【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组...【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组注入等量生理盐水,通过收集患犬基础信息、回访跟踪记录,检测血常规和血液因子含量以及影像学等方法评估犬UC-MSCs的治疗效果。【结果】与常规手术组对比,术后第1、7天干细胞治疗组白细胞介素-6(IL-6)含量极显著或显著降低(P<0.01;P<0.05),两组间转化生长因子-β1(TGF-β1)、基质金属蛋白酶13(MMP-13)及肿瘤坏死因子α(TNF-α)和白细胞总数、中性粒细胞总数均无显著差异(P>0.05)。术后第30天数字X线摄影复查结果显示,干细胞治疗组关节腔清晰,骨损位置有明显的软骨及骨组织生长,无再次脱出和关节炎等并发症。常规手术组的骨损伤处骨生长情况缓慢,2例患犬髌骨再次脱位(2/10)。【结论】滑车沟再造术后,在常规术后护理(使用抗炎、抗菌和止疼药物)条件下,关节腔内注射UC-MSCs能促进软骨和骨组织生长,降低再次脱出发生的风险。UC-MSCs联合滑车沟再造术能提升犬髌骨脱位的临床治疗效果。展开更多
目的:肺癌患者肌少症发病率高,对预后影响大。选择一种精确可行的肌少症筛查工具有助于普及临床肌少症的评估。本研究验证并比较7种肌少症评估工具在肺癌人群中的筛查效能,为早期筛查肺癌肌少症提供科学可行的评估工具。方法:便利选取2...目的:肺癌患者肌少症发病率高,对预后影响大。选择一种精确可行的肌少症筛查工具有助于普及临床肌少症的评估。本研究验证并比较7种肌少症评估工具在肺癌人群中的筛查效能,为早期筛查肺癌肌少症提供科学可行的评估工具。方法:便利选取2022年9月至2023年4月广州市某三级甲等综合性医院收治的252例肺癌患者作为调查对象,分别使用体重指数、小腿围、肌少症五条目(Strength,Assistance in Walk,Rise From Chair,Climb Stairs,Fall,SARC-F)量表、肌少症五条目联合小腿围(SARC-F Combined with Calf Circumference,SARC-CalF)量表、SARC-F联合老龄和体重指数(SARC-F Adding Elderly and Body Mass Index Information,SARC-F+EBM)量表、Ishii评分以及营养风险指数对肺癌患者进行肌少症风险筛查,分别使用敏感度、特异度、约登指数以及受试者操作特征曲线下面积(area under the curve,AUC)对上述7种评估工具进行诊断效能评价。结果:肺癌患者肌少症发生率为24.21%(61/252)。在最优截断值下,体重指数、小腿围、SARC-F量表、SARC-CalF量表、SARC-F+EBM量表、Ishii评分以及营养风险指数的AUC值分别为0.843、0.850、0.747、0.824、0.854、0.923、0.784,约登指数分别为0.550、0.583、0.429、0.489、0.534、0.721、0.506。结论:7种肌少症评估工具中,Ishii评分的筛查效能最佳,推荐使用Ishii评分对肺癌患者进行肌少症的快速筛查。展开更多
Strain is a powerful tool to engineer the band structure of bilayer phosphorene.The band gap can be decreased by vertical tensile strain or in-plane compressive strain.At a critical strain,the gap is closed and the bi...Strain is a powerful tool to engineer the band structure of bilayer phosphorene.The band gap can be decreased by vertical tensile strain or in-plane compressive strain.At a critical strain,the gap is closed and the bilayer phosphorene is turn to be a semi-Dirac semimetal material.If the strain is stronger than the criterion,a band-inversion occurs and it re-happens when the strain is larger than another certain value.For the zigzag bilayer phosphorene ribbon,there are two edge band dispersions and each dispersion curve represents two degenerate edge bands.When the first band-inversion happens,one of the edge band dispersion disappears between the band-cross points while the other survives,and the latter will be eliminated between another pair of band-cross points of the second band-inversion.The optical absorption of bilayer phosphorene is highly polarized along armchair direction.When the strain is turn on,the optical absorption edge changes.The absorption rate for armchair polarized light is decreased by gap shrinking,while that for zigzag polarized light increases.The bandtouch and band-inversion respectively result in the sublinear and linear of absorption curve versus light frequency in low frequency limit.展开更多
