A concept of tissue adaptation to hypoxia(i.e. hypoxic preconditioning) was developed and its corresponding animal models were reproduced in 1966s. The methods of model reproduction in rat,rabbit,and mouse in particul...A concept of tissue adaptation to hypoxia(i.e. hypoxic preconditioning) was developed and its corresponding animal models were reproduced in 1966s. The methods of model reproduction in rat,rabbit,and mouse in particular and the main results are brifly introduced in this review. The tolerance to hypoxia of preconditioned animals is significantly increased. Regular changes in animals’ behavior,neurophysiology,respiratory and circulatory physiology,neuromorphology in vivo and function of brain and spinal cord in vitro are briefly demonstrated.The protective effects in vivo and in vitro of homogenate extract taken from the brain of preconditioned animals,neurochemcals and molecular neurobiological alterations are briefly presented. The essence and significance of tissue adaption to hypoxia/hypoxic preconditioning are discussed in the review in terms of evolution and practical implication.展开更多
本工作用细胞内记录技术,研究并分析了蟾蜍离体脊神经节神经元对重复刺激其外周突(坐骨神经)的反应。所记录的66个神经元的传导速度,刺激阈值和静息膜电位分別为5.3—20.0m/s,0.02—0.10mA 和-50—-80mV。随着重复刺激频率的增加,脊神...本工作用细胞内记录技术,研究并分析了蟾蜍离体脊神经节神经元对重复刺激其外周突(坐骨神经)的反应。所记录的66个神经元的传导速度,刺激阈值和静息膜电位分別为5.3—20.0m/s,0.02—0.10mA 和-50—-80mV。随着重复刺激频率的增加,脊神经节神经元的细胞内动作电位进行性地出现潜伏期动摇或延迟、振幅降低、后超极化减弱和时程延长。与此同时,锋电位分解成 S、NM 和 M 三种亚波成分,并进而出现脱失。S、NM 和 M 成分对刺激频率的跟随能力为 S<NM<M,锋电位或 S 波出现脱失的频率范围为16.7—250Hz。结果提示,蟾蜍脊神经节 A 型神经元具有三个兴奋性显著有别的区域;部分 A 型神经元可能具有突触或接头性活动。展开更多
An inner abilitv of organism to protect itself can be triggered or motivated by pretreatment of brief intermittent ischemia or repetitive slight hypoxia and a POwerful defence and protection from severe injury of succ...An inner abilitv of organism to protect itself can be triggered or motivated by pretreatment of brief intermittent ischemia or repetitive slight hypoxia and a POwerful defence and protection from severe injury of successive ischemia or hypoxia can thus be achieved, The neuroprotective action exerted by preconditioning seems to be re1ated to up/down regulation of contents or activity of some known neuroactive chemicals and/or generation of some unknown antihypoxic/ischemic neuroactive chemicals or mechanisms in the brain.展开更多
文摘A concept of tissue adaptation to hypoxia(i.e. hypoxic preconditioning) was developed and its corresponding animal models were reproduced in 1966s. The methods of model reproduction in rat,rabbit,and mouse in particular and the main results are brifly introduced in this review. The tolerance to hypoxia of preconditioned animals is significantly increased. Regular changes in animals’ behavior,neurophysiology,respiratory and circulatory physiology,neuromorphology in vivo and function of brain and spinal cord in vitro are briefly demonstrated.The protective effects in vivo and in vitro of homogenate extract taken from the brain of preconditioned animals,neurochemcals and molecular neurobiological alterations are briefly presented. The essence and significance of tissue adaption to hypoxia/hypoxic preconditioning are discussed in the review in terms of evolution and practical implication.
文摘本工作用细胞内记录技术,研究并分析了蟾蜍离体脊神经节神经元对重复刺激其外周突(坐骨神经)的反应。所记录的66个神经元的传导速度,刺激阈值和静息膜电位分別为5.3—20.0m/s,0.02—0.10mA 和-50—-80mV。随着重复刺激频率的增加,脊神经节神经元的细胞内动作电位进行性地出现潜伏期动摇或延迟、振幅降低、后超极化减弱和时程延长。与此同时,锋电位分解成 S、NM 和 M 三种亚波成分,并进而出现脱失。S、NM 和 M 成分对刺激频率的跟随能力为 S<NM<M,锋电位或 S 波出现脱失的频率范围为16.7—250Hz。结果提示,蟾蜍脊神经节 A 型神经元具有三个兴奋性显著有别的区域;部分 A 型神经元可能具有突触或接头性活动。
文摘An inner abilitv of organism to protect itself can be triggered or motivated by pretreatment of brief intermittent ischemia or repetitive slight hypoxia and a POwerful defence and protection from severe injury of successive ischemia or hypoxia can thus be achieved, The neuroprotective action exerted by preconditioning seems to be re1ated to up/down regulation of contents or activity of some known neuroactive chemicals and/or generation of some unknown antihypoxic/ischemic neuroactive chemicals or mechanisms in the brain.
