目的评估十堰市理发及美容场所室内空气质量(indoor air quality,IAQ)水平,探究其与从业人员健康状况间的关联。方法2019—2021年在十堰市抽取理发及美容场所开展室内空气质量监测,收集从业人员健康信息,采用多元Logistic回归分析室内...目的评估十堰市理发及美容场所室内空气质量(indoor air quality,IAQ)水平,探究其与从业人员健康状况间的关联。方法2019—2021年在十堰市抽取理发及美容场所开展室内空气质量监测,收集从业人员健康信息,采用多元Logistic回归分析室内空气质量与从业人员自报健康症状间的关联。结果共收集5轮次场所室内空气质量和212人次从业人员健康数据。室内空气中氨、甲醛及PM_(2.5)存在超标情况,从业人员眼部、呼吸系统及皮肤症状自报率分别为22.2%、20.2%及16.5%。多元Logistic回归分析结果显示,空气中氨的暴露浓度越高,从业人员出现眼部症状的风险越高,OR(95%CI)值为5.83(1.11,36.98);甲醛、氨及PM_(2.5)暴露浓度越高,出现呼吸系统症状的风险越高,OR(95%CI)值分别为4.73(1.08,23.38)、5.60(1.46,24.77)及4.51(1.15,20.56);甲醛、氨及PM_(2.5)暴露浓度越高,出现皮肤症状的风险越高,OR(95%CI)值分别为6.08(1.03,41.71)、5.82(1.16,36.35)及7.13(1.41,47.59)。此外,室内温度较低、年龄较小和每日工作超8 h也是影响从业人员健康状况的危险因素。结论十堰市理发及美容场所室内空气质量对从业人员存在健康风险,特别应重视超标污染物的潜在危害;此外,场所室内温度和每日工作时长等因素所致潜在健康隐患亦不容忽视。展开更多
Summary： The contribution of particles to cardiovascular mortality and morbidity has been enlightened by epidemiologic and experimental studies. However, adverse biological effects of the particles with different siz...Summary： The contribution of particles to cardiovascular mortality and morbidity has been enlightened by epidemiologic and experimental studies. However, adverse biological effects of the particles with different sizes on cardiovascular cells have not been well recognized. In this study, sub-cultured human umbilical vein endothelial cells （HUVECs） were exposed to increasing concentrations of pure quartz particles （DQ） of three sizes （DQPM1, 〈1 μm; DQPM3-5, 3-5 μm; DQPM5, 5 μm） and carbon black particles of two sizes （CB0.1, 〈0.1 μm; CB 1, 〈 1 μm） for 24 h. Cytotoxicity was estimated by measuring the activity of lactate dehydrogenase （LDH） and cell viability. Nitric oxide （NO） generation and cyto- kines （TNF-α and IL-1β） releases were analyzed by using NO assay and enzyme-linked immunoabsorbent assay （ELISA）, respectively. It was found that both particles induced adverse biological effects on HUVECs in a dose-dependent manner. The size of particle directly influenced the biological activity. For quartz, the smaller particles induced stronger cytotoxicity and higher levels of cytokine responses than those particles of big size. For carbon black particles, CB0.1 was more capable of inducing adverse responses on HUVECs than CB 1 only at lower particle concentrations, in contrast to those at higher concentrations. Meanwhile, our data also revealed that quartz particles performed stronger cell damage and produced higher levels of TNF-α than carbon black particles, even if particles size was similar. In conclusion, particle size as well as particle composition should be both considered in assessing vascular endothelial cells injury and inflammation responses induced by particles.展开更多
文摘目的评估十堰市理发及美容场所室内空气质量(indoor air quality,IAQ)水平,探究其与从业人员健康状况间的关联。方法2019—2021年在十堰市抽取理发及美容场所开展室内空气质量监测,收集从业人员健康信息,采用多元Logistic回归分析室内空气质量与从业人员自报健康症状间的关联。结果共收集5轮次场所室内空气质量和212人次从业人员健康数据。室内空气中氨、甲醛及PM_(2.5)存在超标情况,从业人员眼部、呼吸系统及皮肤症状自报率分别为22.2%、20.2%及16.5%。多元Logistic回归分析结果显示,空气中氨的暴露浓度越高,从业人员出现眼部症状的风险越高,OR(95%CI)值为5.83(1.11,36.98);甲醛、氨及PM_(2.5)暴露浓度越高,出现呼吸系统症状的风险越高,OR(95%CI)值分别为4.73(1.08,23.38)、5.60(1.46,24.77)及4.51(1.15,20.56);甲醛、氨及PM_(2.5)暴露浓度越高,出现皮肤症状的风险越高,OR(95%CI)值分别为6.08(1.03,41.71)、5.82(1.16,36.35)及7.13(1.41,47.59)。此外,室内温度较低、年龄较小和每日工作超8 h也是影响从业人员健康状况的危险因素。结论十堰市理发及美容场所室内空气质量对从业人员存在健康风险,特别应重视超标污染物的潜在危害;此外,场所室内温度和每日工作时长等因素所致潜在健康隐患亦不容忽视。
基金supported by grants from the National Basic Research Program of China(No.2011CB503804)the National Natural Science Foundation of China(No.81372967)
文摘Summary： The contribution of particles to cardiovascular mortality and morbidity has been enlightened by epidemiologic and experimental studies. However, adverse biological effects of the particles with different sizes on cardiovascular cells have not been well recognized. In this study, sub-cultured human umbilical vein endothelial cells （HUVECs） were exposed to increasing concentrations of pure quartz particles （DQ） of three sizes （DQPM1, 〈1 μm; DQPM3-5, 3-5 μm; DQPM5, 5 μm） and carbon black particles of two sizes （CB0.1, 〈0.1 μm; CB 1, 〈 1 μm） for 24 h. Cytotoxicity was estimated by measuring the activity of lactate dehydrogenase （LDH） and cell viability. Nitric oxide （NO） generation and cyto- kines （TNF-α and IL-1β） releases were analyzed by using NO assay and enzyme-linked immunoabsorbent assay （ELISA）, respectively. It was found that both particles induced adverse biological effects on HUVECs in a dose-dependent manner. The size of particle directly influenced the biological activity. For quartz, the smaller particles induced stronger cytotoxicity and higher levels of cytokine responses than those particles of big size. For carbon black particles, CB0.1 was more capable of inducing adverse responses on HUVECs than CB 1 only at lower particle concentrations, in contrast to those at higher concentrations. Meanwhile, our data also revealed that quartz particles performed stronger cell damage and produced higher levels of TNF-α than carbon black particles, even if particles size was similar. In conclusion, particle size as well as particle composition should be both considered in assessing vascular endothelial cells injury and inflammation responses induced by particles.
