Objective Apolipoprotein (apo) A IV genetic polymorphism and its effect on serum lipids, apoA I and apoA IV were investigated in order to clarify the role of apoA IV gene during the development of hyperlipidemia....Objective Apolipoprotein (apo) A IV genetic polymorphism and its effect on serum lipids, apoA I and apoA IV were investigated in order to clarify the role of apoA IV gene during the development of hyperlipidemia. Methods Results In Group Ⅰ, frequencies of the alleles were 0.648 and 0.352 in codon 127; 0.972 and 0.028 in codon 167;0.817 and 0.183 in codon 347. Two common alleles were 0.941 and 0.059 in codon 360. The results indicated that cases of codon 127 heterozygotes had a significantly higher serum TC level and cases of apoA IV Ser127 homozygotes kept a markedly low TG level. Both homozygotes and heterozygotes which carried apoA IV His 360 exhibited a significantly higher concentration of TC in comparing with that of apoA IV Gln 360 homozygotes. The data from Group Ⅱ showed that the allele frequency of His 360 had a significant difference between patients and controls. Conclusions Certain polymorphic sites of apoA IV gene might influence the serum lipid levels in both healthy persons and hyperlipidemic patients. His 360 polymorphic position might have a relationship with the development of hyperlipidemia.展开更多
文摘Objective Apolipoprotein (apo) A IV genetic polymorphism and its effect on serum lipids, apoA I and apoA IV were investigated in order to clarify the role of apoA IV gene during the development of hyperlipidemia. Methods Results In Group Ⅰ, frequencies of the alleles were 0.648 and 0.352 in codon 127; 0.972 and 0.028 in codon 167;0.817 and 0.183 in codon 347. Two common alleles were 0.941 and 0.059 in codon 360. The results indicated that cases of codon 127 heterozygotes had a significantly higher serum TC level and cases of apoA IV Ser127 homozygotes kept a markedly low TG level. Both homozygotes and heterozygotes which carried apoA IV His 360 exhibited a significantly higher concentration of TC in comparing with that of apoA IV Gln 360 homozygotes. The data from Group Ⅱ showed that the allele frequency of His 360 had a significant difference between patients and controls. Conclusions Certain polymorphic sites of apoA IV gene might influence the serum lipid levels in both healthy persons and hyperlipidemic patients. His 360 polymorphic position might have a relationship with the development of hyperlipidemia.
