Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on ...Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on the clinicopathologic characterics and clinical behaviors of salivary gland tumors of various locations and subtype. The management of salivary gland tumors is also contraversial. Biopsy is not suggested because of seeding of tumor cells. Therefore adjunctive methods are important for preoperative diagnosis. Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristis and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor. These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and biobehavior of different types of slivary gland tumors. We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland. Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.展开更多
In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SM...In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SMG have been performed. The results showed that functional α 1A- and α 1B-adrenoceptors（AR） were expressed in human SMG, and might contribute to the regulation of saliva synthesis and secretion. Both β1- and β2-AR were expressed in rabbit SMG. β1-AR was the predominant subtype and might play an important role in regulating saliva and α-amylase secretion. Vanilloid receptor1（VR1） mRNA and protein were detected in rabbit SMG. Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1. On the rabbit model of microvascular transfer of SMG, phenylephrine（10 -7 mol/L）was infused into SMG through the Wharton’s duct. The secretion of transferred SMG was significantly increased without significant changes of cardiovascular function. The effective mechanism of phenylephrine might involve the increased expression of α1-AR, translocation of AQP5 from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland. These results provided a experimental basis for deeply understanding of secretion mechanism of normal and transferred SMG, and effective regulation of secretion of the transferred SMG.展开更多
文摘Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on the clinicopathologic characterics and clinical behaviors of salivary gland tumors of various locations and subtype. The management of salivary gland tumors is also contraversial. Biopsy is not suggested because of seeding of tumor cells. Therefore adjunctive methods are important for preoperative diagnosis. Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristis and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor. These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and biobehavior of different types of slivary gland tumors. We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland. Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.
文摘In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG,serial studies on the secretion function of normal and transferred SMG have been performed. The results showed that functional α 1A- and α 1B-adrenoceptors（AR） were expressed in human SMG, and might contribute to the regulation of saliva synthesis and secretion. Both β1- and β2-AR were expressed in rabbit SMG. β1-AR was the predominant subtype and might play an important role in regulating saliva and α-amylase secretion. Vanilloid receptor1（VR1） mRNA and protein were detected in rabbit SMG. Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1. On the rabbit model of microvascular transfer of SMG, phenylephrine（10 -7 mol/L）was infused into SMG through the Wharton’s duct. The secretion of transferred SMG was significantly increased without significant changes of cardiovascular function. The effective mechanism of phenylephrine might involve the increased expression of α1-AR, translocation of AQP5 from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland. These results provided a experimental basis for deeply understanding of secretion mechanism of normal and transferred SMG, and effective regulation of secretion of the transferred SMG.
