Objective：To evaluate the synergistic effects of tetrandrine（TET）on the antifungal activity of topical ketoconazole（KCZ）in the treatment of dermatophytoses.Methods：The minimum inhibitory concentrations（MICs）fo...Objective：To evaluate the synergistic effects of tetrandrine（TET）on the antifungal activity of topical ketoconazole（KCZ）in the treatment of dermatophytoses.Methods：The minimum inhibitory concentrations（MICs）for KCZ and combined KCZ and TET were compared in vitro.A randomized,double-blind trial was conducted among 97 patients with dermatophytoses who were assigned to 3 groups and received： treatment with combination of 2%KZC and 2%TET cream（KCZ＋TET group）,or only 2%KZC cream（KCZ group）,or 2%TET cream（TET group）.Patients with tinea corporis and/or tinea cruris were treated for 2 weeks, separately.The patients with tinea pedis and/or tinea manuum were treated for 4 weeks.Results：Compared with KZC alone,combined use of KZC and TET showed lower MICs against clinical isolates of dermatophytes （P0.05 for all）.In the patients with tinea corporis and/or tinea cruris,the rates of overall cure（clinical cure plus mycologic clearance）were 81.25%vs.33.33%for combined treatment and KZC monotherapy,respectively, after 4 weeks.All clinical indices were significantly different between the combination therapy and only KCZ therapy groups（P0.05）.Among the patients with tinea pedis and/or tinea manuum after 4 weeks treatment,the overall cure rates in the KCZ ＋ TET group and KCZ group were 75.00%vs.40.00%,respectively.In the KCZ ＋ TET group,all the clinical indices were significantly better than those in the KCZ group and TET group（P0.05）. The rates of overall efficacy in the TET group were all zero.No local skin redness or itching was observed during TET treatment.No clinically significant changes were found in post-treatment routine blood,urine,or stool tests, ECG,or tests for liver and kidney function;no serious adverse events occurred.Conclusion：TET synergistically enhanced the clinical efficacy of topical KZC cream in the treatment of dermatophytoses.展开更多
基金Supported by the National Naturral Science Foundation of China(No.30972660)Foundation of Science and Technology Planning Project of Guangdong Province,China(No. 2009B030801015 and No.2008B030301350)
文摘Objective：To evaluate the synergistic effects of tetrandrine（TET）on the antifungal activity of topical ketoconazole（KCZ）in the treatment of dermatophytoses.Methods：The minimum inhibitory concentrations（MICs）for KCZ and combined KCZ and TET were compared in vitro.A randomized,double-blind trial was conducted among 97 patients with dermatophytoses who were assigned to 3 groups and received： treatment with combination of 2%KZC and 2%TET cream（KCZ＋TET group）,or only 2%KZC cream（KCZ group）,or 2%TET cream（TET group）.Patients with tinea corporis and/or tinea cruris were treated for 2 weeks, separately.The patients with tinea pedis and/or tinea manuum were treated for 4 weeks.Results：Compared with KZC alone,combined use of KZC and TET showed lower MICs against clinical isolates of dermatophytes （P0.05 for all）.In the patients with tinea corporis and/or tinea cruris,the rates of overall cure（clinical cure plus mycologic clearance）were 81.25%vs.33.33%for combined treatment and KZC monotherapy,respectively, after 4 weeks.All clinical indices were significantly different between the combination therapy and only KCZ therapy groups（P0.05）.Among the patients with tinea pedis and/or tinea manuum after 4 weeks treatment,the overall cure rates in the KCZ ＋ TET group and KCZ group were 75.00%vs.40.00%,respectively.In the KCZ ＋ TET group,all the clinical indices were significantly better than those in the KCZ group and TET group（P0.05）. The rates of overall efficacy in the TET group were all zero.No local skin redness or itching was observed during TET treatment.No clinically significant changes were found in post-treatment routine blood,urine,or stool tests, ECG,or tests for liver and kidney function;no serious adverse events occurred.Conclusion：TET synergistically enhanced the clinical efficacy of topical KZC cream in the treatment of dermatophytoses.
