目的:研究盐酸左氧氟沙星胶囊的人体生物等效性。方法:健康志愿者20名,随机双交叉单剂量口服试验和参比的盐酸左氧氟沙星胶囊,剂量分别为200 mg,剂间间隔为2周。分别于服药后24 h 内多点抽取静脉血;用高效液相色谱(HPLC)法测定血浆中左...目的:研究盐酸左氧氟沙星胶囊的人体生物等效性。方法:健康志愿者20名,随机双交叉单剂量口服试验和参比的盐酸左氧氟沙星胶囊,剂量分别为200 mg,剂间间隔为2周。分别于服药后24 h 内多点抽取静脉血;用高效液相色谱(HPLC)法测定血浆中左氧氟沙星的浓度。用3p97药代动力学程序计算相对生物利用度并评价两种制剂生物等效性。结果:单剂量口服试验制剂和参比制剂后血浆中的左氧氟沙星的 C_(max)分别为(2.316±O.312)mg·L^(-1)及(2.419±0.244)mg·L^(-1);T_(max)分别为(1.008±0.326)h 及(1.067±0.244)h;AUC_(0-24)分别为(16.277±2.204)mg·h·L^(-1)及(16.951±2.088)mg·h·L^(-1);AUC_(0-inf)分别为(17.750±2.301)mg·h·L^(-1)及(18.289±2.482)mg·h·L^(-1)。C_(max)、AUC_(0-24)、AUC_(0-inf)的90%可信区间分别为91.0%～100.0%,91.7%～100.4%,92.6%～102.0%。结论:试验制剂与参比制剂的人体相对生物利用度为(96.7±11.9)%,试验制剂与参比制剂具有生物学等效性。展开更多
Five 2 methyl 5 nitroimidazol derivatives were synthesized primarily from oxalaldehyde,ethanal via cyclization,nitration,esterification.The strutures of these compounds have been examined and confirmed by IR, 1H NMR,U...Five 2 methyl 5 nitroimidazol derivatives were synthesized primarily from oxalaldehyde,ethanal via cyclization,nitration,esterification.The strutures of these compounds have been examined and confirmed by IR, 1H NMR,UV spectra as well as elementary analysis.展开更多
文摘Five 2 methyl 5 nitroimidazol derivatives were synthesized primarily from oxalaldehyde,ethanal via cyclization,nitration,esterification.The strutures of these compounds have been examined and confirmed by IR, 1H NMR,UV spectra as well as elementary analysis.
