Objective: To study the clinical effect of Fuzheng Jiedu granule (扶正解毒颗粒,FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and microelements in patients with coronary heart disease w...Objective: To study the clinical effect of Fuzheng Jiedu granule (扶正解毒颗粒,FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and microelements in patients with coronary heart disease who are in long-term contact with nickel. Methods: Sixty patients were randomly divided into two groups, the treated group and the control group, 30 in each group. Conventional Western medicinal treatment was applied to both groups, but to the treated group, FJG was given additionally by oral intake, and the therapeutic course for both groups was 4 weeks. Besides, a health control group was set up with 15 healthy subjects selected from the same area, who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO, NOS and microelements were observed before and after treatment. Results: The total effective rate on clinical symptoms in the treated group was 93. 3% and that in the control group 63. 3% , comparison between the two showing significant difference (P<0.05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively, which also showed significant difference (P<0.05). After treatment, levels of serum NO, NOS, Mg, Zn and Ca increased and those of Ni, Mn and Fe decreased significantly (P<0.05 or P<0.01) in the treated group, while in the control group, changes in these laboratory indexes were insignificant. Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements, help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.展开更多
目的探讨脓毒症并发急性肾损伤(AKI)患者血浆铁与中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的相关性。方法选取2019年1月-2020年6月上海市普陀区利群医院急诊医学科诊治的120例脓毒症患者,首先根据入院时是否并发AKI分为入院非AKI组65例...目的探讨脓毒症并发急性肾损伤(AKI)患者血浆铁与中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的相关性。方法选取2019年1月-2020年6月上海市普陀区利群医院急诊医学科诊治的120例脓毒症患者,首先根据入院时是否并发AKI分为入院非AKI组65例和入院AKI组55例,另将入院非AKI组根据患者入院48 h后是否并发AKI分为48 h AKI组和48 h非AKI组,比较各组血浆铁和NGAL水平,并采用Spearman相关性分析入院非AKI组及48 h AKI组入院时、入院后48 h血浆铁与NGAL水平的关系。结果入院AKI组入院时NGAL、血浆铁及入院后48 h NGAL高于入院非AKI组,差异有统计学意义(P<0.05);48 h AKI组与48 h非AKI组入院时、入院后48 h血浆铁、NGAL水平比较,差异有统计学意义(P<0.05);Spearman相关性分析显示,入院AKI组在入院时及入院后48 h的血浆铁与血浆NGAL呈正相关(r=0.535、0.498,P<0.05);48 h AKI组入院时、入院后48 h血浆铁与血浆NGAL呈正相关(r=0.593、0.641,P<0.05)。结论脓毒症并发AKI患者血浆铁与NGAL可能存在一定相关性,血浆铁水平升高可能是脓毒症并发AKI的一个重要预警。展开更多
文摘Objective: To study the clinical effect of Fuzheng Jiedu granule (扶正解毒颗粒,FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and microelements in patients with coronary heart disease who are in long-term contact with nickel. Methods: Sixty patients were randomly divided into two groups, the treated group and the control group, 30 in each group. Conventional Western medicinal treatment was applied to both groups, but to the treated group, FJG was given additionally by oral intake, and the therapeutic course for both groups was 4 weeks. Besides, a health control group was set up with 15 healthy subjects selected from the same area, who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO, NOS and microelements were observed before and after treatment. Results: The total effective rate on clinical symptoms in the treated group was 93. 3% and that in the control group 63. 3% , comparison between the two showing significant difference (P<0.05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively, which also showed significant difference (P<0.05). After treatment, levels of serum NO, NOS, Mg, Zn and Ca increased and those of Ni, Mn and Fe decreased significantly (P<0.05 or P<0.01) in the treated group, while in the control group, changes in these laboratory indexes were insignificant. Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements, help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.
文摘目的探讨脓毒症并发急性肾损伤(AKI)患者血浆铁与中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的相关性。方法选取2019年1月-2020年6月上海市普陀区利群医院急诊医学科诊治的120例脓毒症患者,首先根据入院时是否并发AKI分为入院非AKI组65例和入院AKI组55例,另将入院非AKI组根据患者入院48 h后是否并发AKI分为48 h AKI组和48 h非AKI组,比较各组血浆铁和NGAL水平,并采用Spearman相关性分析入院非AKI组及48 h AKI组入院时、入院后48 h血浆铁与NGAL水平的关系。结果入院AKI组入院时NGAL、血浆铁及入院后48 h NGAL高于入院非AKI组,差异有统计学意义(P<0.05);48 h AKI组与48 h非AKI组入院时、入院后48 h血浆铁、NGAL水平比较,差异有统计学意义(P<0.05);Spearman相关性分析显示,入院AKI组在入院时及入院后48 h的血浆铁与血浆NGAL呈正相关(r=0.535、0.498,P<0.05);48 h AKI组入院时、入院后48 h血浆铁与血浆NGAL呈正相关(r=0.593、0.641,P<0.05)。结论脓毒症并发AKI患者血浆铁与NGAL可能存在一定相关性,血浆铁水平升高可能是脓毒症并发AKI的一个重要预警。
