Sand production is a critical issue during the development of offshore oil and gas fields.Certain gas fields(e.g.the AB gas field)have high porosity and high permeability,and with water at the bottom of the reservoir,...Sand production is a critical issue during the development of offshore oil and gas fields.Certain gas fields(e.g.the AB gas field)have high porosity and high permeability,and with water at the bottom of the reservoir,the risk of sand production greatly increases at high differential pressures.Based on reservoir properties,geological conditions,production requirements,and well logging data,in this study an ultrasonic time difference method,a B index method,and a S index method are used together with a model of rock mass failure(accounting for water influx and pressure depletion)to qualitatively predict sand production.The results show that considered sample gas field has an overall high risk of sand production.The critical differential pressure(CDP)without water influx is in the range of 1.40 to 2.35 MPa,the CDP after water influx is from 0.60 to 1.41MPa.The CDP under pressure depletion is in the range of 1.20 to 1.92 MPa.The differential pressure charts of sand production are plotted,and the safe differential pressure windows with or without water influx are obtained.The model calculation results and the experimental results are consistent with the field production data,which indicates that the implemented prediction method could be taken as a reference for sand production prediction in similar deep water gas fields.展开更多
AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The bio...AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P＜0.05). The rate of H pylori colonization of chronic gastritis in ＜30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and ＞70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in ＜30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and ＞70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with gastric ulcer. In the other age- groups,the rate of H pylori colonization was highest in corpus,lower in antrum and lowest in angulus (all P＜0.05). The rates of glandular atrophy and intestinal metaplasia were higher and earlier in H pylori-positive patients than those without H pylori infection (both P＜0.01). In comparison of gastric ulcer patients with chronic gastritis patients,the rate of glandular atrophy and intestinal metaplasia was higher in H pylori-positive patients with gastric ulcer than in H pylori-positive patients with chronic gastritis(both P＜0.01); the rate of glandular atrophy and intestinal metaplasia were also higher in H pylori-negative patients with gastric ulcer than in H pylori-negative patients with chronic gastritis (both P＜0.01). Both glandular atrophy and intestinal metaplasia were much more commonly identified in the angulus than in the antrum, lowest in corpus (all P＜0.01).CONCLUSION: Rate of H pylori infection, glandular atrophy and intestinal metaplasia in gastric ulcer were higher than in chronic gastritis in all-different age -groups. Distribution of H pylori colonization is pangastric in the younger patients. It is highest in corpus, lower in antrum and lowest in angulus in the older age groups. Progression of glandular atrophy and intestinal metaplasia seem to have a key role in the distribution of H pylori colonization. H pylori appears to be the most important risk factor for the development of glandular atrophy and intestinal metaplasia, but it is not the only risk.展开更多
Lactobacillus delbrueckii and Bacillus subtilis were employed as a new combination of strains to treat rapeseed meal by solid-state fermentation,aiming to efficiently degrade the glucosinolates,which are the main toxi...Lactobacillus delbrueckii and Bacillus subtilis were employed as a new combination of strains to treat rapeseed meal by solid-state fermentation,aiming to efficiently degrade the glucosinolates,which are the main toxin in the meal.Single-factor tests and Response surface methodology(RSM)were used to optimize the fermentation parameters.Under the optimum fermentation parameters of 15%total injection volume of the mixture of Lactobacillus delbrueckii and Bacillus subtilis with a ratio of 2:1,bran content of16%,feed to water ratio of 1:1.5,fermentation temperature of 36°C and fermentation time of 72 h,the content of glucosinolates in rapeseed meal was decreased from 64.558μmol/g to 3.473μmol/g,reaching a high degradation rate(94.62%).The high detoxification rate by a consortium of Lactobacillus delbrueckii and Bacillus subtilis provides a bright application prospect in feed utilization of rapeseed meal.展开更多
Major duodenal papilla cancer(MDPC) represents the primary type of duodenal cancer, and is typically considered a periampullary carcinoma as most tumors arise in this region. This report describes an extremely rare ca...Major duodenal papilla cancer(MDPC) represents the primary type of duodenal cancer, and is typically considered a periampullary carcinoma as most tumors arise in this region. This report describes an extremely rare case involving a patient with rapidly and extensively recurrent MDPC following pancreaticoduodenectomy, who achieved complete response by concurrent image-guided radiation and intravenous oxaliplatin plus oral capecitabine therapies. The patient was a 50-year-old female who was admitted to our hospital 6 wk after resection for MDPC for evaluation of a nontender and enlarged node in the left side of her neck. After clinical work-up, the patient was diagnosed with postoperatively recurrent MDPC with widespread lymph node metastases at the bilateral cervix, mediastinum, abdominal cavity, and retroperitoneal area. She was administered whole field image-guided radiation therapy along with four cycles of the intravenous oxaliplatin plus oral capecitabine regimen. A complete response by positron emission tomography with 18-fluorodeoxyglucose was observed 4 months after treatment. The patient continues to be disease-free 2 years after the diagnosis of recurrence.展开更多
