It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd203/CuS hybrid nanodo...It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd203/CuS hybrid nanodots (NDs) has been developed for multimodal imaging guided photothermal tumor ablation. Gd2O3/CuS NDs are found to possess particle size of 4.4 ± 1.1nm, enhanced longitudinal relaxivity, effective photothermal conversion of 45.5%, as well as remarkable near-infrared fluorescence (NIRF) from Cy7.5-conjugated on albumin corona. The Gd203/CuS NDs further exhibited good photostability, en- hanced cellular uptake, and preferable tumor accumulation. Thus, the Gd203/CuS NDs generate remarkable NIRF imag- ing and Tl-weighted magnetic resonance (MR) imaging, and simultaneously result in effective photothermal tumor ab- lation upon irradiation. The albumin nanoreactor provides a facile and general strategy to synthesize multifunctional nanoparticles for cancer theranostics.展开更多
基金financially supported by the National Natural Science Foundation of China (31422021, 51473109, and 81501585)National Basic Research Program of China (2014CB931900)+5 种基金Natural Science Foundation of Jiangsu Province of China (BK20150348)Natural Science Foundation of the Jiangsu Higher Education Institutions of China (15KJB310019)China Postdoctoral Science Foundation (2015M570475 and 2016T90496)Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-PsychoDiseases, Open Fund of CAS Key Laboratory of Nano-Bio Interface (16NBI02)Jiangsu Undergraduates Innovation and Entrepreneurship Program (20150285075Y)
文摘It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd203/CuS hybrid nanodots (NDs) has been developed for multimodal imaging guided photothermal tumor ablation. Gd2O3/CuS NDs are found to possess particle size of 4.4 ± 1.1nm, enhanced longitudinal relaxivity, effective photothermal conversion of 45.5%, as well as remarkable near-infrared fluorescence (NIRF) from Cy7.5-conjugated on albumin corona. The Gd203/CuS NDs further exhibited good photostability, en- hanced cellular uptake, and preferable tumor accumulation. Thus, the Gd203/CuS NDs generate remarkable NIRF imag- ing and Tl-weighted magnetic resonance (MR) imaging, and simultaneously result in effective photothermal tumor ab- lation upon irradiation. The albumin nanoreactor provides a facile and general strategy to synthesize multifunctional nanoparticles for cancer theranostics.