Background:Clear-cell renal cell carcinoma(ccRCC)is the most common malignant kidney cancer.However,the tumor microenvironment and crosstalk involved in metabolic reprogramming in ccRCC are not well-understood.Methods...Background:Clear-cell renal cell carcinoma(ccRCC)is the most common malignant kidney cancer.However,the tumor microenvironment and crosstalk involved in metabolic reprogramming in ccRCC are not well-understood.Methods:We used The Cancer Genome Atlas to obtain ccRCC transcriptome data and clinical information.The EMTAB-1980 cohort was used for external validation.The GENECARDS database contains the first 100 solute carrier(SLC)-related genes.The predictive value of SLC-related genes for ccRCC prognosis and treatment was assessed using univariate Cox regression analysis.An SLC-related predictive signature was developed through Lasso regression analysis and used to determine the risk profiles of patients with ccRCC.Patients in each cohort were separated into high-and low-risk groups based on their risk scores.The clinical importance of the signature was assessed through survival,immune microenvironment,drug sensitivity,and nomogram analyses using R software.Results:SLC25A23,SLC25A42,SLC5A1,SLC3A1,SLC25A37,SLC5A6,SLCO5A1,and SCP2 comprised the signatures of the eight SLCrelated genes.Patients with ccRCC were separated into high-and low-risk groups based on the risk value in the training and validation cohorts;the high-risk group had a significantly worse prognosis(p<0.001).The risk score was an independent predictive indicator of ccRCC in the two cohorts according to univariate and multivariate Cox regression(p<0.05).Analysis of the immune microenvironment showed that immune cell infiltration and immune checkpoint gene expression differed between the two groups(p<0.05).Drug sensitivity analysis showed that compared to the low-risk group,the high-risk group was more sensitive to sunitinib,nilotinib,JNK-inhibitor-VIII,dasatinib,bosutinib,and bortezomib(p<0.001).Survival analysis and receiver operating characteristic curves were validated using the E-MTAB-1980 cohort.Conclusions:SLC-related genes have predictive relevance in ccRCC and play roles in the immunological milieu.Our results provide insight into metabolic reprogramming in ccRCC and identify promising treatment targets for ccRCC.展开更多
Under the tide of"Internet+education",the new means of information technology education is constantly used in education and teaching,and the traditional teaching models and teaching methods urgently need to ...Under the tide of"Internet+education",the new means of information technology education is constantly used in education and teaching,and the traditional teaching models and teaching methods urgently need to be changed.There is no doubt about the integration of online teaching and offline teaching.On the basis of reviewing the research on the mixed teaching model at home and abroad,this paper puts forward the idea of constructing the mixed teaching model in colleges and universities in the context of"Internet+",and sets up the mixed teaching model in colleges and universities in the context of"Internet+".Through the detailed and concrete design of the operation process of the mixed teaching model,we can break the single shackles of online teaching and face-to-face teaching,and form an interactive and collaborative teaching ecosystem to realize the common development of online teaching and offline teaching.展开更多
With transformation of Chinese sports talents cultivation mode, sports team construction at high level in universities has made great achievements. Especially establishing reserves in key universities is the key step ...With transformation of Chinese sports talents cultivation mode, sports team construction at high level in universities has made great achievements. Especially establishing reserves in key universities is the key step of new mode, which is the primary mode of sports team at high level in ordinary universities. To research the situation of key sports team construction at high level, from the degree of competitive sports sustainable development, we research and analyze the cultivation mode of Chinese sports talents and influence factors, aiming at building a talents cultivation mode suitable for Chinese professional competitive sports development and exploring the sustainable way for athletes sports in theory.展开更多
Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains unclear.In this nati...Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains unclear.In this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May 2022.We included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular disease.Multivariable Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for HF.Newly diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for HF.No significant difference in the risk of CHD was observed.We found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting models.These findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.展开更多
Ethylene-propylene block copolymer(EbP) is a vital component in impact polypropylene copolymer(IPC), yet its distribution in the multiphase composite material and how it influences the phase structure and the mechanic...Ethylene-propylene block copolymer(EbP) is a vital component in impact polypropylene copolymer(IPC), yet its distribution in the multiphase composite material and how it influences the phase structure and the mechanical properties are not well understood. In this work,four IPCs were investigated by atomic force microscopy-infrared(AFM-IR) to assess the phase compositions in situ, based on which in conjunction with the chain microstructure information obtained ex situ the distributions of the copolymer components were derived for each alloy. For the IPCs whose EbP comprises long P and long E segments, the EbP fraction was found to phase separate from the rubber and the PP matrix to form the cores of the disperse particles with the E-P segmented copolymer(EsP). In contrast, in the IPC with EbP composed of long P and short E segments, the EbP fraction formed an outer shell for the rubber particles with the cores comprising the EsP alone, and this IPC, containing a lower E comonomer content than its counterpart, exhibited both better impact resistance and higher flexural modulus. These results clarify how the chain structure of EbP governs the phase morphology in IPC, which in turn impacts the properties of the composite material.展开更多
