目的:探讨保留肝实质的治疗方式在结直肠癌肝转移(colorectal liver metastases,CRLM)手术切除中的意义。方法:回顾性分析北京大学肿瘤医院2000年1月至2016年5月手术切除的CRLM患者377例,根据手术方式分为保留肝实质(parenchymalsparing...目的:探讨保留肝实质的治疗方式在结直肠癌肝转移(colorectal liver metastases,CRLM)手术切除中的意义。方法:回顾性分析北京大学肿瘤医院2000年1月至2016年5月手术切除的CRLM患者377例,根据手术方式分为保留肝实质(parenchymalsparing hepatectomy,PSH)组305例和大范围肝切除(major hepatectomy,MH)组72例。比较两组患者的临床特征、手术情况、术后并发症及预后。结果:PSH组肝转移灶个数少于MH组,差异比较具有统计学意义(P=0.000)。全组采用PSH治疗的患者占80.9%,且随时间增长逐渐增多。PSH组手术时间比MH组短(177.5 min vs.220 min,P=0.000),手术出血比MH组少(150 m L vs.300 m L,P=0.000),术后并发症发生率比MH组低(47.4%vs.64.8%,P=0.008)。PSH组与MH组患者的总生存(overall survival,OS)时间、肝内无复发生存(hepatic recurrence free survival,HFRS)时间差异无统计学意义。PSH组患者复发后接受局部治疗的比例明显增加(42.8%vs.25.6%,P=0.040),复发患者中接受局部治疗的患者生存期明显延长(58个月vs.24个月,P=0.000)。结论:CRLM患者手术时采用PSH的治疗方式肝内复发率更低,安全性更高,复发后再次接受局部治疗的可能性明显增加,是推荐的治疗模式。展开更多
Objective： To explore the correlation between the Cdx2 expression and clinicopathologic features of patients with gastric carcinoma, and to evaluate the role of Cdx2 as a prognostic indicator of gastric carcinoma. Me...Objective： To explore the correlation between the Cdx2 expression and clinicopathologic features of patients with gastric carcinoma, and to evaluate the role of Cdx2 as a prognostic indicator of gastric carcinoma. Methods： The expression of Cdx2 was studied using immunohistochemistry of paraffin-embedded tumor specimens from 154 patients who underwent D2 resection for gastric adenocarcinoma from 1994 to 1998. Results： Cdx2 expression was detected in 35.1% （54 of 154） of gastric carcinoma cases. Expression of Cdx2 was significantly higher in intestinal-type carcinomas than in diffuse-type carcinomas, and in cases with TNM stage Ⅰ and Ⅱ than those with TNM stage Ⅲ and Ⅳ （P〈0.001 and P=-0.012, respectively）. There was a clear negative correlation between Cdx2 expression and lymph node metastasis （P=-0.049）. The patients with Cdx2-positive expression showed higher survival rate than those with Cdx2-negative expression （P〈0.0001）. Multivariate analysis revealed that the expression of Cdx2 was the independent prognostic indicator in this series （P〈0.001）. Conclusion： These data suggest that Cdx2 has significant value in predicting prognosis of gastric carcinoma.展开更多
Tomographic particle image velocimetry(Tomo-PIV) is a state-of-the-art experimental technique based on a method of optical tomography to achieve the three-dimensional(3D) reconstruction for threedimensional three-comp...Tomographic particle image velocimetry(Tomo-PIV) is a state-of-the-art experimental technique based on a method of optical tomography to achieve the three-dimensional(3D) reconstruction for threedimensional three-component(3D-3C) flow velocity measurements. 3D reconstruction for Tomo-PIV is carried out herein. Meanwhile, a 3D simplified tomographic reconstruction model reduced from a 3D volume light intensity field with 2D projection images into a 2D Tomo-slice plane with 1D projecting lines, i.e., simplifying this 3D reconstruction into a problem of 2D Tomo-slice plane reconstruction, is applied thereafter. Two kinds of the most well-known algebraic reconstruction techniques, algebraic reconstruction technique(ART) and multiple algebraic reconstruction technique(MART), are compared as well. The principles of the two reconstruction algorithms are discussed in detail, which has been performed by a series of simulation images, yielding the corresponding reconstruction images that show different features between the ART and MART algorithm, and then their advantages and disadvantages are discussed. Further discussions are made for the standard particle image reconstruction when the background noise of the pre-initial particle image has been removed. Results show that the particle image reconstruction has been greatly improved. The MART algorithm is much better than the ART. Furthermore, the computational analyses of two parameters(the particle density and the number of cameras), are performed to study their effects on the reconstruction. Lastly, the 3D volume particle field is reconstructed by using the improved algorithm based on the simplified 3D tomographic reconstruction model, which proves that the algorithm simplification is feasible and it can be applied to the reconstruction of 3D volume particle field in a Tomo-PIV system.展开更多