The modulation of the intensity of nascent Tibetan Plateau vortices(ITPV) by atmospheric quasi-biweekly oscillation(QBWO) is investigated based on final operational global analysis data from the National Centers for E...The modulation of the intensity of nascent Tibetan Plateau vortices(ITPV) by atmospheric quasi-biweekly oscillation(QBWO) is investigated based on final operational global analysis data from the National Centers for Environmental Prediction. The spatial and temporal distributions of the ITPV show distinct features of 10–20-day QBWO. The average ITPV is much higher in the positive phases than in the negative phases, and the number of strong TPVs is much larger in the former,with a peak that appears in phase 3. In addition, the maximum centers of the ITPV stretch eastward in the positive phases,indicating periodic variations in the locations where strong TPVs are generated. The large-scale circulations and related thermodynamic fields are discussed to investigate the mechanism by which the 10–20-day QBWO modulates the ITPV. The atmospheric circulations and heating fields of the 10–20-day QBWO have a major impact on the ITPV. In the positive QBWO phases, the anomalous convergence at 500 hPa and divergence at 200 hPa are conducive to ascending motion. In addition, the convergence centers of the water vapor and the atmospheric unstable stratification are found in the positive QBWO phases and move eastward. Correspondingly, condensational latent heat is released and shifts eastward with the heating centers located at 400 hPa, which favors a higher ITPV by depressing the isobaric surface at 500 hPa. All of the dynamic and thermodynamic conditions in the positive QBWO phases are conducive to the generation of stronger TPVs and their eastward expansion.展开更多
基金This research is financially supported by the National Natural Science Foundation of China(Grant No.52174015)supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT_14R58).
文摘Sand production is a critical issue during the development of offshore oil and gas fields.Certain gas fields(e.g.the AB gas field)have high porosity and high permeability,and with water at the bottom of the reservoir,the risk of sand production greatly increases at high differential pressures.Based on reservoir properties,geological conditions,production requirements,and well logging data,in this study an ultrasonic time difference method,a B index method,and a S index method are used together with a model of rock mass failure(accounting for water influx and pressure depletion)to qualitatively predict sand production.The results show that considered sample gas field has an overall high risk of sand production.The critical differential pressure(CDP)without water influx is in the range of 1.40 to 2.35 MPa,the CDP after water influx is from 0.60 to 1.41MPa.The CDP under pressure depletion is in the range of 1.20 to 1.92 MPa.The differential pressure charts of sand production are plotted,and the safe differential pressure windows with or without water influx are obtained.The model calculation results and the experimental results are consistent with the field production data,which indicates that the implemented prediction method could be taken as a reference for sand production prediction in similar deep water gas fields.
文摘AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P＜0.05). The rate of H pylori colonization of chronic gastritis in ＜30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and ＞70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in ＜30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and ＞70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with gastric ulcer. In the other age- groups,the rate of H pylori colonization was highest in corpus,lower in antrum and lowest in angulus (all P＜0.05). The rates of glandular atrophy and intestinal metaplasia were higher and earlier in H pylori-positive patients than those without H pylori infection (both P＜0.01). In comparison of gastric ulcer patients with chronic gastritis patients,the rate of glandular atrophy and intestinal metaplasia was higher in H pylori-positive patients with gastric ulcer than in H pylori-positive patients with chronic gastritis(both P＜0.01); the rate of glandular atrophy and intestinal metaplasia were also higher in H pylori-negative patients with gastric ulcer than in H pylori-negative patients with chronic gastritis (both P＜0.01). Both glandular atrophy and intestinal metaplasia were much more commonly identified in the angulus than in the antrum, lowest in corpus (all P＜0.01).CONCLUSION: Rate of H pylori infection, glandular atrophy and intestinal metaplasia in gastric ulcer were higher than in chronic gastritis in all-different age -groups. Distribution of H pylori colonization is pangastric in the younger patients. It is highest in corpus, lower in antrum and lowest in angulus in the older age groups. Progression of glandular atrophy and intestinal metaplasia seem to have a key role in the distribution of H pylori colonization. H pylori appears to be the most important risk factor for the development of glandular atrophy and intestinal metaplasia, but it is not the only risk.
