Acne inversa(Al,OMIM#142690)is an autosomal dominant chronic inflammatory disease of the hair follicles[1].Despite medications and procedures aimed at treating Al,patient responses vary widely to different therapies,a...Acne inversa(Al,OMIM#142690)is an autosomal dominant chronic inflammatory disease of the hair follicles[1].Despite medications and procedures aimed at treating Al,patient responses vary widely to different therapies,and no curative regimen or treatment is available[2].In 2010,our group first idenrified nicas-trin(NCSTN),an y-secretase component gene,as a pathogenic gene for familial Al patients[3].展开更多
基金supported by the National Key Research and Development Program of China (2020YFC1316602, 2016YFC0905100, and 2020YFA0509503)the National Natural Science Foundation of China (31925036, 81788101, 81671274, 31801031, 81230015, and 31701073)+3 种基金the Strategic Priority Research Programs of CAS (XDA16030101)the National Transgenic Project of China (2016ZX08009003-006-007)the CAMS Innovation Fund for Medical Sciences (2016-I2M-1002)the Central Research Institutes of Basic Research and Public Service Special Operations (2017PT31016)。
文摘Acne inversa(Al,OMIM#142690)is an autosomal dominant chronic inflammatory disease of the hair follicles[1].Despite medications and procedures aimed at treating Al,patient responses vary widely to different therapies,and no curative regimen or treatment is available[2].In 2010,our group first idenrified nicas-trin(NCSTN),an y-secretase component gene,as a pathogenic gene for familial Al patients[3].
