A novel responsive stabilizing Janus nanosilica as a nanoplugging agent in water-based drilling fluids for exploiting hostile shale environments

Thermo-responsive nanocomposites have recently emerged as potential nanoplugging agents for shale stabilization in high-temperature water-based drilling fluids(WBDFs). However, their inhibitory properties have not been very effective in high-temperature drilling operations. Thermo-responsive Janus nanocomposites are expected to strongly interact with clay particles from the inward hemisphere of nanomaterials, which drive the establishment of a tighter hydrophobic membrane over the shale surface at the outward hemisphere under geothermal conditions for shale stabilization. This work combines the synergistic benefits of thermo-responsive and zwitterionic nanomaterials to synchronously enhance the chemical inhibitions and plugging performances in shale under harsh conditions. A novel thermoresponsive Janus nanosilica(TRJS) exhibiting zwitterionic character was synthesized, characterized,and assessed as shale stabilizer for WBDFs at high temperatures. Compared to pristine nanosilica(Si NP)and symmetrical thermo-responsive nanosilica(TRS), TRJS exhibited anti-polyelectrolyte behaviour, in which electrolyte ions screened the electrostatic attraction between the charged particles, potentially stabilizing nanomaterial in hostile shaly environments(i.e., up to saturated brine or API brine). Macroscopically, TRJS exhibited higher chemical inhibition than Si NP and TRS in brine, prompting a better capability to control pressure penetration. TRJS adsorbed onto the clay surface via chemisorption and hydrogen bonding, and the interactions became substantial in brine, according to the results of electrophoretic mobility, surface wettability, and X-ray diffraction. Thus, contributing to the firm trapping of TRJS into the nanopore structure of the shale, triggering the formation of a tight hydrophobic membrane over the shale surface from the outward hemisphere. The addition of TRJS into WBDF had no deleterious effect on fluid properties after hot-treatment at 190℃, implying that TRJS could find potential use as a shale stabilizer in WBDFs in hostile environments.

帕金森病膀胱功能障碍治疗的研究进展

膀胱功能障碍是帕金森病自主神经功能障碍的常见症状,其主要表现为膀胱过度活动症,给患者的生活质量带来了极大的负面影响。目前对于帕金森病相关膀胱功能障碍的治疗主要包括行为治疗、药物治疗、神经调节治疗、手术治疗、中医药治疗等,本文对其相关治疗方法最新进展进行综述。

河道内源治理与水力冲挖综合技术的研究与应用

为研究河道内源污染治理方式,对河道防洪标准和水质产出目标进行分析,确定污染河道清淤范围和施工方法。分析了潮水水位和河道行洪能力,圈定了清淤范围和纵向清淤深度。分析内源污染污染物负荷和底泥物化性质,确定河道清淤厚度及泥浆处理要求。为实现河道环保清淤施工,采用水力冲挖排干清淤施工方法,实现目标污染物的有效去除,降低了河道清淤方量。通过控制多级泵送系统传输压力,实现了长距离、高陡坡泥浆传输。

Spatiotemporal Variability and Environmental Controls of Temperature Sensitivity of Ecosystem Respiration across the Tibetan Plateau

Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ecosystems.Here,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental factors.Moreover,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing seasons.The results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial patterns.NDVI was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global warming.Note that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing season.These findings are conducive to improving our understanding of alpine grassland ecosystem carbon-climate feedbacks under warming climates.

Absence of BCS–BEC crossover in FeSe_(0.45)Te_(0.55) superconductor

In iron-based superconductor Fe(Se,Te), a flat band-like feature near the Fermi level was observed around the Brillouin zone center in the superconducting state. It is under debate whether this is the evidence on the presence of the BCS–BEC[Bardeen–Cooper–Schrieffer(BCS), Bose–Einstein condensation(BEC)] crossover in the superconductor. High-resolution laser-based angle-resolved photoemission measurements are carried out on high quality single crystals of FeSe_(0.45)Te_(0.55) superconductor to address the issue. By employing different polarization geometries, we have resolved and isolated the dyz band and the topological surface band, making it possible to study their superconducting behaviors separately. The dyz band alone does not form a flat band-like feature in the superconducting state and the measured dispersion can be well described by the BCS picture. We find that the flat band-like feature is formed from the combination of the dyz band and the topological surface state band in the superconducting state. These results reveal the origin of the flat band-like feature and rule out the presence of BCS-BEC crossover in Fe(Se,Te) superconductor.

Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade Structure Tuning for Highly Stable Biomass Upgrading

Electrocatalytic 5-hydroxymethylfurfural oxidation reaction(HMFOR)provides a promising strategy to convert biomass derivative to highvalue-added chemicals.Herein,a cascade strategy is proposed to construct Pd-NiCo_(2)O_(4)electrocatalyst by Pd loading on Ni-doped Co3O4 and for highly active and stable synergistic HMF oxidation.An elevated current density of 800 mA cm^(-2)can be achieved at 1.5 V,and both Faradaic efficiency and yield of 2,5-furandicarboxylic acid remained close to 100%over 10 consecutive electrolysis.Experimental and theoretical results unveil that the introduction of Pd atoms can modulate the local electronic structure of Ni/Co,which not only balances the competitive adsorption of HMF and OH-species,but also promote the active Ni^(3+)species formation,inducing high indirect oxidation activity.We have also discovered that Ni incorporation facilitates the Co2+pre-oxidation and electrophilic OH*generation to contribute direct oxidation process.This work provides a new approach to design advanced electrocatalyst for biomass upgrading.

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to PD.Methods:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of PDF.HE and Masson staining were performed to evaluate the extent of PF.The therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function analyses.Epithelial-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%PDF.Cells were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Cell Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 cells.Results:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to BMSCs.The RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD mice.We found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD mice.Compared with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious fibroproliferative response,with markedly increased peritoneal thickness and higher expression ofα-SMA,collagen-I,fibronectin,and ECM1.The mice with PD showed decreased miR-27a-3p.Peritoneal structural and functional damage was significantly attenuated after BMSC-Exos treatment,while PF and mesothelial damage were significantly ameliorated.Additionally,markers of fibrosis(α-SMA,collagen-I,fibronectin,ECM1)and profibrotic cytokines(TGF-β1,PDGF)were downregulated at the mRNA and protein levels after BMSC-Exos treatment.In HMrSV5 cells,BMSC-Exos reversed the decrease in cell viability and the increase in cell migratory capacity caused by high-glucose PDF.Western blotting and RT-qPCR analysis revealed that BMSC-Exos treatment resulted in increased expression of E-cadherin(epithelial marker)and decreased expression ofα-SMA,Snail,and vimentin(mesenchymal markers)compared to those of the 4.25%PDF-treated cells.Importantly,a dual-luciferase reporter assay showed that TP53 was a target gene of miR-27a-3p.TP53 overexpression significantly reversed the decreases in PF and EMT progression induced by BMSC-Exos.Conclusion:The present results demonstrate that BMSC-Exos showed an obvious protective effect on PD-related PF and suggest that BMSC-derived exosomal miR-27a-3p may exert its inhibitory effect on PF and EMT progression by targeting TP53.

Negligible normal fluid in superconducting state of heavily overdoped Bi_(2)Sr_(2)CaCu_(2)O_(8+δ) detected by ultra-low temperature angle-resolved photoemission spectroscopy

In high temperature cuprate superconductors,it was found that the superfluid density decreases with the increase of hole doping.One natural question is whether there exists normal fluid in the superconducting state in the overdoped region.In this paper,we have carried out high-resolution ultra-low temperature laser-based angle-resolved photoemission measurements on a heavily overdoped Bi2212 sample with a T_(c) of 48 K.We find that this heavily overdoped Bi2212 remains in the strong coupling regime with 2Δ_(0)/(k_(B)T_(c))=5.8.The single-particle scattering rate is very small along the nodal direction(~5 meV) and increases as the momentum moves from the nodal to the antinodal regions.A hard superconducting gap opening is observed near the antinodal region with the spectral weight at the Fermi level fully suppressed to zero.The normal fluid is found to be negligibly small in the superconducting state of this heavily overdoped Bi2212.These results provide key information to understand the high T_(c) mechanism in the cuprate superconductors.

