目的:通过分析3种中药注射液文献报道的个案不良事件(adverse drug events,ADE)的规律及特点,探究其发生的影响因素,为临床合理用药提供有价值的参考。方法:本文采用文献计量学方法,对CNKI数据库收录近15年的文献进行分类统计分析。结果...目的:通过分析3种中药注射液文献报道的个案不良事件(adverse drug events,ADE)的规律及特点,探究其发生的影响因素,为临床合理用药提供有价值的参考。方法:本文采用文献计量学方法,对CNKI数据库收录近15年的文献进行分类统计分析。结果:喜炎平(65.00%)和热毒宁(75.86%)14岁以下患者构成比较高;原患疾病主要为呼吸系统疾病;损伤系统主要为皮肤及其附件,其次为全身;不良事件大部分发生在用药开始后30min内;联合用药以抗微生物药物为主。结论:不良事件的发生和药物本身因素、患者自身情况等相关,建议临床医生合理用药,降低药物使用风险。展开更多
Andrographolide total ester sulfonate(ATES) injection is one of the products of traditional Chinese medicine(TCM) currently used against viral infection in China.ATES injection was approved for manufacturing and marke...Andrographolide total ester sulfonate(ATES) injection is one of the products of traditional Chinese medicine(TCM) currently used against viral infection in China.ATES injection was approved for manufacturing and marketing in January 2002.It is indicated for acute respiratory infections,tonsillitis,chronic obstructive pulmonary disease,influenza,foot and mouth disease,bronchiolitis,herpangina,mumps,infectious mononucleosis and psychosis.However,its usage also carries risk.We investigated the use of ATES at the Wuhan Union Hospital from January 2014 to December 2014 and evaluated its real-world clinical application using the hospital centralized monitoring method.A total of 848 cases were enrolled in this study.In these cases,it was mainly used for postoperative anti-inflammation and treating upper respiratory infection,pneumonia and bronchitis.Among them,39.86% were contraindicated.Irregular medication of adults and children accounted for 1.91% and 23.38%,respectively.Improper choice of solvent accounted for 3.18%.The choice of intravenous drip versus aerosol inhalation was reasonable.A case of adverse events(AEs) was observed in the monitoring period,and the incidence of adverse drug reaction(ADR) of ATES injection was 0.12%.ATES injection in our hospital is relatively safe with a low incidence of adverse reactions.The study assesses the clinical usage and adverse reactions of ATES injection,and provides suggestions for rational use in clinical practice.展开更多
文摘目的:通过分析3种中药注射液文献报道的个案不良事件(adverse drug events,ADE)的规律及特点,探究其发生的影响因素,为临床合理用药提供有价值的参考。方法:本文采用文献计量学方法,对CNKI数据库收录近15年的文献进行分类统计分析。结果:喜炎平(65.00%)和热毒宁(75.86%)14岁以下患者构成比较高;原患疾病主要为呼吸系统疾病;损伤系统主要为皮肤及其附件,其次为全身;不良事件大部分发生在用药开始后30min内;联合用药以抗微生物药物为主。结论:不良事件的发生和药物本身因素、患者自身情况等相关,建议临床医生合理用药,降低药物使用风险。
基金supported by the Guangdong Pharmacological Society of China(No.2009ZX09502-030)
文摘Andrographolide total ester sulfonate(ATES) injection is one of the products of traditional Chinese medicine(TCM) currently used against viral infection in China.ATES injection was approved for manufacturing and marketing in January 2002.It is indicated for acute respiratory infections,tonsillitis,chronic obstructive pulmonary disease,influenza,foot and mouth disease,bronchiolitis,herpangina,mumps,infectious mononucleosis and psychosis.However,its usage also carries risk.We investigated the use of ATES at the Wuhan Union Hospital from January 2014 to December 2014 and evaluated its real-world clinical application using the hospital centralized monitoring method.A total of 848 cases were enrolled in this study.In these cases,it was mainly used for postoperative anti-inflammation and treating upper respiratory infection,pneumonia and bronchitis.Among them,39.86% were contraindicated.Irregular medication of adults and children accounted for 1.91% and 23.38%,respectively.Improper choice of solvent accounted for 3.18%.The choice of intravenous drip versus aerosol inhalation was reasonable.A case of adverse events(AEs) was observed in the monitoring period,and the incidence of adverse drug reaction(ADR) of ATES injection was 0.12%.ATES injection in our hospital is relatively safe with a low incidence of adverse reactions.The study assesses the clinical usage and adverse reactions of ATES injection,and provides suggestions for rational use in clinical practice.
