Great attention has been paid to the synthesis and structural analysis of 1, 3-anhydro-pyranose derivatives since B. Samuelsson reported the structure and strong biological activities of Thromboxane A<sub>2</...Great attention has been paid to the synthesis and structural analysis of 1, 3-anhydro-pyranose derivatives since B. Samuelsson reported the structure and strong biological activities of Thromboxane A<sub>2</sub>（TXA<sub>2</sub>） for platelet aggregation, vasoconstriction and contraction of smooth muscle in 1975. The nucleus of 2, 6-dioxabicyclo [3,1,1] heptane has been considered to play an important role in the strong bioactiv ities of TXA<sub>2</sub>. It is difficult to investigate the molecular structure of TXA<sub>2</sub>展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘Great attention has been paid to the synthesis and structural analysis of 1, 3-anhydro-pyranose derivatives since B. Samuelsson reported the structure and strong biological activities of Thromboxane A<sub>2</sub>（TXA<sub>2</sub>） for platelet aggregation, vasoconstriction and contraction of smooth muscle in 1975. The nucleus of 2, 6-dioxabicyclo [3,1,1] heptane has been considered to play an important role in the strong bioactiv ities of TXA<sub>2</sub>. It is difficult to investigate the molecular structure of TXA<sub>2</sub>
