目的比较动态三维超声造影(D-3D-CEUS)与增强CT(CECT)诊断肝细胞癌及评价微波消融后疗效的价值。方法选取我院行微波消融治疗的肝细胞癌患者80例,均行D-3D-CEUS和CECT检查,比较两种方法对肝细胞癌的诊断情况、动脉期肿瘤内部显示、肿瘤...目的比较动态三维超声造影(D-3D-CEUS)与增强CT(CECT)诊断肝细胞癌及评价微波消融后疗效的价值。方法选取我院行微波消融治疗的肝细胞癌患者80例,均行D-3D-CEUS和CECT检查,比较两种方法对肝细胞癌的诊断情况、动脉期肿瘤内部显示、肿瘤供血血管情况及肿瘤边界情况。所有患者随访1年,以临床随访的最终诊断结果为标准,应用D-3D-CEUS和CECT评价肝细胞癌微波消融后的疗效。结果80例患者均经D-3D-CEUS诊断为肝细胞癌,其中直径<3 cm 55例,直径≥3 cm 25例,肿瘤内部坏死21例;80例患者均经CECT诊断为肝细胞癌,其中直径<3 cm 53例,直径≥3 cm 27例,肿瘤内部坏死22例;两种方法测量肝细胞癌直径及内部坏死诊断比较差异均无统计学意义。D-3D-CEUS显示肝细胞癌肿瘤供血血管清晰度优于CECT,CECT显示肿瘤边界清晰度优于D-3D-CEUS,差异均有统计学意义(均P<0.05);两种方法显示动脉期肿瘤内部情况比较差异无统计学意义。随访1年后,80例患者最终诊断为局部残留11例,消融完全69例;D-3D-CEUS疗效评价准确率为91.25%(73/80),CECT疗效评价准确率为90.00%(72/80),差异无统计学意义。结论D-3D-CEUS显示肝细胞癌肿瘤供血血管清晰度优于CECT,CECT显示肿瘤边界清晰度优于D-3D-CEUS,两者对肝细胞癌微波消融后疗效评价均有较好价值。展开更多
Objective: To study the effect of Xiongshao Capsule (芎芍胶囊, XSC), a TCM herb that can promote blood circulation to remove blood stasis, on the endothelial dependent relaxation function, serum nitric oxide (NO), and...Objective: To study the effect of Xiongshao Capsule (芎芍胶囊, XSC), a TCM herb that can promote blood circulation to remove blood stasis, on the endothelial dependent relaxation function, serum nitric oxide (NO), and plasma endothelin-KET-1) of the patients with cervical atherosclerosis. Methods: Forty patients were randomly divided into two groups; XSC group and Probucol group (western medicine control). In addition, 20 healthy people were set as a normal control group. Plasma ET-1, serum NO, the internal diameter of basal brachial artery, endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results; Compared to the healthy control group, FMD of patients with atherosclerosis was damaged obviously, the serum NO level decreased, plasma ET-1 increased (P< 0. 01), NID also decreased (P<0. 05), the internal diameter of basal brachial artery has no obvious difference (P>0. 05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks, FMD increased evidently, plasma ET-1 decreased, serum NO and the ratio of NO/ET-1 increased, compared with the level before therapy and Probucol group, the difference was significant (P<0.05, P<0.01), NID didn't change obviously (P>0.05). Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.展开更多
文摘目的比较动态三维超声造影(D-3D-CEUS)与增强CT(CECT)诊断肝细胞癌及评价微波消融后疗效的价值。方法选取我院行微波消融治疗的肝细胞癌患者80例,均行D-3D-CEUS和CECT检查,比较两种方法对肝细胞癌的诊断情况、动脉期肿瘤内部显示、肿瘤供血血管情况及肿瘤边界情况。所有患者随访1年,以临床随访的最终诊断结果为标准,应用D-3D-CEUS和CECT评价肝细胞癌微波消融后的疗效。结果80例患者均经D-3D-CEUS诊断为肝细胞癌,其中直径<3 cm 55例,直径≥3 cm 25例,肿瘤内部坏死21例;80例患者均经CECT诊断为肝细胞癌,其中直径<3 cm 53例,直径≥3 cm 27例,肿瘤内部坏死22例;两种方法测量肝细胞癌直径及内部坏死诊断比较差异均无统计学意义。D-3D-CEUS显示肝细胞癌肿瘤供血血管清晰度优于CECT,CECT显示肿瘤边界清晰度优于D-3D-CEUS,差异均有统计学意义(均P<0.05);两种方法显示动脉期肿瘤内部情况比较差异无统计学意义。随访1年后,80例患者最终诊断为局部残留11例,消融完全69例;D-3D-CEUS疗效评价准确率为91.25%(73/80),CECT疗效评价准确率为90.00%(72/80),差异无统计学意义。结论D-3D-CEUS显示肝细胞癌肿瘤供血血管清晰度优于CECT,CECT显示肿瘤边界清晰度优于D-3D-CEUS,两者对肝细胞癌微波消融后疗效评价均有较好价值。
文摘Objective: To study the effect of Xiongshao Capsule (芎芍胶囊, XSC), a TCM herb that can promote blood circulation to remove blood stasis, on the endothelial dependent relaxation function, serum nitric oxide (NO), and plasma endothelin-KET-1) of the patients with cervical atherosclerosis. Methods: Forty patients were randomly divided into two groups; XSC group and Probucol group (western medicine control). In addition, 20 healthy people were set as a normal control group. Plasma ET-1, serum NO, the internal diameter of basal brachial artery, endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results; Compared to the healthy control group, FMD of patients with atherosclerosis was damaged obviously, the serum NO level decreased, plasma ET-1 increased (P< 0. 01), NID also decreased (P<0. 05), the internal diameter of basal brachial artery has no obvious difference (P>0. 05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks, FMD increased evidently, plasma ET-1 decreased, serum NO and the ratio of NO/ET-1 increased, compared with the level before therapy and Probucol group, the difference was significant (P<0.05, P<0.01), NID didn't change obviously (P>0.05). Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.
