移植物抗宿主病(GVHD)是异基因造血干细胞移植后的主要并发症,主要源于移植物中的免疫活性细胞(特别是T淋巴细胞)对宿主组织发动免疫攻击所引起,是导致移植后复发及死亡的主要原因之一。因此,早期预测及识别GVHD,可以更好地提供干预措施...移植物抗宿主病(GVHD)是异基因造血干细胞移植后的主要并发症,主要源于移植物中的免疫活性细胞(特别是T淋巴细胞)对宿主组织发动免疫攻击所引起,是导致移植后复发及死亡的主要原因之一。因此,早期预测及识别GVHD,可以更好地提供干预措施,有助于提高患者的生存率并改善预后。本文主要探讨T淋巴细胞亚群中的CD4+ T细胞、CD8+ T细胞以及NK细胞在GVHD免疫方面中的意义及相关性。Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation, which is mainly caused by the immune attack of the grafted cells (especially T lymphocytes) on the host tissue, and is one of the main causes of recurrence and death after transplantation. Therefore, early prediction and identification of GVHD can provide better interventions to improve patient survival and prognosis. This paper mainly discusses the significance and correlation of CD4+ T cells, CD8+ T cells and NK cells in T lymphocyte subsets in GVHD immunity.展开更多
文摘移植物抗宿主病(GVHD)是异基因造血干细胞移植后的主要并发症,主要源于移植物中的免疫活性细胞(特别是T淋巴细胞)对宿主组织发动免疫攻击所引起,是导致移植后复发及死亡的主要原因之一。因此,早期预测及识别GVHD,可以更好地提供干预措施,有助于提高患者的生存率并改善预后。本文主要探讨T淋巴细胞亚群中的CD4+ T细胞、CD8+ T细胞以及NK细胞在GVHD免疫方面中的意义及相关性。Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation, which is mainly caused by the immune attack of the grafted cells (especially T lymphocytes) on the host tissue, and is one of the main causes of recurrence and death after transplantation. Therefore, early prediction and identification of GVHD can provide better interventions to improve patient survival and prognosis. This paper mainly discusses the significance and correlation of CD4+ T cells, CD8+ T cells and NK cells in T lymphocyte subsets in GVHD immunity.