Low-resource text plagiarism detection faces a significant challenge due to the limited availability of labeled data for training.This task requires the development of sophisticated algorithms capable of identifying s...Low-resource text plagiarism detection faces a significant challenge due to the limited availability of labeled data for training.This task requires the development of sophisticated algorithms capable of identifying similarities and differences in texts,particularly in the realm of semantic rewriting and translation-based plagiarism detection.In this paper,we present an enhanced attentive Siamese Long Short-Term Memory(LSTM)network designed for Tibetan-Chinese plagiarism detection.Our approach begins with the introduction of translation-based data augmentation,aimed at expanding the bilingual training dataset.Subsequently,we propose a pre-detection method leveraging abstract document vectors to enhance detection efficiency.Finally,we introduce an improved attentive Siamese LSTM network tailored for Tibetan-Chinese plagiarism detection.We conduct comprehensive experiments to showcase the effectiveness of our proposed plagiarism detection framework.展开更多
How to fabricate high-quality microcavities simply and at low cost without causing damage to environmentally sensitive active layers such as perovskites are crucial for the studies of exciton–polaritons,however,it re...How to fabricate high-quality microcavities simply and at low cost without causing damage to environmentally sensitive active layers such as perovskites are crucial for the studies of exciton–polaritons,however,it remains challenging in the field of microcavity fabrication.Usually,once the top mirror is deposited,the detuning of the microcavity is fixed and there is no easy way to tune it.Here,we have developed a method for deterministically transferring silver mirrors,which is relatively simple and guarantees the active layer from damaging of high temperature,particle bombardment,etc.,during the deposition of the top mirror.Furthermore,with the help of a glass probe,we demonstrate a replaceable silver transfer method to tune the detuning of the microcavity,thereby changing the coupling of photons and excitons therein.The developed deterministic and replaceable silver mirror transfer methods will provide the capability to fabricate high-quality and tunable microcavities and play an active role in the development of the exciton–polariton field.展开更多
基金supported by the National Natural Science Foundation of China[Grant Numbers 82170769,81900684,and 81870512].
文摘Background:Clear-cell renal cell carcinoma(ccRCC)is the most common malignant kidney cancer.However,the tumor microenvironment and crosstalk involved in metabolic reprogramming in ccRCC are not well-understood.Methods:We used The Cancer Genome Atlas to obtain ccRCC transcriptome data and clinical information.The EMTAB-1980 cohort was used for external validation.The GENECARDS database contains the first 100 solute carrier(SLC)-related genes.The predictive value of SLC-related genes for ccRCC prognosis and treatment was assessed using univariate Cox regression analysis.An SLC-related predictive signature was developed through Lasso regression analysis and used to determine the risk profiles of patients with ccRCC.Patients in each cohort were separated into high-and low-risk groups based on their risk scores.The clinical importance of the signature was assessed through survival,immune microenvironment,drug sensitivity,and nomogram analyses using R software.Results:SLC25A23,SLC25A42,SLC5A1,SLC3A1,SLC25A37,SLC5A6,SLCO5A1,and SCP2 comprised the signatures of the eight SLCrelated genes.Patients with ccRCC were separated into high-and low-risk groups based on the risk value in the training and validation cohorts;the high-risk group had a significantly worse prognosis(p<0.001).The risk score was an independent predictive indicator of ccRCC in the two cohorts according to univariate and multivariate Cox regression(p<0.05).Analysis of the immune microenvironment showed that immune cell infiltration and immune checkpoint gene expression differed between the two groups(p<0.05).Drug sensitivity analysis showed that compared to the low-risk group,the high-risk group was more sensitive to sunitinib,nilotinib,JNK-inhibitor-VIII,dasatinib,bosutinib,and bortezomib(p<0.001).Survival analysis and receiver operating characteristic curves were validated using the E-MTAB-1980 cohort.Conclusions:SLC-related genes have predictive relevance in ccRCC and play roles in the immunological milieu.Our results provide insight into metabolic reprogramming in ccRCC and identify promising treatment targets for ccRCC.
基金Educational and Scientific Research Planning Project of Anhui Vocational and Adult Education Society—Exploration and Practice of the Mixed Teaching Model of Public Relations in Higher Vocational Colleges in the Context of"Internet+"(AGZ18121)。
文摘Under the tide of"Internet+education",the new means of information technology education is constantly used in education and teaching,and the traditional teaching models and teaching methods urgently need to be changed.There is no doubt about the integration of online teaching and offline teaching.On the basis of reviewing the research on the mixed teaching model at home and abroad,this paper puts forward the idea of constructing the mixed teaching model in colleges and universities in the context of"Internet+",and sets up the mixed teaching model in colleges and universities in the context of"Internet+".Through the detailed and concrete design of the operation process of the mixed teaching model,we can break the single shackles of online teaching and face-to-face teaching,and form an interactive and collaborative teaching ecosystem to realize the common development of online teaching and offline teaching.
