The dynamic behavior,rapid mobility,abrupt changes in network topology,and numerous other flying constraints in unmanned aerial vehicle(UAV)networks make the design of a routing protocol a challenging task.The data ro...The dynamic behavior,rapid mobility,abrupt changes in network topology,and numerous other flying constraints in unmanned aerial vehicle(UAV)networks make the design of a routing protocol a challenging task.The data routing for communication between UAVs faces numerous challenges,such as low link quality,data loss,and routing path failure.This work proposes greedy perimeter stateless routing(GPSR)based design and implementation of a new adaptive communication routing protocol technique for UAVs,allowing multiple UAVs to communicate more effectively with each other in a group.Close imitation of the real environment is accomplished by considering UAVs’three-dimensional(3D)mobility in the simulations.The performance of the proposed intelligent greedy perimeter stateless routing(IGPSR)scheme has been evaluated based on end-to-end(E2E)delay,network throughput,and data loss ratio.The adapted scheme displayed on average 40%better results.The scenario has been implemented holistically on the network simulator software NS-3.展开更多
目的淋巴转移是恶性肿瘤最常见的转移途径之一。黄芪对肿瘤淋巴转移具有积极的治疗作用。本文通过对黄芪的网络药理学分析,探讨黄芪治疗淋巴转移的潜在靶点及作用机制,为后续研究提供有针对性的指导。方法利用中药系统药理学数据库与分...目的淋巴转移是恶性肿瘤最常见的转移途径之一。黄芪对肿瘤淋巴转移具有积极的治疗作用。本文通过对黄芪的网络药理学分析,探讨黄芪治疗淋巴转移的潜在靶点及作用机制,为后续研究提供有针对性的指导。方法利用中药系统药理学数据库与分析平台、台湾中医药数据库、中药整合数据库及瑞士靶点预测网站建立黄芪有效成分和靶点数据库,利用比较基因组数据库、DisGeNET数据库及在线人类孟德尔遗传数据库建立淋巴转移相关靶点数据库,并与黄芪靶点数据库相匹配。在匹配结果的基础上,应用STRING数据库分析靶标之间的相互作用,并利用生物学信息注释数据库进行靶点基因本体(gene ontology,GO)生物学过程分析和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)信号通路富集分析,运用Cytoscape3.6.0软件进行网络分析。结果共发现黄芪治疗肿瘤淋巴转移有51个可能的重要靶点,经GO富集分析得到炎症相关的20个细胞生物学过程(P<0.05),经KEGG富集分析得到炎症相关的8个通路(P<0.05),其中主要包括肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、Toll样受体(Toll like receptor,TLR)信号通路及核因子κB(nuclear factor kappa-B,NF-κB)信号通路等。结论黄芪对肿瘤淋巴转移的治疗作用可能是多靶点、多途径、多层次的,槲皮素和山奈酚可能是其中较重要的两个有效成分,而TNF信号通路、TLR信号通路及NF-κB信号通路可能是本药发挥作用较重要的三条信号通路。展开更多
基金Shanghai Summit Discipline in Design,ChinaSpecial Project Funding for the Shanghai Municipal Commission of Economy and Information Civil-Military Inosculation Project,China(No.JMRH-2018-1042)。
文摘The dynamic behavior,rapid mobility,abrupt changes in network topology,and numerous other flying constraints in unmanned aerial vehicle(UAV)networks make the design of a routing protocol a challenging task.The data routing for communication between UAVs faces numerous challenges,such as low link quality,data loss,and routing path failure.This work proposes greedy perimeter stateless routing(GPSR)based design and implementation of a new adaptive communication routing protocol technique for UAVs,allowing multiple UAVs to communicate more effectively with each other in a group.Close imitation of the real environment is accomplished by considering UAVs’three-dimensional(3D)mobility in the simulations.The performance of the proposed intelligent greedy perimeter stateless routing(IGPSR)scheme has been evaluated based on end-to-end(E2E)delay,network throughput,and data loss ratio.The adapted scheme displayed on average 40%better results.The scenario has been implemented holistically on the network simulator software NS-3.
文摘目的淋巴转移是恶性肿瘤最常见的转移途径之一。黄芪对肿瘤淋巴转移具有积极的治疗作用。本文通过对黄芪的网络药理学分析,探讨黄芪治疗淋巴转移的潜在靶点及作用机制,为后续研究提供有针对性的指导。方法利用中药系统药理学数据库与分析平台、台湾中医药数据库、中药整合数据库及瑞士靶点预测网站建立黄芪有效成分和靶点数据库,利用比较基因组数据库、DisGeNET数据库及在线人类孟德尔遗传数据库建立淋巴转移相关靶点数据库,并与黄芪靶点数据库相匹配。在匹配结果的基础上,应用STRING数据库分析靶标之间的相互作用,并利用生物学信息注释数据库进行靶点基因本体(gene ontology,GO)生物学过程分析和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)信号通路富集分析,运用Cytoscape3.6.0软件进行网络分析。结果共发现黄芪治疗肿瘤淋巴转移有51个可能的重要靶点,经GO富集分析得到炎症相关的20个细胞生物学过程(P<0.05),经KEGG富集分析得到炎症相关的8个通路(P<0.05),其中主要包括肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、Toll样受体(Toll like receptor,TLR)信号通路及核因子κB(nuclear factor kappa-B,NF-κB)信号通路等。结论黄芪对肿瘤淋巴转移的治疗作用可能是多靶点、多途径、多层次的,槲皮素和山奈酚可能是其中较重要的两个有效成分,而TNF信号通路、TLR信号通路及NF-κB信号通路可能是本药发挥作用较重要的三条信号通路。
