析。与C组相比,DS组患儿恢复时间更短,MAP、HR和不良反应发生率更低。两组患儿用药起效时间、治疗时间的差异无统计学意义(P>0.05)。结论:右美托咪定滴鼻联合舒芬太尼能安全地应用于儿童肿瘤放射治疗并缩短恢复时间。

ALC1蛋白在食管鳞癌中的表达及其对细胞增殖侵袭迁移的影响

目的:探讨ALC1(amplified in liver cancer 1)在食管鳞癌组织中的表达及与临床病理特征及总生存率关系,检测过表达ALC1基因对食管癌细胞恶性生物学行为的影响。方法:采用免疫组织化学方法检测245例食管鳞癌组织及癌旁组织中ALC1蛋白的表达,并探讨其与食管鳞癌患者性别、年龄、分化程度、浸润深度、TNM分期、远处淋巴结转移关系及总生存率关系;采用MTT法、克隆形成实验、Transwell实验及细胞划痕实验等观察高表达ALC1基因在食管癌细胞中的增殖、侵袭及迁移作用。结果:ALC1蛋白在食管癌组织中的阳性表达率明显高于癌旁组织(41.6%vs.21.2%,P<0.05);ALC1的高表达与肿瘤的浸润深度、TNM分期和淋巴结转移明显相关(P<0.05)。ALC1高表达的食管鳞癌患者总生存率低。ALC1基因能够促进KYSE30食管癌细胞过度增殖、侵袭和迁移。结论:ALC1表达升高可能与食管鳞癌的发生、发展相关,导致总生存率下降,高表达的ALC1基因增强KYSE30食管癌细胞的增殖、侵袭及迁移能力,检测ALC1可能为食管癌预后判断提供依据。

Research Progress and Prospect of Well Integrity Technology

Well integrity technology can effectively ensure the safety of the entire life cycle of oil and gas wells. With the exploration and development of more and more high-temperature, high-pressure, high-yield and deep wells, and the constantly increasing requirements for safety and environmental protection in various countries, well integrity technology has become a research hot spot in the oil industry. Based on the analysis of the four basic concepts of well integrity: full life cycle, well integrity management system, well barrier, and risk assessment, this article conducts a comparative analysis of the development history of well integrity technologies at home and abroad, and systematically summarizes foreign wells. The current status of integrity technology, based on the above investigation and analysis, puts forward suggestions for the next development direction of well integrity technology, which has certain guiding significance for the development of the integrity of the next step.

应用嵌合基因实例拓展遗传学染色体畸变的教学

染色体结构变异,会扰乱机体的固有平衡系统,影响生殖和发育。在本科遗传学教学中,如何进一步诠释导致机体平衡系统紊乱的机理,是教师常面临的教学难题。一些嵌合基因(chimericgene)是染色体结构变异的产物,具有特异的生物功能,可能是致使固有平衡系统紊乱的原因之一,但很少见到在课堂或教科书中讲述与嵌合基因相关的内容。本文结合近年本团队对嵌合基因的研究成果及遗传学教学实践,以一个司法案例创设情境,引入嵌合基因实例,以激发学生的学习兴趣;进而通过对嵌合基因通性的梳理,辅助学生总结知识点,发展思维融汇力,从而拓展染色体畸变的教学,以期使学生对基因的变异及其功能有更深入的理解,提高遗传学教学效果。

短学时有机化学教材建设与应用实践

对短学时有机化学课程的核心内容,即典型有机物的主要化学性质,按照反应本质以及反应物与产物在结构上的关系进行了重新分类与整理;同时,以楔形式手性分子的R/S构型的判断技巧为例对课程常见难点进行了形象化阐释;此外,顺应国内重视化学品安全的大趋势,在课程教学过程中补充了典型有机物与有机反应的危险性、急救措施等相关知识。基于上述改革内容建设并出版了新教材《有机化学简明教程》,并将其用于北京石油化工学院5个专业、两届学生共计19个行政班的短学时有机化学课程学习中,学生反映良好,课程成绩呈逐年上升的趋势。

高层建筑基础底板大体积混凝土冬季施工技术研究与应用

针对大体积混凝土冬季施工的特点,通过分析研究材料和温度对大体积混凝土冬季施工的影响,设计和优化冬季施工方案,并结合实际工程案例研究北方民用建筑大体积混凝土冬季施工技术。结果表明,通过施工方案的优化和精心的施工组织管理,可以避免大体积混凝土冬季施工过程中裂缝的产生,确保地下结构冬季的施工质量。

MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression

AIM To explore the mechanism by which microRNA-155 (miR-155) regulates the pathogenesis of experimental colitis. METHODS A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3'-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established and then utilized in gain-and loss-of-function studies performed in raw264.7 cells and primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium (DSS)-induced colitis mouse model with or without antagomiR-155 treatment was established, and the levels of miR-155 and SHIP-1, as well as the pro-inflammatory capabilities, were measured by western blot, quantitative polymerase chain reaction, and immunohistochemistry. RESULTS MiR-155 directly bound to the 3'-UTR of SHIP-1 mRNA and induced a significant decrease in SHIP-1 expression in both raw264.7 cells and primary BMDMs. MiR-155 markedly promoted cell proliferation and proinflammatory secretions including IL-6, TNF-alpha, IL-1 beta, and IFN-gamma, whereas these effects could be reversed by the restoration of SHIP-1 expression. In vivo studies showed that antagomiR-155 administration could alleviate DSS-induced intestinal inflammation in Balb/c mice. Moreover, significantly increased SHIP-1 expression, as well as decreased Akt activation and in-flammatory response, were observed in the antagomiR-155-treated mice. CONCLUSION MiR-155 promotes experimental colitis by repressing SHIP-1 expression. Thus, the inhibition of miR-155 might be a promising strategy for therapy.