BPSK-QPSK和QPSK-16QAM的光调制格式转换

信号在调制方式不同的系统之间传输时,需要对信号调制格式进行转换,而调制格式转换通常在电信号上进行,要将光信号恢复成电信号。在电信号上进行调制格式转换后,再经电光调制器变换成光信号发射。频繁的光电或电光转换通常会增加系统成本,针对该问题,提出了利用相干叠加在光域上实现二进制相移键控(BPSK)到正交相移键控(QPSK)以及QPSK到正交幅度调制(16QAM)的调制格式转换的方法。实验通过Optisystem软件对转换模型进行仿真,采用10 Gpbs伪随机信号作为测试信源,通过星座图观测出信号成功转换为QPSK和16QAM;并在不同光信噪比、光源线宽和信号功率下对转换模型与直接QPSK、16QAM传输模型进行误码分析对比,在相同条件下转换模型和直接传输的误码率高度保持一致,表明这种调制格式转换方法具有较高的稳定性和准确性,能够适用于不同系统间的信号传输。

脂蛋白相关磷脂酶A2和高敏C反应蛋白联合检测对冠状动脉粥样硬化性心脏病的诊断价值

目的探讨脂蛋白相关磷脂酶A2(Lp-PLA2)和高敏C反应蛋白(hs-CRP)联合检测对冠状动脉粥样硬化性心脏病(简称“冠心病”)的诊断价值。方法选择2022年4月至2023年4月就诊于东莞市中西医结合医院的52例冠心病患者设为病例组(病变程度:轻度16例,中度20例,重度16例),52例健康体检者设为参考组。采集所有受检者3 ml外周血液,检测hs-CRP、Lp-PLA2。比较两组hs-CRP、Lp-PLA2检测值差异,并分析hs-CRP、Lp-PLA2单一与联合检测诊断冠心病的价值。结果病例组的hs-CRP、Lp-PLA2检测值高于参考组,差异有统计学意义(P<0.05);重度组患者的hs-CRP、Lp-PLA2检测值高于中度组和轻度组,且中度组的hs-CRP、Lp-PLA2检测值高于轻度组,差异有统计学意义(P<0.05)。hs-CRP、Lp-PLA2联合检测诊断冠心病的曲线下面积(AUC)为0.880(95%CI:0.815~0.944),灵敏度为0.904,特异度为0.732,约登指数为0.636,均高于单一检测。结论hs-CRP、Lp-PLA2均是诊断冠心病的有效指标,两者联合检测可提高诊断准确性,为临床治疗提供参考依据。

基于IGWO-BP-PID的管廊吊具液压缸同步控制研究

综合管廊吊装吨位重且存在偏载起吊的不利工况,易发生危险事故。为保证管廊节段偏载吊装工况下的安全稳定性,提高吊具液压缸组的同步控制精度,提出IGWO-BP-PID与状态差值反馈同步控制策略。通过分析专用吊具结构及液压原理,将液压缸按纵向分为2组。通过在GWO中对灰狼位置进行更新,实现IGWO对BP-PID参数的优化。采用3种控制器进行系统控制分析,验证IGWO-BP-PID的控制效果。最后,采用IGWO-BP-PID与状态差值反馈相结合的同步控制策略,对吊具液压缸组进行AMESim/Simulink联合仿真,并与试验数据进行对比分析。研究结果表明:IGWO-BP-PID控制器无超调量、具有更好的控制效果;相比于常规PID控制,该方法缩短了液压缸组震荡调节时间,同步控制精度更高;试验验证了管廊吊具同步控制策略的有效性,满足工程施工要求。

