目的:探讨双背侧前额叶高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗精神分裂症难治性阴性症状的疗效和安全性,并观察不良反应。方法:本研究为双盲随机对照临床试验。研究对象来源于2002年11月1日至2003...目的:探讨双背侧前额叶高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗精神分裂症难治性阴性症状的疗效和安全性,并观察不良反应。方法:本研究为双盲随机对照临床试验。研究对象来源于2002年11月1日至2003年12月31日期间就诊于北京大学第六医院和北京安定医院的门诊和住院患者,符合美国精神疾病诊断与统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-IV)中精神分裂症诊断标准。23例以难治性阴性症状为主的精神分裂症患者随机分为rTMS治疗组(n=12)和对照组(n=11),分别给予10次20Hz rTMS真刺激和伪刺激治疗,治疗期间维持原有抗精神病药种类及剂量不变。采用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评估临床症状,采用治疗中需处理的不良反应症状量表(Treatment Emergent Symptom Scale,TESS)及其他检查评估不良反应。结果:23例患者均完成治疗。治疗组有效率高于对照组(34%vs.17%,P<0.05)。未观察到明显不良反应。结论:抗精神病药合并20Hz双背侧前额叶重复经颅磁刺激治疗精神分裂症难治性阴性症状有效、安全。展开更多
AIM:To evaluate the effectiveness of hospitalized occupational rehabilitation for chronic schizophrenic patients in social functioning.METHODS:79 qualified cases were selected from chronic psychiatric inpatient depart...AIM:To evaluate the effectiveness of hospitalized occupational rehabilitation for chronic schizophrenic patients in social functioning.METHODS:79 qualified cases were selected from chronic psychiatric inpatient departments,divided into two groups randomly,of which 45 cases of treatment group accepted hospitalized occupational rehabilitation,another 34 cases of control group accepted ordinary treatment.Social functioning was evaluated by the Scale of Social Skills of Chronic Schizophrenic In patients(SSSI). RESULTS:6 month course of research figured out that the rank of improvement of the total disability degree of the treatment was significantly larger than that of the control group(P< 0.05).Items of which rank of improvement of the treatment was significantly larger than those of the control group are participating in the occupational rehabilitation,social withdraw and concern and care about others (P< 0.01-0.05).The level of disability of 55.6%of the treatment decreased more than that of the control (26.5%) (P< 0.05) evaluated by SSSI.CONCLUSION:Hospitalized occupational rehabilitation is effective in improving social functioning of chronic schizophrenic patients,especially in improving items like participating in the occupational rehabilitation, social withdraw and concern and care about others.展开更多
文摘目的:探讨双背侧前额叶高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗精神分裂症难治性阴性症状的疗效和安全性,并观察不良反应。方法:本研究为双盲随机对照临床试验。研究对象来源于2002年11月1日至2003年12月31日期间就诊于北京大学第六医院和北京安定医院的门诊和住院患者,符合美国精神疾病诊断与统计手册第4版(Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DSM-IV)中精神分裂症诊断标准。23例以难治性阴性症状为主的精神分裂症患者随机分为rTMS治疗组(n=12)和对照组(n=11),分别给予10次20Hz rTMS真刺激和伪刺激治疗,治疗期间维持原有抗精神病药种类及剂量不变。采用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评估临床症状,采用治疗中需处理的不良反应症状量表(Treatment Emergent Symptom Scale,TESS)及其他检查评估不良反应。结果:23例患者均完成治疗。治疗组有效率高于对照组(34%vs.17%,P<0.05)。未观察到明显不良反应。结论:抗精神病药合并20Hz双背侧前额叶重复经颅磁刺激治疗精神分裂症难治性阴性症状有效、安全。
文摘AIM:To evaluate the effectiveness of hospitalized occupational rehabilitation for chronic schizophrenic patients in social functioning.METHODS:79 qualified cases were selected from chronic psychiatric inpatient departments,divided into two groups randomly,of which 45 cases of treatment group accepted hospitalized occupational rehabilitation,another 34 cases of control group accepted ordinary treatment.Social functioning was evaluated by the Scale of Social Skills of Chronic Schizophrenic In patients(SSSI). RESULTS:6 month course of research figured out that the rank of improvement of the total disability degree of the treatment was significantly larger than that of the control group(P< 0.05).Items of which rank of improvement of the treatment was significantly larger than those of the control group are participating in the occupational rehabilitation,social withdraw and concern and care about others (P< 0.01-0.05).The level of disability of 55.6%of the treatment decreased more than that of the control (26.5%) (P< 0.05) evaluated by SSSI.CONCLUSION:Hospitalized occupational rehabilitation is effective in improving social functioning of chronic schizophrenic patients,especially in improving items like participating in the occupational rehabilitation, social withdraw and concern and care about others.