Preparation and Characterization of an Intelligent Multitarget Tracking HA-RGD-CLB-QDs Drug Delivery System

This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGDchlorambucil-quantum dots（HA-RGD-CLB-QDs） drug delivery system. After deacetylated, hyaluronic acid was reacted with anticancer drug chlorambucil, RGD, and quantum dots to obtain the HA-RGD-CLB-QDs drug delivery system. The characterization by FT-IR, ~1 H NMR, TEM, XPS, DLS, and UV-vis absorption and fluorescence spectra show that the system is successfully constructed with an average particle size of about 70 nm. The results of the drug release profile show that that the system has a p H and enzyme sensitive controlled release behaviour. Moreover, cellular uptake and toxicity results show that the system has an ideal dual receptormediated endocytosis pathway that significantly enhances the efficacy of CLB tumor therapy and has a lower toxicity to normal cells.The system shows the potential application as a carrier for cancer therapy.

冷水七皂苷提取工艺研究

土家族药冷水七（Impatiens pritzellii Hook.f.var.hupehensis Hook.f.）为凤仙花科凤仙花属植物,是鄂西土家族常用民族药,药用部位为冷水七根茎,其性味辛、甘、凉,毒性小,具有祛风除湿,散瘀消肿、镇痛止血,清热解毒之功效。用于风湿疼痛、四肢麻木、关节肿大、急性脘腹疼痛、食积腹胀泄泻、月经不调、经来腹痛、肠炎痢疾等症[1-3]。