A new method for synthesizing 5-chloro-1-methyl-4-nitroimidazole had been devoloped with diethyl oxalate,aqueous methylamine formate,phosphorus pentachloride,mixed acid etc as starting materials.Target molecule was ob...A new method for synthesizing 5-chloro-1-methyl-4-nitroimidazole had been devoloped with diethyl oxalate,aqueous methylamine formate,phosphorus pentachloride,mixed acid etc as starting materials.Target molecule was obtained through aminolysis reaction,semi-ring reaction and nitration reaction.The process provided an energy saving,high yield synthetic methodology.The yield of producing 5-chloro-1-methyl-4-nitroimidazole was up to 64%.All products were determined by MS,NMR and FT-IR.展开更多
文摘A new method for synthesizing 5-chloro-1-methyl-4-nitroimidazole had been devoloped with diethyl oxalate,aqueous methylamine formate,phosphorus pentachloride,mixed acid etc as starting materials.Target molecule was obtained through aminolysis reaction,semi-ring reaction and nitration reaction.The process provided an energy saving,high yield synthetic methodology.The yield of producing 5-chloro-1-methyl-4-nitroimidazole was up to 64%.All products were determined by MS,NMR and FT-IR.
