咳喘三伏贴防治小儿哮喘临床疗效观察

目的：探讨咳喘三伏贴防治小儿哮喘的临床疗效.方法：将我院2009年6月到2010年9月收治的90例哮喘患儿随机分为对照组与观察组,每组45例.对照组采用常规哮喘治疗方法;观察组在对照组基础上给予咳喘三伏贴治疗.记录两组治疗前后肺功能最大呼气峰流速值（PEF）和用力呼气容积（FEV1）;比较两组的临床疗效及不良反应.结果：治疗后,观察组的PEF和PEV1均明显高于对照组（P〈0.05）;观察组的显效率和总有效率均明显高于对照组（P〈0.05）;两组不良反应发生率比较差异无统计学意义（P〉0.05）.结论：咳喘三伏贴防治小儿哮喘的临床疗效优于传统治疗方法,且不良反应小,值得推广应用.

X-ray absorption near-edge structure study on the configuration of Cu2＋/histidine complexes at different pH values

The local configurations around metal ions in metalloproteins are of great significance for understanding their biolog- ical functions. Cu2＋/histidine （His） is a typical complex existing in many metalloproteins and plays an important role in lots of physiological functions. The three-dimensional （3D） structural configurations of Cu2＋/His complexes at different pH values （2.5, 6.5, and 8.5） are quantitatively determined by x-ray absorption near-edge structure （XANES）. Generally Cu2＋/His complex keeps an octahedral configuration consisting of oxygen atoms from water molecules and oxygen or nitrogen atoms from histidine molecules coordinated around Cu2＋. It is proved in this work that the oxygen atoms from water molecules, when increasing the pH value from acid to basic value, are gradually substituted by the Ocarboxy1, Nam, and Nim from hisitidine molecules. Furthermore, the symmetries of Cu2＋/His complexes at pH 6.5 and pH 8.5 are found to be lower than at pH 2.5.

阿斯美联合孟鲁司特钠治疗咳嗽变异型哮喘疗效观察

目的：探讨阿斯美联合孟鲁司特钠治疗咳嗽变异型哮喘临床疗效.方法：将我院2009年11月～2010年12月收治的60例咳嗽变异型哮喘随机分为对照组与治疗组,每组30例.对照组采用常规治疗方法治疗;治疗组采用阿斯美联合孟鲁司特钠联合治疗.两组患者均治疗4周,观察治疗后的临床疗效及不良反应发生情况,并进行统计分析.结果：治疗组的显效率为86.7%,总有效率为93.3%;对照组的显效率为73.3%,总有效率为83.3%.治疗组的显效率与总有效率明显高于对照组,两组比较差异具有统计学意义（P〈0.05）;治疗组不良反应发生率为3.3%明显低于对照组的13.3%,两组不良反应发生率比较差异有统计学意义（P〈0.05）.结论：阿斯美联合孟鲁司特钠治疗咳嗽变异型哮喘临床疗效确切,不良反应小,值得推广应用.