目的探究限制性液体复苏对脓毒症休克患者的治疗效果。方法计算检索Pubmed、Cochrane Library、Embase、Web of science、中国知网及维普和万方的数据库,搜集有关限制性液体复苏对脓毒症休克患者治疗效果和预后的影响的随机对照试验(RC...目的探究限制性液体复苏对脓毒症休克患者的治疗效果。方法计算检索Pubmed、Cochrane Library、Embase、Web of science、中国知网及维普和万方的数据库,搜集有关限制性液体复苏对脓毒症休克患者治疗效果和预后的影响的随机对照试验(RCT),检索时限均为建库至2020年9月30日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果本文共纳入7个RCT,614例患者。Meta分析结果显示,限制液体复苏组和常规足量液体复苏组相比病死率降低,(OR=0.65,95%CI=0.43~0.98,P<0.05),重症监护病房(ICU)住院时间(LoS)同样降低,差异有统计学意义[平均差异(MD)=-3.28,95%CI=-4.08~2.49,P<0.05],但急性肾损伤发生率差异无明显统计学意义(OR=0.69,95%CI=0.53~2.26,P>0.05)。结论对于脓毒症休克患者与常规足量液体复苏相比,限制性液体复苏的病死率和ICU住院时间都降低,但是虽然液体输入总量减少,急性肾损伤的副作用不良反应却没有改善。总体而言限制性液体复苏,在治疗效果和经济角度都优于常规足量液体复苏,可以根据病情适当选用。展开更多
Metal oxide hollow structures are of great inter- est in many current and emerging areas of technology. This paper presents a facile and controlled protocol for the syn- thesis of Al-doped CeO2 hollow-shell spheres （...Metal oxide hollow structures are of great inter- est in many current and emerging areas of technology. This paper presents a facile and controlled protocol for the syn- thesis of Al-doped CeO2 hollow-shell spheres （CHS）, where the dopant confers enhanced stability and activity to the ma- terial. These Al-doped CeO2 hollow-shell spheres （ACHS） possess a controllable shell number of up to three, where the sizes of the exterior, middle, and interior spheres were about 250-100 nm,150-50 nm, and 40-10 nm, respectively, and the average shell thickness was -15 nm. The thermal stability of the ACHS structure was enhanced by the homogeneous in- corporation of AI atoms, and more active oxygen species were present compared with those in the non-doped congener. Au NPs supported on ACHS （Au/ACHS） showed superior cat- alytic performance for the reduction of p-nitrophenol. For the same Au NP content, the reaction rate constant （k） of the Au/ACHS was nearly twice that of the non-doped Au/CHS, indicating that AI doping is promising for improving the per- formance of inert or unstable oxides as catalyst supports.展开更多
文摘目的探究限制性液体复苏对脓毒症休克患者的治疗效果。方法计算检索Pubmed、Cochrane Library、Embase、Web of science、中国知网及维普和万方的数据库,搜集有关限制性液体复苏对脓毒症休克患者治疗效果和预后的影响的随机对照试验(RCT),检索时限均为建库至2020年9月30日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果本文共纳入7个RCT,614例患者。Meta分析结果显示,限制液体复苏组和常规足量液体复苏组相比病死率降低,(OR=0.65,95%CI=0.43~0.98,P<0.05),重症监护病房(ICU)住院时间(LoS)同样降低,差异有统计学意义[平均差异(MD)=-3.28,95%CI=-4.08~2.49,P<0.05],但急性肾损伤发生率差异无明显统计学意义(OR=0.69,95%CI=0.53~2.26,P>0.05)。结论对于脓毒症休克患者与常规足量液体复苏相比,限制性液体复苏的病死率和ICU住院时间都降低,但是虽然液体输入总量减少,急性肾损伤的副作用不良反应却没有改善。总体而言限制性液体复苏,在治疗效果和经济角度都优于常规足量液体复苏,可以根据病情适当选用。
基金financially supported by the National Natural Science Foundation of China (51472025 and 21671016)Beijing Nova Programme Interdisciplinary Cooperation Project
文摘Metal oxide hollow structures are of great inter- est in many current and emerging areas of technology. This paper presents a facile and controlled protocol for the syn- thesis of Al-doped CeO2 hollow-shell spheres （CHS）, where the dopant confers enhanced stability and activity to the ma- terial. These Al-doped CeO2 hollow-shell spheres （ACHS） possess a controllable shell number of up to three, where the sizes of the exterior, middle, and interior spheres were about 250-100 nm,150-50 nm, and 40-10 nm, respectively, and the average shell thickness was -15 nm. The thermal stability of the ACHS structure was enhanced by the homogeneous in- corporation of AI atoms, and more active oxygen species were present compared with those in the non-doped congener. Au NPs supported on ACHS （Au/ACHS） showed superior cat- alytic performance for the reduction of p-nitrophenol. For the same Au NP content, the reaction rate constant （k） of the Au/ACHS was nearly twice that of the non-doped Au/CHS, indicating that AI doping is promising for improving the per- formance of inert or unstable oxides as catalyst supports.
