Photon-measurement density function （PMDF）, which is the kernel of fluorescence molecular tomography （FMT）, largely determines the accuracy of reconstruction result of FMT. Based on the direct method, we propose a...Photon-measurement density function （PMDF）, which is the kernel of fluorescence molecular tomography （FMT）, largely determines the accuracy of reconstruction result of FMT. Based on the direct method, we propose an expression of PMDF in FMT, which is derived from the finite element method （FEM） solution of the diffusion equation. Compared with the traditional expression based on the perturbation method, the accuracy of expression based on the direct method is shown in theory. Lastly the reconstruction results of phantoms prove this accuracy in experiment.展开更多
A fluorescence molecular tomography system for in vivo tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source.A high sensitivity cooled charge-coupled device （CCD） camera with ...A fluorescence molecular tomography system for in vivo tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source.A high sensitivity cooled charge-coupled device （CCD） camera with excitation and emission filters is utilized to obtain the excitation and fluorescence images.The laser beam performs fast raster scanning using a dual-axis galvanometric scanner.The accuracy of the laser spot position at the source window is within ±200 μm.Based on the phantom experimental results,the spatial resolution is less than 1.7 mm,and the relative quantitation error is about 10%.In vivo imaging of a tumor-bearing nude mouse tagged with near-infrared dye demonstrates the feasibility of the system.展开更多
基金Supported by the National High-Tech Research and Development Program of China （2006AA020801）, the National Natural Science Foundation of China （61078072）, and the Specialized Research Fund for the Doctoral Program of Higher Education of China （20070487058）.
文摘Photon-measurement density function （PMDF）, which is the kernel of fluorescence molecular tomography （FMT）, largely determines the accuracy of reconstruction result of FMT. Based on the direct method, we propose an expression of PMDF in FMT, which is derived from the finite element method （FEM） solution of the diffusion equation. Compared with the traditional expression based on the perturbation method, the accuracy of expression based on the direct method is shown in theory. Lastly the reconstruction results of phantoms prove this accuracy in experiment.
基金supported by the National High-Tech Research and Development ("863") Program of China under Grant No. 2006AA020801
文摘A fluorescence molecular tomography system for in vivo tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source.A high sensitivity cooled charge-coupled device （CCD） camera with excitation and emission filters is utilized to obtain the excitation and fluorescence images.The laser beam performs fast raster scanning using a dual-axis galvanometric scanner.The accuracy of the laser spot position at the source window is within ±200 μm.Based on the phantom experimental results,the spatial resolution is less than 1.7 mm,and the relative quantitation error is about 10%.In vivo imaging of a tumor-bearing nude mouse tagged with near-infrared dye demonstrates the feasibility of the system.
