Objective To investigate the effect of trichostatin A(TSA)and 5-azacitidine(5-Aza C)on pancreaticβ-cells impaired by cytokine,via measuring the proliferation,apoptosis,and function of pancreaticβ-cells.Methods RIN-m...Objective To investigate the effect of trichostatin A(TSA)and 5-azacitidine(5-Aza C)on pancreaticβ-cells impaired by cytokine,via measuring the proliferation,apoptosis,and function of pancreaticβ-cells.Methods RIN-m5f was impaired by interleukin-1βand interferon-γin vitro,and treated with TSA and 5-Aza C.Experiment groups included blank control group,cytokine induction group,0.05/0.10μmol/L TSA group,0.63/1.25μmol/L 5-Aza C group,and 0.10μmol/L展开更多
文摘Objective To investigate the effect of trichostatin A(TSA)and 5-azacitidine(5-Aza C)on pancreaticβ-cells impaired by cytokine,via measuring the proliferation,apoptosis,and function of pancreaticβ-cells.Methods RIN-m5f was impaired by interleukin-1βand interferon-γin vitro,and treated with TSA and 5-Aza C.Experiment groups included blank control group,cytokine induction group,0.05/0.10μmol/L TSA group,0.63/1.25μmol/L 5-Aza C group,and 0.10μmol/L
