目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为...目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为研究对象,根据28d临床结局将其分为病死组27例和存活组51例。比较两组的一般资料、24hLac清除率、NLR、PCT,采用多因素一般Logistic回归模型分析28d内病死的影响因素,采用受试者工作特征(ROC)曲线评估24hLac清除率联合NLR、PCT对28d内病死风险的预测价值。结果两组的性别、年龄、吸烟史、基础疾病、氧合指数、体温、平均动脉压、白细胞计数、血小板计数、抗菌药物使用时间比较,差异均无统计学意义(P>0.05);病死组肺炎严重程度评分(PSI)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、机械通气治疗占比均高于存活组(P<0.05);病死组24 h Lac清除率低于存活组,NLR、PCT水平高于存活组(P<0.05);经多因素一般Logistic回归分析,PSI评分[O^R=9.440(95%CI:4.108,21.697)]、APACHEⅡ评分[O^R=3.904(95%CI:1.699,8.972)]、24 h Lac清除率[O^R=5.068(95%CI:2.205,11.648)]、NLR[O^R=8.199(95%CI:3.567,18.843)]、PCT[O^R=5.766(95%CI:2.509,13.252)]均为28 d内病死的影响因素(P<0.05);ROC曲线分析结果显示,24 h Lac清除率、NLR、PCT预测28 d内病死的最佳截断值为26.10%、5.95和11.27μg/L,敏感性为81.48%(95%CI:0.613,0.930)、59.26%(95%CI:0.390,0.770)、66.67%(95%CI:0.460,0.828),特异性为72.55%(95%CI:0.580,0.837)、82.35%(95%CI:0.686,0.911)、90.20%(95%CI:0.778,0.963),AUC值为0.809(95%CI:0.704,0.889)、0.736(95%CI:0.624,0.830)、0.802(95%CI:0.697,0.884),联合预测的敏感性为92.59%(95%CI:0.742,0.987)、特异性为86.27%(95%CI:0.731,0.938)、AUC值为0.946(95%CI:0.871,0.985)。结论ICU重症肺炎28 d内病死患者的24 h Lac清除率、NLR、PCT明显异常变化,其对预后评估具有良好预测价值。展开更多
In：ZnO nanoparticles are prepared by the sol-gel process. The ratios of In/（Zn＋In） are 0%, 5%, 8%, 10%, and 15%, respectively. Crystal phase structures and optoelectronic properties of these samples are characteri...In：ZnO nanoparticles are prepared by the sol-gel process. The ratios of In/（Zn＋In） are 0%, 5%, 8%, 10%, and 15%, respectively. Crystal phase structures and optoelectronic properties of these samples are characterized and the chromaticity coordinates of different samples are also calculated in CIE-XYZ colour system. The results show that preferred growth direction of ZnO changes from （002） plane to （001） plane and interplanar distance becomes shorter. When the doping amount of In is 5%, Zn atoms are completely replaced by In atoms. The resistivities of the samples first decrease, then increase afterwards with the increase of the amount of In. With the increase of In, the ultraviolet emission is redshifted and new peaks occur at 465 nm, 535 nm, and 630 nm. The sample with 10% indium has white-light emission. The band structures of samples with 0% and 12.5% indium are investigated by the first principle method. The mechanism of white emission is discussed from the viewpoint of additional energy levels.展开更多
目的探讨肺复张术对机械通气患者血压、血氧饱和度(SaO2)的影响及临床效果。方法选择2008年2月至2009年8月38例实施肺复张术患者,分析其复张效果、肺复张术的不良反应等。肺复张采取固定驱动压、逐渐增加呼气末正压(PEEP)的方法,所有肺...目的探讨肺复张术对机械通气患者血压、血氧饱和度(SaO2)的影响及临床效果。方法选择2008年2月至2009年8月38例实施肺复张术患者,分析其复张效果、肺复张术的不良反应等。肺复张采取固定驱动压、逐渐增加呼气末正压(PEEP)的方法,所有肺复张患者均进行有创动脉血压监测。结果 38例患者进行了162次肺复张术,其中2例慢性阻塞性肺病急性加重(AECOPD)患者发生气胸,肺复张总有效率90%。肺复张中有效PEEP变化较大,最低6 cm H2O(1 cm H2O=0.098 kPa),最高30 cm H2O;SaO2维持最短0.5 h,最长126 h;平均每例患者接受4.26次,其中有1例患者最多接受8次肺复张术。18例(47%)患者在肺复张中曾经发生过低氧血症,162次肺复张术中发生72次(44%)低氧血症;开始诱发低氧血症的最低PEEP为6 cm H2O,最高为20 cm H2O,平均13.0 cm H2O。21例(55%)患者肺复张中曾发生过血压短暂降低,162次肺复张中有68次(41%)血压短暂降低;开始出现血压下降的最低PEEP为6 cm H2O,最高为21cm H2O,平均13.5 cm H2O。结论肺复张术可以有效改善SaO2,PEEP的设定应遵循个体化的原则。展开更多
