Results of comparative study of Human Leu-cocytic Antigen (HLA-A), -B typing in 73 breast cancer (BC) patients having different estrogen receptor (ER) status and 50 healthy individuals in the northern part of China ar...Results of comparative study of Human Leu-cocytic Antigen (HLA-A), -B typing in 73 breast cancer (BC) patients having different estrogen receptor (ER) status and 50 healthy individuals in the northern part of China are reported. In 58 of the 73 patients, HLA-C, -DR typing were also studied in addition. The results of this study showed that HLA-Bw61 (40) were negatively associated with BC, while -Cw7 and -DRw6 were positively associated with BC. Moreover, -DR was more closely associated with ER(+) status with a RR value of 8.621. In the ER(-) group, there were no specific related antigens. In the light of the differences in pathology, prognosis and effect of endocrine therapy between ER(+) and ER(-) status, the authors are inclined to the view that the two kinds of breast cancer may be a heterogeneous disease.展开更多
外照射急性放射病的发生是从核武器研制丌始的。美国曼哈顿计划为此作了准备，1946年5月美国LosAlamos科学实验室发生临界事故，有12人受剑γ线和中子照射，其中2人分别于照后9d和24d死亡.1952年内科学年鉴（Ann Int Med）全文报道了其...外照射急性放射病的发生是从核武器研制丌始的。美国曼哈顿计划为此作了准备，1946年5月美国LosAlamos科学实验室发生临界事故，有12人受剑γ线和中子照射，其中2人分别于照后9d和24d死亡.1952年内科学年鉴（Ann Int Med）全文报道了其中9例并附有局部放射性烧伤图片.展开更多
文摘Results of comparative study of Human Leu-cocytic Antigen (HLA-A), -B typing in 73 breast cancer (BC) patients having different estrogen receptor (ER) status and 50 healthy individuals in the northern part of China are reported. In 58 of the 73 patients, HLA-C, -DR typing were also studied in addition. The results of this study showed that HLA-Bw61 (40) were negatively associated with BC, while -Cw7 and -DRw6 were positively associated with BC. Moreover, -DR was more closely associated with ER(+) status with a RR value of 8.621. In the ER(-) group, there were no specific related antigens. In the light of the differences in pathology, prognosis and effect of endocrine therapy between ER(+) and ER(-) status, the authors are inclined to the view that the two kinds of breast cancer may be a heterogeneous disease.
