目的考察Fe_(3)O_(4)纳米颗粒在低频振动磁场(low-frequency vibrating magnetic field,VMF)驱动下通过磁场机械力杀伤肿瘤细胞的效果。方法通过共沉淀法合成一种磁性强、具有不规则形貌的立方相Fe_(3)O_(4)纳米颗粒。将其置于本课题组...目的考察Fe_(3)O_(4)纳米颗粒在低频振动磁场(low-frequency vibrating magnetic field,VMF)驱动下通过磁场机械力杀伤肿瘤细胞的效果。方法通过共沉淀法合成一种磁性强、具有不规则形貌的立方相Fe_(3)O_(4)纳米颗粒。将其置于本课题组自制的VMF中,研究其介导的磁场机械力对肿瘤细胞的杀伤效果。结果单纯施加VMF对细胞活力无影响;加入Fe_(3)O_(4)纳米颗粒后,细胞活力随VMF处理时间和Fe_(3)O_(4)纳米颗粒浓度的增加而降低,受损细胞释放的乳酸脱氢酶也随磁场处理时间延长而增加。结论不规则形貌Fe_(3)O_(4)纳米颗粒在VMF下可将机械力转移到肿瘤细胞,破坏细胞结构,导致细胞死亡;所采用的VMF装置结构简单、使用安全、操作方便。所采用的磁性粒子及其杀伤肿瘤细胞的方法,有临床转化潜力。展开更多
Drug-loaded microspheres are usually used as a biophysically targeted delivery system.The morphology and size distribution of the microspheres are key effects on the efficiency in therapy.The microspheres could be pre...Drug-loaded microspheres are usually used as a biophysically targeted delivery system.The morphology and size distribution of the microspheres are key effects on the efficiency in therapy.The microspheres could be prepared by the spray drying method, and the characterization could be controlled by varying the drying conditions.The whole preparation process is highly efficient, and suitable for commercialization.In this work,a case for preparation of the microspheres of tanshinone (TAN) solid dispersions was studied, and the mechanisms of morphology and size control of microspheres during the spray drying process were investigated.The effects of inlet temperature,concentration and components of precursors, and feed rate on the morphology and size distribution of products were studied.The results showed that the morphology of the dry products depended on the inlet temperature, the components of precursor and feed rate.Among them,temperature was the most important factor.The size of microspheres was mainly controlled by the concentration of the precursor.This work might be a reference for morphology and size control of targeted drug delivery microspheres by the spray drying method.展开更多
文摘目的考察Fe_(3)O_(4)纳米颗粒在低频振动磁场(low-frequency vibrating magnetic field,VMF)驱动下通过磁场机械力杀伤肿瘤细胞的效果。方法通过共沉淀法合成一种磁性强、具有不规则形貌的立方相Fe_(3)O_(4)纳米颗粒。将其置于本课题组自制的VMF中,研究其介导的磁场机械力对肿瘤细胞的杀伤效果。结果单纯施加VMF对细胞活力无影响;加入Fe_(3)O_(4)纳米颗粒后,细胞活力随VMF处理时间和Fe_(3)O_(4)纳米颗粒浓度的增加而降低,受损细胞释放的乳酸脱氢酶也随磁场处理时间延长而增加。结论不规则形貌Fe_(3)O_(4)纳米颗粒在VMF下可将机械力转移到肿瘤细胞,破坏细胞结构,导致细胞死亡;所采用的VMF装置结构简单、使用安全、操作方便。所采用的磁性粒子及其杀伤肿瘤细胞的方法,有临床转化潜力。
文摘Drug-loaded microspheres are usually used as a biophysically targeted delivery system.The morphology and size distribution of the microspheres are key effects on the efficiency in therapy.The microspheres could be prepared by the spray drying method, and the characterization could be controlled by varying the drying conditions.The whole preparation process is highly efficient, and suitable for commercialization.In this work,a case for preparation of the microspheres of tanshinone (TAN) solid dispersions was studied, and the mechanisms of morphology and size control of microspheres during the spray drying process were investigated.The effects of inlet temperature,concentration and components of precursors, and feed rate on the morphology and size distribution of products were studied.The results showed that the morphology of the dry products depended on the inlet temperature, the components of precursor and feed rate.Among them,temperature was the most important factor.The size of microspheres was mainly controlled by the concentration of the precursor.This work might be a reference for morphology and size control of targeted drug delivery microspheres by the spray drying method.
