Alternative triglyceride(TG)synthesis pathways have yet to be identified in mammalian cells.In a recent article published in Nature,Brummelkamp and colleagues reported that the acyltransferase transmembrane protein 68...Alternative triglyceride(TG)synthesis pathways have yet to be identified in mammalian cells.In a recent article published in Nature,Brummelkamp and colleagues reported that the acyltransferase transmembrane protein 68(TMEM68)/DIESL synthesizes TG in the absence of the canonical enzymes dia-cylglycerol acyltransferase 1(DGAT1)and DGAT2.展开更多
Processes that regulate energy expenditure have been the subject of intense study in recent years,both for their physiological importance and for their potential to be targeted for the treatment of metabolic diseases....Processes that regulate energy expenditure have been the subject of intense study in recent years,both for their physiological importance and for their potential to be targeted for the treatment of metabolic diseases.De novo cholesterol synthesis from acetyl-CoA involves many steps and is an energetically costly pathway.展开更多
文摘Alternative triglyceride(TG)synthesis pathways have yet to be identified in mammalian cells.In a recent article published in Nature,Brummelkamp and colleagues reported that the acyltransferase transmembrane protein 68(TMEM68)/DIESL synthesizes TG in the absence of the canonical enzymes dia-cylglycerol acyltransferase 1(DGAT1)and DGAT2.
文摘Processes that regulate energy expenditure have been the subject of intense study in recent years,both for their physiological importance and for their potential to be targeted for the treatment of metabolic diseases.De novo cholesterol synthesis from acetyl-CoA involves many steps and is an energetically costly pathway.
