Riboswitches are functional RNA elements that regulate gene expression by directly detecting metabolites.Twenty years have passed since it was first discovered,researches on riboswitches are becoming increasingly stan...Riboswitches are functional RNA elements that regulate gene expression by directly detecting metabolites.Twenty years have passed since it was first discovered,researches on riboswitches are becoming increasingly standardized and refined,which could significantly promote people’s cognition of RNA function as well.Here,we focus on some representative orphan riboswitches,enumerate the structural and functional transformation and artificial design of riboswitches including the coupling with ribozymes,hoping to attain a comprehensive understanding of riboswitch research.展开更多
基金the National Key Research and Development Program of China(2021YFC2100700)the National Natural Science Foundation of China(Grant NSFC-22278313).
文摘Riboswitches are functional RNA elements that regulate gene expression by directly detecting metabolites.Twenty years have passed since it was first discovered,researches on riboswitches are becoming increasingly standardized and refined,which could significantly promote people’s cognition of RNA function as well.Here,we focus on some representative orphan riboswitches,enumerate the structural and functional transformation and artificial design of riboswitches including the coupling with ribozymes,hoping to attain a comprehensive understanding of riboswitch research.