生化检验指标对肝病患者的诊断价值评价

目的探讨生化检验指标对肝病患者的诊断价值。方法选取100例肝病患者设为研究组,另选取100例健康体检的健康志愿者设为对照组。采集两组受检者清晨空腹状态下外周静脉血液,离心处理后取血清检测生化检验指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、总胆汁酸(TBA)、总胆红素(TBIL)]。对比研究组与对照组的生化检验指标;对比病毒性肝炎与肝硬化患者的生化检验指标。以肝硬化患者作为阳性病例,以病毒性肝炎患者作为阴性病例,对比生化检验指标单一检测与联合检测对不同类型肝病的鉴别诊断效能。结果研究组血清AST(46.97±8.05)U/L、ALT(47.15±9.28)U/L、ALP(128.14±15.24)U/L、TBA(12.87±3.12)μmol/L、TBIL(20.90±4.19)μmol/L均高于的(24.53±4.68)U/L、(26.10±4.91)U/L、(84.37±10.46)U/L、(5.46±1.70)μmol/L、(12.81±3.37)μmol/L(P<0.05)。肝硬化患者血清AST(50.62±4.73)U/L、ALT(51.89±5.64)U/L、ALP(141.48±8.35)U/L、TBA(14.68±2.29)μmol/L、TBIL(24.07±3.82)μmol/L均高于病毒性肝炎患者的(45.33±4.29)U/L、(45.02±5.13)U/L、(122.15±7.67)U/L、(12.06±1.85)μmol/L、(19.48±3.04)μmol/L(P<0.05)。生化检验指标联合检测的灵敏度、特异度、准确率、阳性预测值、阴性预测值均比AST、ALT、ALP、TBA、TBIL单一检测更高(P<0.05);生化检验指标AST、ALT、ALP、TBA、TBIL单一检测的灵敏度、特异度、准确率、阳性预测值、阴性预测值对比,差异均无统计学意义(P>0.05)。结论肝病患者的生化检验指标水平均出现异常升高,其可准确检出肝病,并对不同类型的肝病进行准确的鉴别诊断,具有良好的诊断价值。

The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years

Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin （OCN） in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen （CTX） and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant （NGT） women at baseline were invited for follow-up. The incidence of diabetes and prediabetes （collectively defined as dysglycemia） was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3% （95% confidence interval （CI）, 6.8%-30.70/0）] compared with the lower [31.0% （95% CI, 17.2%-46.1%）] and upper [46.5% （95% CI, 31.2%-62.6%）] tertiles of CTX, with a significant difference seen between the middle and upper tertiles （P = 0.002 5）. After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09 （95% CI, 1.73-28.99） when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia.

On the source of the quasi-Carrington Rotation periodic magnetic variations on the Martian surface: InSight observations and modeling

In a recent paper(Luo H et al.,2022),we found that the peak amplitudes of diurnal magnetic variations,measured during martian days(sols)at the InSight landing site,exhibited quasi Carrington-Rotation(qCR)periods at higher eigenmodes of the natural orthogonal components(NOC);these results were based on~664 sols of magnetic field measurements.However,the source of these periodic variations is still unknown.In this paper we introduce the neutral-wind driven ionospheric dynamo current model(e.g.,Lillis et al.,2019)to investigate the source.Four candidates-the draped IMF,electron density/plasma density,the neutral densities,and the electron temperature in the ionosphere with artificial qCR periodicity,are applied in the modeling to find the main factor likely to be causing the observed surface magnetic field variations that exhibit the same qCR periods.Results show that the electron density/plasma density,which controls the total conductivity in the dynamo region,appears to account for the greatest part of the surface qCR variations;its contribution reaches about 67.6%.The draped IMF,the neutral densities,and the electron temperature account,respectively,for only about 12.9%,10.3%,and 9.2%of the variations.Our study implies that the qCR magnetic variations on the Martian surface are due primarily to variations of the dynamo currents caused by the electron density variations.We suggest also that the timevarying fields with the qCR period could be used to probe the Martian interior's electrical conductivity structure to a depth of at least 700 km.

Research on Vector Road Data Matching Method Based on Deep Learning

Most of the existing vector data matching methods use traditional feature geometry attribute features to match, however, many of the similarity indicators are not suitable for cross-scale data, resulting in less accuracy in identifying objects. In order to solve this problem effectively, a deep learning model for vector road data matching is proposed based on siamese neural network and VGG16 convolutional neural network, and matching experiments are carried out. Experimental results show that the proposed vector road data matching model can achieve an accuracy of more than 90% under certain data support and threshold conditions.

Multidisciplinary management of hepatobiliary tumors in the era of precision medicine

Hepatobiliary tumor (HBT), one of the leading causes of cancer deaths globally, is more frequent in East Asia including China [1].HBTincludeslivercancer,cholangiocarcinomaandgallbladder cancer.HBTburdenvariesmarkedlybygenderandgeographic regionduetotheexposureofriskfactors.MajorityofthehepatocellularcarcinomasareassociatedwithhepatitisB-typevirus

Evidence for bosonic mode coupling in electron dynamics of LiFeAs superconductor

Super-high resolution laser-based angle-resolved photoemission measurements are carried out on LiFeAs superconductor to investigate its electron dynamics. Three energy scales at ~ 20 meV, ~ 34 meV, and ~ 55 meV are revealed for the first time in the electron self-energy both in the superconducting state and normal state. The ~ 20 meV and ~ 34 meV scales can be attributed to the coupling of electrons with sharp bosonic modes which are most likely phonons. These observations provide definitive evidence on the existence of mode coupling in iron-based superconductors.

