Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of...Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of the disease is studied using 7T magnetic resonance imaging （MRI）. Pseudo image and multi-weight MRI methods show that the fat of seipin mice is virtually absent compared with WT mice. The three-dimensional （3-D） small animal visualization system for 7T MRI developed in this project facilitates to obtain the interested feature with stroke-based classification method. Student＇s t-test statistic result confirms that total fat and subcutaneous fat are less in seipin mice than those in WT mice. However, the visceral fat difference is not found in the experiment. Based on 7T MIRI, the study gives more reliable information on location and lipid contents of the tissue about seipin mice, thus it is important to explore the pathophysiological characteristics of the disease.展开更多
基金Supported by the National Natural Science Foundation of China (30830039)the National High Technology Research and Development Program of China ("863"Program) (2007AA02Z211)~~
文摘Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of the disease is studied using 7T magnetic resonance imaging （MRI）. Pseudo image and multi-weight MRI methods show that the fat of seipin mice is virtually absent compared with WT mice. The three-dimensional （3-D） small animal visualization system for 7T MRI developed in this project facilitates to obtain the interested feature with stroke-based classification method. Student＇s t-test statistic result confirms that total fat and subcutaneous fat are less in seipin mice than those in WT mice. However, the visceral fat difference is not found in the experiment. Based on 7T MIRI, the study gives more reliable information on location and lipid contents of the tissue about seipin mice, thus it is important to explore the pathophysiological characteristics of the disease.
