Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio-and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and r...Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio-and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy. Among them 55 cases were treated together with FZBZD (group A),30 cases together with Zhenqi Fuzheng Granules (group B), and the other 32 cases treated with radio-and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy in treating transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted experimentally. Results: Effective rates (CR + PR) of group A, B and C were 63. 6%, 43. 3 % and 37. 5% respectively, that of group A being the best (P < 0. 05). The survival quality of life was improved the most in group A (P < 0. 05).The picture of peripheral blood (WBC, Hb, PLT count) of group A after treatment was better than that of the other two groups (P < 0. 05 ). And CD3, CD4, NK activity, interleukin-2 levels were also improved more significantly in group A (P < 0. 01 ) than those in the other two. Animal experiment showed that FZBZD could improve the effect of chemotherapy in inhibiting tumor growth (P < 0. 01 ), raising cAMP/cGMP ratio (P < 0.01 ) by increasing the cAMP level in cancer tissue, and enhancing cells of G0/G1 phase and reducing cells of S phase. Conclusion: FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and halting tumor cells in G0/G1 phase.展开更多
文摘Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio-and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy. Among them 55 cases were treated together with FZBZD (group A),30 cases together with Zhenqi Fuzheng Granules (group B), and the other 32 cases treated with radio-and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy in treating transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted experimentally. Results: Effective rates (CR + PR) of group A, B and C were 63. 6%, 43. 3 % and 37. 5% respectively, that of group A being the best (P < 0. 05). The survival quality of life was improved the most in group A (P < 0. 05).The picture of peripheral blood (WBC, Hb, PLT count) of group A after treatment was better than that of the other two groups (P < 0. 05 ). And CD3, CD4, NK activity, interleukin-2 levels were also improved more significantly in group A (P < 0. 01 ) than those in the other two. Animal experiment showed that FZBZD could improve the effect of chemotherapy in inhibiting tumor growth (P < 0. 01 ), raising cAMP/cGMP ratio (P < 0.01 ) by increasing the cAMP level in cancer tissue, and enhancing cells of G0/G1 phase and reducing cells of S phase. Conclusion: FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and halting tumor cells in G0/G1 phase.