文摘【目的】探究犬脐带间充质干细胞(UC-MSCs)联合滑车沟再造术对髌骨脱位治疗的效果。【方法】将20只髌骨脱位患犬随机分为干细胞治疗组和常规手术组,每组10只。手术当天,干细胞治疗组关节腔注射0.5 mL UC-MSCs(106/kg)混悬液,常规手术组注入等量生理盐水,通过收集患犬基础信息、回访跟踪记录,检测血常规和血液因子含量以及影像学等方法评估犬UC-MSCs的治疗效果。【结果】与常规手术组对比,术后第1、7天干细胞治疗组白细胞介素-6(IL-6)含量极显著或显著降低(P<0.01;P<0.05),两组间转化生长因子-β1(TGF-β1)、基质金属蛋白酶13(MMP-13)及肿瘤坏死因子α(TNF-α)和白细胞总数、中性粒细胞总数均无显著差异(P>0.05)。术后第30天数字X线摄影复查结果显示,干细胞治疗组关节腔清晰,骨损位置有明显的软骨及骨组织生长,无再次脱出和关节炎等并发症。常规手术组的骨损伤处骨生长情况缓慢,2例患犬髌骨再次脱位(2/10)。【结论】滑车沟再造术后,在常规术后护理(使用抗炎、抗菌和止疼药物)条件下,关节腔内注射UC-MSCs能促进软骨和骨组织生长,降低再次脱出发生的风险。UC-MSCs联合滑车沟再造术能提升犬髌骨脱位的临床治疗效果。
文摘目的:肺癌患者肌少症发病率高,对预后影响大。选择一种精确可行的肌少症筛查工具有助于普及临床肌少症的评估。本研究验证并比较7种肌少症评估工具在肺癌人群中的筛查效能,为早期筛查肺癌肌少症提供科学可行的评估工具。方法:便利选取2022年9月至2023年4月广州市某三级甲等综合性医院收治的252例肺癌患者作为调查对象,分别使用体重指数、小腿围、肌少症五条目(Strength,Assistance in Walk,Rise From Chair,Climb Stairs,Fall,SARC-F)量表、肌少症五条目联合小腿围(SARC-F Combined with Calf Circumference,SARC-CalF)量表、SARC-F联合老龄和体重指数(SARC-F Adding Elderly and Body Mass Index Information,SARC-F+EBM)量表、Ishii评分以及营养风险指数对肺癌患者进行肌少症风险筛查,分别使用敏感度、特异度、约登指数以及受试者操作特征曲线下面积(area under the curve,AUC)对上述7种评估工具进行诊断效能评价。结果:肺癌患者肌少症发生率为24.21%(61/252)。在最优截断值下,体重指数、小腿围、SARC-F量表、SARC-CalF量表、SARC-F+EBM量表、Ishii评分以及营养风险指数的AUC值分别为0.843、0.850、0.747、0.824、0.854、0.923、0.784,约登指数分别为0.550、0.583、0.429、0.489、0.534、0.721、0.506。结论:7种肌少症评估工具中,Ishii评分的筛查效能最佳,推荐使用Ishii评分对肺癌患者进行肌少症的快速筛查。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774100 and 11474106)
文摘Strain is a powerful tool to engineer the band structure of bilayer phosphorene.The band gap can be decreased by vertical tensile strain or in-plane compressive strain.At a critical strain,the gap is closed and the bilayer phosphorene is turn to be a semi-Dirac semimetal material.If the strain is stronger than the criterion,a band-inversion occurs and it re-happens when the strain is larger than another certain value.For the zigzag bilayer phosphorene ribbon,there are two edge band dispersions and each dispersion curve represents two degenerate edge bands.When the first band-inversion happens,one of the edge band dispersion disappears between the band-cross points while the other survives,and the latter will be eliminated between another pair of band-cross points of the second band-inversion.The optical absorption of bilayer phosphorene is highly polarized along armchair direction.When the strain is turn on,the optical absorption edge changes.The absorption rate for armchair polarized light is decreased by gap shrinking,while that for zigzag polarized light increases.The bandtouch and band-inversion respectively result in the sublinear and linear of absorption curve versus light frequency in low frequency limit.