文摘With transformation of Chinese sports talents cultivation mode, sports team construction at high level in universities has made great achievements. Especially establishing reserves in key universities is the key step of new mode, which is the primary mode of sports team at high level in ordinary universities. To research the situation of key sports team construction at high level, from the degree of competitive sports sustainable development, we research and analyze the cultivation mode of Chinese sports talents and influence factors, aiming at building a talents cultivation mode suitable for Chinese professional competitive sports development and exploring the sustainable way for athletes sports in theory.
基金the National Key R&D Program of China(grant No.2021YFC2500501)the Strategic Priority Research Program of Chinese Academy of Sciences(grant no.XDB38010100)+4 种基金the National Natural Science Foundation of China(grant no.82030022 and 82330020)Program for Innovative Research Team of The First Affiliated Hospital of USTC(grant no.CXGG02)the Program of Introducing Talents of Discipline to Universities,111 Plan(grant no.D18005)Guangdong Provincial Clinical Research Center for Kidney Disease(2020B1111170013)Key Technologies R&D Program of Guangdong Province(grant no.2023B1111030004).
文摘Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains unclear.In this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May 2022.We included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular disease.Multivariable Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for HF.Newly diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for HF.No significant difference in the risk of CHD was observed.We found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting models.These findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.
基金financially supported by the National Natural Science Foundation of China (No.52073277)the Science and Technology Department of Fujian Province (No.2020HZ06019)。
文摘Ethylene-propylene block copolymer(EbP) is a vital component in impact polypropylene copolymer(IPC), yet its distribution in the multiphase composite material and how it influences the phase structure and the mechanical properties are not well understood. In this work,four IPCs were investigated by atomic force microscopy-infrared(AFM-IR) to assess the phase compositions in situ, based on which in conjunction with the chain microstructure information obtained ex situ the distributions of the copolymer components were derived for each alloy. For the IPCs whose EbP comprises long P and long E segments, the EbP fraction was found to phase separate from the rubber and the PP matrix to form the cores of the disperse particles with the E-P segmented copolymer(EsP). In contrast, in the IPC with EbP composed of long P and short E segments, the EbP fraction formed an outer shell for the rubber particles with the cores comprising the EsP alone, and this IPC, containing a lower E comonomer content than its counterpart, exhibited both better impact resistance and higher flexural modulus. These results clarify how the chain structure of EbP governs the phase morphology in IPC, which in turn impacts the properties of the composite material.
基金supported by the National Natural Science Foundation of China(No.62271456)the Open Projects Program of State Key Laboratory of Multimodal Artificial Intelligence Systems.
文摘Low-resource text plagiarism detection faces a significant challenge due to the limited availability of labeled data for training.This task requires the development of sophisticated algorithms capable of identifying similarities and differences in texts,particularly in the realm of semantic rewriting and translation-based plagiarism detection.In this paper,we present an enhanced attentive Siamese Long Short-Term Memory(LSTM)network designed for Tibetan-Chinese plagiarism detection.Our approach begins with the introduction of translation-based data augmentation,aimed at expanding the bilingual training dataset.Subsequently,we propose a pre-detection method leveraging abstract document vectors to enhance detection efficiency.Finally,we introduce an improved attentive Siamese LSTM network tailored for Tibetan-Chinese plagiarism detection.We conduct comprehensive experiments to showcase the effectiveness of our proposed plagiarism detection framework.
基金supported by the National Natural Science Foundation of China(No.61875001)and the Beijing Natural Science Foundation(No.JQ21018)W.B.acknowledge support from National Science Foundation(Award No.DMR-2143041)T.T.acknowledges support from the JSPS KAKENHI(Grant Nos.19H05790 and 20H00354)and A3 Foresight by JSPS.
文摘How to fabricate high-quality microcavities simply and at low cost without causing damage to environmentally sensitive active layers such as perovskites are crucial for the studies of exciton–polaritons,however,it remains challenging in the field of microcavity fabrication.Usually,once the top mirror is deposited,the detuning of the microcavity is fixed and there is no easy way to tune it.Here,we have developed a method for deterministically transferring silver mirrors,which is relatively simple and guarantees the active layer from damaging of high temperature,particle bombardment,etc.,during the deposition of the top mirror.Furthermore,with the help of a glass probe,we demonstrate a replaceable silver transfer method to tune the detuning of the microcavity,thereby changing the coupling of photons and excitons therein.The developed deterministic and replaceable silver mirror transfer methods will provide the capability to fabricate high-quality and tunable microcavities and play an active role in the development of the exciton–polariton field.