文摘目的:探讨保留肝实质的治疗方式在结直肠癌肝转移(colorectal liver metastases,CRLM)手术切除中的意义。方法:回顾性分析北京大学肿瘤医院2000年1月至2016年5月手术切除的CRLM患者377例,根据手术方式分为保留肝实质(parenchymalsparing hepatectomy,PSH)组305例和大范围肝切除(major hepatectomy,MH)组72例。比较两组患者的临床特征、手术情况、术后并发症及预后。结果:PSH组肝转移灶个数少于MH组,差异比较具有统计学意义(P=0.000)。全组采用PSH治疗的患者占80.9%,且随时间增长逐渐增多。PSH组手术时间比MH组短(177.5 min vs.220 min,P=0.000),手术出血比MH组少(150 m L vs.300 m L,P=0.000),术后并发症发生率比MH组低(47.4%vs.64.8%,P=0.008)。PSH组与MH组患者的总生存(overall survival,OS)时间、肝内无复发生存(hepatic recurrence free survival,HFRS)时间差异无统计学意义。PSH组患者复发后接受局部治疗的比例明显增加(42.8%vs.25.6%,P=0.040),复发患者中接受局部治疗的患者生存期明显延长(58个月vs.24个月,P=0.000)。结论:CRLM患者手术时采用PSH的治疗方式肝内复发率更低,安全性更高,复发后再次接受局部治疗的可能性明显增加,是推荐的治疗模式。
基金This work was supported by the grants from the Key Technologies Research and Development Program of China (No. 2002BA711A06) the National Basic Research Priorities Program 973 Project from the Ministry of Science and Technology of China(No. 1998051203) and the grant from the Beijing Science and Technology Commission.(No. H020920030390).
文摘Objective： To explore the correlation between the Cdx2 expression and clinicopathologic features of patients with gastric carcinoma, and to evaluate the role of Cdx2 as a prognostic indicator of gastric carcinoma. Methods： The expression of Cdx2 was studied using immunohistochemistry of paraffin-embedded tumor specimens from 154 patients who underwent D2 resection for gastric adenocarcinoma from 1994 to 1998. Results： Cdx2 expression was detected in 35.1% （54 of 154） of gastric carcinoma cases. Expression of Cdx2 was significantly higher in intestinal-type carcinomas than in diffuse-type carcinomas, and in cases with TNM stage Ⅰ and Ⅱ than those with TNM stage Ⅲ and Ⅳ （P〈0.001 and P=-0.012, respectively）. There was a clear negative correlation between Cdx2 expression and lymph node metastasis （P=-0.049）. The patients with Cdx2-positive expression showed higher survival rate than those with Cdx2-negative expression （P〈0.0001）. Multivariate analysis revealed that the expression of Cdx2 was the independent prognostic indicator in this series （P〈0.001）. Conclusion： These data suggest that Cdx2 has significant value in predicting prognosis of gastric carcinoma.
基金Supported by the National Natural Science Foundation of China(No.11332006No.11272233 and No.11411130150)+2 种基金the Foundation from China Scholarship Council(CSCNo.201306250092)the Foundation Project for Outstanding Doctoral Dissertations of Tianjin University
文摘Tomographic particle image velocimetry(Tomo-PIV) is a state-of-the-art experimental technique based on a method of optical tomography to achieve the three-dimensional(3D) reconstruction for threedimensional three-component(3D-3C) flow velocity measurements. 3D reconstruction for Tomo-PIV is carried out herein. Meanwhile, a 3D simplified tomographic reconstruction model reduced from a 3D volume light intensity field with 2D projection images into a 2D Tomo-slice plane with 1D projecting lines, i.e., simplifying this 3D reconstruction into a problem of 2D Tomo-slice plane reconstruction, is applied thereafter. Two kinds of the most well-known algebraic reconstruction techniques, algebraic reconstruction technique(ART) and multiple algebraic reconstruction technique(MART), are compared as well. The principles of the two reconstruction algorithms are discussed in detail, which has been performed by a series of simulation images, yielding the corresponding reconstruction images that show different features between the ART and MART algorithm, and then their advantages and disadvantages are discussed. Further discussions are made for the standard particle image reconstruction when the background noise of the pre-initial particle image has been removed. Results show that the particle image reconstruction has been greatly improved. The MART algorithm is much better than the ART. Furthermore, the computational analyses of two parameters(the particle density and the number of cameras), are performed to study their effects on the reconstruction. Lastly, the 3D volume particle field is reconstructed by using the improved algorithm based on the simplified 3D tomographic reconstruction model, which proves that the algorithm simplification is feasible and it can be applied to the reconstruction of 3D volume particle field in a Tomo-PIV system.
