Hemodynamic responses to hypoxic challenge on rats werechecked either in anesthetic state or in awake state. The rats in awake state wereunder taken hemodynamic study at 48 hours after Pentobarbital（PB） anesthesiaan...Hemodynamic responses to hypoxic challenge on rats werechecked either in anesthetic state or in awake state. The rats in awake state wereunder taken hemodynamic study at 48 hours after Pentobarbital（PB） anesthesiaand catheterization. Hemodynamic responses to hypoxic ventilation on dogs wasconducted either at 2 hours or at 4 hours after PB. During hypoxic ventilationflaxidel was used to maintain skeletal muscular relaxation, yet PB was not re-peated to diminish it’s influence on hypoxic responses. Blood gas assay was car-ried out in dogs during normoxia and hypoxic challenge. Hypoxic challengecaused significant increase of pulmonary artery pressure （Ppa） and almost nochange in systemic artery pressure （Psa） in awake rats. However in anestheticrats hypoxic challenge had little effect on Ppa, without influence on Psa. At 2and 4 hours after PB administration and catheterization hypoxic ventilationcaused similar change in blood gas （PaO<sub>2</sub> and PvO<sub>2</sub>）. However the second hy-poxic ventilation （4h） produced more significant pulmonary hemodynamic re-sponses （Ppa and TPVR greatly increased）. These results suggested thatpreferable acute hypoxic pulmonary hypertension developed either in awake ratsor in relatively shallow anesthetic state of dogs, indicating that PB anesthesiamay inhibit hypoxic pulmonary hemodynamic responses.展开更多
文摘Hemodynamic responses to hypoxic challenge on rats werechecked either in anesthetic state or in awake state. The rats in awake state wereunder taken hemodynamic study at 48 hours after Pentobarbital（PB） anesthesiaand catheterization. Hemodynamic responses to hypoxic ventilation on dogs wasconducted either at 2 hours or at 4 hours after PB. During hypoxic ventilationflaxidel was used to maintain skeletal muscular relaxation, yet PB was not re-peated to diminish it’s influence on hypoxic responses. Blood gas assay was car-ried out in dogs during normoxia and hypoxic challenge. Hypoxic challengecaused significant increase of pulmonary artery pressure （Ppa） and almost nochange in systemic artery pressure （Psa） in awake rats. However in anestheticrats hypoxic challenge had little effect on Ppa, without influence on Psa. At 2and 4 hours after PB administration and catheterization hypoxic ventilationcaused similar change in blood gas （PaO<sub>2</sub> and PvO<sub>2</sub>）. However the second hy-poxic ventilation （4h） produced more significant pulmonary hemodynamic re-sponses （Ppa and TPVR greatly increased）. These results suggested thatpreferable acute hypoxic pulmonary hypertension developed either in awake ratsor in relatively shallow anesthetic state of dogs, indicating that PB anesthesiamay inhibit hypoxic pulmonary hemodynamic responses.