基金financially supported by the Education Department of Sichuan Province(18ZB0289)。
文摘Lactobacillus delbrueckii and Bacillus subtilis were employed as a new combination of strains to treat rapeseed meal by solid-state fermentation,aiming to efficiently degrade the glucosinolates,which are the main toxin in the meal.Single-factor tests and Response surface methodology(RSM)were used to optimize the fermentation parameters.Under the optimum fermentation parameters of 15%total injection volume of the mixture of Lactobacillus delbrueckii and Bacillus subtilis with a ratio of 2:1,bran content of16%,feed to water ratio of 1:1.5,fermentation temperature of 36°C and fermentation time of 72 h,the content of glucosinolates in rapeseed meal was decreased from 64.558μmol/g to 3.473μmol/g,reaching a high degradation rate(94.62%).The high detoxification rate by a consortium of Lactobacillus delbrueckii and Bacillus subtilis provides a bright application prospect in feed utilization of rapeseed meal.
基金Supported by Sichuan Cancer Hospital and InstituteChengdu+1 种基金Sichuan ProvinceChina
文摘Major duodenal papilla cancer(MDPC) represents the primary type of duodenal cancer, and is typically considered a periampullary carcinoma as most tumors arise in this region. This report describes an extremely rare case involving a patient with rapidly and extensively recurrent MDPC following pancreaticoduodenectomy, who achieved complete response by concurrent image-guided radiation and intravenous oxaliplatin plus oral capecitabine therapies. The patient was a 50-year-old female who was admitted to our hospital 6 wk after resection for MDPC for evaluation of a nontender and enlarged node in the left side of her neck. After clinical work-up, the patient was diagnosed with postoperatively recurrent MDPC with widespread lymph node metastases at the bilateral cervix, mediastinum, abdominal cavity, and retroperitoneal area. She was administered whole field image-guided radiation therapy along with four cycles of the intravenous oxaliplatin plus oral capecitabine regimen. A complete response by positron emission tomography with 18-fluorodeoxyglucose was observed 4 months after treatment. The patient continues to be disease-free 2 years after the diagnosis of recurrence.
基金supported by the National Key Research and Development Program (Grant Nos. 2016YFA0601504 and 2016YFA0600602)the National Natural Science Foundation of China (Grant No. 41775059)+2 种基金the China National 973 Project (Grant No. 2015CB453203)the Basic Scientific Research and Operation Foundation of CAMS (Grant Nos. 2016Y001 and 2018Z006)the Science and Technology Development Fund of CAMS (Grant No. 2018KJ029)
文摘The modulation of the intensity of nascent Tibetan Plateau vortices(ITPV) by atmospheric quasi-biweekly oscillation(QBWO) is investigated based on final operational global analysis data from the National Centers for Environmental Prediction. The spatial and temporal distributions of the ITPV show distinct features of 10–20-day QBWO. The average ITPV is much higher in the positive phases than in the negative phases, and the number of strong TPVs is much larger in the former,with a peak that appears in phase 3. In addition, the maximum centers of the ITPV stretch eastward in the positive phases,indicating periodic variations in the locations where strong TPVs are generated. The large-scale circulations and related thermodynamic fields are discussed to investigate the mechanism by which the 10–20-day QBWO modulates the ITPV. The atmospheric circulations and heating fields of the 10–20-day QBWO have a major impact on the ITPV. In the positive QBWO phases, the anomalous convergence at 500 hPa and divergence at 200 hPa are conducive to ascending motion. In addition, the convergence centers of the water vapor and the atmospheric unstable stratification are found in the positive QBWO phases and move eastward. Correspondingly, condensational latent heat is released and shifts eastward with the heating centers located at 400 hPa, which favors a higher ITPV by depressing the isobaric surface at 500 hPa. All of the dynamic and thermodynamic conditions in the positive QBWO phases are conducive to the generation of stronger TPVs and their eastward expansion.