Genetic analysis and QTL mapping of growth period traits and plant height traits in soybean recombinant inbred lines from Dongnong 47 × PI 317334-B

High and stable yield is the main goal of soybean genetic improvement.In this study,association analysis was used to detect the quantitative trait loci(QTL)for the plant height,and soybean growth period using 182 SSR markers in the RIL population of 136 F_(4:8) lines,which developed from a cross between photoperiod-insensitive cultivar‘Dongnong 47’and photoperiod-sensitive variety PI317334–B.The results showed that 33 QTLs related to soybean growth period and plant height traits were detected by compound interval mapping,and were located on 12 linkage groups including N,C1,C2,J,D1a,B2,E,G,A2,O,L,I,with the contribution rate of 7.85–33.84%.These QTL loci and linkage markers related to soybean photoperiod sensitivity,would be helpful to identify key genes that control soybean photoperiod sensitivity,and provide an important basis for the breeding of new photoperiod-insensitive soybean varieties based on molecular design breeding.

BRMS1 performs an anti-tumor effect on renal cell carcinoma via inhibition of PI3K/AKT/mTOR signaling pathway

Objective:To explore the anti-tumor of breast cancer metastasis suppressor 1(BRMS1)on renal cell carcinoma.Methods:BRSM1 stabilized overexpressed and knockdown cell models were constructed to detect the effect of BRMS1 overexpression and knockdown on viability rate of 769-P cells.Activation of PI3K/AKT-mTOR-NFκB signaling pathway,expression of cellular apoptosis-related proteins,DNA damage repair-related proteins and angiogenesis-related proteins were detected using Western blotting analysis.Results:The viability rate of 769-P cells were significantly decreased in BRMS1 overexpression cells while significantly increased in BRMS1 knockdown cells(P<0.05).The activity of PI3K/AKT-mTOR-NFκB signaling pathway was significantly inhibited with BRMS1 overexpression(P<0.05),and expression of BAX was significantly increased with significantly decreased expression of Bcl-2(P<0.05).Besides,BRMS1 overexpression could significantly decrease the expression of DNA damage repair-related proteins and angiogenesis and cell-matrix degradation related proteins(P<0.05).Conclusion:BRMS1 induces apoptosis of renal cell carcinoma and performs an anti-tumor effect via inhibition of PI3K/AKT-mTOR-NFκB signaling pathway,expression of DNA damage repair-related proteins and angiogenesis-related proteins.

中国脑卒中环境危险因素的系统评价

目的 中国脑卒中患者人数呈上升趋势,而环境危险因素对该疾病发展的影响缺乏综合性概述。本研究旨在探讨影响脑卒中的环境危险因素,为决策者制定卫生政策和干预措施提供依据。方法 检索中国知网、万方、维普、PubMed、Web of Science、Scopus数据库有关中国脑卒中环境危险因素的文献,检索时限为2012年1月至2022年5月。对环境危险因素的种类、频次进行描述性分析,对脑卒中与环境因素之间的关系进行叙述性分析。结果 初检共获取文献12 774篇,最终纳入文献215篇,涉及8类43种环境因素。研究最多的因素是气象因素(52.56%),其次是空气污染(47.44%);最常报告的指标分别是气温(40.47%)和PM_(2.5)(28.37%)。气象因素中,涉及气温的大部分研究提示其是脑卒中发生的影响因素,并发现脑卒中及其亚型存在季节性,近一半的研究发现较高的气压与较高的脑卒中及其亚型发生风险相关。对于空气污染,研究发现较高水平的PM_(2.5)、PM_(10)、CO、NO_(2)、O_(3)、SO_(2)与较高的脑卒中发生风险相关。此外,燃料暴露、被动吸烟也与脑卒中风险增加相关。结论 环境因素对中国人群脑卒中发生风险具有一定程度的影响,需进一步的研究评估这些关联,阐明涉及的具体机制,并探索更多的环境因素对脑卒中的潜在影响。