文摘目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为研究对象,根据28d临床结局将其分为病死组27例和存活组51例。比较两组的一般资料、24hLac清除率、NLR、PCT,采用多因素一般Logistic回归模型分析28d内病死的影响因素,采用受试者工作特征(ROC)曲线评估24hLac清除率联合NLR、PCT对28d内病死风险的预测价值。结果两组的性别、年龄、吸烟史、基础疾病、氧合指数、体温、平均动脉压、白细胞计数、血小板计数、抗菌药物使用时间比较,差异均无统计学意义(P>0.05);病死组肺炎严重程度评分(PSI)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、机械通气治疗占比均高于存活组(P<0.05);病死组24 h Lac清除率低于存活组,NLR、PCT水平高于存活组(P<0.05);经多因素一般Logistic回归分析,PSI评分[O^R=9.440(95%CI:4.108,21.697)]、APACHEⅡ评分[O^R=3.904(95%CI:1.699,8.972)]、24 h Lac清除率[O^R=5.068(95%CI:2.205,11.648)]、NLR[O^R=8.199(95%CI:3.567,18.843)]、PCT[O^R=5.766(95%CI:2.509,13.252)]均为28 d内病死的影响因素(P<0.05);ROC曲线分析结果显示,24 h Lac清除率、NLR、PCT预测28 d内病死的最佳截断值为26.10%、5.95和11.27μg/L,敏感性为81.48%(95%CI:0.613,0.930)、59.26%(95%CI:0.390,0.770)、66.67%(95%CI:0.460,0.828),特异性为72.55%(95%CI:0.580,0.837)、82.35%(95%CI:0.686,0.911)、90.20%(95%CI:0.778,0.963),AUC值为0.809(95%CI:0.704,0.889)、0.736(95%CI:0.624,0.830)、0.802(95%CI:0.697,0.884),联合预测的敏感性为92.59%(95%CI:0.742,0.987)、特异性为86.27%(95%CI:0.731,0.938)、AUC值为0.946(95%CI:0.871,0.985)。结论ICU重症肺炎28 d内病死患者的24 h Lac清除率、NLR、PCT明显异常变化,其对预后评估具有良好预测价值。
基金supported by the Natural Science Foundation of Shandong Province of China (Grant No. Y2007G14)the Science and Technology Development Projects of Shandong Province of China (Grant Nos. 2009GG2003028 and 2010G0020423)+2 种基金the Doctoral Foundation of University of Jinan,China (Grant No. XBS0845)the Key Laboratory of Luminescence and Optical Information,Ministry of Education,Beijing Jiaotong University,China (Grant No. 2010L0101)the Scientific Research Foundation of University of Jinan,China (Grant No. XKY1029)
文摘In：ZnO nanoparticles are prepared by the sol-gel process. The ratios of In/（Zn＋In） are 0%, 5%, 8%, 10%, and 15%, respectively. Crystal phase structures and optoelectronic properties of these samples are characterized and the chromaticity coordinates of different samples are also calculated in CIE-XYZ colour system. The results show that preferred growth direction of ZnO changes from （002） plane to （001） plane and interplanar distance becomes shorter. When the doping amount of In is 5%, Zn atoms are completely replaced by In atoms. The resistivities of the samples first decrease, then increase afterwards with the increase of the amount of In. With the increase of In, the ultraviolet emission is redshifted and new peaks occur at 465 nm, 535 nm, and 630 nm. The sample with 10% indium has white-light emission. The band structures of samples with 0% and 12.5% indium are investigated by the first principle method. The mechanism of white emission is discussed from the viewpoint of additional energy levels.
文摘目的探讨肺复张术对机械通气患者血压、血氧饱和度(SaO2)的影响及临床效果。方法选择2008年2月至2009年8月38例实施肺复张术患者,分析其复张效果、肺复张术的不良反应等。肺复张采取固定驱动压、逐渐增加呼气末正压(PEEP)的方法,所有肺复张患者均进行有创动脉血压监测。结果 38例患者进行了162次肺复张术,其中2例慢性阻塞性肺病急性加重(AECOPD)患者发生气胸,肺复张总有效率90%。肺复张中有效PEEP变化较大,最低6 cm H2O(1 cm H2O=0.098 kPa),最高30 cm H2O;SaO2维持最短0.5 h,最长126 h;平均每例患者接受4.26次,其中有1例患者最多接受8次肺复张术。18例(47%)患者在肺复张中曾经发生过低氧血症,162次肺复张术中发生72次(44%)低氧血症;开始诱发低氧血症的最低PEEP为6 cm H2O,最高为20 cm H2O,平均13.0 cm H2O。21例(55%)患者肺复张中曾发生过血压短暂降低,162次肺复张中有68次(41%)血压短暂降低;开始出现血压下降的最低PEEP为6 cm H2O,最高为21cm H2O,平均13.5 cm H2O。结论肺复张术可以有效改善SaO2,PEEP的设定应遵循个体化的原则。
