For the first time,a group-Ⅵsingle element nanomaterial was used as the optical saturable absorber(SA)to generate laser pulses.With two-dimensional(2D)tellurene as a passive Q-switch,1.06μm and 1.3μm pulse laser op...For the first time,a group-Ⅵsingle element nanomaterial was used as the optical saturable absorber(SA)to generate laser pulses.With two-dimensional(2D)tellurene as a passive Q-switch,1.06μm and 1.3μm pulse laser operations were realized from a diode-pumped Nd:YAG crystal.The shortest pulse widths were 98 ns and 178 ns,and the highest peak powers were 2.68 W and 2.45 W,respectively.Our research determines that tellurene is an excellent SA material in the near-infrared region.展开更多
文摘目的:阐明病理性周期性张应力诱导人牙周膜细胞凋亡的分子机制。方法:人牙周膜细胞取自健康前磨牙,经过3?5代传代,细胞受到20%牵张力,时间为6 h或24 h,通过用膜联蛋白异硫氰酸荧光素(V-FITC)和碘化丙啶(PI)结合流式细胞仪检测细胞凋亡,用Western Blot法研究caspase-3,cleaved caspase-3,116 kDa PARP-1和85 k Da PARP-1蛋白的表达变化。结果:人PDL细胞受到病理性周期性张应力时存在凋亡,并以一种时间依赖的方式增加。受到病理性周期性张应力后裂解的caspase-3和PARP蛋白随着时间增加,然而抑制caspase-3的活性却可以抑制细胞的凋亡,但并不能抑制由其他通路导致的凋亡。结论:病理性周期性张应力通过caspase-3/PARP途径诱导人牙周膜细胞的凋亡。
基金supported by the National Natural Science Foundation of China(No.61975096)Basic Research and Free Exploration Project of Shenzhen City(No.JCYJ20180305164316517)the Natural Science Foundation of Shandong Province(No.ZR2017MF031)。
文摘For the first time,a group-Ⅵsingle element nanomaterial was used as the optical saturable absorber(SA)to generate laser pulses.With two-dimensional(2D)tellurene as a passive Q-switch,1.06μm and 1.3μm pulse laser operations were realized from a diode-pumped Nd:YAG crystal.The shortest pulse widths were 98 ns and 178 ns,and the highest peak powers were 2.68 W and 2.45 W,respectively.Our research determines that tellurene is an excellent SA material in the near-infrared region.
